GREMLIN Database
TYPA - GTP-binding protein TypA/BipA
UniProt: P32132 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11837
Length: 607 (464)
Sequences: 8308 (3617)
Seq/√Len: 167.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
268_A274_V5.8881.00
136_R139_W3.9761.00
232_K267_L3.9021.00
442_V470_S3.8121.00
206_Q228_R3.6251.00
126_V165_A3.5411.00
163_V189_A3.4661.00
165_A186_L3.3471.00
230_K267_L3.1221.00
402_N470_S3.1081.00
392_I397_Q2.9691.00
442_V473_D2.9371.00
419_L424_G2.8481.00
102_F132_R2.8371.00
235_Q290_D2.7781.00
402_N440_D2.7711.00
402_N468_T2.7681.00
200_D203_G2.7281.00
374_R379_E2.5861.00
189_A193_H2.5821.00
400_Y473_D2.5181.00
407_V415_V2.4991.00
418_A451_F2.4431.00
277_T280_G2.3791.00
425_D473_D2.3641.00
390_R397_Q2.3171.00
142_D146_D2.3131.00
28_Q184_T2.2981.00
427_K442_V2.2831.00
141_V162_I2.2761.00
253_K264_E2.2221.00
442_V471_H2.2131.00
188_Q192_D2.1981.00
407_V463_G2.1141.00
8_I70_I2.0951.00
428_N440_D2.0721.00
230_K269_E2.0411.00
459_T463_G2.0331.00
213_D223_I2.0141.00
126_V167_A1.9971.00
203_G228_R1.9971.00
304_E346_R1.9431.00
64_K67_D1.9281.00
220_V340_V1.9241.00
236_Q248_N1.9131.00
256_G265_T1.9121.00
455_F463_G1.9081.00
418_A458_M1.9041.00
32_F42_V1.9021.00
308_S359_S1.9011.00
265_T268_A1.8871.00
205_F237_V1.8781.00
232_K235_Q1.8771.00
403_V465_L1.8721.00
314_N379_E1.8671.00
334_R373_M1.8641.00
43_M61_T1.8621.00
233_P266_D1.8561.00
24_K27_Q1.8441.00
409_E437_V1.8341.00
226_I268_A1.8261.00
431_P437_V1.8231.00
94_S194_V1.8201.00
139_W143_Q1.7921.00
224_G276_I1.7921.00
348_E359_S1.7681.00
4_K68_Y1.7641.00
68_Y191_V1.7581.00
99_V109_T1.7441.00
100_D103_D1.7321.00
65_W188_Q1.7221.00
130_V171_I1.7211.00
268_A272_D1.7111.00
481_G485_N1.7001.00
412_Q437_V1.6961.00
10_I22_V1.6941.00
209_I222_G1.6921.00
22_V72_I1.6801.00
394_G474_D1.6761.00
402_N442_V1.6731.00
350_T353_A1.6661.00
222_G282_L1.6481.00
73_V92_V1.6401.00
425_D442_V1.6221.00
110_R462_T1.6151.00
345_L369_L1.5991.00
141_V164_Y1.5981.00
404_T440_D1.5971.00
247_R281_E1.5571.00
405_L419_L1.5491.00
339_L345_L1.5481.00
345_L358_V1.5441.00
152_D155_D1.5351.00
249_A252_G1.5351.00
48_L56_I1.5291.00
221_I275_A1.5281.00
415_V459_T1.5231.00
424_G443_I1.5161.00
265_T274_V1.5011.00
314_N381_A1.4751.00
403_V448_L1.4701.00
269_E272_D1.4581.00
406_D438_R1.4571.00
201_L270_A1.4551.00
7_N71_N1.4541.00
332_L349_E1.4501.00
11_I97_L1.4491.00
371_E375_R1.4431.00
237_V251_V1.4421.00
28_Q183_M1.4421.00
224_G274_V1.4321.00
480_V484_Q1.4281.00
228_R295_E1.4271.00
389_F446_R1.4211.00
62_A69_R1.4201.00
332_L336_N1.4141.00
21_L98_V1.4081.00
475_V483_R1.3991.00
454_E458_M1.3981.00
32_F35_R1.3951.00
140_V143_Q1.3931.00
101_A127_I1.3901.00
25_L63_I1.3851.00
308_S357_R1.3801.00
33_D37_E1.3761.00
312_C381_A1.3691.00
404_T438_R1.3681.00
290_D293_N1.3631.00
240_I289_C1.3621.00
417_Q421_E1.3611.00
248_N252_G1.3581.00
475_V479_E1.3581.00
66_N188_Q1.3551.00
408_E462_T1.3501.00
25_L183_M1.3491.00
226_I274_V1.3461.00
29_S63_I1.3351.00
370_I382_V1.3351.00
327_T330_Q1.3351.00
96_L126_V1.3271.00
238_T248_N1.3241.00
128_N167_A1.3211.00
9_A92_V1.3181.00
21_L186_L1.3171.00
469_F472_Y1.3141.00
403_V443_I1.3111.00
205_F226_I1.3071.00
125_V144_V1.3051.00
201_L230_K1.2931.00
11_I95_V1.2881.00
95_V121_L1.2841.00
231_V251_V1.2831.00
184_T188_Q1.2821.00
64_K69_R1.2771.00
136_R140_V1.2731.00
201_L269_E1.2661.00
46_N57_L1.2621.00
418_A454_E1.2611.00
101_A130_V1.2581.00
482_Q486_G1.2441.00
348_E357_R1.2331.00
470_S473_D1.2301.00
112_V115_K1.2251.00
405_L415_V1.2181.00
419_L443_I1.2151.00
6_R197_P1.2041.00
421_E454_E1.2011.00
63_I72_I1.1951.00
58_A73_V1.1931.00
83_G344_A1.1881.00
392_I395_R1.1861.00
238_T243_E1.1821.00
207_M224_G1.1751.00
51_E375_R1.1661.00
47_D375_R1.1631.00
363_E450_G1.1631.00
124_I194_V1.1601.00
430_N440_D1.1501.00
402_N427_K1.1491.00
400_Y476_R1.1481.00
206_Q297_L1.1441.00
409_E434_K1.1391.00
252_G256_G1.1381.00
4_K67_D1.1381.00
31_T63_I1.1381.00
199_V228_R1.1251.00
156_E162_I1.1221.00
416_M439_L1.1151.00
26_L42_V1.1151.00
45_S59_K1.1141.00
336_N349_E1.1111.00
94_S195_P1.1101.00
389_F396_K1.1091.00
28_Q170_G1.1091.00
238_T294_V1.1061.00
268_A275_A1.1031.00
127_I141_V1.1001.00
118_A301_S1.0921.00
48_L368_V1.0871.00
239_I282_L1.0871.00
48_L372_N1.0831.00
22_V43_M1.0801.00
182_D185_P1.0761.00
289_C294_V1.0650.99
403_V467_S1.0650.99
137_P140_V1.0620.99
205_F231_V1.0580.99
331_I378_F1.0540.99
9_A89_M1.0440.99
405_L455_F1.0410.99
477_P481_G1.0380.99
47_D51_E1.0370.99
429_M437_V1.0360.99
401_E445_S1.0350.99
238_T291_T1.0350.99
242_S283_N1.0320.99
401_E448_L1.0310.99
8_I190_I1.0290.99
43_M55_T1.0270.99
241_D286_D1.0230.99
412_Q429_M1.0210.99
142_D145_F1.0200.99
161_P193_H1.0200.99
205_F230_K1.0190.99
29_S187_Y1.0180.99
26_L31_T1.0170.99
389_F472_Y1.0150.99
358_V369_L1.0020.99
138_D142_D0.9990.99
47_D50_K0.9970.99
43_M59_K0.9930.99
32_F38_T0.9930.99
127_I164_Y0.9910.99
113_T117_F0.9900.99
39_Q50_K0.9890.99
414_S458_M0.9890.99
400_Y471_H0.9870.99
127_I137_P0.9830.99
403_V419_L0.9820.99
153_A156_E0.9780.99
400_Y470_S0.9760.99
12_A16_H0.9740.99
451_F458_M0.9740.99
309_M382_V0.9720.99
233_P252_G0.9710.99
100_D132_R0.9700.99
233_P264_E0.9700.99
5_L272_D0.9690.99
109_T125_V0.9680.99
63_I70_I0.9670.99
102_F134_G0.9660.99
232_K266_D0.9640.99
69_R272_D0.9640.99
391_E394_G0.9580.99
410_Q460_S0.9570.99
417_Q420_G0.9550.99
412_Q439_L0.9550.99
279_L282_L0.9540.99
186_L190_I0.9540.99
200_D204_P0.9540.99
202_D230_K0.9540.99
27_Q34_S0.9530.99
204_P293_N0.9480.99
237_V288_V0.9470.99
272_D275_A0.9430.99
105_P148_F0.9420.99
152_D156_E0.9390.99
11_I89_M0.9370.99
426_L429_M0.9370.99
247_R253_K0.9350.99
97_L112_V0.9270.99
283_N302_V0.9250.99
116_A123_P0.9240.99
38_T42_V0.9120.98
249_A253_K0.9100.98
38_T41_R0.9100.98
239_I288_V0.9080.98
233_P254_V0.9080.98
5_L69_R0.9030.98
137_P164_Y0.9010.98
479_E482_Q0.9010.98
256_G272_D0.9000.98
204_P290_D0.8990.98
90_S227_K0.8980.98
236_Q291_T0.8980.98
236_Q250_K0.8950.98
100_D140_V0.8930.98
209_I282_L0.8920.98
327_T379_E0.8920.98
21_L167_A0.8910.98
339_L347_V0.8870.98
258_L263_I0.8870.98
114_K436_R0.8870.98
397_Q474_D0.8860.98
403_V441_Y0.8850.98
169_N183_M0.8830.98
398_E423_K0.8780.98
304_E466_Y0.8750.98
249_A282_L0.8710.98
124_I189_A0.8670.98
254_V276_I0.8620.98
249_A279_L0.8620.98
182_D186_L0.8610.98
342_N365_H0.8560.98
97_L125_V0.8550.98
248_N253_K0.8540.98
416_M426_L0.8540.98
265_T272_D0.8530.98
69_R256_G0.8510.98
126_V186_L0.8500.98
393_D397_Q0.8500.98
207_M276_I0.8470.97
39_Q42_V0.8460.97
124_I163_V0.8420.97
415_V455_F0.8400.97
207_M226_I0.8380.97
240_I296_A0.8370.97
370_I374_R0.8290.97
35_R170_G0.8270.97
247_R252_G0.8240.97
25_L29_S0.8210.97
401_E467_S0.8190.97
389_F475_V0.8190.97
400_Y442_V0.8170.97
32_F36_A0.8160.97
165_A182_D0.8150.97
286_D299_A0.8140.97
48_L52_R0.8140.97
420_G441_Y0.8130.97
93_D225_R0.8130.97
423_K447_G0.8090.97
329_R333_D0.8070.97
231_V276_I0.8070.97
10_I96_L0.8060.97
15_D54_I0.8060.97
484_Q487_V0.8050.97
171_I183_M0.8040.97
117_F123_P0.8020.96
324_K327_T0.7990.96
89_M119_Y0.7990.96
260_L268_A0.7970.96
312_C355_A0.7960.96
153_A161_P0.7960.96
310_F355_A0.7940.96
430_N438_R0.7930.96
96_L186_L0.7920.96
451_F463_G0.7900.96
256_G260_L0.7890.96
255_L264_E0.7860.96
206_Q295_E0.7860.96
256_G268_A0.7830.96
12_A15_D0.7820.96
257_H260_L0.7810.96
48_L371_E0.7800.96
143_Q147_L0.7800.96
19_T22_V0.7790.96
347_V356_F0.7790.96
407_V439_L0.7780.96
422_R454_E0.7770.96
155_D161_P0.7770.96
455_F459_T0.7760.96
171_I182_D0.7730.96
415_V458_M0.7720.96
224_G231_V0.7720.96
432_D436_R0.7710.96
20_T167_A0.7660.95
21_L183_M0.7660.95
27_Q38_T0.7650.95
363_E453_S0.7640.95
450_G454_E0.7640.95
98_V167_A0.7640.95
165_A169_N0.7620.95
54_I364_L0.7620.95
99_V144_V0.7610.95
103_D132_R0.7610.95
254_V258_L0.7610.95
338_E373_M0.7600.95
226_I231_V0.7600.95
98_V128_N0.7590.95
117_F148_F0.7580.95
411_H460_S0.7550.95
66_N184_T0.7550.95
131_D166_S0.7540.95
101_A135_A0.7540.95
239_I249_A0.7540.95
231_V235_Q0.7540.95
137_P141_V0.7500.95
12_A55_T0.7490.95
33_D36_A0.7470.95
100_D129_K0.7460.95
29_S65_W0.7460.95
25_L187_Y0.7460.95
409_E431_P0.7430.95
419_L441_Y0.7400.95
336_N347_V0.7400.95
443_I448_L0.7390.94
336_N339_L0.7380.94
70_I191_V0.7380.94
143_Q146_D0.7360.94
99_V125_V0.7360.94
51_E371_E0.7350.94
268_A273_I0.7340.94
26_L61_T0.7310.94
221_I277_T0.7300.94
331_I373_M0.7300.94
334_R338_E0.7280.94
62_A71_N0.7270.94
253_K277_T0.7270.94
24_K183_M0.7270.94
119_Y227_K0.7260.94
135_A140_V0.7240.94
311_F358_V0.7240.94
212_L222_G0.7220.94
91_M210_S0.7220.94
125_V160_F0.7220.94
325_F330_Q0.7220.94
8_I22_V0.7210.94
144_V162_I0.7210.94
66_N191_V0.7180.94
214_Y340_V0.7170.94
344_A369_L0.7150.93
54_I78_H0.7120.93
146_D434_K0.7110.93
138_D164_Y0.7100.93
189_A192_D0.7080.93
233_P253_K0.7070.93
155_D162_I0.7060.93
384_R450_G0.7050.93
262_R275_A0.7040.93
97_L109_T0.7030.93
36_A261_E0.6990.93
373_M380_L0.6990.93
61_T258_L0.6990.93
42_V261_E0.6970.93
100_D143_Q0.6960.93
249_A256_G0.6950.92
330_Q334_R0.6950.92
310_F383_S0.6950.92
400_Y475_V0.6950.92
205_F288_V0.6940.92
432_D438_R0.6910.92
58_A213_D0.6900.92
196_A199_V0.6900.92
367_S370_I0.6900.92
256_G274_V0.6890.92
206_Q227_K0.6890.92
5_L71_N0.6860.92
30_G33_D0.6860.92
350_T355_A0.6860.92
483_R487_V0.6850.92
190_I194_V0.6830.92
397_Q472_Y0.6820.92
25_L28_Q0.6810.92
203_G295_E0.6810.92
221_I262_R0.6800.92
448_L465_L0.6780.92
252_G257_H0.6780.92
313_V324_K0.6770.91
426_L441_Y0.6770.91
29_S64_K0.6750.91
355_A383_S0.6750.91
479_E483_R0.6720.91
309_M358_V0.6710.91
416_M420_G0.6690.91
401_E443_I0.6690.91
234_N252_G0.6670.91
213_D426_L0.6670.91
86_E118_A0.6660.91
75_T85_V0.6640.91
427_K440_D0.6630.91
220_V282_L0.6620.91
199_V203_G0.6620.91
257_H272_D0.6580.90
4_K66_N0.6580.90
122_K156_E0.6560.90
200_D230_K0.6550.90
48_L59_K0.6540.90
79_A111_F0.6540.90
265_T275_A0.6530.90
163_V193_H0.6530.90
339_L358_V0.6520.90
56_I368_V0.6520.90
312_C383_S0.6510.90
52_R367_S0.6510.90
231_V237_V0.6510.90
451_F455_F0.6480.90
9_A190_I0.6400.89
224_G268_A0.6400.89
23_D41_R0.6400.89
263_I266_D0.6390.89
144_V148_F0.6390.89
117_F120_G0.6380.89
41_R50_K0.6340.89
199_V270_A0.6340.89
307_V449_I0.6330.89
357_R386_K0.6320.88
482_Q485_N0.6310.88
289_C293_N0.6310.88
144_V151_L0.6300.88
163_V186_L0.6290.88
102_F139_W0.6290.88
254_V265_T0.6270.88
258_L261_E0.6270.88
371_E374_R0.6270.88
403_V424_G0.6270.88
35_R38_T0.6260.88
411_H462_T0.6250.88
408_E411_H0.6240.88
86_E112_V0.6230.88
260_L274_V0.6220.88
445_S467_S0.6220.88
393_D396_K0.6210.88
50_K260_L0.6210.88
24_K28_Q0.6200.87
78_H87_R0.6200.87
330_Q333_D0.6200.87
90_S300_L0.6190.87
45_S213_D0.6190.87
370_I381_A0.6170.87
487_V492_G0.6170.87
257_H275_A0.6160.87
214_Y337_K0.6160.87
88_V92_V0.6160.87
113_T123_P0.6150.87
420_G429_M0.6140.87
91_M121_L0.6140.87
325_F378_F0.6130.87
37_E40_E0.6130.87
45_S57_L0.6120.87
247_R256_G0.6110.87
485_N488_L0.6100.87
452_R465_L0.6090.87
9_A95_V0.6090.87
248_N291_T0.6080.86
240_I294_V0.6070.86
110_R147_L0.6060.86
98_V183_M0.6040.86
338_E342_N0.6040.86
391_E397_Q0.6020.86
25_L96_L0.6020.86
332_L356_F0.6020.86
480_V483_R0.6010.86
409_E412_Q0.6010.86
241_D247_R0.6000.86
70_I187_Y0.5990.86
249_A254_V0.5970.85
223_I275_A0.5970.85
15_D129_K0.5970.85
226_I269_E0.5960.85
260_L275_A0.5950.85
425_D476_R0.5950.85
26_L32_F0.5920.85
64_K258_L0.5910.85
339_L343_V0.5890.85
411_H414_S0.5890.85
490_S493_Q0.5880.85
112_V116_A0.5870.85
50_K53_G0.5870.85
406_D436_R0.5870.85
14_V54_I0.5870.85
115_K119_Y0.5860.84
253_K265_T0.5850.84
264_E275_A0.5850.84
187_Y191_V0.5850.84
423_K446_R0.5840.84
11_I116_A0.5830.84
96_L190_I0.5810.84
297_L300_L0.5800.84
8_I186_L0.5800.84
70_I190_I0.5790.84
28_Q182_D0.5790.84
208_Q299_A0.5770.83
324_K379_E0.5750.83
86_E115_K0.5740.83
30_G105_P0.5740.83
487_V490_S0.5740.83
427_K470_S0.5730.83
306_T309_M0.5720.83
24_K170_G0.5720.83
46_N372_N0.5710.83
206_Q294_V0.5710.83
207_M274_V0.5700.83
417_Q458_M0.5700.83
163_V182_D0.5690.83
103_D106_M0.5690.83
231_V254_V0.5690.83
489_I492_G0.5670.82
392_I474_D0.5670.82
248_N254_V0.5660.82
33_D38_T0.5650.82
372_N376_E0.5650.82
66_N187_Y0.5640.82
215_N218_V0.5640.82
57_L61_T0.5630.82
106_M132_R0.5620.82
82_G115_K0.5610.82
155_D193_H0.5610.82
220_V344_A0.5610.82
239_I247_R0.5600.82
8_I19_T0.5590.82
253_K256_G0.5580.81
405_L463_G0.5570.81
218_V262_R0.5570.81
8_I72_I0.5560.81
333_D336_N0.5550.81
13_H109_T0.5550.81
28_Q165_A0.5540.81
141_V145_F0.5530.81
134_G137_P0.5520.81
82_G303_D0.5510.81
423_K476_R0.5510.81
10_I98_V0.5490.80
95_V116_A0.5490.80
210_S223_I0.5490.80
485_N489_I0.5490.80
207_M231_V0.5480.80
96_L124_I0.5480.80
52_R371_E0.5480.80
168_L183_M0.5480.80
484_Q489_I0.5470.80
62_A272_D0.5470.80
306_T401_E0.5460.80
167_A183_M0.5460.80
32_F37_E0.5460.80
6_R195_P0.5450.80
406_D464_L0.5450.80
14_V78_H0.5440.80
350_T357_R0.5440.80
80_D85_V0.5440.80
25_L70_I0.5410.79
165_A171_I0.5400.79
205_F251_V0.5390.79
31_T258_L0.5340.79
130_V164_Y0.5340.79
270_A274_V0.5340.79
239_I242_S0.5330.78
85_V112_V0.5330.78
274_V277_T0.5330.78
125_V162_I0.5320.78
79_A108_Q0.5320.78
391_E396_K0.5310.78
270_A275_A0.5310.78
489_I493_Q0.5300.78
309_M366_L0.5290.78
370_I380_L0.5280.78
412_Q426_L0.5270.78
406_D432_D0.5270.78
414_S459_T0.5260.78
153_A162_I0.5260.78
255_L275_A0.5260.78
15_D55_T0.5250.77
391_E395_R0.5240.77
263_I267_L0.5240.77
270_A273_I0.5240.77
110_R114_K0.5230.77
93_D122_K0.5220.77
15_D78_H0.5210.77
226_I230_K0.5210.77
46_N375_R0.5210.77
15_D20_T0.5200.77
58_A210_S0.5200.77
102_F127_I0.5200.77
412_Q431_P0.5200.77
105_P109_T0.5190.77
424_G441_Y0.5190.77
15_D108_Q0.5190.77
481_G493_Q0.5190.77
223_I426_L0.5180.76
338_E345_L0.5170.76
481_G489_I0.5160.76
55_T75_T0.5160.76
238_T242_S0.5160.76
205_F224_G0.5150.76
84_E87_R0.5140.76
335_L358_V0.5140.76
102_F168_L0.5130.76
31_T61_T0.5130.76
113_T147_L0.5120.76
313_V328_S0.5110.75
212_L284_I0.5110.75
14_V55_T0.5090.75
422_R450_G0.5090.75
419_L451_F0.5080.75
28_Q185_P0.5080.75
452_R456_M0.5060.75
46_N56_I0.5060.75
31_T42_V0.5050.75
289_C295_E0.5040.75
82_G304_E0.5040.75
206_Q289_C0.5030.74
482_Q488_L0.5030.74
250_K253_K0.5020.74
482_Q489_I0.5010.74
347_V358_V0.5000.74
108_Q111_F0.5000.74
136_R143_Q0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4zciA 1 0.9226 100 0.214 Contact Map
2yweA 1 0.799 100 0.301 Contact Map
3cb4D 1 0.8023 100 0.306 Contact Map
4qjty 1 0.8748 100 0.32 Contact Map
4kiyV 1 0.7496 100 0.396 Contact Map
1darA 1 0.6425 100 0.398 Contact Map
2xexA 1 0.7479 100 0.398 Contact Map
4w224 1 0.8204 100 0.406 Contact Map
3j25A 1 0.7792 100 0.407 Contact Map
4fn5A 1 0.7216 100 0.41 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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