FCL - ECOLI - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

FCL - GDP-L-fucose synthase

UniProt:	P32055	Sequences: MSKQRVFIAGHRGMVGSAIRRQLEQRGDVELVLRTRDELNLLDSRAVHDFFASERIDQVYLAAAKVGGIVANNTYPADFIYQNMMIESNIIHAAHQNDVNKLLFLGSSCIYPKLAKQPMAESELLQGTLEPTNEPYAIAKIAGIKLCESYNRQYGRDYRSVMPTNLYGPHDNFHPSNSHVIPALLRRFHEATAQNAPDVVVWGSGTPMREFLHVDDMAAASIHVMELAHEVWLENTQPMLSHINVGTGVDCTIRELAQTIAKVVGYKGRVVFDASKPDGTPRKLLDVTRLHQLGWYHEISLEAGLASTYQWFLENQDRFRG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11788
Length:	321 (281)
Sequences:	54478 (37850)
Seq/√Len:	2257.9

ECOLI - FCL RMLB1 RMLB2 GALE GM4D HLDD YBJS YFCH RMLD YEEZ ARNA QOR2 YBJT
BACSU - YFNG GALE YTCB RMLB SPSK YFHF YTBQ YESF YWNB YHFK YHEG EPSC
HALSA - Q9HSU9 Q9HSV1 Q9HRD1 Q9HSE7 Q9HS50 Q9HML4 Q9HSQ3 Q9HNV3 Q9HPF1 Q9HR86
SULSO - Q97VN5 Q980W1 Q7LXG5 Q97XJ9 Q97XG1 Q7LXE8 Q97UM3 Q7LX44 Q7LXE6 Q97XF9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
259_T	302_E	3.059	1.00
11_H	32_V	2.831	1.00
220_A	245_V	2.665	1.00
22_Q	219_A	2.596	1.00
81_Y	85_M	2.491	1.00
5_R	29_V	2.454	1.00
241_S	289_R	2.442	1.00
58_Q	225_M	2.405	1.00
105_L	221_S	2.378	1.00
22_Q	222_I	2.312	1.00
263_V	306_A	2.311	1.00
75_Y	78_D	2.301	1.00
288_T	292_Q	2.178	1.00
300_S	303_A	2.163	1.00
22_Q	26_R	2.101	1.00
48_H	96_Q	2.088	1.00
101_K	157_D	2.076	1.00
262_K	302_E	2.008	1.00
219_A	298_E	1.996	1.00
60_Y	225_M	1.993	1.00
120_A	123_E	1.966	1.00
163_P	221_S	1.952	1.00
61_L	104_F	1.947	1.00
259_T	262_K	1.931	1.00
254_R	258_Q	1.919	1.00
5_R	31_L	1.899	1.00
26_R	222_I	1.889	1.00
43_D	46_A	1.881	1.00
161_V	224_V	1.853	1.00
39_L	46_A	1.843	1.00
88_S	146_L	1.835	1.00
252_T	255_E	1.822	1.00
248_G	291_H	1.822	1.00
147_C	158_Y	1.815	1.00
215_D	307_S	1.803	1.00
33_L	39_L	1.788	1.00
9_A	61_L	1.783	1.00
219_A	223_H	1.782	1.00
291_H	296_Y	1.741	1.00
7_F	56_I	1.713	1.00
31_L	56_I	1.692	1.00
167_Y	304_G	1.649	1.00
222_I	226_E	1.648	1.00
141_I	145_K	1.641	1.00
186_R	190_E	1.639	1.00
26_R	226_E	1.620	1.00
6_V	28_D	1.612	1.00
198_D	271_V	1.610	1.00
48_H	93_A	1.601	1.00
8_I	20_R	1.600	1.00
287_V	291_H	1.598	1.00
19_I	218_A	1.593	1.00
80_I	142_A	1.548	1.00
19_I	60_Y	1.547	1.00
85_M	88_S	1.544	1.00
213_H	307_S	1.544	1.00
88_S	92_H	1.529	1.00
223_H	227_L	1.526	1.00
31_L	35_T	1.521	1.00
19_I	62_A	1.516	1.00
87_E	143_G	1.515	1.00
259_T	263_V	1.491	1.00
22_Q	218_A	1.474	1.00
22_Q	25_Q	1.474	1.00
200_V	271_V	1.471	1.00
101_K	159_R	1.469	1.00
290_L	293_L	1.467	1.00
121_E	289_R	1.465	1.00
163_P	217_M	1.454	1.00
95_H	154_Y	1.432	1.00
44_S	92_H	1.426	1.00
42_L	81_Y	1.415	1.00
15_V	166_L	1.409	1.00
77_A	81_Y	1.406	1.00
306_A	310_Q	1.384	1.00
31_L	37_D	1.381	1.00
130_E	141_I	1.380	1.00
46_A	49_D	1.372	1.00
106_G	110_I	1.358	1.00
208_M	250_D	1.356	1.00
59_V	94_A	1.352	1.00
212_L	217_M	1.351	1.00
57_D	100_N	1.345	1.00
21_R	170_H	1.345	1.00
105_L	163_P	1.339	1.00
299_I	307_S	1.320	1.00
62_A	105_L	1.316	1.00
11_H	20_R	1.312	1.00
44_S	48_H	1.301	1.00
164_T	285_L	1.295	1.00
254_R	272_F	1.280	1.00
48_H	97_N	1.279	1.00
29_V	35_T	1.278	1.00
148_E	160_S	1.275	1.00
190_E	197_P	1.274	1.00
145_K	148_E	1.270	1.00
52_A	97_N	1.268	1.00
60_Y	221_S	1.268	1.00
213_H	304_G	1.259	1.00
44_S	89_N	1.253	1.00
5_R	57_D	1.244	1.00
104_F	143_G	1.243	1.00
119_M	123_E	1.237	1.00
161_V	221_S	1.235	1.00
214_V	218_A	1.233	1.00
23_L	222_I	1.227	1.00
28_D	226_E	1.218	1.00
136_Y	140_K	1.218	1.00
20_R	32_V	1.216	1.00
138_I	142_A	1.199	1.00
255_E	258_Q	1.195	1.00
61_L	87_E	1.189	1.00
220_A	290_L	1.183	1.00
51_F	56_I	1.179	1.00
101_K	228_A	1.176	1.00
303_A	306_A	1.174	1.00
198_D	269_R	1.170	1.00
18_A	215_D	1.167	1.00
71_A	75_Y	1.167	1.00
22_Q	215_D	1.157	1.00
206_T	252_T	1.156	1.00
92_H	95_H	1.153	1.00
303_A	307_S	1.146	1.00
151_N	158_Y	1.144	1.00
6_V	23_L	1.143	1.00
146_L	149_S	1.123	1.00
18_A	214_V	1.119	1.00
210_E	248_G	1.115	1.00
187_R	197_P	1.113	1.00
92_H	96_Q	1.110	1.00
246_G	285_L	1.096	1.00
122_S	289_R	1.095	1.00
91_I	150_Y	1.095	1.00
206_T	254_R	1.088	1.00
111_Y	244_N	1.083	1.00
251_C	301_L	1.075	1.00
83_N	139_A	1.068	1.00
258_Q	261_A	1.064	1.00
162_M	242_H	1.059	1.00
148_E	242_H	1.059	1.00
104_F	160_S	1.058	1.00
116_K	120_A	1.056	1.00
120_A	286_D	1.056	1.00
250_D	284_L	1.036	1.00
261_A	267_K	1.032	1.00
223_H	293_L	1.030	1.00
148_E	158_Y	1.026	1.00
94_A	102_L	1.025	1.00
41_L	86_I	1.022	1.00
149_S	153_Q	1.020	1.00
190_E	196_A	1.017	1.00
251_C	255_E	1.017	1.00
90_I	102_L	1.016	1.00
65_K	82_Q	1.013	1.00
93_A	97_N	1.007	1.00
48_H	52_A	1.004	1.00
148_E	152_R	0.997	1.00
6_V	58_Q	0.994	1.00
159_R	224_V	0.993	1.00
85_M	89_N	0.992	1.00
302_E	306_A	0.990	1.00
157_D	239_M	0.990	1.00
104_F	147_C	0.990	1.00
270_V	273_D	0.986	1.00
41_L	63_A	0.979	1.00
93_A	96_Q	0.974	1.00
21_R	25_Q	0.973	1.00
287_V	297_H	0.971	1.00
264_V	309_Y	0.967	1.00
7_F	33_L	0.965	1.00
166_L	217_M	0.958	1.00
263_V	309_Y	0.957	1.00
12_R	34_R	0.957	1.00
250_D	282_R	0.951	1.00
91_I	102_L	0.951	1.00
49_D	52_A	0.950	1.00
17_S	170_H	0.948	1.00
223_H	226_E	0.947	1.00
219_A	299_I	0.937	1.00
103_L	161_V	0.930	1.00
95_H	156_R	0.929	1.00
102_L	147_C	0.923	1.00
208_M	282_R	0.923	1.00
288_T	291_H	0.923	1.00
219_A	295_W	0.922	1.00
80_I	84_M	0.922	1.00
213_H	299_I	0.918	1.00
289_R	292_Q	0.915	1.00
161_V	245_V	0.909	1.00
9_A	90_I	0.908	1.00
263_V	302_E	0.906	1.00
84_M	142_A	0.906	1.00
208_M	252_T	0.905	1.00
246_G	287_V	0.903	1.00
14_M	214_V	0.902	1.00
14_M	168_G	0.901	1.00
94_A	99_V	0.898	1.00
183_A	187_R	0.897	1.00
89_N	92_H	0.894	1.00
62_A	221_S	0.892	1.00
18_A	21_R	0.892	1.00
51_F	93_A	0.888	1.00
116_K	123_E	0.887	1.00
200_V	273_D	0.886	1.00
162_M	244_N	0.883	1.00
160_S	242_H	0.883	1.00
307_S	310_Q	0.881	1.00
215_D	299_I	0.881	1.00
243_I	289_R	0.880	1.00
216_D	247_T	0.879	1.00
144_I	162_M	0.876	1.00
188_F	261_A	0.875	1.00
58_Q	101_K	0.875	1.00
213_H	216_D	0.874	1.00
82_Q	86_I	0.872	1.00
46_A	50_F	0.870	1.00
220_A	295_W	0.870	1.00
5_R	56_I	0.867	1.00
183_A	186_R	0.867	1.00
91_I	147_C	0.862	1.00
45_R	49_D	0.861	1.00
47_V	93_A	0.859	1.00
142_A	145_K	0.857	1.00
299_I	303_A	0.853	1.00
80_I	85_M	0.847	1.00
45_R	48_H	0.845	1.00
6_V	60_Y	0.841	1.00
261_A	268_G	0.841	1.00
249_V	300_S	0.837	1.00
44_S	96_Q	0.834	1.00
51_F	59_V	0.829	1.00
5_R	28_D	0.826	1.00
87_E	147_C	0.818	1.00
89_N	93_A	0.818	1.00
205_G	254_R	0.817	1.00
59_V	90_I	0.815	1.00
33_L	46_A	0.812	1.00
65_K	78_D	0.810	1.00
79_F	139_A	0.808	1.00
108_S	164_T	0.808	1.00
255_E	259_T	0.806	1.00
100_N	157_D	0.806	1.00
219_A	222_I	0.801	1.00
108_S	285_L	0.798	1.00
9_A	63_A	0.796	1.00
167_Y	213_H	0.794	1.00
6_V	225_M	0.793	1.00
248_G	287_V	0.792	1.00
166_L	212_L	0.790	1.00
76_P	138_I	0.789	1.00
78_D	82_Q	0.786	1.00
51_F	97_N	0.782	1.00
263_V	310_Q	0.778	1.00
179_H	182_P	0.775	1.00
261_A	266_Y	0.767	1.00
145_K	149_S	0.765	1.00
37_D	50_F	0.765	1.00
18_A	218_A	0.764	1.00
180_V	184_L	0.762	1.00
20_R	30_E	0.760	1.00
18_A	22_Q	0.757	1.00
223_H	295_W	0.755	1.00
106_G	144_I	0.748	1.00
19_I	23_L	0.746	1.00
224_V	290_L	0.743	1.00
224_V	293_L	0.738	1.00
15_V	217_M	0.738	1.00
159_R	228_A	0.738	1.00
196_A	199_V	0.735	1.00
42_L	82_Q	0.734	1.00
61_L	90_I	0.731	1.00
263_V	305_L	0.730	1.00
24_E	30_E	0.729	1.00
142_A	146_L	0.729	1.00
19_I	221_S	0.723	1.00
17_S	21_R	0.721	1.00
31_L	55_R	0.719	1.00
87_E	91_I	0.717	1.00
186_R	189_H	0.715	1.00
78_D	81_Y	0.712	1.00
245_V	290_L	0.711	1.00
118_P	286_D	0.708	1.00
150_Y	154_Y	0.707	1.00
223_H	294_G	0.707	1.00
299_I	304_G	0.704	1.00
112_P	131_P	0.703	1.00
92_H	150_Y	0.701	1.00
80_I	139_A	0.700	1.00
258_Q	262_K	0.699	1.00
115_A	123_E	0.698	1.00
33_L	47_V	0.692	1.00
59_V	102_L	0.684	1.00
33_L	50_F	0.683	1.00
308_T	311_W	0.678	1.00
259_T	301_L	0.678	1.00
158_Y	240_L	0.677	1.00
169_P	307_S	0.675	1.00
65_K	79_F	0.672	1.00
138_I	145_K	0.666	1.00
216_D	219_A	0.664	1.00
157_D	229_H	0.656	1.00
181_I	184_L	0.652	1.00
182_P	186_R	0.652	1.00
164_T	246_G	0.650	1.00
118_P	284_L	0.649	1.00
134_E	137_A	0.649	1.00
251_C	256_L	0.645	1.00
95_H	155_G	0.644	1.00
91_I	146_L	0.644	1.00
86_I	89_N	0.641	1.00
169_P	213_H	0.639	1.00
163_P	166_L	0.639	1.00
95_H	150_Y	0.635	1.00
218_A	222_I	0.634	1.00
51_F	94_A	0.626	1.00
291_H	297_H	0.626	1.00
72_N	79_F	0.626	1.00
30_E	34_R	0.625	1.00
23_L	225_M	0.624	1.00
103_L	221_S	0.622	1.00
20_R	24_E	0.622	1.00
32_V	36_R	0.621	1.00
271_V	274_A	0.620	1.00
73_N	135_P	0.620	1.00
31_L	34_R	0.619	1.00
18_A	170_H	0.618	1.00
110_I	144_I	0.612	1.00
120_A	288_T	0.611	1.00
103_L	225_M	0.611	1.00
28_D	32_V	0.610	1.00
28_D	57_D	0.608	1.00
135_P	138_I	0.604	1.00
208_M	284_L	0.599	1.00
58_Q	100_N	0.597	1.00
243_I	290_L	0.596	1.00
256_L	301_L	0.596	1.00
151_N	156_R	0.591	1.00
132_T	137_A	0.589	1.00
28_D	34_R	0.589	1.00
159_R	243_I	0.588	1.00
28_D	31_L	0.588	1.00
80_I	138_I	0.586	1.00
26_R	223_H	0.585	1.00
149_S	152_R	0.584	1.00
138_I	149_S	0.584	1.00
161_V	220_A	0.582	1.00
28_D	58_Q	0.582	1.00
298_E	303_A	0.579	1.00
165_N	209_R	0.579	1.00
19_I	222_I	0.578	1.00
68_G	71_A	0.577	1.00
187_R	196_A	0.576	1.00
43_D	47_V	0.576	1.00
109_C	137_A	0.575	1.00
257_A	261_A	0.575	1.00
117_Q	282_R	0.570	1.00
185_L	189_H	0.568	1.00
27_G	30_E	0.568	1.00
196_A	266_Y	0.567	1.00
114_L	119_M	0.567	1.00
139_A	143_G	0.566	1.00
251_C	259_T	0.565	1.00
261_A	264_V	0.563	1.00
26_R	219_A	0.563	1.00
280_T	283_K	0.560	1.00
21_R	215_D	0.559	1.00
210_E	247_T	0.558	1.00
216_D	298_E	0.557	1.00
160_S	240_L	0.557	1.00
58_Q	103_L	0.557	1.00
150_Y	156_R	0.556	1.00
110_I	130_E	0.556	1.00
143_G	147_C	0.556	1.00
101_K	229_H	0.555	1.00
64_A	83_N	0.551	1.00
187_R	190_E	0.551	1.00
210_E	250_D	0.548	1.00
40_N	43_D	0.546	1.00
8_I	23_L	0.545	1.00
185_L	309_Y	0.541	1.00
47_V	51_F	0.541	1.00
268_G	273_D	0.541	1.00
7_F	59_V	0.539	1.00
261_A	270_V	0.538	1.00
5_R	55_R	0.536	1.00
76_P	135_P	0.536	1.00
52_A	55_R	0.535	1.00
24_E	27_G	0.535	1.00
7_F	50_F	0.535	1.00
47_V	89_N	0.534	1.00
157_D	228_A	0.534	1.00
37_D	46_A	0.534	1.00
169_P	215_D	0.532	1.00
207_P	253_I	0.532	1.00
94_A	97_N	0.532	1.00
146_L	150_Y	0.531	1.00
84_M	88_S	0.531	1.00
103_L	224_V	0.530	1.00
147_C	160_S	0.528	1.00
121_E	290_L	0.528	1.00
217_M	245_V	0.527	1.00
159_R	241_S	0.521	1.00
170_H	311_W	0.520	1.00
76_P	80_I	0.519	1.00
151_N	240_L	0.519	1.00
265_G	269_R	0.516	1.00
290_L	297_H	0.514	1.00
132_T	141_I	0.513	1.00
61_L	102_L	0.513	1.00
269_R	272_F	0.511	1.00
201_V	272_F	0.510	1.00
185_L	260_I	0.509	1.00
59_V	99_V	0.509	1.00
268_G	272_F	0.508	1.00
7_F	51_F	0.508	1.00
290_L	295_W	0.508	1.00
135_P	139_A	0.506	1.00
87_E	104_F	0.504	1.00
213_H	308_T	0.503	1.00
65_K	83_N	0.503	1.00
222_I	225_M	0.501	1.00
44_S	93_A	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1e6uA	2	0.972	100	0.193	Contact Map
3rufA	2	0.9221	100	0.21	Contact Map
1sb8A	2	0.9252	100	0.212	Contact Map
2hunA	2	0.919	100	0.215	Contact Map
2q1sA	2	0.8972	100	0.228	Contact Map
1oc2A	2	0.9128	100	0.229	Contact Map
4lisA	2	0.9502	100	0.231	Contact Map
2c20A	2	0.9408	100	0.233	Contact Map
1rkxA	3	0.9283	100	0.235	Contact Map
1gy8A	2	0.972	100	0.235	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0105 seconds.