GREMLIN Database
YIHG - Probable acyltransferase YihG
UniProt: P32129 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11833
Length: 310 (271)
Sequences: 1375 (919)
Seq/√Len: 55.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
237_C299_L7.3301.00
233_N262_D7.2271.00
262_D294_E4.8911.00
189_V288_L4.0471.00
129_Q150_K3.7971.00
207_Q300_T3.6361.00
230_K263_L3.4701.00
82_Q256_R3.4641.00
86_H260_H3.3221.00
248_D253_K3.0631.00
129_Q132_A2.8521.00
299_L303_M2.7231.00
260_H298_L2.7051.00
208_N300_T2.6401.00
84_E258_V2.5701.00
231_L266_I2.3171.00
128_K151_R2.2731.00
208_N303_M2.2621.00
300_T304_S2.2511.00
19_L247_F2.1311.00
278_K282_R2.0401.00
107_A244_Q1.9861.00
84_E260_H1.9681.00
196_Q200_Q1.9651.00
258_V302_L1.9591.00
301_S305_S1.9001.00
84_E256_R1.8731.00
194_F199_H1.8731.00
208_N296_D1.7760.99
277_D280_F1.7620.99
264_Q294_E1.7320.99
195_T198_K1.7260.99
193_R198_K1.7020.99
202_T211_P1.6690.99
88_L261_V1.6590.99
98_L217_I1.6510.99
111_V259_V1.6510.99
290_S294_E1.6310.99
286_Q290_S1.6090.98
240_D256_R1.6050.98
113_C146_M1.6000.98
166_K169_E1.5910.98
127_L148_F1.5830.98
153_S164_R1.5620.98
278_K287_W1.5550.98
240_D255_T1.5300.98
207_Q296_D1.5160.98
290_S293_Q1.5100.98
232_L263_L1.5060.98
20_L23_I1.5040.98
97_Y184_T1.4800.97
200_Q204_S1.4700.97
196_Q199_H1.4690.97
128_K192_S1.4670.97
141_C148_F1.4650.97
151_R216_G1.4640.97
33_C70_G1.4490.97
54_R180_L1.4280.97
112_L188_F1.4120.96
151_R192_S1.4100.96
206_F289_N1.3870.96
25_L29_V1.3850.96
113_C141_C1.3660.96
209_L292_W1.3440.95
97_Y232_L1.3390.95
96_W183_T1.3040.94
127_L131_L1.2980.94
291_L294_E1.2840.94
100_I231_L1.2730.94
106_W193_R1.2700.94
165_G169_E1.2640.94
34_S38_I1.2560.93
301_S304_S1.2530.93
29_V71_L1.2490.93
131_L151_R1.2470.93
192_S216_G1.2460.93
123_N186_V1.2400.93
131_L135_P1.2400.93
297_R301_S1.2390.93
280_F283_H1.2360.93
131_L148_F1.2350.93
138_G148_F1.2250.92
100_I233_N1.2130.92
123_N184_T1.2050.92
293_Q297_R1.2040.92
49_V52_I1.1940.91
128_K216_G1.1930.91
247_F251_S1.1920.91
35_V39_I1.1860.91
26_T74_L1.1800.91
268_D297_R1.1590.90
48_P52_I1.1570.90
100_I288_L1.1530.90
199_H203_H1.1520.90
135_P151_R1.1420.89
191_G216_G1.1400.89
285_Q289_N1.1380.89
72_A114_V1.1360.89
120_I185_I1.1310.89
125_Y186_V1.1290.89
206_F211_P1.1240.89
106_W246_F1.1240.89
126_F220_A1.1040.88
233_N295_K1.1030.88
73_V77_L1.1020.88
75_L114_V1.1010.88
237_C303_M1.0980.88
289_N292_W1.0980.88
95_N230_K1.0970.88
60_C68_C1.0940.87
49_V56_V1.0880.87
38_I41_G1.0880.87
84_E302_L1.0860.87
223_V299_L1.0770.87
140_A186_V1.0740.86
42_I177_K1.0500.85
185_I220_A1.0480.85
111_V257_I1.0480.85
218_A281_K1.0350.84
82_Q293_Q1.0320.84
236_L259_V1.0300.84
281_K285_Q1.0280.84
24_V197_E1.0270.84
24_V27_I1.0270.84
105_S193_R1.0270.84
141_C146_M1.0200.83
217_I284_F1.0190.83
109_I127_L1.0170.83
203_H282_R1.0170.83
221_L252_G1.0170.83
115_L259_V1.0080.83
135_P192_S1.0050.82
106_W109_I1.0030.82
105_S188_F1.0010.82
65_Y69_E0.9960.82
214_A285_Q0.9770.81
102_N295_K0.9700.80
59_F63_M0.9630.80
148_F191_G0.9580.79
95_N263_L0.9490.79
103_H108_D0.9450.78
36_P43_V0.9440.78
75_L250_L0.9430.78
128_K135_P0.9420.78
32_F40_A0.9410.78
131_L192_S0.9400.78
258_V299_L0.9370.78
64_M144_L0.9340.78
135_P138_G0.9340.78
153_S165_G0.9340.78
112_L234_V0.9280.77
282_R286_Q0.9150.76
149_M219_M0.9070.75
128_K131_L0.9070.75
96_W124_K0.9060.75
138_G191_G0.8980.75
105_S125_Y0.8960.75
152_Y165_G0.8960.75
164_R216_G0.8940.74
61_D65_Y0.8910.74
206_F209_L0.8900.74
197_E201_Q0.8900.74
207_Q297_R0.8860.74
103_H212_P0.8840.74
27_I33_C0.8790.73
235_T287_W0.8760.73
127_L146_M0.8700.72
100_I291_L0.8680.72
151_R191_G0.8670.72
55_K58_R0.8670.72
206_F292_W0.8650.72
167_D175_C0.8640.72
234_V305_S0.8620.72
153_S172_R0.8590.71
66_C70_G0.8540.71
109_I113_C0.8540.71
98_L225_G0.8460.70
194_F236_L0.8430.70
121_P182_P0.8430.70
153_S187_N0.8370.69
133_W193_R0.8310.69
169_E173_R0.8310.69
200_Q279_S0.8300.69
209_L299_L0.8280.69
210_L216_G0.8260.68
135_P193_R0.8210.68
92_S95_N0.8210.68
19_L27_I0.8170.68
164_R172_R0.8170.68
262_D301_S0.8140.67
76_H118_K0.8130.67
50_P180_L0.8130.67
153_S221_L0.8080.67
38_I45_L0.8040.66
125_Y147_P0.8030.66
116_F234_V0.8030.66
113_C125_Y0.8020.66
183_T228_F0.7980.66
173_R231_L0.7940.65
171_T187_N0.7940.65
133_W142_W0.7930.65
41_G67_W0.7930.65
67_W106_W0.7880.65
100_I189_V0.7880.65
75_L249_M0.7800.64
104_R217_I0.7790.64
46_L51_V0.7790.64
208_N282_R0.7760.64
102_N235_T0.7720.63
68_C113_C0.7720.63
33_C66_C0.7700.63
67_W71_L0.7660.63
97_Y292_W0.7630.62
37_I41_G0.7580.62
37_I40_A0.7570.62
68_C146_M0.7560.62
235_T238_Y0.7540.61
265_P268_D0.7530.61
71_L134_V0.7490.61
57_S61_D0.7490.61
87_G123_N0.7490.61
21_L39_I0.7480.61
35_V44_K0.7450.60
24_V90_G0.7450.60
79_P249_M0.7450.60
230_K265_P0.7360.59
134_V142_W0.7350.59
201_Q204_S0.7340.59
20_L38_I0.7320.59
95_N184_T0.7310.59
238_Y292_W0.7300.59
134_V139_L0.7290.59
80_H86_H0.7270.58
153_S215_A0.7260.58
100_I290_S0.7250.58
115_L290_S0.7230.58
125_Y141_C0.7150.57
168_V176_E0.7090.57
217_I260_H0.7070.56
25_L35_V0.7050.56
246_F249_M0.7050.56
169_E223_V0.7050.56
113_C186_V0.7030.56
188_F222_N0.7000.56
21_L173_R0.7000.56
233_N264_Q0.6980.55
128_K210_L0.6970.55
104_R107_A0.6940.55
83_W87_G0.6930.55
126_F168_V0.6920.55
217_I231_L0.6890.54
116_F184_T0.6830.54
196_Q297_R0.6810.54
60_C140_A0.6810.54
122_M141_C0.6800.53
262_D291_L0.6790.53
140_A144_L0.6780.53
52_I55_K0.6750.53
27_I92_S0.6730.53
251_S281_K0.6720.53
233_N287_W0.6720.53
199_H202_T0.6710.53
47_L251_S0.6690.52
225_G231_L0.6650.52
87_G265_P0.6650.52
91_L130_Q0.6630.52
36_P39_I0.6630.52
79_P228_F0.6620.52
40_A47_L0.6610.51
147_P236_L0.6560.51
187_N209_L0.6530.51
46_L52_I0.6510.50
128_K191_G0.6470.50
69_E117_R0.6470.50
59_F224_L0.6460.50
99_L184_T0.6460.50
225_G228_F0.6450.50
197_E200_Q0.6440.50
165_G168_V0.6440.50
18_T228_F0.6400.49
152_Y164_R0.6400.49
141_C244_Q0.6390.49
218_A284_F0.6370.49
22_S25_L0.6370.49
47_L53_W0.6360.49
85_V267_A0.6360.49
207_Q279_S0.6330.48
121_P232_L0.6330.48
185_I233_N0.6320.48
53_W95_N0.6310.48
50_P54_R0.6300.48
112_L238_Y0.6290.48
228_F267_A0.6290.48
19_L251_S0.6270.48
109_I125_Y0.6270.48
138_G216_G0.6250.48
237_C302_L0.6240.47
139_L143_S0.6210.47
105_S111_V0.6210.47
218_A222_N0.6200.47
101_C118_K0.6170.47
98_L165_G0.6150.46
55_K255_T0.6140.46
35_V305_S0.6130.46
88_L263_L0.6130.46
277_D304_S0.6120.46
116_F140_A0.6100.46
203_H259_V0.6090.46
23_I29_V0.6090.46
134_V141_C0.6090.46
125_Y148_F0.6070.46
294_E305_S0.6060.45
40_A63_M0.6000.45
268_D290_S0.5990.45
33_C78_N0.5980.45
33_C63_M0.5950.44
107_A241_N0.5950.44
72_A75_L0.5940.44
103_H190_E0.5930.44
224_L227_Q0.5930.44
167_D187_N0.5930.44
36_P42_I0.5910.44
218_A277_D0.5910.44
45_L205_T0.5900.44
221_L266_I0.5870.43
233_N291_L0.5870.43
124_K151_R0.5860.43
108_D190_E0.5850.43
107_A146_M0.5850.43
95_N278_K0.5840.43
102_N108_D0.5810.43
190_E212_P0.5810.43
46_L50_P0.5810.43
61_D181_H0.5800.43
204_S297_R0.5790.43
127_L134_V0.5780.42
20_L26_T0.5770.42
233_N298_L0.5750.42
92_S168_V0.5730.42
217_I220_A0.5720.42
74_L79_P0.5710.42
167_D170_T0.5700.42
69_E72_A0.5700.42
215_A244_Q0.5690.42
24_V30_T0.5670.41
215_A219_M0.5670.41
101_C179_R0.5660.41
106_W113_C0.5640.41
188_F235_T0.5640.41
73_V89_E0.5620.41
137_L141_C0.5610.41
165_G215_A0.5570.40
87_G184_T0.5540.40
140_A189_V0.5530.40
213_K254_L0.5510.40
40_A300_T0.5500.40
67_W246_F0.5450.39
136_F146_M0.5440.39
86_H258_V0.5440.39
109_I146_M0.5420.39
109_I128_K0.5410.39
283_H286_Q0.5410.39
104_R254_L0.5400.39
79_P91_L0.5400.39
75_L85_V0.5390.38
82_Q251_S0.5380.38
127_L219_M0.5350.38
116_F121_P0.5330.38
70_G233_N0.5320.38
110_V137_L0.5320.38
68_C117_R0.5310.38
238_Y295_K0.5310.38
173_R176_E0.5300.38
286_Q293_Q0.5300.38
128_K193_R0.5280.37
128_K134_V0.5280.37
135_P216_G0.5280.37
195_T214_A0.5270.37
202_T205_T0.5270.37
197_E286_Q0.5260.37
28_L268_D0.5260.37
145_D176_E0.5240.37
59_F231_L0.5240.37
109_I188_F0.5230.37
124_K144_L0.5220.37
79_P110_V0.5200.36
100_I187_N0.5200.36
31_I136_F0.5190.36
264_Q277_D0.5170.36
126_F209_L0.5170.36
73_V300_T0.5160.36
138_G192_S0.5150.36
247_F257_I0.5140.36
64_M113_C0.5120.36
126_F147_P0.5120.36
214_A219_M0.5090.35
245_P282_R0.5080.35
47_L282_R0.5070.35
287_W291_L0.5070.35
140_A148_F0.5060.35
86_H221_L0.5060.35
205_T209_L0.5050.35
124_K193_R0.5030.35
299_L305_S0.5010.35
111_V114_V0.5010.35
108_D212_P0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1iuqA 1 0.8968 99.3 0.838 Contact Map
2bg9E 1 0.2355 10.6 0.969 Contact Map
2bg9B 1 0.2387 8.5 0.97 Contact Map
2bg9A 1 0.2387 8.4 0.97 Contact Map
4tnwA 3 0.2323 7.7 0.971 Contact Map
2bg9C 1 0.2452 7.4 0.971 Contact Map
2dyoA 2 0.4161 7.4 0.971 Contact Map
2wnyA 1 0.4032 6.5 0.971 Contact Map
4hfiA 3 0.1839 5.5 0.973 Contact Map
4aoeA 8 0.2355 5.4 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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