GREMLIN Database
FCL - GDP-L-fucose synthase
UniProt: P32055 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11788
Length: 321 (281)
Sequences: 54478 (37850)
Seq/√Len: 2257.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
259_T302_E3.0591.00
11_H32_V2.8311.00
220_A245_V2.6651.00
22_Q219_A2.5961.00
81_Y85_M2.4911.00
5_R29_V2.4541.00
241_S289_R2.4421.00
58_Q225_M2.4051.00
105_L221_S2.3781.00
22_Q222_I2.3121.00
263_V306_A2.3111.00
75_Y78_D2.3011.00
288_T292_Q2.1781.00
300_S303_A2.1631.00
22_Q26_R2.1011.00
48_H96_Q2.0881.00
101_K157_D2.0761.00
262_K302_E2.0081.00
219_A298_E1.9961.00
60_Y225_M1.9931.00
120_A123_E1.9661.00
163_P221_S1.9521.00
61_L104_F1.9471.00
259_T262_K1.9311.00
254_R258_Q1.9191.00
5_R31_L1.8991.00
26_R222_I1.8891.00
43_D46_A1.8811.00
161_V224_V1.8531.00
39_L46_A1.8431.00
88_S146_L1.8351.00
252_T255_E1.8221.00
248_G291_H1.8221.00
147_C158_Y1.8151.00
215_D307_S1.8031.00
33_L39_L1.7881.00
9_A61_L1.7831.00
219_A223_H1.7821.00
291_H296_Y1.7411.00
7_F56_I1.7131.00
31_L56_I1.6921.00
167_Y304_G1.6491.00
222_I226_E1.6481.00
141_I145_K1.6411.00
186_R190_E1.6391.00
26_R226_E1.6201.00
6_V28_D1.6121.00
198_D271_V1.6101.00
48_H93_A1.6011.00
8_I20_R1.6001.00
287_V291_H1.5981.00
19_I218_A1.5931.00
80_I142_A1.5481.00
19_I60_Y1.5471.00
85_M88_S1.5441.00
213_H307_S1.5441.00
88_S92_H1.5291.00
223_H227_L1.5261.00
31_L35_T1.5211.00
19_I62_A1.5161.00
87_E143_G1.5151.00
259_T263_V1.4911.00
22_Q218_A1.4741.00
22_Q25_Q1.4741.00
200_V271_V1.4711.00
101_K159_R1.4691.00
290_L293_L1.4671.00
121_E289_R1.4651.00
163_P217_M1.4541.00
95_H154_Y1.4321.00
44_S92_H1.4261.00
42_L81_Y1.4151.00
15_V166_L1.4091.00
77_A81_Y1.4061.00
306_A310_Q1.3841.00
31_L37_D1.3811.00
130_E141_I1.3801.00
46_A49_D1.3721.00
106_G110_I1.3581.00
208_M250_D1.3561.00
59_V94_A1.3521.00
212_L217_M1.3511.00
57_D100_N1.3451.00
21_R170_H1.3451.00
105_L163_P1.3391.00
299_I307_S1.3201.00
62_A105_L1.3161.00
11_H20_R1.3121.00
44_S48_H1.3011.00
164_T285_L1.2951.00
254_R272_F1.2801.00
48_H97_N1.2791.00
29_V35_T1.2781.00
148_E160_S1.2751.00
190_E197_P1.2741.00
145_K148_E1.2701.00
52_A97_N1.2681.00
60_Y221_S1.2681.00
213_H304_G1.2591.00
44_S89_N1.2531.00
5_R57_D1.2441.00
104_F143_G1.2431.00
119_M123_E1.2371.00
161_V221_S1.2351.00
214_V218_A1.2331.00
23_L222_I1.2271.00
28_D226_E1.2181.00
136_Y140_K1.2181.00
20_R32_V1.2161.00
138_I142_A1.1991.00
255_E258_Q1.1951.00
61_L87_E1.1891.00
220_A290_L1.1831.00
51_F56_I1.1791.00
101_K228_A1.1761.00
303_A306_A1.1741.00
198_D269_R1.1701.00
18_A215_D1.1671.00
71_A75_Y1.1671.00
22_Q215_D1.1571.00
206_T252_T1.1561.00
92_H95_H1.1531.00
303_A307_S1.1461.00
151_N158_Y1.1441.00
6_V23_L1.1431.00
146_L149_S1.1231.00
18_A214_V1.1191.00
210_E248_G1.1151.00
187_R197_P1.1131.00
92_H96_Q1.1101.00
246_G285_L1.0961.00
122_S289_R1.0951.00
91_I150_Y1.0951.00
206_T254_R1.0881.00
111_Y244_N1.0831.00
251_C301_L1.0751.00
83_N139_A1.0681.00
258_Q261_A1.0641.00
162_M242_H1.0591.00
148_E242_H1.0591.00
104_F160_S1.0581.00
116_K120_A1.0561.00
120_A286_D1.0561.00
250_D284_L1.0361.00
261_A267_K1.0321.00
223_H293_L1.0301.00
148_E158_Y1.0261.00
94_A102_L1.0251.00
41_L86_I1.0221.00
149_S153_Q1.0201.00
190_E196_A1.0171.00
251_C255_E1.0171.00
90_I102_L1.0161.00
65_K82_Q1.0131.00
93_A97_N1.0071.00
48_H52_A1.0041.00
148_E152_R0.9971.00
6_V58_Q0.9941.00
159_R224_V0.9931.00
85_M89_N0.9921.00
302_E306_A0.9901.00
157_D239_M0.9901.00
104_F147_C0.9901.00
270_V273_D0.9861.00
41_L63_A0.9791.00
93_A96_Q0.9741.00
21_R25_Q0.9731.00
287_V297_H0.9711.00
264_V309_Y0.9671.00
7_F33_L0.9651.00
166_L217_M0.9581.00
263_V309_Y0.9571.00
12_R34_R0.9571.00
250_D282_R0.9511.00
91_I102_L0.9511.00
49_D52_A0.9501.00
17_S170_H0.9481.00
223_H226_E0.9471.00
219_A299_I0.9371.00
103_L161_V0.9301.00
95_H156_R0.9291.00
102_L147_C0.9231.00
208_M282_R0.9231.00
288_T291_H0.9231.00
219_A295_W0.9221.00
80_I84_M0.9221.00
213_H299_I0.9181.00
289_R292_Q0.9151.00
161_V245_V0.9091.00
9_A90_I0.9081.00
263_V302_E0.9061.00
84_M142_A0.9061.00
208_M252_T0.9051.00
246_G287_V0.9031.00
14_M214_V0.9021.00
14_M168_G0.9011.00
94_A99_V0.8981.00
183_A187_R0.8971.00
89_N92_H0.8941.00
62_A221_S0.8921.00
18_A21_R0.8921.00
51_F93_A0.8881.00
116_K123_E0.8871.00
200_V273_D0.8861.00
162_M244_N0.8831.00
160_S242_H0.8831.00
307_S310_Q0.8811.00
215_D299_I0.8811.00
243_I289_R0.8801.00
216_D247_T0.8791.00
144_I162_M0.8761.00
188_F261_A0.8751.00
58_Q101_K0.8751.00
213_H216_D0.8741.00
82_Q86_I0.8721.00
46_A50_F0.8701.00
220_A295_W0.8701.00
5_R56_I0.8671.00
183_A186_R0.8671.00
91_I147_C0.8621.00
45_R49_D0.8611.00
47_V93_A0.8591.00
142_A145_K0.8571.00
299_I303_A0.8531.00
80_I85_M0.8471.00
45_R48_H0.8451.00
6_V60_Y0.8411.00
261_A268_G0.8411.00
249_V300_S0.8371.00
44_S96_Q0.8341.00
51_F59_V0.8291.00
5_R28_D0.8261.00
87_E147_C0.8181.00
89_N93_A0.8181.00
205_G254_R0.8171.00
59_V90_I0.8151.00
33_L46_A0.8121.00
65_K78_D0.8101.00
79_F139_A0.8081.00
108_S164_T0.8081.00
255_E259_T0.8061.00
100_N157_D0.8061.00
219_A222_I0.8011.00
108_S285_L0.7981.00
9_A63_A0.7961.00
167_Y213_H0.7941.00
6_V225_M0.7931.00
248_G287_V0.7921.00
166_L212_L0.7901.00
76_P138_I0.7891.00
78_D82_Q0.7861.00
51_F97_N0.7821.00
263_V310_Q0.7781.00
179_H182_P0.7751.00
261_A266_Y0.7671.00
145_K149_S0.7651.00
37_D50_F0.7651.00
18_A218_A0.7641.00
180_V184_L0.7621.00
20_R30_E0.7601.00
18_A22_Q0.7571.00
223_H295_W0.7551.00
106_G144_I0.7481.00
19_I23_L0.7461.00
224_V290_L0.7431.00
224_V293_L0.7381.00
15_V217_M0.7381.00
159_R228_A0.7381.00
196_A199_V0.7351.00
42_L82_Q0.7341.00
61_L90_I0.7311.00
263_V305_L0.7301.00
24_E30_E0.7291.00
142_A146_L0.7291.00
19_I221_S0.7231.00
17_S21_R0.7211.00
31_L55_R0.7191.00
87_E91_I0.7171.00
186_R189_H0.7151.00
78_D81_Y0.7121.00
245_V290_L0.7111.00
118_P286_D0.7081.00
150_Y154_Y0.7071.00
223_H294_G0.7071.00
299_I304_G0.7041.00
112_P131_P0.7031.00
92_H150_Y0.7011.00
80_I139_A0.7001.00
258_Q262_K0.6991.00
115_A123_E0.6981.00
33_L47_V0.6921.00
59_V102_L0.6841.00
33_L50_F0.6831.00
308_T311_W0.6781.00
259_T301_L0.6781.00
158_Y240_L0.6771.00
169_P307_S0.6751.00
65_K79_F0.6721.00
138_I145_K0.6661.00
216_D219_A0.6641.00
157_D229_H0.6561.00
181_I184_L0.6521.00
182_P186_R0.6521.00
164_T246_G0.6501.00
118_P284_L0.6491.00
134_E137_A0.6491.00
251_C256_L0.6451.00
95_H155_G0.6441.00
91_I146_L0.6441.00
86_I89_N0.6411.00
169_P213_H0.6391.00
163_P166_L0.6391.00
95_H150_Y0.6351.00
218_A222_I0.6341.00
51_F94_A0.6261.00
291_H297_H0.6261.00
72_N79_F0.6261.00
30_E34_R0.6251.00
23_L225_M0.6241.00
103_L221_S0.6221.00
20_R24_E0.6221.00
32_V36_R0.6211.00
271_V274_A0.6201.00
73_N135_P0.6201.00
31_L34_R0.6191.00
18_A170_H0.6181.00
110_I144_I0.6121.00
120_A288_T0.6111.00
103_L225_M0.6111.00
28_D32_V0.6101.00
28_D57_D0.6081.00
135_P138_I0.6041.00
208_M284_L0.5991.00
58_Q100_N0.5971.00
243_I290_L0.5961.00
256_L301_L0.5961.00
151_N156_R0.5911.00
132_T137_A0.5891.00
28_D34_R0.5891.00
159_R243_I0.5881.00
28_D31_L0.5881.00
80_I138_I0.5861.00
26_R223_H0.5851.00
149_S152_R0.5841.00
138_I149_S0.5841.00
161_V220_A0.5821.00
28_D58_Q0.5821.00
298_E303_A0.5791.00
165_N209_R0.5791.00
19_I222_I0.5781.00
68_G71_A0.5771.00
187_R196_A0.5761.00
43_D47_V0.5761.00
109_C137_A0.5751.00
257_A261_A0.5751.00
117_Q282_R0.5701.00
185_L189_H0.5681.00
27_G30_E0.5681.00
196_A266_Y0.5671.00
114_L119_M0.5671.00
139_A143_G0.5661.00
251_C259_T0.5651.00
261_A264_V0.5631.00
26_R219_A0.5631.00
280_T283_K0.5601.00
21_R215_D0.5591.00
210_E247_T0.5581.00
216_D298_E0.5571.00
160_S240_L0.5571.00
58_Q103_L0.5571.00
150_Y156_R0.5561.00
110_I130_E0.5561.00
143_G147_C0.5561.00
101_K229_H0.5551.00
64_A83_N0.5511.00
187_R190_E0.5511.00
210_E250_D0.5481.00
40_N43_D0.5461.00
8_I23_L0.5451.00
185_L309_Y0.5411.00
47_V51_F0.5411.00
268_G273_D0.5411.00
7_F59_V0.5391.00
261_A270_V0.5381.00
5_R55_R0.5361.00
76_P135_P0.5361.00
52_A55_R0.5351.00
24_E27_G0.5351.00
7_F50_F0.5351.00
47_V89_N0.5341.00
157_D228_A0.5341.00
37_D46_A0.5341.00
169_P215_D0.5321.00
207_P253_I0.5321.00
94_A97_N0.5321.00
146_L150_Y0.5311.00
84_M88_S0.5311.00
103_L224_V0.5301.00
147_C160_S0.5281.00
121_E290_L0.5281.00
217_M245_V0.5271.00
159_R241_S0.5211.00
170_H311_W0.5201.00
76_P80_I0.5191.00
151_N240_L0.5191.00
265_G269_R0.5161.00
290_L297_H0.5141.00
132_T141_I0.5131.00
61_L102_L0.5131.00
269_R272_F0.5111.00
201_V272_F0.5101.00
185_L260_I0.5091.00
59_V99_V0.5091.00
268_G272_F0.5081.00
7_F51_F0.5081.00
290_L295_W0.5081.00
135_P139_A0.5061.00
87_E104_F0.5041.00
213_H308_T0.5031.00
65_K83_N0.5031.00
222_I225_M0.5011.00
44_S93_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1e6uA 2 0.972 100 0.193 Contact Map
3rufA 2 0.9221 100 0.21 Contact Map
1sb8A 2 0.9252 100 0.212 Contact Map
2hunA 2 0.919 100 0.215 Contact Map
2q1sA 2 0.8972 100 0.228 Contact Map
1oc2A 2 0.9128 100 0.229 Contact Map
4lisA 2 0.9502 100 0.231 Contact Map
2c20A 2 0.9408 100 0.233 Contact Map
1rkxA 3 0.9283 100 0.235 Contact Map
1gy8A 2 0.972 100 0.235 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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