GREMLIN Database
PPTA - Tautomerase PptA
UniProt: P31992 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11761
Length: 77 (73)
Sequences: 138 (98)
Seq/√Len: 11.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_D59_E3.1960.97
19_A23_A3.1870.97
53_Q57_D2.6690.91
14_D51_S2.1770.79
24_D31_R2.1490.78
30_I37_D2.1370.78
26_T37_D2.1320.78
10_P46_Q2.1100.77
18_K42_I2.0180.74
39_S42_I2.0050.73
26_T40_I1.7880.64
22_A26_T1.6760.59
6_I25_I1.6560.58
11_R42_I1.6540.58
15_E68_I1.6100.55
16_Q50_E1.5610.53
11_R44_L1.5430.52
28_V32_H1.5350.52
56_W61_A1.5260.51
34_N62_P1.4970.50
4_I40_I1.4780.49
7_K59_E1.4710.49
17_Q27_D1.4210.46
42_I72_G1.3890.45
30_I40_I1.2940.40
18_K25_I1.2860.40
59_E63_Q1.1830.35
5_D45_Q1.1310.33
25_I69_K1.1280.33
8_C18_K1.1130.32
6_I9_F1.1120.32
21_L59_E1.1010.31
13_L24_D1.0410.29
13_L32_H1.0260.28
26_T38_S1.0190.28
21_L25_I0.9960.27
4_I50_E0.9630.26
25_I29_I0.9420.25
21_L43_A0.9340.25
11_R18_K0.9140.24
5_D11_R0.9000.24
36_K56_W0.8650.22
30_I45_Q0.8550.22
53_Q63_Q0.8520.22
37_D56_W0.8420.22
39_S69_K0.8420.22
14_D24_D0.8310.21
29_I36_K0.8300.21
50_E66_A0.8270.21
44_L68_I0.8230.21
11_R68_I0.8170.21
65_E70_K0.8140.21
48_Q54_A0.8100.21
41_S69_K0.8050.20
19_A54_A0.7860.20
17_Q51_S0.7840.20
37_D48_Q0.7800.20
13_L35_S0.7720.19
51_S74_S0.7700.19
63_Q66_A0.7680.19
13_L68_I0.7440.19
35_S70_K0.7430.18
22_A57_D0.7360.18
4_I29_I0.7260.18
13_L64_M0.7250.18
21_L68_I0.7160.18
50_E74_S0.7150.18
6_I42_I0.7010.17
57_D67_L0.7000.17
47_I52_W0.6990.17
11_R32_H0.6980.17
9_F47_I0.6790.17
33_L49_P0.6700.16
48_Q51_S0.6670.16
20_A24_D0.6670.16
22_A42_I0.6640.16
18_K21_L0.6510.16
5_D40_I0.6450.16
18_K41_S0.6340.15
14_D58_A0.6330.15
20_A32_H0.6290.15
15_E66_A0.6270.15
42_I46_Q0.6240.15
24_D48_Q0.6140.15
9_F44_L0.6110.15
36_K49_P0.6080.15
30_I36_K0.5990.15
25_I51_S0.5920.14
21_L30_I0.5910.14
41_S52_W0.5890.14
26_T46_Q0.5870.14
4_I28_V0.5850.14
21_L33_L0.5780.14
17_Q25_I0.5770.14
15_E70_K0.5730.14
11_R72_G0.5720.14
15_E46_Q0.5670.14
43_A64_M0.5660.14
7_K51_S0.5630.14
64_M70_K0.5580.14
45_Q54_A0.5570.14
22_A62_P0.5400.13
21_L29_I0.5370.13
27_D30_I0.5300.13
41_S72_G0.5160.13
57_D61_A0.5160.13
15_E65_E0.5150.13
55_I69_K0.5130.13
13_L44_L0.5130.13
34_N54_A0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1gyxA 2 0.987 99.8 0.424 Contact Map
3mb2B 3 0.7532 99 0.662 Contact Map
4jcuA 3 0.8052 98.8 0.675 Contact Map
1otgA 3 0.7922 98.8 0.681 Contact Map
3e6qA 4 0.7532 98.8 0.681 Contact Map
3ej9B 3 0.7662 98.8 0.685 Contact Map
1u9dA 3 0.7273 98.7 0.687 Contact Map
3abfA 4 0.8312 98.7 0.69 Contact Map
4jj9A 3 0.8312 98.7 0.693 Contact Map
2x4kA 4 0.7792 98.6 0.698 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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