GREMLIN Database
MOBB - Molybdopterin-guanine dinucleotide biosynthesis adapter protein
UniProt: P32125 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11828
Length: 175 (157)
Sequences: 1396 (1011)
Seq/√Len: 80.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_K59_E6.1901.00
40_L60_L4.3161.00
16_S55_K3.7231.00
158_D161_G3.5291.00
32_C66_A3.4521.00
39_G102_L3.1601.00
34_R164_D2.9421.00
75_R81_E2.6291.00
14_A18_T2.5231.00
61_R81_E2.4441.00
39_G97_M2.4161.00
30_A160_E2.3321.00
30_A34_R2.1991.00
50_V79_M2.1801.00
24_L60_L2.1271.00
11_A115_I2.0761.00
58_Y62_K2.0501.00
28_I40_L1.9141.00
34_R167_V1.8981.00
44_T48_M1.8761.00
36_I167_V1.8741.00
9_L94_A1.8301.00
67_Q80_T1.7991.00
107_V115_I1.7791.00
27_L162_L1.7681.00
48_M72_S1.6901.00
11_A107_V1.6881.00
118_I140_A1.6511.00
30_A163_A1.6371.00
89_D92_F1.6251.00
30_A159_V1.6221.00
57_S70_V1.5420.99
69_I78_L1.4970.99
18_T120_L1.4510.99
122_R156_I1.4340.99
23_L162_L1.3880.99
51_D54_G1.3830.99
7_I105_I1.3810.99
154_L165_F1.3730.99
27_L163_A1.3070.98
24_L29_P1.2920.98
30_A33_A1.2710.98
12_F27_L1.2650.98
51_D58_Y1.2520.98
152_A165_F1.2390.98
47_D74_Q1.2340.97
22_T159_V1.2110.97
111_K117_K1.2050.97
48_M79_M1.2010.97
110_F113_E1.1970.97
94_A105_I1.1960.97
71_A93_L1.1690.96
155_D158_D1.1640.96
160_E164_D1.1620.96
48_M77_A1.1560.96
48_M70_V1.1400.96
41_I105_I1.1030.95
123_D145_V1.0980.95
69_I93_L1.0980.95
76_W80_T1.0960.95
10_L169_W1.0890.95
36_I104_L1.0800.95
41_I90_L1.0780.94
24_L106_L1.0690.94
25_K63_A1.0660.94
40_L65_A1.0640.94
38_P104_L1.0530.94
144_D157_N1.0460.94
119_V133_V1.0450.94
48_M51_D1.0420.93
24_L28_I1.0390.93
119_V132_L1.0000.92
17_G55_K0.9840.91
50_V77_A0.9820.91
31_L167_V0.9800.91
121_F145_V0.9750.91
10_L106_L0.9670.91
73_Q87_E0.9580.90
25_K62_K0.9460.90
14_A68_T0.9410.89
12_F118_I0.9350.89
154_L162_L0.9330.89
9_L105_I0.9320.89
159_V162_L0.9240.88
9_L115_I0.9220.88
141_V149_L0.9200.88
70_V77_A0.9140.88
44_T72_S0.9060.87
15_W111_K0.9040.87
10_L166_V0.8960.87
15_W117_K0.8840.86
61_R75_R0.8800.86
49_D75_R0.8740.86
30_A164_D0.8700.85
54_G58_Y0.8480.84
53_P62_K0.8430.83
14_A109_G0.8400.83
10_L118_I0.8290.82
27_L31_L0.8290.82
155_D161_G0.8270.82
57_S60_L0.8170.81
143_S146_P0.8150.81
26_K159_V0.8120.81
144_D156_I0.8090.81
142_A154_L0.8080.81
148_N168_E0.7940.80
140_A154_L0.7920.79
45_H57_S0.7890.79
97_M102_L0.7830.79
119_V138_V0.7810.78
43_H111_K0.7770.78
8_P104_L0.7760.78
164_D168_E0.7740.78
23_L118_I0.7730.78
91_Q113_E0.7730.78
45_H71_A0.7730.78
31_L106_L0.7720.78
149_L153_L0.7710.78
142_A156_I0.7710.78
39_G60_L0.7660.77
67_Q96_R0.7650.77
44_T49_D0.7510.76
142_A155_D0.7390.75
12_F132_L0.7340.74
51_D55_K0.7340.74
14_A60_L0.7320.74
44_T60_L0.7300.74
134_I138_V0.7250.73
82_T87_E0.7210.73
161_G164_D0.7190.72
70_V75_R0.7190.72
26_K157_N0.7130.72
148_N152_A0.7120.72
43_H109_G0.7090.71
13_A119_V0.7080.71
150_D153_L0.7070.71
60_L63_A0.7070.71
10_L139_I0.7050.71
154_L159_V0.7040.71
130_E157_N0.7020.71
36_I103_D0.7000.70
134_I168_E0.6860.69
93_L110_F0.6850.69
118_I142_A0.6850.69
92_F95_S0.6840.69
143_S147_L0.6830.69
16_S24_L0.6800.68
31_L163_A0.6700.67
7_I14_A0.6690.67
43_H72_S0.6680.67
44_T70_V0.6640.66
122_R144_D0.6590.66
119_V144_D0.6580.66
39_G67_Q0.6500.65
149_L152_A0.6500.65
14_A120_L0.6460.64
17_G24_L0.6450.64
142_A162_L0.6450.64
121_F126_G0.6430.64
97_M101_K0.6410.64
159_V163_A0.6400.64
43_H56_D0.6390.63
17_G29_P0.6380.63
97_M105_I0.6370.63
90_L113_E0.6360.63
130_E135_D0.6300.62
71_A87_E0.6290.62
56_D111_K0.6280.62
67_Q100_S0.6250.62
11_A113_E0.6200.61
12_F26_K0.6180.61
67_Q102_L0.6120.60
67_Q78_L0.6100.60
48_M52_K0.6030.59
107_V110_F0.6030.59
14_A19_G0.6020.59
14_A20_K0.5960.58
10_L24_L0.5940.58
51_D77_A0.5870.57
133_V138_V0.5840.57
119_V125_A0.5830.56
26_K74_Q0.5830.56
59_E62_K0.5780.56
159_V166_V0.5770.56
89_D113_E0.5770.56
130_E141_V0.5770.56
54_G152_A0.5770.56
29_P40_L0.5750.55
119_V131_E0.5750.55
44_T73_Q0.5700.55
47_D73_Q0.5690.55
41_I69_I0.5690.55
31_L36_I0.5660.54
37_R66_A0.5660.54
12_F24_L0.5650.54
51_D79_M0.5650.54
80_T96_R0.5650.54
73_Q102_L0.5630.54
76_W82_T0.5630.54
69_I97_M0.5630.54
112_H131_E0.5570.53
23_L140_A0.5570.53
53_P58_Y0.5570.53
44_T74_Q0.5520.52
29_P32_C0.5520.52
22_T31_L0.5510.52
80_T101_K0.5510.52
53_P126_G0.5490.52
16_S120_L0.5480.52
84_D136_R0.5470.52
38_P83_P0.5470.52
27_L159_V0.5460.52
20_K108_E0.5450.52
93_L97_M0.5420.51
71_A82_T0.5410.51
95_S168_E0.5400.51
143_S153_L0.5380.51
41_I93_L0.5350.50
82_T88_L0.5330.50
28_I60_L0.5300.50
164_D167_V0.5280.49
30_A158_D0.5280.49
44_T47_D0.5270.49
130_E133_V0.5240.49
11_A138_V0.5230.49
34_R163_A0.5220.49
132_L138_V0.5220.49
90_L97_M0.5220.49
150_D168_E0.5200.48
153_L164_D0.5190.48
28_I63_A0.5140.48
154_L166_V0.5120.47
43_H117_K0.5120.47
57_S104_L0.5110.47
51_D70_V0.5070.47
62_K120_L0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4nkrA 2 0.9086 100 0.382 Contact Map
1xjcA 2 0.8171 100 0.422 Contact Map
1np6A 2 0.9714 99.9 0.608 Contact Map
2f1rA 2 0.8571 99.7 0.686 Contact Map
4ehxA 1 0.9429 99.3 0.757 Contact Map
2wsmA 2 0.8743 99 0.787 Contact Map
2hf9A 2 0.8971 98.8 0.802 Contact Map
4a0gA 2 0.8971 98.6 0.81 Contact Map
3fgnA 2 0.9371 98.5 0.819 Contact Map
3of5A 2 0.9086 98.4 0.821 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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