GREMLIN Database
YIHF - Uncharacterized protein YihF
UniProt: P32128 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11832
Length: 476 (437)
Sequences: 557 (449)
Seq/√Len: 21.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_Q61_K6.0131.00
248_A273_D4.5081.00
29_Q33_E4.4971.00
21_T63_F4.2271.00
208_S232_N3.9991.00
454_K461_E3.8911.00
210_T230_K3.5541.00
118_K143_T3.2741.00
101_P112_P3.2021.00
356_K361_E3.1481.00
12_A16_I3.0451.00
233_Q247_D2.9600.99
284_S356_K2.7750.99
209_F231_F2.7510.99
66_S97_H2.7230.99
6_A9_V2.6570.99
70_M93_V2.6490.99
453_G463_S2.6080.98
21_T101_P2.5750.98
187_I213_S2.5390.98
25_G61_K2.4910.98
440_D445_S2.4290.97
263_Y293_S2.3500.97
272_L275_L2.3070.96
10_I329_E2.2740.96
72_M91_F2.2620.96
99_P148_F2.2410.96
346_E371_A2.2210.96
287_W353_V2.2190.96
19_G22_W2.2030.95
6_A13_L2.1790.95
455_V467_F2.1460.95
456_V461_E2.1370.95
362_L397_V2.1270.94
387_L448_L2.1180.94
61_K97_H2.1020.94
225_G342_L2.0940.94
214_L226_E2.0860.94
283_G355_W2.0530.93
55_S71_Q2.0440.93
169_G209_F2.0310.93
19_G23_Y2.0170.93
68_F95_V2.0100.93
412_D415_K2.0010.92
175_F229_S1.9810.92
415_K418_K1.9650.92
212_D230_K1.9560.91
455_V462_M1.9540.91
93_V119_V1.9110.90
25_G97_H1.9100.90
220_K296_P1.8850.90
463_S466_E1.8820.90
101_P347_P1.8730.90
453_G465_E1.8630.89
186_D214_L1.8440.89
91_F119_V1.8080.88
31_G34_K1.7940.87
123_N128_Q1.7780.87
364_A391_V1.7770.87
178_D184_N1.7770.87
357_N400_E1.7740.87
226_E254_R1.7740.87
16_I63_F1.7560.86
32_V56_Y1.7400.86
99_P347_P1.7260.85
114_L148_F1.7240.85
93_V117_A1.7170.85
24_T148_F1.7130.85
285_G355_W1.7010.84
142_A156_L1.6730.83
294_I342_L1.6630.83
37_K231_F1.6500.82
140_V144_L1.6430.82
7_T11_V1.6410.82
65_N136_N1.6400.82
20_G110_V1.6230.81
288_S351_Q1.5940.80
135_K298_A1.5880.80
18_G187_I1.5870.80
95_V117_A1.5860.80
24_T101_P1.5790.80
6_A17_W1.5780.79
210_T232_N1.5760.79
28_I95_V1.5610.79
132_I136_N1.5490.78
59_F62_G1.5370.78
247_D274_K1.5130.77
188_E212_D1.5100.76
433_M453_G1.4970.76
333_A414_E1.4970.76
112_P283_G1.4960.76
21_T99_P1.4750.75
95_V208_S1.4660.74
22_W63_F1.4660.74
25_G98_G1.4640.74
21_T148_F1.4640.74
292_E348_T1.4470.73
286_E352_P1.4420.73
139_P159_A1.4410.73
219_E260_D1.4410.73
290_I351_Q1.4220.72
147_A151_S1.4170.72
72_M89_V1.4160.71
295_D459_G1.4010.71
89_V100_L1.3990.71
65_N137_K1.3930.70
13_L17_W1.3650.69
166_F376_S1.3580.68
261_K460_Q1.3570.68
222_F312_K1.3490.68
362_L396_N1.3440.67
69_Q90_V1.3400.67
22_W25_G1.3370.67
68_F93_V1.3330.67
119_V142_A1.3310.67
4_K132_I1.3300.67
137_K234_I1.3290.66
271_E275_L1.3280.66
398_V411_M1.3280.66
343_Q347_P1.3200.66
206_A214_L1.3200.66
52_M140_V1.3150.66
56_Y68_F1.3080.65
13_L167_S1.3060.65
189_G211_I1.3000.65
61_K98_G1.2990.65
24_T66_S1.2960.64
248_A438_T1.2960.64
5_S14_A1.2950.64
14_A390_D1.2830.64
248_A275_L1.2750.63
265_N292_E1.2680.63
136_N139_P1.2680.63
8_G11_V1.2670.63
267_N290_I1.2660.63
414_E457_F1.2560.62
295_D298_A1.2500.62
72_M256_D1.2500.62
428_M437_I1.2430.61
141_E157_D1.2390.61
417_Q421_D1.2340.61
394_P445_S1.2270.60
403_K407_L1.2140.59
124_N301_Q1.2090.59
11_V17_W1.2070.59
168_F263_Y1.2060.59
419_Q460_Q1.2050.59
101_P148_F1.1990.58
294_I370_I1.1980.58
20_G413_A1.1950.58
12_A19_G1.1930.58
59_F97_H1.1920.58
146_F185_L1.1900.58
12_A166_F1.1870.58
451_T462_M1.1850.57
58_N69_Q1.1840.57
310_M401_T1.1780.57
64_F158_V1.1750.57
62_G66_S1.1750.57
96_E103_T1.1710.56
308_I448_L1.1710.56
53_T275_L1.1700.56
266_V343_Q1.1680.56
431_G437_I1.1650.56
396_N442_N1.1610.56
189_G406_N1.1560.55
125_E128_Q1.1530.55
3_R11_V1.1520.55
413_A417_Q1.1460.55
6_A24_T1.1390.54
407_L413_A1.1370.54
29_Q59_F1.1370.54
67_R94_D1.1310.54
414_E418_K1.1150.53
361_E450_Y1.1150.53
248_A349_I1.1130.53
191_V194_I1.1110.52
24_T131_F1.1110.52
95_V266_V1.1030.52
18_G21_T1.1020.52
70_M139_P1.1010.52
26_T61_K1.1000.52
120_N218_E1.0990.52
176_N335_F1.0940.51
428_M439_I1.0910.51
342_L354_R1.0890.51
284_S358_A1.0830.51
14_A440_D1.0830.51
230_K274_K1.0770.50
53_T140_V1.0770.50
325_V407_L1.0770.50
326_A330_V1.0770.50
170_E296_P1.0660.49
13_L377_S1.0630.49
283_G360_G1.0550.49
285_G451_T1.0530.49
416_A420_A1.0470.48
254_R264_I1.0450.48
286_E354_R1.0450.48
395_L439_I1.0430.48
29_Q84_K1.0430.48
218_E257_R1.0400.48
36_I144_L1.0390.48
23_Y28_I1.0340.47
161_A168_F1.0290.47
101_P113_A1.0290.47
21_T223_P1.0250.47
300_R304_I1.0180.46
10_I14_A1.0180.46
261_K294_I1.0170.46
1_M23_Y1.0170.46
25_G65_N1.0170.46
282_L357_N1.0130.46
189_G242_D1.0120.46
12_A23_Y1.0080.46
222_F294_I0.9960.45
271_E312_K0.9960.45
25_G360_G0.9950.45
266_V364_A0.9890.44
250_V294_I0.9840.44
119_V144_L0.9780.44
233_Q386_S0.9780.44
4_K344_K0.9720.43
23_Y444_A0.9710.43
8_G16_I0.9700.43
282_L386_S0.9690.43
206_A330_V0.9680.43
390_D447_Q0.9650.43
256_D309_A0.9640.43
158_V375_K0.9600.42
204_V447_Q0.9580.42
264_I335_F0.9570.42
66_S298_A0.9560.42
205_T235_N0.9560.42
1_M16_I0.9540.42
155_T174_T0.9520.42
37_K204_V0.9520.42
77_G178_D0.9460.41
95_V115_A0.9450.41
324_E328_Q0.9440.41
437_I454_K0.9400.41
3_R40_N0.9380.41
100_L285_G0.9360.41
54_L197_Q0.9350.41
21_T102_I0.9340.41
185_L349_I0.9340.41
276_T281_Q0.9250.40
101_P283_G0.9250.40
92_D122_V0.9230.40
302_F340_P0.9210.40
17_W26_T0.9180.40
14_A18_G0.9140.39
206_A209_F0.9130.39
138_S159_A0.9130.39
76_N414_E0.9080.39
103_T121_L0.9060.39
189_G221_K0.9010.39
293_S298_A0.8970.38
462_M467_F0.8970.38
54_L57_Q0.8920.38
144_L154_T0.8920.38
139_P263_Y0.8900.38
144_L150_G0.8900.38
193_D207_K0.8890.38
14_A19_G0.8870.38
196_L262_D0.8860.38
70_M357_N0.8850.38
231_F277_K0.8850.38
28_I113_A0.8840.37
262_D401_T0.8830.37
357_N397_V0.8810.37
165_K199_S0.8810.37
287_W446_L0.8800.37
1_M9_V0.8790.37
168_F355_W0.8760.37
264_I415_K0.8750.37
277_K355_W0.8740.37
146_F162_E0.8740.37
142_A333_A0.8720.37
19_G64_F0.8710.37
27_Q30_P0.8700.37
216_R353_V0.8660.36
153_S274_K0.8640.36
4_K110_V0.8640.36
249_F264_I0.8630.36
232_N304_I0.8630.36
22_W26_T0.8630.36
131_F387_L0.8620.36
213_S467_F0.8620.36
158_V196_L0.8600.36
150_G192_E0.8540.36
272_L339_L0.8510.35
131_F148_F0.8500.35
1_M458_N0.8490.35
206_A213_S0.8490.35
255_L264_I0.8460.35
33_E183_S0.8460.35
208_S265_N0.8450.35
21_T25_G0.8450.35
8_G41_D0.8430.35
197_Q221_K0.8430.35
428_M435_Q0.8420.35
39_F189_G0.8410.35
196_L404_Q0.8410.35
343_Q370_I0.8390.35
6_A112_P0.8350.34
24_T448_L0.8320.34
133_A231_F0.8310.34
13_L144_L0.8310.34
128_Q132_I0.8290.34
160_P393_L0.8290.34
269_T436_L0.8250.34
174_T390_D0.8250.34
30_P440_D0.8230.34
14_A89_V0.8220.34
17_W352_P0.8190.33
59_F395_L0.8150.33
12_A402_A0.8150.33
216_R335_F0.8130.33
131_F283_G0.8110.33
166_F196_L0.8080.33
298_A302_F0.8080.33
380_T383_D0.8080.33
9_V153_S0.8060.33
452_P456_V0.8060.33
99_P458_N0.8060.33
154_T270_Y0.8050.33
236_I296_P0.8050.33
448_L455_V0.8010.32
40_N96_E0.8000.32
91_F150_G0.7990.32
27_Q31_G0.7960.32
185_L350_K0.7940.32
27_Q384_I0.7940.32
14_A17_W0.7930.32
64_F100_L0.7910.32
34_K229_S0.7910.32
264_I380_T0.7910.32
64_F403_K0.7860.32
8_G13_L0.7850.31
337_E441_N0.7830.31
18_G227_S0.7810.31
22_W99_P0.7800.31
305_Q369_S0.7790.31
342_L464_E0.7780.31
275_L297_S0.7770.31
194_I304_I0.7760.31
125_E210_T0.7760.31
11_V306_Y0.7750.31
264_I333_A0.7740.31
6_A10_I0.7730.31
227_S341_L0.7710.31
206_A222_F0.7700.31
142_A437_I0.7700.31
178_D181_S0.7690.31
230_K329_E0.7690.31
229_S242_D0.7680.31
38_D146_F0.7680.31
126_L342_L0.7660.30
24_T112_P0.7630.30
246_I440_D0.7620.30
155_T188_E0.7620.30
262_D296_P0.7600.30
60_D71_Q0.7590.30
197_Q203_K0.7580.30
61_K225_G0.7560.30
180_S452_P0.7510.30
185_L196_L0.7510.30
407_L417_Q0.7510.30
352_P355_W0.7500.29
415_K423_Q0.7490.29
124_N127_T0.7450.29
234_I329_E0.7450.29
170_E194_I0.7420.29
300_R389_F0.7390.29
347_P453_G0.7360.29
17_W21_T0.7360.29
304_I412_D0.7350.29
141_E156_L0.7330.29
65_N294_I0.7320.28
121_L159_A0.7300.28
13_L82_N0.7300.28
142_A172_Q0.7290.28
63_F291_A0.7280.28
135_K162_E0.7280.28
312_K385_K0.7270.28
140_V185_L0.7260.28
180_S229_S0.7250.28
11_V14_A0.7240.28
25_G295_D0.7230.28
144_L407_L0.7230.28
246_I265_N0.7190.28
117_A146_F0.7180.28
10_I18_G0.7170.28
163_Y452_P0.7170.28
8_G203_K0.7120.27
184_N275_L0.7120.27
22_W40_N0.7110.27
2_I9_V0.7110.27
457_F467_F0.7100.27
22_W283_G0.7090.27
22_W354_R0.7050.27
157_D236_I0.7050.27
57_Q302_F0.7050.27
63_F227_S0.7040.27
194_I387_L0.7020.27
302_F355_W0.7010.27
142_A324_E0.7000.27
64_F347_P0.6990.27
99_P115_A0.6990.27
21_T24_T0.6970.27
220_K260_D0.6970.27
156_L209_F0.6960.27
274_K354_R0.6960.27
167_S325_V0.6960.27
22_W64_F0.6940.26
141_E266_V0.6930.26
295_D345_S0.6920.26
136_N379_S0.6900.26
95_V194_I0.6880.26
185_L194_I0.6880.26
352_P441_N0.6870.26
1_M12_A0.6860.26
385_K414_E0.6860.26
204_V231_F0.6860.26
299_V375_K0.6850.26
351_Q441_N0.6850.26
64_F384_I0.6840.26
411_M419_Q0.6830.26
1_M4_K0.6800.26
232_N308_I0.6780.26
234_I390_D0.6780.26
168_F284_S0.6770.26
3_R431_G0.6760.26
145_R242_D0.6760.26
66_S300_R0.6750.25
20_G71_Q0.6740.25
33_E262_D0.6740.25
19_G24_T0.6700.25
191_V415_K0.6700.25
40_N99_P0.6650.25
389_F406_N0.6650.25
9_V17_W0.6640.25
25_G62_G0.6630.25
362_L437_I0.6610.25
92_D173_F0.6610.25
415_K419_Q0.6600.25
299_V389_F0.6600.25
198_L246_I0.6590.25
342_L364_A0.6580.25
329_E333_A0.6580.25
277_K282_L0.6550.24
72_M335_F0.6550.24
297_S414_E0.6500.24
62_G97_H0.6480.24
275_L433_M0.6470.24
40_N361_E0.6460.24
404_Q441_N0.6450.24
402_A423_Q0.6440.24
68_F171_G0.6430.24
228_E252_K0.6420.24
206_A265_N0.6410.24
58_N67_R0.6380.24
241_E286_E0.6370.24
154_T209_F0.6370.24
131_F134_A0.6370.24
15_V181_S0.6350.23
209_F378_S0.6350.23
222_F351_Q0.6340.23
2_I212_D0.6340.23
265_N445_S0.6340.23
173_F441_N0.6340.23
82_N289_L0.6330.23
281_Q351_Q0.6300.23
1_M10_I0.6290.23
244_A275_L0.6260.23
215_A292_E0.6250.23
217_L223_P0.6230.23
282_L285_G0.6220.23
393_L438_T0.6200.23
98_G115_A0.6200.23
279_N403_K0.6200.23
172_Q208_S0.6190.23
113_A435_Q0.6190.23
434_F438_T0.6190.23
39_F278_G0.6190.23
287_W304_I0.6180.23
112_P355_W0.6170.23
168_F171_G0.6160.23
200_P441_N0.6150.23
240_G447_Q0.6150.23
135_K165_K0.6150.23
251_A272_L0.6130.22
189_G380_T0.6130.22
134_A146_F0.6130.22
173_F241_E0.6120.22
71_Q90_V0.6110.22
21_T364_A0.6100.22
216_R226_E0.6090.22
257_R346_E0.6080.22
254_R286_E0.6080.22
301_Q304_I0.6080.22
34_K254_R0.6060.22
5_S20_G0.6050.22
218_E224_V0.6050.22
273_D358_A0.6020.22
32_V64_F0.6020.22
177_G436_L0.6010.22
12_A448_L0.6000.22
36_I40_N0.6000.22
62_G254_R0.5970.22
54_L450_Y0.5970.22
273_D450_Y0.5960.22
411_M414_E0.5960.22
21_T173_F0.5950.22
25_G59_F0.5950.22
113_A148_F0.5940.22
285_G289_L0.5940.22
331_N335_F0.5930.22
209_F271_E0.5930.22
38_D211_I0.5930.22
128_Q264_I0.5920.21
119_V225_G0.5920.21
331_N424_I0.5920.21
284_S466_E0.5880.21
226_E407_L0.5880.21
67_R307_N0.5870.21
214_L445_S0.5870.21
431_G434_F0.5870.21
95_V249_F0.5830.21
8_G453_G0.5820.21
189_G209_F0.5810.21
155_T236_I0.5810.21
98_G101_P0.5810.21
357_N444_A0.5800.21
73_T391_V0.5800.21
8_G158_V0.5800.21
70_M456_V0.5800.21
28_I366_L0.5780.21
92_D370_I0.5770.21
26_T86_G0.5750.21
18_G116_A0.5740.21
298_A340_P0.5720.21
4_K368_I0.5720.21
198_L237_I0.5710.21
214_L260_D0.5700.20
355_W454_K0.5690.20
8_G69_Q0.5670.20
27_Q448_L0.5670.20
431_G446_L0.5660.20
275_L447_Q0.5660.20
231_F465_E0.5650.20
260_D271_E0.5640.20
205_T234_I0.5640.20
74_F199_S0.5640.20
28_I182_L0.5630.20
20_G188_E0.5630.20
119_V299_V0.5620.20
226_E246_I0.5620.20
65_N414_E0.5620.20
13_L349_I0.5620.20
218_E221_K0.5610.20
294_I358_A0.5600.20
177_G292_E0.5600.20
2_I110_V0.5590.20
89_V381_N0.5580.20
375_K379_S0.5580.20
223_P251_A0.5580.20
272_L455_V0.5580.20
18_G447_Q0.5570.20
3_R9_V0.5570.20
196_L297_S0.5560.20
22_W101_P0.5560.20
244_A376_S0.5530.20
248_A285_G0.5530.20
153_S176_N0.5520.20
213_S227_S0.5520.20
150_G342_L0.5510.20
251_A339_L0.5510.20
30_P125_E0.5510.20
282_L368_I0.5490.20
234_I271_E0.5490.20
265_N426_G0.5480.20
209_F252_K0.5480.20
2_I190_K0.5470.20
25_G64_F0.5460.19
212_D268_L0.5460.19
39_F54_L0.5450.19
430_L435_Q0.5450.19
301_Q305_Q0.5440.19
279_N294_I0.5430.19
60_D441_N0.5430.19
337_E343_Q0.5420.19
330_V460_Q0.5420.19
14_A254_R0.5410.19
356_K365_N0.5410.19
222_F225_G0.5410.19
12_A117_A0.5410.19
13_L112_P0.5400.19
115_A283_G0.5390.19
328_Q393_L0.5390.19
73_T199_S0.5390.19
411_M418_K0.5380.19
363_N405_L0.5380.19
10_I453_G0.5380.19
254_R267_N0.5370.19
25_G115_A0.5360.19
147_A370_I0.5350.19
184_N194_I0.5340.19
65_N285_G0.5330.19
231_F235_N0.5320.19
341_L445_S0.5320.19
181_S195_V0.5320.19
413_A421_D0.5320.19
129_P132_I0.5310.19
214_L254_R0.5310.19
69_Q92_D0.5310.19
189_G229_S0.5300.19
292_E367_D0.5290.19
94_D194_I0.5290.19
95_V285_G0.5290.19
360_G366_L0.5280.19
282_L302_F0.5260.19
186_D246_I0.5260.19
100_L115_A0.5260.19
220_K370_I0.5240.19
92_D331_N0.5220.18
449_R453_G0.5210.18
158_V298_A0.5210.18
120_N176_N0.5210.18
229_S335_F0.5210.18
142_A343_Q0.5200.18
238_N307_N0.5190.18
231_F436_L0.5180.18
18_G63_F0.5180.18
269_T288_S0.5150.18
128_Q230_K0.5150.18
272_L330_V0.5140.18
161_A276_T0.5120.18
261_K353_V0.5110.18
142_A154_T0.5110.18
362_L450_Y0.5110.18
12_A90_V0.5090.18
82_N91_F0.5090.18
7_T34_K0.5090.18
121_L139_P0.5080.18
53_T70_M0.5080.18
286_E384_I0.5080.18
245_Q253_T0.5070.18
184_N260_D0.5070.18
194_I198_L0.5060.18
140_V280_Q0.5030.18
231_F262_D0.5030.18
59_F66_S0.5000.18
1_M440_D0.5000.18
89_V377_S0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j46n 1 0.1975 21.3 0.97 Contact Map
2jwkA 2 0.0735 16.6 0.971 Contact Map
2pfuA 1 0.1113 14.1 0.972 Contact Map
3zbiC 1 0.0588 12.9 0.973 Contact Map
3dh3A 1 0.1471 11.9 0.973 Contact Map
3j7aM 1 0.0924 11.4 0.973 Contact Map
4rb5I 1 0.0924 9.7 0.974 Contact Map
3j20K 1 0.0945 9.1 0.975 Contact Map
3j60Q 1 0.0651 8.6 0.975 Contact Map
4tp8I 1 0.0924 8.5 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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