GREMLIN Database
GMM - GDP-mannose mannosyl hydrolase
UniProt: P32056 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11789
Length: 159 (147)
Sequences: 230 (165)
Seq/√Len: 13.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
143_N146_A4.8641.00
92_N98_F4.8261.00
25_E108_R3.9361.00
26_N30_E3.0600.97
4_R7_D2.9740.97
59_E76_I2.9350.97
39_R91_D2.7660.95
62_F79_G2.5670.93
86_Q104_V2.4160.90
134_L148_F2.1130.83
52_V103_V2.0200.80
65_L143_N2.0140.80
55_D92_N2.0020.80
81_F93_F1.9220.77
111_V116_L1.8960.76
42_Q95_G1.8690.75
17_L100_T1.8470.74
89_Y102_Y1.8130.72
82_Y85_W1.7040.67
52_V58_L1.6810.66
47_V104_V1.6480.65
81_F86_Q1.6330.64
88_F92_N1.6280.64
55_D99_T1.5820.61
86_Q107_F1.5680.61
46_F87_H1.5530.60
94_S98_F1.4970.57
92_N148_F1.4700.56
134_L145_R1.4560.55
30_E84_V1.4340.54
142_A146_A1.4070.52
119_P126_Y1.4050.52
37_T124_D1.3750.50
129_L143_N1.3410.49
14_S53_Q1.3410.49
8_F51_R1.3380.48
97_D138_D1.3160.47
72_L117_L1.3070.47
127_R137_S1.2990.46
58_L81_F1.2920.46
33_L84_V1.2810.45
19_S65_L1.2530.44
129_L137_S1.2520.44
82_Y107_F1.2460.44
34_G102_Y1.2450.44
118_L126_Y1.2390.43
3_L106_G1.2290.43
18_V147_Y1.2160.42
84_V104_V1.2130.42
34_G89_Y1.2030.41
37_T125_D1.1830.40
43_G58_L1.1800.40
30_E130_T1.1770.40
122_Q128_W1.1490.39
53_Q65_L1.1490.39
135_L145_R1.1320.38
84_V105_L1.1310.38
12_V93_F1.1270.37
93_F104_V1.1200.37
45_W58_L1.0730.35
46_F89_Y1.0700.35
41_A87_H1.0590.34
29_G68_A1.0510.34
81_F105_L1.0470.34
35_K112_S1.0430.33
41_A46_F1.0330.33
8_F17_L1.0260.33
26_N118_L1.0150.32
23_I81_F1.0030.31
104_V147_Y0.9800.30
87_H141_H0.9770.30
33_L129_L0.9650.30
4_R15_T0.9540.29
46_F141_H0.9530.29
45_W140_V0.9480.29
60_A124_D0.9380.29
15_T143_N0.9350.28
109_F118_L0.9350.28
25_E131_S0.9300.28
6_E99_T0.9230.28
87_H102_Y0.9160.28
46_F102_Y0.9130.27
42_Q63_E0.9130.27
3_L8_F0.8970.27
115_E118_L0.8920.27
63_E73_R0.8870.26
51_R128_W0.8800.26
31_F144_S0.8770.26
26_N119_P0.8760.26
110_R125_D0.8750.26
17_L20_L0.8660.25
68_A121_E0.8620.25
63_E142_A0.8600.25
5_Q24_V0.8600.25
144_S148_F0.8570.25
67_M138_D0.8570.25
112_S125_D0.8570.25
55_D81_F0.8560.25
80_Q108_R0.8550.25
145_R148_F0.8530.25
28_R117_L0.8440.25
77_T138_D0.8430.25
30_E133_A0.8370.24
120_D149_L0.8360.24
31_F134_L0.8330.24
13_R39_R0.8280.24
121_E139_N0.8270.24
41_A141_H0.8260.24
114_E117_L0.8170.24
25_E110_R0.8140.23
102_Y141_H0.8110.23
6_E138_D0.8010.23
77_T139_N0.7970.23
75_P78_A0.7900.23
106_G147_Y0.7870.22
76_I117_L0.7760.22
8_F100_T0.7740.22
8_F46_F0.7680.22
102_Y123_H0.7610.21
7_D11_V0.7590.21
11_V15_T0.7580.21
89_Y141_H0.7570.21
111_V120_D0.7550.21
4_R66_T0.7450.21
9_A107_F0.7400.21
9_A97_D0.7400.21
44_Y106_G0.7360.21
72_L80_Q0.7350.21
12_V43_G0.7320.20
67_M132_D0.7310.20
135_L149_L0.7260.20
18_V146_A0.7240.20
28_R136_A0.7230.20
121_E138_D0.7220.20
52_V97_D0.7200.20
30_E60_A0.7150.20
10_T74_L0.7110.20
35_K125_D0.7090.20
10_T44_Y0.7070.20
34_G46_F0.7070.20
25_E113_E0.7020.19
20_L52_V0.6990.19
10_T14_S0.6980.19
20_L124_D0.6900.19
8_F87_H0.6840.19
142_A149_L0.6790.19
5_Q12_V0.6790.19
5_Q125_D0.6780.19
6_E13_R0.6760.19
19_S102_Y0.6730.18
26_N94_S0.6730.18
22_F45_W0.6710.18
134_L140_V0.6670.18
23_I86_Q0.6660.18
20_L65_L0.6630.18
28_R77_T0.6620.18
39_R42_Q0.6590.18
91_D128_W0.6590.18
8_F88_F0.6590.18
34_G87_H0.6580.18
31_F117_L0.6530.18
24_V111_V0.6500.18
13_R92_N0.6440.18
80_Q110_R0.6430.18
19_S46_F0.6410.17
23_I140_V0.6380.17
66_T94_S0.6360.17
74_L117_L0.6300.17
34_G41_A0.6280.17
11_V81_F0.6240.17
63_E90_D0.6230.17
105_L147_Y0.6220.17
113_E116_L0.6210.17
35_K67_M0.6200.17
46_F123_H0.6120.17
28_R129_L0.6120.17
116_L131_S0.6100.17
89_Y123_H0.6040.16
19_S147_Y0.6030.16
51_R91_D0.6030.16
3_L103_V0.6010.16
5_Q72_L0.5980.16
65_L119_P0.5980.16
52_V135_L0.5970.16
13_R42_Q0.5960.16
65_L84_V0.5940.16
23_I134_L0.5900.16
58_L129_L0.5890.16
31_F53_Q0.5780.16
100_T140_V0.5770.16
22_F65_L0.5720.15
27_S112_S0.5670.15
78_A125_D0.5670.15
110_R142_A0.5660.15
4_R13_R0.5610.15
73_R110_R0.5610.15
108_R133_A0.5580.15
38_N54_K0.5550.15
91_D95_G0.5510.15
103_V136_A0.5490.15
74_L120_D0.5490.15
19_S34_G0.5470.15
77_T133_A0.5460.15
82_Y88_F0.5430.15
141_H147_Y0.5420.15
6_E28_R0.5410.15
77_T121_E0.5360.14
72_L142_A0.5360.14
22_F31_F0.5340.14
25_E85_W0.5330.14
32_L40_P0.5260.14
30_E86_Q0.5250.14
24_V121_E0.5200.14
46_F65_L0.5190.14
73_R124_D0.5180.14
60_A73_R0.5080.14
133_A136_A0.5070.14
57_T75_P0.5040.14
82_Y148_F0.5010.14
34_G141_H0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ryaA 2 1 100 0.615 Contact Map
4ktbA 4 0.9057 99.7 0.746 Contact Map
4dywA 2 0.805 99.7 0.747 Contact Map
3gz5A 2 0.8553 99.7 0.75 Contact Map
5bonA 4 0.8742 99.6 0.758 Contact Map
2qjoA 3 0.956 99.6 0.759 Contact Map
2b0vA 2 0.8553 99.6 0.762 Contact Map
3cngA 4 0.9119 99.6 0.762 Contact Map
2fmlA 2 0.956 99.6 0.764 Contact Map
3f6aA 2 0.8616 99.6 0.765 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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