LPLA - ECOLI - GREMLIN Contacts

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LPLA - Lipoate-protein ligase A

UniProt:	P32099	Sequences: MSTLRLLISDSYDPWFNLAVEECIFRQMPATQRVLFLWRNADTVVIGRAQNPWKECNTRRMEEDNVRLARRSSGGGAVFHDLGNTCFTFMAGKPEYDKTISTSIVLNALNALGVSAEASGRNDLVVKTVEGDRKVSGSAYRETKDRGFHHGTLLLNADLSRLANYLNPDKKKLAAKGITSVRSRVTNLTELLPGITHEQVCEAITEAFFAHYGERVEAEIISPNKTPDLPNFAETFARQSSWEWNFGQAPAFSHLLDERFTWGGVELHFDVEKGHITRAQVFTDSLNPAPLEALAGRLQGCLYRADMLQQECEALLVDFPEQEKELRELSAWMAGAVR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11796
Length:	338 (314)
Sequences:	1421 (1048)
Seq/√Len:	59.2

ECOLI - LPLA
BACSU - LPLJ LIPM LIPL
HALSA - Q9HSK8
SULSO - Q97Z28 Q97U65 Q97Z70 Q97U62

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
156_N	189_T	4.000	1.00
272_E	277_T	3.504	1.00
186_T	191_L	3.388	1.00
259_R	264_G	3.281	1.00
110_N	115_S	3.189	1.00
231_N	237_A	3.132	1.00
103_S	107_N	2.840	1.00
80_H	86_C	2.764	1.00
170_K	174_A	2.614	1.00
38_W	88_T	2.596	1.00
111_A	207_A	2.527	1.00
119_S	125_V	2.523	1.00
196_T	199_Q	2.491	1.00
61_M	68_L	2.459	1.00
280_Q	295_A	2.365	1.00
60_R	64_D	2.346	1.00
41_A	67_R	2.329	1.00
64_D	165_Y	2.281	1.00
228_D	231_N	2.256	1.00
173_L	177_G	2.219	1.00
112_L	203_A	2.212	1.00
73_S	141_R	2.191	1.00
46_I	52_P	2.109	1.00
305_A	309_Q	2.098	1.00
60_R	165_Y	2.022	1.00
294_L	315_L	2.005	1.00
135_V	186_T	2.003	1.00
124_L	135_V	1.975	1.00
44_V	61_M	1.950	1.00
172_K	284_D	1.937	1.00
59_R	63_E	1.935	1.00
85_T	197_H	1.860	1.00
307_M	310_Q	1.857	1.00
242_W	247_G	1.851	1.00
116_A	126_V	1.836	1.00
304_R	307_M	1.807	0.99
84_N	152_T	1.792	0.99
72_S	238_R	1.769	0.99
325_E	328_E	1.760	0.99
301_C	311_E	1.758	0.99
133_R	186_T	1.757	0.99
136_S	152_T	1.743	0.99
302_L	307_M	1.723	0.99
231_N	234_E	1.722	0.99
111_A	210_A	1.721	0.99
278_R	299_Q	1.692	0.99
12_Y	82_L	1.646	0.99
222_S	225_K	1.622	0.99
122_N	172_K	1.619	0.99
22_E	26_R	1.602	0.99
40_N	80_H	1.595	0.99
154_L	157_A	1.593	0.99
26_R	143_T	1.589	0.99
69_A	245_N	1.587	0.99
133_R	190_E	1.576	0.99
54_K	179_T	1.569	0.99
107_N	210_A	1.566	0.98
16_F	226_T	1.549	0.98
158_D	161_R	1.547	0.98
224_N	227_P	1.544	0.98
230_P	234_E	1.543	0.98
186_T	190_E	1.526	0.98
115_S	130_E	1.525	0.98
275_H	302_L	1.507	0.98
54_K	175_A	1.505	0.98
45_V	78_V	1.503	0.98
17_N	40_N	1.493	0.98
24_I	28_M	1.488	0.98
253_S	270_D	1.487	0.98
289_A	294_L	1.466	0.98
33_R	92_G	1.466	0.98
58_T	62_E	1.465	0.98
297_R	315_L	1.460	0.98
20_V	229_L	1.453	0.98
87_F	151_G	1.447	0.97
45_V	80_H	1.442	0.97
242_W	249_A	1.439	0.97
159_L	163_A	1.431	0.97
252_F	303_Y	1.429	0.97
289_A	319_F	1.409	0.97
269_F	279_A	1.404	0.97
108_A	207_A	1.390	0.97
125_V	131_G	1.389	0.97
38_W	45_V	1.388	0.97
122_N	263_G	1.387	0.97
232_F	239_Q	1.386	0.97
172_K	184_R	1.384	0.97
66_V	165_Y	1.372	0.97
22_E	238_R	1.366	0.96
45_V	84_N	1.362	0.96
8_I	201_C	1.359	0.96
252_F	271_V	1.345	0.96
85_T	200_V	1.339	0.96
78_V	84_N	1.336	0.96
310_Q	313_E	1.316	0.96
80_H	84_N	1.313	0.96
43_T	80_H	1.312	0.95
116_A	124_L	1.303	0.95
139_A	150_H	1.294	0.95
78_V	152_T	1.293	0.95
255_L	268_H	1.293	0.95
22_E	239_Q	1.292	0.95
126_V	188_L	1.284	0.95
18_L	239_Q	1.264	0.94
242_W	302_L	1.263	0.94
155_L	195_I	1.263	0.94
279_A	298_L	1.258	0.94
309_Q	327_R	1.243	0.94
233_A	240_S	1.241	0.94
296_G	299_Q	1.237	0.94
39_R	197_H	1.237	0.94
311_E	314_A	1.236	0.94
88_T	149_H	1.235	0.94
64_D	161_R	1.234	0.94
21_E	150_H	1.232	0.94
292_E	296_G	1.208	0.93
316_L	319_F	1.197	0.93
309_Q	313_E	1.187	0.92
107_N	207_A	1.183	0.92
130_E	191_L	1.181	0.92
155_L	200_V	1.176	0.92
311_E	315_L	1.162	0.92
313_E	326_L	1.158	0.91
13_D	240_S	1.150	0.91
38_W	149_H	1.150	0.91
281_V	291_L	1.142	0.91
277_T	300_G	1.141	0.91
126_V	191_L	1.137	0.91
297_R	311_E	1.117	0.90
301_C	307_M	1.116	0.90
40_N	69_A	1.115	0.90
171_K	259_R	1.112	0.90
24_I	34_V	1.106	0.89
18_L	21_E	1.105	0.89
45_V	152_T	1.098	0.89
173_L	254_H	1.097	0.89
310_Q	314_A	1.094	0.89
40_N	86_C	1.090	0.89
54_K	173_L	1.088	0.89
162_L	185_V	1.086	0.89
101_S	104_I	1.083	0.88
160_S	163_A	1.081	0.88
18_L	80_H	1.081	0.88
99_T	103_S	1.079	0.88
195_I	203_A	1.078	0.88
46_I	77_A	1.077	0.88
184_R	284_D	1.073	0.88
18_L	45_V	1.072	0.88
126_V	135_V	1.071	0.88
169_D	257_D	1.071	0.88
14_P	69_A	1.069	0.88
93_K	145_D	1.069	0.88
80_H	157_A	1.066	0.88
35_L	208_F	1.060	0.87
73_S	148_F	1.053	0.87
106_L	124_L	1.052	0.87
37_L	88_T	1.049	0.87
260_F	265_V	1.049	0.87
14_P	80_H	1.048	0.87
120_G	184_R	1.047	0.87
60_R	66_V	1.046	0.87
126_V	186_T	1.045	0.87
138_S	141_R	1.044	0.86
301_C	308_L	1.036	0.86
120_G	172_K	1.034	0.86
117_E	131_G	1.027	0.86
38_W	43_T	1.024	0.85
93_K	147_G	1.022	0.85
17_N	80_H	1.022	0.85
52_P	68_L	1.020	0.85
234_E	240_S	1.015	0.85
262_W	324_K	1.013	0.85
16_F	20_V	1.011	0.85
202_E	206_E	1.010	0.85
44_V	56_C	1.005	0.84
58_T	246_F	1.004	0.84
154_L	159_L	0.999	0.84
122_N	184_R	0.998	0.84
15_W	67_R	0.984	0.83
35_L	252_F	0.982	0.83
307_M	311_E	0.982	0.83
171_K	257_D	0.977	0.83
62_E	305_A	0.975	0.82
22_E	141_R	0.974	0.82
24_I	33_R	0.970	0.82
172_K	263_G	0.969	0.82
207_A	210_A	0.968	0.82
106_L	116_A	0.966	0.82
14_P	86_C	0.964	0.82
140_Y	149_H	0.964	0.82
27_Q	228_D	0.959	0.81
289_A	293_A	0.955	0.81
168_P	172_K	0.951	0.81
109_L	135_V	0.942	0.80
121_R	181_V	0.934	0.80
18_L	86_C	0.930	0.79
11_S	16_F	0.926	0.79
41_A	82_L	0.923	0.79
227_P	234_E	0.922	0.79
120_G	284_D	0.920	0.79
209_F	216_V	0.914	0.78
42_D	161_R	0.914	0.78
309_Q	326_L	0.910	0.78
49_A	141_R	0.898	0.77
17_N	21_E	0.898	0.77
159_L	162_L	0.894	0.77
146_R	159_L	0.894	0.77
324_K	328_E	0.893	0.77
255_L	266_E	0.888	0.76
40_N	84_N	0.887	0.76
261_T	328_E	0.885	0.76
9_S	20_V	0.884	0.76
108_A	203_A	0.881	0.76
173_L	178_I	0.881	0.76
78_V	86_C	0.881	0.76
23_C	27_Q	0.876	0.75
161_R	164_N	0.875	0.75
87_F	138_S	0.874	0.75
122_N	176_K	0.873	0.75
306_D	310_Q	0.867	0.74
251_A	272_E	0.865	0.74
102_T	118_A	0.865	0.74
77_A	166_L	0.861	0.74
88_T	150_H	0.859	0.74
51_N	244_W	0.857	0.74
232_F	238_R	0.853	0.73
242_W	274_G	0.850	0.73
114_V	126_V	0.848	0.73
221_I	229_L	0.840	0.72
90_M	148_F	0.839	0.72
52_P	249_A	0.837	0.72
98_K	121_R	0.836	0.72
49_A	140_Y	0.833	0.71
57_N	60_R	0.829	0.71
72_S	138_S	0.826	0.71
59_R	62_E	0.825	0.71
85_T	201_C	0.825	0.71
263_G	284_D	0.823	0.70
254_H	303_Y	0.821	0.70
39_R	201_C	0.817	0.70
279_A	299_Q	0.813	0.70
46_I	114_V	0.813	0.70
9_S	36_F	0.812	0.69
257_D	266_E	0.811	0.69
297_R	304_R	0.809	0.69
184_R	263_G	0.803	0.69
297_R	314_A	0.802	0.68
39_R	42_D	0.797	0.68
72_S	141_R	0.796	0.68
169_D	264_G	0.793	0.68
122_N	284_D	0.793	0.68
135_V	188_L	0.792	0.68
88_T	148_F	0.792	0.68
22_E	72_S	0.790	0.67
60_R	164_N	0.790	0.67
25_F	49_A	0.789	0.67
249_A	274_G	0.788	0.67
39_R	85_T	0.786	0.67
45_V	86_C	0.782	0.67
160_S	296_G	0.780	0.66
57_N	167_N	0.779	0.66
50_Q	55_E	0.776	0.66
133_R	191_L	0.771	0.65
164_N	246_F	0.770	0.65
276_I	308_L	0.769	0.65
171_K	258_E	0.766	0.65
42_D	79_F	0.761	0.64
110_N	114_V	0.757	0.64
15_W	239_Q	0.756	0.64
25_F	152_T	0.754	0.64
91_A	147_G	0.754	0.64
199_Q	202_E	0.750	0.63
242_W	245_N	0.749	0.63
259_R	284_D	0.743	0.63
89_F	105_V	0.741	0.62
21_E	45_V	0.740	0.62
56_C	61_M	0.735	0.62
115_S	191_L	0.735	0.62
9_S	16_F	0.734	0.62
270_D	278_R	0.731	0.61
283_T	286_L	0.730	0.61
74_G	137_G	0.730	0.61
14_P	46_I	0.726	0.61
206_E	210_A	0.726	0.61
321_E	324_K	0.724	0.61
101_S	140_Y	0.721	0.60
73_S	150_H	0.719	0.60
293_A	297_R	0.718	0.60
138_S	151_G	0.715	0.60
195_I	206_E	0.713	0.59
38_W	73_S	0.712	0.59
102_T	138_S	0.710	0.59
323_E	326_L	0.710	0.59
93_K	142_E	0.709	0.59
293_A	311_E	0.703	0.58
125_V	130_E	0.700	0.58
318_D	325_E	0.699	0.58
267_L	281_V	0.696	0.58
27_Q	232_F	0.696	0.58
130_E	133_R	0.695	0.57
80_H	150_H	0.694	0.57
116_A	135_V	0.693	0.57
38_W	140_Y	0.692	0.57
60_R	63_E	0.690	0.57
188_L	200_V	0.689	0.57
322_Q	328_E	0.689	0.57
294_L	321_E	0.688	0.57
73_S	138_S	0.686	0.56
17_N	51_N	0.684	0.56
80_H	152_T	0.679	0.56
285_S	291_L	0.679	0.56
198_E	202_E	0.677	0.55
45_V	183_S	0.672	0.55
90_M	151_G	0.671	0.55
260_F	263_G	0.663	0.54
48_R	150_H	0.662	0.54
21_E	88_T	0.661	0.54
83_G	187_N	0.660	0.54
306_D	311_E	0.659	0.53
20_V	36_F	0.655	0.53
88_T	139_A	0.655	0.53
259_R	262_W	0.654	0.53
163_A	181_V	0.653	0.53
172_K	259_R	0.653	0.53
203_A	206_E	0.652	0.53
26_R	199_Q	0.650	0.52
253_S	272_E	0.649	0.52
99_T	117_E	0.647	0.52
171_K	174_A	0.645	0.52
56_C	283_T	0.645	0.52
200_V	204_I	0.644	0.52
155_L	189_T	0.644	0.52
53_W	252_F	0.643	0.52
85_T	153_L	0.643	0.52
317_V	326_L	0.638	0.51
119_S	183_S	0.637	0.51
14_P	40_N	0.637	0.51
172_K	176_K	0.635	0.51
138_S	150_H	0.633	0.51
28_M	32_Q	0.633	0.51
173_L	181_V	0.631	0.50
49_A	84_N	0.629	0.50
42_D	66_V	0.628	0.50
36_F	101_S	0.628	0.50
72_S	239_Q	0.628	0.50
40_N	45_V	0.628	0.50
45_V	149_H	0.627	0.50
314_A	317_V	0.626	0.50
25_F	143_T	0.625	0.50
146_R	188_L	0.625	0.50
251_A	273_K	0.625	0.50
169_D	259_R	0.623	0.49
269_F	276_I	0.621	0.49
68_L	249_A	0.621	0.49
54_K	268_H	0.620	0.49
189_T	194_G	0.619	0.49
16_F	25_F	0.616	0.49
18_L	35_L	0.615	0.49
62_E	306_D	0.613	0.48
210_A	299_Q	0.612	0.48
13_D	69_A	0.612	0.48
49_A	152_T	0.612	0.48
60_R	219_E	0.607	0.48
318_D	321_E	0.605	0.47
57_N	164_N	0.604	0.47
305_A	315_L	0.602	0.47
171_K	264_G	0.602	0.47
38_W	155_L	0.602	0.47
100_I	103_S	0.601	0.47
81_D	180_S	0.598	0.47
25_F	100_I	0.598	0.47
291_L	295_A	0.597	0.47
142_E	147_G	0.594	0.46
79_F	175_A	0.594	0.46
84_N	183_S	0.592	0.46
310_Q	318_D	0.592	0.46
14_P	67_R	0.591	0.46
48_R	139_A	0.590	0.46
151_G	187_N	0.590	0.46
39_R	43_T	0.589	0.46
135_V	170_K	0.588	0.46
40_N	43_T	0.588	0.46
153_L	188_L	0.587	0.45
96_Y	153_L	0.586	0.45
102_T	124_L	0.584	0.45
136_S	151_G	0.583	0.45
14_P	18_L	0.582	0.45
36_F	173_L	0.579	0.45
79_F	246_F	0.579	0.45
9_S	24_I	0.577	0.44
205_T	209_F	0.576	0.44
158_D	164_N	0.575	0.44
95_E	265_V	0.574	0.44
17_N	187_N	0.574	0.44
172_K	283_T	0.573	0.44
80_H	187_N	0.570	0.44
18_L	232_F	0.568	0.43
72_S	148_F	0.568	0.43
102_T	140_Y	0.568	0.43
318_D	322_Q	0.567	0.43
111_A	206_E	0.566	0.43
66_V	86_C	0.566	0.43
292_E	295_A	0.565	0.43
260_F	324_K	0.565	0.43
283_T	312_C	0.564	0.43
219_E	225_K	0.564	0.43
98_K	104_I	0.563	0.43
258_E	261_T	0.561	0.43
275_H	278_R	0.561	0.43
77_A	184_R	0.561	0.43
205_T	308_L	0.558	0.42
44_V	148_F	0.558	0.42
318_D	323_E	0.557	0.42
271_V	274_G	0.557	0.42
120_G	168_P	0.556	0.42
97_D	100_I	0.553	0.42
17_N	84_N	0.551	0.41
304_R	309_Q	0.549	0.41
17_N	150_H	0.549	0.41
223_P	227_P	0.549	0.41
52_P	245_N	0.547	0.41
84_N	150_H	0.547	0.41
310_Q	327_R	0.543	0.41
135_V	154_L	0.543	0.41
224_N	292_E	0.543	0.41
57_N	154_L	0.542	0.41
37_L	151_G	0.542	0.41
225_K	229_L	0.541	0.40
163_A	178_I	0.541	0.40
72_S	232_F	0.541	0.40
84_N	180_S	0.540	0.40
87_F	102_T	0.537	0.40
110_N	273_K	0.536	0.40
64_D	164_N	0.534	0.40
124_L	297_R	0.532	0.39
39_R	155_L	0.531	0.39
183_S	274_G	0.531	0.39
63_E	227_P	0.531	0.39
45_V	150_H	0.530	0.39
248_Q	278_R	0.530	0.39
199_Q	203_A	0.530	0.39
14_P	24_I	0.529	0.39
80_H	85_T	0.527	0.39
26_R	146_R	0.527	0.39
139_A	180_S	0.526	0.39
258_E	324_K	0.526	0.39
169_D	174_A	0.526	0.39
57_N	77_A	0.524	0.39
121_R	180_S	0.521	0.38
36_F	88_T	0.520	0.38
318_D	326_L	0.518	0.38
140_Y	188_L	0.518	0.38
121_R	183_S	0.517	0.38
110_N	204_I	0.516	0.38
298_L	301_C	0.515	0.38
211_H	214_E	0.515	0.38
293_A	296_G	0.514	0.38
270_D	277_T	0.514	0.38
310_Q	319_F	0.514	0.38
98_K	101_S	0.513	0.37
72_S	77_A	0.513	0.37
289_A	297_R	0.509	0.37
172_K	285_S	0.509	0.37
63_E	222_S	0.507	0.37
56_C	68_L	0.507	0.37
98_K	239_Q	0.507	0.37
21_E	36_F	0.503	0.36
293_A	321_E	0.501	0.36
40_N	152_T	0.501	0.36
200_V	287_N	0.500	0.36
271_V	279_A	0.500	0.36

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3a7rA	1	0.997	100	0.219	Contact Map
2e5aA	1	0.9408	100	0.258	Contact Map
1vqzA	1	0.9645	100	0.283	Contact Map
2c8mA	1	0.6864	100	0.439	Contact Map
2p0lA	1	0.6864	100	0.536	Contact Map
2p5iA	1	0.6864	100	0.554	Contact Map
2qhsA	1	0.5947	100	0.597	Contact Map
1w66A	1	0.5858	100	0.627	Contact Map
3r07C	1	0.2515	99.3	0.87	Contact Map
2dxuA	2	0.6243	96.3	0.937	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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