GREMLIN Database
LPLA - Lipoate-protein ligase A
UniProt: P32099 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11796
Length: 338 (314)
Sequences: 1421 (1048)
Seq/√Len: 59.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
156_N189_T4.0001.00
272_E277_T3.5041.00
186_T191_L3.3881.00
259_R264_G3.2811.00
110_N115_S3.1891.00
231_N237_A3.1321.00
103_S107_N2.8401.00
80_H86_C2.7641.00
170_K174_A2.6141.00
38_W88_T2.5961.00
111_A207_A2.5271.00
119_S125_V2.5231.00
196_T199_Q2.4911.00
61_M68_L2.4591.00
280_Q295_A2.3651.00
60_R64_D2.3461.00
41_A67_R2.3291.00
64_D165_Y2.2811.00
228_D231_N2.2561.00
173_L177_G2.2191.00
112_L203_A2.2121.00
73_S141_R2.1911.00
46_I52_P2.1091.00
305_A309_Q2.0981.00
60_R165_Y2.0221.00
294_L315_L2.0051.00
135_V186_T2.0031.00
124_L135_V1.9751.00
44_V61_M1.9501.00
172_K284_D1.9371.00
59_R63_E1.9351.00
85_T197_H1.8601.00
307_M310_Q1.8571.00
242_W247_G1.8511.00
116_A126_V1.8361.00
304_R307_M1.8070.99
84_N152_T1.7920.99
72_S238_R1.7690.99
325_E328_E1.7600.99
301_C311_E1.7580.99
133_R186_T1.7570.99
136_S152_T1.7430.99
302_L307_M1.7230.99
231_N234_E1.7220.99
111_A210_A1.7210.99
278_R299_Q1.6920.99
12_Y82_L1.6460.99
222_S225_K1.6220.99
122_N172_K1.6190.99
22_E26_R1.6020.99
40_N80_H1.5950.99
154_L157_A1.5930.99
26_R143_T1.5890.99
69_A245_N1.5870.99
133_R190_E1.5760.99
54_K179_T1.5690.99
107_N210_A1.5660.98
16_F226_T1.5490.98
158_D161_R1.5470.98
224_N227_P1.5440.98
230_P234_E1.5430.98
186_T190_E1.5260.98
115_S130_E1.5250.98
275_H302_L1.5070.98
54_K175_A1.5050.98
45_V78_V1.5030.98
17_N40_N1.4930.98
24_I28_M1.4880.98
253_S270_D1.4870.98
289_A294_L1.4660.98
33_R92_G1.4660.98
58_T62_E1.4650.98
297_R315_L1.4600.98
20_V229_L1.4530.98
87_F151_G1.4470.97
45_V80_H1.4420.97
242_W249_A1.4390.97
159_L163_A1.4310.97
252_F303_Y1.4290.97
289_A319_F1.4090.97
269_F279_A1.4040.97
108_A207_A1.3900.97
125_V131_G1.3890.97
38_W45_V1.3880.97
122_N263_G1.3870.97
232_F239_Q1.3860.97
172_K184_R1.3840.97
66_V165_Y1.3720.97
22_E238_R1.3660.96
45_V84_N1.3620.96
8_I201_C1.3590.96
252_F271_V1.3450.96
85_T200_V1.3390.96
78_V84_N1.3360.96
310_Q313_E1.3160.96
80_H84_N1.3130.96
43_T80_H1.3120.95
116_A124_L1.3030.95
139_A150_H1.2940.95
78_V152_T1.2930.95
255_L268_H1.2930.95
22_E239_Q1.2920.95
126_V188_L1.2840.95
18_L239_Q1.2640.94
242_W302_L1.2630.94
155_L195_I1.2630.94
279_A298_L1.2580.94
309_Q327_R1.2430.94
233_A240_S1.2410.94
296_G299_Q1.2370.94
39_R197_H1.2370.94
311_E314_A1.2360.94
88_T149_H1.2350.94
64_D161_R1.2340.94
21_E150_H1.2320.94
292_E296_G1.2080.93
316_L319_F1.1970.93
309_Q313_E1.1870.92
107_N207_A1.1830.92
130_E191_L1.1810.92
155_L200_V1.1760.92
311_E315_L1.1620.92
313_E326_L1.1580.91
13_D240_S1.1500.91
38_W149_H1.1500.91
281_V291_L1.1420.91
277_T300_G1.1410.91
126_V191_L1.1370.91
297_R311_E1.1170.90
301_C307_M1.1160.90
40_N69_A1.1150.90
171_K259_R1.1120.90
24_I34_V1.1060.89
18_L21_E1.1050.89
45_V152_T1.0980.89
173_L254_H1.0970.89
310_Q314_A1.0940.89
40_N86_C1.0900.89
54_K173_L1.0880.89
162_L185_V1.0860.89
101_S104_I1.0830.88
160_S163_A1.0810.88
18_L80_H1.0810.88
99_T103_S1.0790.88
195_I203_A1.0780.88
46_I77_A1.0770.88
184_R284_D1.0730.88
18_L45_V1.0720.88
126_V135_V1.0710.88
169_D257_D1.0710.88
14_P69_A1.0690.88
93_K145_D1.0690.88
80_H157_A1.0660.88
35_L208_F1.0600.87
73_S148_F1.0530.87
106_L124_L1.0520.87
37_L88_T1.0490.87
260_F265_V1.0490.87
14_P80_H1.0480.87
120_G184_R1.0470.87
60_R66_V1.0460.87
126_V186_T1.0450.87
138_S141_R1.0440.86
301_C308_L1.0360.86
120_G172_K1.0340.86
117_E131_G1.0270.86
38_W43_T1.0240.85
93_K147_G1.0220.85
17_N80_H1.0220.85
52_P68_L1.0200.85
234_E240_S1.0150.85
262_W324_K1.0130.85
16_F20_V1.0110.85
202_E206_E1.0100.85
44_V56_C1.0050.84
58_T246_F1.0040.84
154_L159_L0.9990.84
122_N184_R0.9980.84
15_W67_R0.9840.83
35_L252_F0.9820.83
307_M311_E0.9820.83
171_K257_D0.9770.83
62_E305_A0.9750.82
22_E141_R0.9740.82
24_I33_R0.9700.82
172_K263_G0.9690.82
207_A210_A0.9680.82
106_L116_A0.9660.82
14_P86_C0.9640.82
140_Y149_H0.9640.82
27_Q228_D0.9590.81
289_A293_A0.9550.81
168_P172_K0.9510.81
109_L135_V0.9420.80
121_R181_V0.9340.80
18_L86_C0.9300.79
11_S16_F0.9260.79
41_A82_L0.9230.79
227_P234_E0.9220.79
120_G284_D0.9200.79
209_F216_V0.9140.78
42_D161_R0.9140.78
309_Q326_L0.9100.78
49_A141_R0.8980.77
17_N21_E0.8980.77
159_L162_L0.8940.77
146_R159_L0.8940.77
324_K328_E0.8930.77
255_L266_E0.8880.76
40_N84_N0.8870.76
261_T328_E0.8850.76
9_S20_V0.8840.76
108_A203_A0.8810.76
173_L178_I0.8810.76
78_V86_C0.8810.76
23_C27_Q0.8760.75
161_R164_N0.8750.75
87_F138_S0.8740.75
122_N176_K0.8730.75
306_D310_Q0.8670.74
251_A272_E0.8650.74
102_T118_A0.8650.74
77_A166_L0.8610.74
88_T150_H0.8590.74
51_N244_W0.8570.74
232_F238_R0.8530.73
242_W274_G0.8500.73
114_V126_V0.8480.73
221_I229_L0.8400.72
90_M148_F0.8390.72
52_P249_A0.8370.72
98_K121_R0.8360.72
49_A140_Y0.8330.71
57_N60_R0.8290.71
72_S138_S0.8260.71
59_R62_E0.8250.71
85_T201_C0.8250.71
263_G284_D0.8230.70
254_H303_Y0.8210.70
39_R201_C0.8170.70
279_A299_Q0.8130.70
46_I114_V0.8130.70
9_S36_F0.8120.69
257_D266_E0.8110.69
297_R304_R0.8090.69
184_R263_G0.8030.69
297_R314_A0.8020.68
39_R42_D0.7970.68
72_S141_R0.7960.68
169_D264_G0.7930.68
122_N284_D0.7930.68
135_V188_L0.7920.68
88_T148_F0.7920.68
22_E72_S0.7900.67
60_R164_N0.7900.67
25_F49_A0.7890.67
249_A274_G0.7880.67
39_R85_T0.7860.67
45_V86_C0.7820.67
160_S296_G0.7800.66
57_N167_N0.7790.66
50_Q55_E0.7760.66
133_R191_L0.7710.65
164_N246_F0.7700.65
276_I308_L0.7690.65
171_K258_E0.7660.65
42_D79_F0.7610.64
110_N114_V0.7570.64
15_W239_Q0.7560.64
25_F152_T0.7540.64
91_A147_G0.7540.64
199_Q202_E0.7500.63
242_W245_N0.7490.63
259_R284_D0.7430.63
89_F105_V0.7410.62
21_E45_V0.7400.62
56_C61_M0.7350.62
115_S191_L0.7350.62
9_S16_F0.7340.62
270_D278_R0.7310.61
283_T286_L0.7300.61
74_G137_G0.7300.61
14_P46_I0.7260.61
206_E210_A0.7260.61
321_E324_K0.7240.61
101_S140_Y0.7210.60
73_S150_H0.7190.60
293_A297_R0.7180.60
138_S151_G0.7150.60
195_I206_E0.7130.59
38_W73_S0.7120.59
102_T138_S0.7100.59
323_E326_L0.7100.59
93_K142_E0.7090.59
293_A311_E0.7030.58
125_V130_E0.7000.58
318_D325_E0.6990.58
267_L281_V0.6960.58
27_Q232_F0.6960.58
130_E133_R0.6950.57
80_H150_H0.6940.57
116_A135_V0.6930.57
38_W140_Y0.6920.57
60_R63_E0.6900.57
188_L200_V0.6890.57
322_Q328_E0.6890.57
294_L321_E0.6880.57
73_S138_S0.6860.56
17_N51_N0.6840.56
80_H152_T0.6790.56
285_S291_L0.6790.56
198_E202_E0.6770.55
45_V183_S0.6720.55
90_M151_G0.6710.55
260_F263_G0.6630.54
48_R150_H0.6620.54
21_E88_T0.6610.54
83_G187_N0.6600.54
306_D311_E0.6590.53
20_V36_F0.6550.53
88_T139_A0.6550.53
259_R262_W0.6540.53
163_A181_V0.6530.53
172_K259_R0.6530.53
203_A206_E0.6520.53
26_R199_Q0.6500.52
253_S272_E0.6490.52
99_T117_E0.6470.52
171_K174_A0.6450.52
56_C283_T0.6450.52
200_V204_I0.6440.52
155_L189_T0.6440.52
53_W252_F0.6430.52
85_T153_L0.6430.52
317_V326_L0.6380.51
119_S183_S0.6370.51
14_P40_N0.6370.51
172_K176_K0.6350.51
138_S150_H0.6330.51
28_M32_Q0.6330.51
173_L181_V0.6310.50
49_A84_N0.6290.50
42_D66_V0.6280.50
36_F101_S0.6280.50
72_S239_Q0.6280.50
40_N45_V0.6280.50
45_V149_H0.6270.50
314_A317_V0.6260.50
25_F143_T0.6250.50
146_R188_L0.6250.50
251_A273_K0.6250.50
169_D259_R0.6230.49
269_F276_I0.6210.49
68_L249_A0.6210.49
54_K268_H0.6200.49
189_T194_G0.6190.49
16_F25_F0.6160.49
18_L35_L0.6150.49
62_E306_D0.6130.48
210_A299_Q0.6120.48
13_D69_A0.6120.48
49_A152_T0.6120.48
60_R219_E0.6070.48
318_D321_E0.6050.47
57_N164_N0.6040.47
305_A315_L0.6020.47
171_K264_G0.6020.47
38_W155_L0.6020.47
100_I103_S0.6010.47
81_D180_S0.5980.47
25_F100_I0.5980.47
291_L295_A0.5970.47
142_E147_G0.5940.46
79_F175_A0.5940.46
84_N183_S0.5920.46
310_Q318_D0.5920.46
14_P67_R0.5910.46
48_R139_A0.5900.46
151_G187_N0.5900.46
39_R43_T0.5890.46
135_V170_K0.5880.46
40_N43_T0.5880.46
153_L188_L0.5870.45
96_Y153_L0.5860.45
102_T124_L0.5840.45
136_S151_G0.5830.45
14_P18_L0.5820.45
36_F173_L0.5790.45
79_F246_F0.5790.45
9_S24_I0.5770.44
205_T209_F0.5760.44
158_D164_N0.5750.44
95_E265_V0.5740.44
17_N187_N0.5740.44
172_K283_T0.5730.44
80_H187_N0.5700.44
18_L232_F0.5680.43
72_S148_F0.5680.43
102_T140_Y0.5680.43
318_D322_Q0.5670.43
111_A206_E0.5660.43
66_V86_C0.5660.43
292_E295_A0.5650.43
260_F324_K0.5650.43
283_T312_C0.5640.43
219_E225_K0.5640.43
98_K104_I0.5630.43
258_E261_T0.5610.43
275_H278_R0.5610.43
77_A184_R0.5610.43
205_T308_L0.5580.42
44_V148_F0.5580.42
318_D323_E0.5570.42
271_V274_G0.5570.42
120_G168_P0.5560.42
97_D100_I0.5530.42
17_N84_N0.5510.41
304_R309_Q0.5490.41
17_N150_H0.5490.41
223_P227_P0.5490.41
52_P245_N0.5470.41
84_N150_H0.5470.41
310_Q327_R0.5430.41
135_V154_L0.5430.41
224_N292_E0.5430.41
57_N154_L0.5420.41
37_L151_G0.5420.41
225_K229_L0.5410.40
163_A178_I0.5410.40
72_S232_F0.5410.40
84_N180_S0.5400.40
87_F102_T0.5370.40
110_N273_K0.5360.40
64_D164_N0.5340.40
124_L297_R0.5320.39
39_R155_L0.5310.39
183_S274_G0.5310.39
63_E227_P0.5310.39
45_V150_H0.5300.39
248_Q278_R0.5300.39
199_Q203_A0.5300.39
14_P24_I0.5290.39
80_H85_T0.5270.39
26_R146_R0.5270.39
139_A180_S0.5260.39
258_E324_K0.5260.39
169_D174_A0.5260.39
57_N77_A0.5240.39
121_R180_S0.5210.38
36_F88_T0.5200.38
318_D326_L0.5180.38
140_Y188_L0.5180.38
121_R183_S0.5170.38
110_N204_I0.5160.38
298_L301_C0.5150.38
211_H214_E0.5150.38
293_A296_G0.5140.38
270_D277_T0.5140.38
310_Q319_F0.5140.38
98_K101_S0.5130.37
72_S77_A0.5130.37
289_A297_R0.5090.37
172_K285_S0.5090.37
63_E222_S0.5070.37
56_C68_L0.5070.37
98_K239_Q0.5070.37
21_E36_F0.5030.36
293_A321_E0.5010.36
40_N152_T0.5010.36
200_V287_N0.5000.36
271_V279_A0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3a7rA 1 0.997 100 0.219 Contact Map
2e5aA 1 0.9408 100 0.258 Contact Map
1vqzA 1 0.9645 100 0.283 Contact Map
2c8mA 1 0.6864 100 0.439 Contact Map
2p0lA 1 0.6864 100 0.536 Contact Map
2p5iA 1 0.6864 100 0.554 Contact Map
2qhsA 1 0.5947 100 0.597 Contact Map
1w66A 1 0.5858 100 0.627 Contact Map
3r07C 1 0.2515 99.3 0.87 Contact Map
2dxuA 2 0.6243 96.3 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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