TYPA - ECOLI - GREMLIN Contacts

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TYPA - GTP-binding protein TypA/BipA

UniProt:	P32132	Sequences: MIEKLRNIAIIAHVDHGKTTLVDKLLQQSGTFDSRAETQERVMDSNDLEKERGITILAKNTAIKWNDYRINIVDTPGHADFGGEVERVMSMVDSVLLVVDAFDGPMPQTRFVTKKAFAYGLKPIVVINKVDRPGARPDWVVDQVFDLFVNLDATDEQLDFPIVYASALNGIAGLDHEDMAEDMTPLYQAIVDHVPAPDVDLDGPFQMQISQLDYNSYVGVIGIGRIKRGKVKPNQQVTIIDSEGKTRNAKVGKVLGHLGLERIETDLAEAGDIVAITGLGELNISDTVCDTQNVEALPALSVDEPTVSMFFCVNTSPFCGKEGKFVTSRQILDRLNKELVHNVALRVEETEDADAFRVSGRGELHLSVLIENMRREGFELAVSRPKVIFREIDGRKQEPYENVTLDVEEQHQGSVMQALGERKGDLKNMNPDGKGRVRLDYVIPSRGLIGFRSEFMTMTSGTGLLYSTFSHYDDVRPGEVGQRQNGVLISNGQGKAVAFALFGLQDRGKLFLGHGAEVYEGQIIGIHSRSNDLTVNCLTGKKLTNMRASGTDEAVVLVPPIRMTLEQALEFIDDDELVEVTPTSIRIRKRHLTENDRRRANRAPKDD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11837
Length:	607 (464)
Sequences:	8308 (3617)
Seq/√Len:	167.9

ECOLI - TYPA LEPA EFG RF3
BACSU - TYPA LEPA EFG
HALSA - EF2
SULSO - EF2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
268_A	274_V	5.888	1.00
136_R	139_W	3.976	1.00
232_K	267_L	3.902	1.00
442_V	470_S	3.812	1.00
206_Q	228_R	3.625	1.00
126_V	165_A	3.541	1.00
163_V	189_A	3.466	1.00
165_A	186_L	3.347	1.00
230_K	267_L	3.122	1.00
402_N	470_S	3.108	1.00
392_I	397_Q	2.969	1.00
442_V	473_D	2.937	1.00
419_L	424_G	2.848	1.00
102_F	132_R	2.837	1.00
235_Q	290_D	2.778	1.00
402_N	440_D	2.771	1.00
402_N	468_T	2.768	1.00
200_D	203_G	2.728	1.00
374_R	379_E	2.586	1.00
189_A	193_H	2.582	1.00
400_Y	473_D	2.518	1.00
407_V	415_V	2.499	1.00
418_A	451_F	2.443	1.00
277_T	280_G	2.379	1.00
425_D	473_D	2.364	1.00
390_R	397_Q	2.317	1.00
142_D	146_D	2.313	1.00
28_Q	184_T	2.298	1.00
427_K	442_V	2.283	1.00
141_V	162_I	2.276	1.00
253_K	264_E	2.222	1.00
442_V	471_H	2.213	1.00
188_Q	192_D	2.198	1.00
407_V	463_G	2.114	1.00
8_I	70_I	2.095	1.00
428_N	440_D	2.072	1.00
230_K	269_E	2.041	1.00
459_T	463_G	2.033	1.00
213_D	223_I	2.014	1.00
126_V	167_A	1.997	1.00
203_G	228_R	1.997	1.00
304_E	346_R	1.943	1.00
64_K	67_D	1.928	1.00
220_V	340_V	1.924	1.00
236_Q	248_N	1.913	1.00
256_G	265_T	1.912	1.00
455_F	463_G	1.908	1.00
418_A	458_M	1.904	1.00
32_F	42_V	1.902	1.00
308_S	359_S	1.901	1.00
265_T	268_A	1.887	1.00
205_F	237_V	1.878	1.00
232_K	235_Q	1.877	1.00
403_V	465_L	1.872	1.00
314_N	379_E	1.867	1.00
334_R	373_M	1.864	1.00
43_M	61_T	1.862	1.00
233_P	266_D	1.856	1.00
24_K	27_Q	1.844	1.00
409_E	437_V	1.834	1.00
226_I	268_A	1.826	1.00
431_P	437_V	1.823	1.00
94_S	194_V	1.820	1.00
139_W	143_Q	1.792	1.00
224_G	276_I	1.792	1.00
348_E	359_S	1.768	1.00
4_K	68_Y	1.764	1.00
68_Y	191_V	1.758	1.00
99_V	109_T	1.744	1.00
100_D	103_D	1.732	1.00
65_W	188_Q	1.722	1.00
130_V	171_I	1.721	1.00
268_A	272_D	1.711	1.00
481_G	485_N	1.700	1.00
412_Q	437_V	1.696	1.00
10_I	22_V	1.694	1.00
209_I	222_G	1.692	1.00
22_V	72_I	1.680	1.00
394_G	474_D	1.676	1.00
402_N	442_V	1.673	1.00
350_T	353_A	1.666	1.00
222_G	282_L	1.648	1.00
73_V	92_V	1.640	1.00
425_D	442_V	1.622	1.00
110_R	462_T	1.615	1.00
345_L	369_L	1.599	1.00
141_V	164_Y	1.598	1.00
404_T	440_D	1.597	1.00
247_R	281_E	1.557	1.00
405_L	419_L	1.549	1.00
339_L	345_L	1.548	1.00
345_L	358_V	1.544	1.00
152_D	155_D	1.535	1.00
249_A	252_G	1.535	1.00
48_L	56_I	1.529	1.00
221_I	275_A	1.528	1.00
415_V	459_T	1.523	1.00
424_G	443_I	1.516	1.00
265_T	274_V	1.501	1.00
314_N	381_A	1.475	1.00
403_V	448_L	1.470	1.00
269_E	272_D	1.458	1.00
406_D	438_R	1.457	1.00
201_L	270_A	1.455	1.00
7_N	71_N	1.454	1.00
332_L	349_E	1.450	1.00
11_I	97_L	1.449	1.00
371_E	375_R	1.443	1.00
237_V	251_V	1.442	1.00
28_Q	183_M	1.442	1.00
224_G	274_V	1.432	1.00
480_V	484_Q	1.428	1.00
228_R	295_E	1.427	1.00
389_F	446_R	1.421	1.00
62_A	69_R	1.420	1.00
332_L	336_N	1.414	1.00
21_L	98_V	1.408	1.00
475_V	483_R	1.399	1.00
454_E	458_M	1.398	1.00
32_F	35_R	1.395	1.00
140_V	143_Q	1.393	1.00
101_A	127_I	1.390	1.00
25_L	63_I	1.385	1.00
308_S	357_R	1.380	1.00
33_D	37_E	1.376	1.00
312_C	381_A	1.369	1.00
404_T	438_R	1.368	1.00
290_D	293_N	1.363	1.00
240_I	289_C	1.362	1.00
417_Q	421_E	1.361	1.00
248_N	252_G	1.358	1.00
475_V	479_E	1.358	1.00
66_N	188_Q	1.355	1.00
408_E	462_T	1.350	1.00
25_L	183_M	1.349	1.00
226_I	274_V	1.346	1.00
29_S	63_I	1.335	1.00
370_I	382_V	1.335	1.00
327_T	330_Q	1.335	1.00
96_L	126_V	1.327	1.00
238_T	248_N	1.324	1.00
128_N	167_A	1.321	1.00
9_A	92_V	1.318	1.00
21_L	186_L	1.317	1.00
469_F	472_Y	1.314	1.00
403_V	443_I	1.311	1.00
205_F	226_I	1.307	1.00
125_V	144_V	1.305	1.00
201_L	230_K	1.293	1.00
11_I	95_V	1.288	1.00
95_V	121_L	1.284	1.00
231_V	251_V	1.283	1.00
184_T	188_Q	1.282	1.00
64_K	69_R	1.277	1.00
136_R	140_V	1.273	1.00
201_L	269_E	1.266	1.00
46_N	57_L	1.262	1.00
418_A	454_E	1.261	1.00
101_A	130_V	1.258	1.00
482_Q	486_G	1.244	1.00
348_E	357_R	1.233	1.00
470_S	473_D	1.230	1.00
112_V	115_K	1.225	1.00
405_L	415_V	1.218	1.00
419_L	443_I	1.215	1.00
6_R	197_P	1.204	1.00
421_E	454_E	1.201	1.00
63_I	72_I	1.195	1.00
58_A	73_V	1.193	1.00
83_G	344_A	1.188	1.00
392_I	395_R	1.186	1.00
238_T	243_E	1.182	1.00
207_M	224_G	1.175	1.00
51_E	375_R	1.166	1.00
47_D	375_R	1.163	1.00
363_E	450_G	1.163	1.00
124_I	194_V	1.160	1.00
430_N	440_D	1.150	1.00
402_N	427_K	1.149	1.00
400_Y	476_R	1.148	1.00
206_Q	297_L	1.144	1.00
409_E	434_K	1.139	1.00
252_G	256_G	1.138	1.00
4_K	67_D	1.138	1.00
31_T	63_I	1.138	1.00
199_V	228_R	1.125	1.00
156_E	162_I	1.122	1.00
416_M	439_L	1.115	1.00
26_L	42_V	1.115	1.00
45_S	59_K	1.114	1.00
336_N	349_E	1.111	1.00
94_S	195_P	1.110	1.00
389_F	396_K	1.109	1.00
28_Q	170_G	1.109	1.00
238_T	294_V	1.106	1.00
268_A	275_A	1.103	1.00
127_I	141_V	1.100	1.00
118_A	301_S	1.092	1.00
48_L	368_V	1.087	1.00
239_I	282_L	1.087	1.00
48_L	372_N	1.083	1.00
22_V	43_M	1.080	1.00
182_D	185_P	1.076	1.00
289_C	294_V	1.065	0.99
403_V	467_S	1.065	0.99
137_P	140_V	1.062	0.99
205_F	231_V	1.058	0.99
331_I	378_F	1.054	0.99
9_A	89_M	1.044	0.99
405_L	455_F	1.041	0.99
477_P	481_G	1.038	0.99
47_D	51_E	1.037	0.99
429_M	437_V	1.036	0.99
401_E	445_S	1.035	0.99
238_T	291_T	1.035	0.99
242_S	283_N	1.032	0.99
401_E	448_L	1.031	0.99
8_I	190_I	1.029	0.99
43_M	55_T	1.027	0.99
241_D	286_D	1.023	0.99
412_Q	429_M	1.021	0.99
142_D	145_F	1.020	0.99
161_P	193_H	1.020	0.99
205_F	230_K	1.019	0.99
29_S	187_Y	1.018	0.99
26_L	31_T	1.017	0.99
389_F	472_Y	1.015	0.99
358_V	369_L	1.002	0.99
138_D	142_D	0.999	0.99
47_D	50_K	0.997	0.99
43_M	59_K	0.993	0.99
32_F	38_T	0.993	0.99
127_I	164_Y	0.991	0.99
113_T	117_F	0.990	0.99
39_Q	50_K	0.989	0.99
414_S	458_M	0.989	0.99
400_Y	471_H	0.987	0.99
127_I	137_P	0.983	0.99
403_V	419_L	0.982	0.99
153_A	156_E	0.978	0.99
400_Y	470_S	0.976	0.99
12_A	16_H	0.974	0.99
451_F	458_M	0.974	0.99
309_M	382_V	0.972	0.99
233_P	252_G	0.971	0.99
100_D	132_R	0.970	0.99
233_P	264_E	0.970	0.99
5_L	272_D	0.969	0.99
109_T	125_V	0.968	0.99
63_I	70_I	0.967	0.99
102_F	134_G	0.966	0.99
232_K	266_D	0.964	0.99
69_R	272_D	0.964	0.99
391_E	394_G	0.958	0.99
410_Q	460_S	0.957	0.99
417_Q	420_G	0.955	0.99
412_Q	439_L	0.955	0.99
279_L	282_L	0.954	0.99
186_L	190_I	0.954	0.99
200_D	204_P	0.954	0.99
202_D	230_K	0.954	0.99
27_Q	34_S	0.953	0.99
204_P	293_N	0.948	0.99
237_V	288_V	0.947	0.99
272_D	275_A	0.943	0.99
105_P	148_F	0.942	0.99
152_D	156_E	0.939	0.99
11_I	89_M	0.937	0.99
426_L	429_M	0.937	0.99
247_R	253_K	0.935	0.99
97_L	112_V	0.927	0.99
283_N	302_V	0.925	0.99
116_A	123_P	0.924	0.99
38_T	42_V	0.912	0.98
249_A	253_K	0.910	0.98
38_T	41_R	0.910	0.98
239_I	288_V	0.908	0.98
233_P	254_V	0.908	0.98
5_L	69_R	0.903	0.98
137_P	164_Y	0.901	0.98
479_E	482_Q	0.901	0.98
256_G	272_D	0.900	0.98
204_P	290_D	0.899	0.98
90_S	227_K	0.898	0.98
236_Q	291_T	0.898	0.98
236_Q	250_K	0.895	0.98
100_D	140_V	0.893	0.98
209_I	282_L	0.892	0.98
327_T	379_E	0.892	0.98
21_L	167_A	0.891	0.98
339_L	347_V	0.887	0.98
258_L	263_I	0.887	0.98
114_K	436_R	0.887	0.98
397_Q	474_D	0.886	0.98
403_V	441_Y	0.885	0.98
169_N	183_M	0.883	0.98
398_E	423_K	0.878	0.98
304_E	466_Y	0.875	0.98
249_A	282_L	0.871	0.98
124_I	189_A	0.867	0.98
254_V	276_I	0.862	0.98
249_A	279_L	0.862	0.98
182_D	186_L	0.861	0.98
342_N	365_H	0.856	0.98
97_L	125_V	0.855	0.98
248_N	253_K	0.854	0.98
416_M	426_L	0.854	0.98
265_T	272_D	0.853	0.98
69_R	256_G	0.851	0.98
126_V	186_L	0.850	0.98
393_D	397_Q	0.850	0.98
207_M	276_I	0.847	0.97
39_Q	42_V	0.846	0.97
124_I	163_V	0.842	0.97
415_V	455_F	0.840	0.97
207_M	226_I	0.838	0.97
240_I	296_A	0.837	0.97
370_I	374_R	0.829	0.97
35_R	170_G	0.827	0.97
247_R	252_G	0.824	0.97
25_L	29_S	0.821	0.97
401_E	467_S	0.819	0.97
389_F	475_V	0.819	0.97
400_Y	442_V	0.817	0.97
32_F	36_A	0.816	0.97
165_A	182_D	0.815	0.97
286_D	299_A	0.814	0.97
48_L	52_R	0.814	0.97
420_G	441_Y	0.813	0.97
93_D	225_R	0.813	0.97
423_K	447_G	0.809	0.97
329_R	333_D	0.807	0.97
231_V	276_I	0.807	0.97
10_I	96_L	0.806	0.97
15_D	54_I	0.806	0.97
484_Q	487_V	0.805	0.97
171_I	183_M	0.804	0.97
117_F	123_P	0.802	0.96
324_K	327_T	0.799	0.96
89_M	119_Y	0.799	0.96
260_L	268_A	0.797	0.96
312_C	355_A	0.796	0.96
153_A	161_P	0.796	0.96
310_F	355_A	0.794	0.96
430_N	438_R	0.793	0.96
96_L	186_L	0.792	0.96
451_F	463_G	0.790	0.96
256_G	260_L	0.789	0.96
255_L	264_E	0.786	0.96
206_Q	295_E	0.786	0.96
256_G	268_A	0.783	0.96
12_A	15_D	0.782	0.96
257_H	260_L	0.781	0.96
48_L	371_E	0.780	0.96
143_Q	147_L	0.780	0.96
19_T	22_V	0.779	0.96
347_V	356_F	0.779	0.96
407_V	439_L	0.778	0.96
422_R	454_E	0.777	0.96
155_D	161_P	0.777	0.96
455_F	459_T	0.776	0.96
171_I	182_D	0.773	0.96
415_V	458_M	0.772	0.96
224_G	231_V	0.772	0.96
432_D	436_R	0.771	0.96
20_T	167_A	0.766	0.95
21_L	183_M	0.766	0.95
27_Q	38_T	0.765	0.95
363_E	453_S	0.764	0.95
450_G	454_E	0.764	0.95
98_V	167_A	0.764	0.95
165_A	169_N	0.762	0.95
54_I	364_L	0.762	0.95
99_V	144_V	0.761	0.95
103_D	132_R	0.761	0.95
254_V	258_L	0.761	0.95
338_E	373_M	0.760	0.95
226_I	231_V	0.760	0.95
98_V	128_N	0.759	0.95
117_F	148_F	0.758	0.95
411_H	460_S	0.755	0.95
66_N	184_T	0.755	0.95
131_D	166_S	0.754	0.95
101_A	135_A	0.754	0.95
239_I	249_A	0.754	0.95
231_V	235_Q	0.754	0.95
137_P	141_V	0.750	0.95
12_A	55_T	0.749	0.95
33_D	36_A	0.747	0.95
100_D	129_K	0.746	0.95
29_S	65_W	0.746	0.95
25_L	187_Y	0.746	0.95
409_E	431_P	0.743	0.95
419_L	441_Y	0.740	0.95
336_N	347_V	0.740	0.95
443_I	448_L	0.739	0.94
336_N	339_L	0.738	0.94
70_I	191_V	0.738	0.94
143_Q	146_D	0.736	0.94
99_V	125_V	0.736	0.94
51_E	371_E	0.735	0.94
268_A	273_I	0.734	0.94
26_L	61_T	0.731	0.94
221_I	277_T	0.730	0.94
331_I	373_M	0.730	0.94
334_R	338_E	0.728	0.94
62_A	71_N	0.727	0.94
253_K	277_T	0.727	0.94
24_K	183_M	0.727	0.94
119_Y	227_K	0.726	0.94
135_A	140_V	0.724	0.94
311_F	358_V	0.724	0.94
212_L	222_G	0.722	0.94
91_M	210_S	0.722	0.94
125_V	160_F	0.722	0.94
325_F	330_Q	0.722	0.94
8_I	22_V	0.721	0.94
144_V	162_I	0.721	0.94
66_N	191_V	0.718	0.94
214_Y	340_V	0.717	0.94
344_A	369_L	0.715	0.93
54_I	78_H	0.712	0.93
146_D	434_K	0.711	0.93
138_D	164_Y	0.710	0.93
189_A	192_D	0.708	0.93
233_P	253_K	0.707	0.93
155_D	162_I	0.706	0.93
384_R	450_G	0.705	0.93
262_R	275_A	0.704	0.93
97_L	109_T	0.703	0.93
36_A	261_E	0.699	0.93
373_M	380_L	0.699	0.93
61_T	258_L	0.699	0.93
42_V	261_E	0.697	0.93
100_D	143_Q	0.696	0.93
249_A	256_G	0.695	0.92
330_Q	334_R	0.695	0.92
310_F	383_S	0.695	0.92
400_Y	475_V	0.695	0.92
205_F	288_V	0.694	0.92
432_D	438_R	0.691	0.92
58_A	213_D	0.690	0.92
196_A	199_V	0.690	0.92
367_S	370_I	0.690	0.92
256_G	274_V	0.689	0.92
206_Q	227_K	0.689	0.92
5_L	71_N	0.686	0.92
30_G	33_D	0.686	0.92
350_T	355_A	0.686	0.92
483_R	487_V	0.685	0.92
190_I	194_V	0.683	0.92
397_Q	472_Y	0.682	0.92
25_L	28_Q	0.681	0.92
203_G	295_E	0.681	0.92
221_I	262_R	0.680	0.92
448_L	465_L	0.678	0.92
252_G	257_H	0.678	0.92
313_V	324_K	0.677	0.91
426_L	441_Y	0.677	0.91
29_S	64_K	0.675	0.91
355_A	383_S	0.675	0.91
479_E	483_R	0.672	0.91
309_M	358_V	0.671	0.91
416_M	420_G	0.669	0.91
401_E	443_I	0.669	0.91
234_N	252_G	0.667	0.91
213_D	426_L	0.667	0.91
86_E	118_A	0.666	0.91
75_T	85_V	0.664	0.91
427_K	440_D	0.663	0.91
220_V	282_L	0.662	0.91
199_V	203_G	0.662	0.91
257_H	272_D	0.658	0.90
4_K	66_N	0.658	0.90
122_K	156_E	0.656	0.90
200_D	230_K	0.655	0.90
48_L	59_K	0.654	0.90
79_A	111_F	0.654	0.90
265_T	275_A	0.653	0.90
163_V	193_H	0.653	0.90
339_L	358_V	0.652	0.90
56_I	368_V	0.652	0.90
312_C	383_S	0.651	0.90
52_R	367_S	0.651	0.90
231_V	237_V	0.651	0.90
451_F	455_F	0.648	0.90
9_A	190_I	0.640	0.89
224_G	268_A	0.640	0.89
23_D	41_R	0.640	0.89
263_I	266_D	0.639	0.89
144_V	148_F	0.639	0.89
117_F	120_G	0.638	0.89
41_R	50_K	0.634	0.89
199_V	270_A	0.634	0.89
307_V	449_I	0.633	0.89
357_R	386_K	0.632	0.88
482_Q	485_N	0.631	0.88
289_C	293_N	0.631	0.88
144_V	151_L	0.630	0.88
163_V	186_L	0.629	0.88
102_F	139_W	0.629	0.88
254_V	265_T	0.627	0.88
258_L	261_E	0.627	0.88
371_E	374_R	0.627	0.88
403_V	424_G	0.627	0.88
35_R	38_T	0.626	0.88
411_H	462_T	0.625	0.88
408_E	411_H	0.624	0.88
86_E	112_V	0.623	0.88
260_L	274_V	0.622	0.88
445_S	467_S	0.622	0.88
393_D	396_K	0.621	0.88
50_K	260_L	0.621	0.88
24_K	28_Q	0.620	0.87
78_H	87_R	0.620	0.87
330_Q	333_D	0.620	0.87
90_S	300_L	0.619	0.87
45_S	213_D	0.619	0.87
370_I	381_A	0.617	0.87
487_V	492_G	0.617	0.87
257_H	275_A	0.616	0.87
214_Y	337_K	0.616	0.87
88_V	92_V	0.616	0.87
113_T	123_P	0.615	0.87
420_G	429_M	0.614	0.87
91_M	121_L	0.614	0.87
325_F	378_F	0.613	0.87
37_E	40_E	0.613	0.87
45_S	57_L	0.612	0.87
247_R	256_G	0.611	0.87
485_N	488_L	0.610	0.87
452_R	465_L	0.609	0.87
9_A	95_V	0.609	0.87
248_N	291_T	0.608	0.86
240_I	294_V	0.607	0.86
110_R	147_L	0.606	0.86
98_V	183_M	0.604	0.86
338_E	342_N	0.604	0.86
391_E	397_Q	0.602	0.86
25_L	96_L	0.602	0.86
332_L	356_F	0.602	0.86
480_V	483_R	0.601	0.86
409_E	412_Q	0.601	0.86
241_D	247_R	0.600	0.86
70_I	187_Y	0.599	0.86
249_A	254_V	0.597	0.85
223_I	275_A	0.597	0.85
15_D	129_K	0.597	0.85
226_I	269_E	0.596	0.85
260_L	275_A	0.595	0.85
425_D	476_R	0.595	0.85
26_L	32_F	0.592	0.85
64_K	258_L	0.591	0.85
339_L	343_V	0.589	0.85
411_H	414_S	0.589	0.85
490_S	493_Q	0.588	0.85
112_V	116_A	0.587	0.85
50_K	53_G	0.587	0.85
406_D	436_R	0.587	0.85
14_V	54_I	0.587	0.85
115_K	119_Y	0.586	0.84
253_K	265_T	0.585	0.84
264_E	275_A	0.585	0.84
187_Y	191_V	0.585	0.84
423_K	446_R	0.584	0.84
11_I	116_A	0.583	0.84
96_L	190_I	0.581	0.84
297_L	300_L	0.580	0.84
8_I	186_L	0.580	0.84
70_I	190_I	0.579	0.84
28_Q	182_D	0.579	0.84
208_Q	299_A	0.577	0.83
324_K	379_E	0.575	0.83
86_E	115_K	0.574	0.83
30_G	105_P	0.574	0.83
487_V	490_S	0.574	0.83
427_K	470_S	0.573	0.83
306_T	309_M	0.572	0.83
24_K	170_G	0.572	0.83
46_N	372_N	0.571	0.83
206_Q	294_V	0.571	0.83
207_M	274_V	0.570	0.83
417_Q	458_M	0.570	0.83
163_V	182_D	0.569	0.83
103_D	106_M	0.569	0.83
231_V	254_V	0.569	0.83
489_I	492_G	0.567	0.82
392_I	474_D	0.567	0.82
248_N	254_V	0.566	0.82
33_D	38_T	0.565	0.82
372_N	376_E	0.565	0.82
66_N	187_Y	0.564	0.82
215_N	218_V	0.564	0.82
57_L	61_T	0.563	0.82
106_M	132_R	0.562	0.82
82_G	115_K	0.561	0.82
155_D	193_H	0.561	0.82
220_V	344_A	0.561	0.82
239_I	247_R	0.560	0.82
8_I	19_T	0.559	0.82
253_K	256_G	0.558	0.81
405_L	463_G	0.557	0.81
218_V	262_R	0.557	0.81
8_I	72_I	0.556	0.81
333_D	336_N	0.555	0.81
13_H	109_T	0.555	0.81
28_Q	165_A	0.554	0.81
141_V	145_F	0.553	0.81
134_G	137_P	0.552	0.81
82_G	303_D	0.551	0.81
423_K	476_R	0.551	0.81
10_I	98_V	0.549	0.80
95_V	116_A	0.549	0.80
210_S	223_I	0.549	0.80
485_N	489_I	0.549	0.80
207_M	231_V	0.548	0.80
96_L	124_I	0.548	0.80
52_R	371_E	0.548	0.80
168_L	183_M	0.548	0.80
484_Q	489_I	0.547	0.80
62_A	272_D	0.547	0.80
306_T	401_E	0.546	0.80
167_A	183_M	0.546	0.80
32_F	37_E	0.546	0.80
6_R	195_P	0.545	0.80
406_D	464_L	0.545	0.80
14_V	78_H	0.544	0.80
350_T	357_R	0.544	0.80
80_D	85_V	0.544	0.80
25_L	70_I	0.541	0.79
165_A	171_I	0.540	0.79
205_F	251_V	0.539	0.79
31_T	258_L	0.534	0.79
130_V	164_Y	0.534	0.79
270_A	274_V	0.534	0.79
239_I	242_S	0.533	0.78
85_V	112_V	0.533	0.78
274_V	277_T	0.533	0.78
125_V	162_I	0.532	0.78
79_A	108_Q	0.532	0.78
391_E	396_K	0.531	0.78
270_A	275_A	0.531	0.78
489_I	493_Q	0.530	0.78
309_M	366_L	0.529	0.78
370_I	380_L	0.528	0.78
412_Q	426_L	0.527	0.78
406_D	432_D	0.527	0.78
414_S	459_T	0.526	0.78
153_A	162_I	0.526	0.78
255_L	275_A	0.526	0.78
15_D	55_T	0.525	0.77
391_E	395_R	0.524	0.77
263_I	267_L	0.524	0.77
270_A	273_I	0.524	0.77
110_R	114_K	0.523	0.77
93_D	122_K	0.522	0.77
15_D	78_H	0.521	0.77
226_I	230_K	0.521	0.77
46_N	375_R	0.521	0.77
15_D	20_T	0.520	0.77
58_A	210_S	0.520	0.77
102_F	127_I	0.520	0.77
412_Q	431_P	0.520	0.77
105_P	109_T	0.519	0.77
424_G	441_Y	0.519	0.77
15_D	108_Q	0.519	0.77
481_G	493_Q	0.519	0.77
223_I	426_L	0.518	0.76
338_E	345_L	0.517	0.76
481_G	489_I	0.516	0.76
55_T	75_T	0.516	0.76
238_T	242_S	0.516	0.76
205_F	224_G	0.515	0.76
84_E	87_R	0.514	0.76
335_L	358_V	0.514	0.76
102_F	168_L	0.513	0.76
31_T	61_T	0.513	0.76
113_T	147_L	0.512	0.76
313_V	328_S	0.511	0.75
212_L	284_I	0.511	0.75
14_V	55_T	0.509	0.75
422_R	450_G	0.509	0.75
419_L	451_F	0.508	0.75
28_Q	185_P	0.508	0.75
452_R	456_M	0.506	0.75
46_N	56_I	0.506	0.75
31_T	42_V	0.505	0.75
289_C	295_E	0.504	0.75
82_G	304_E	0.504	0.75
206_Q	289_C	0.503	0.74
482_Q	488_L	0.503	0.74
250_K	253_K	0.502	0.74
482_Q	489_I	0.501	0.74
347_V	358_V	0.500	0.74
108_Q	111_F	0.500	0.74
136_R	143_Q	0.500	0.74

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4zciA	1	0.9226	100	0.214	Contact Map
2yweA	1	0.799	100	0.301	Contact Map
3cb4D	1	0.8023	100	0.306	Contact Map
4qjty	1	0.8748	100	0.32	Contact Map
4kiyV	1	0.7496	100	0.396	Contact Map
1darA	1	0.6425	100	0.398	Contact Map
2xexA	1	0.7479	100	0.398	Contact Map
4w224	1	0.8204	100	0.406	Contact Map
3j25A	1	0.7792	100	0.407	Contact Map
4fn5A	1	0.7216	100	0.41	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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