GREMLIN Database
NUOF - NADH-quinone oxidoreductase subunit F
UniProt: P31979 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11774
Length: 445 (403)
Sequences: 3426 (1687)
Seq/√Len: 84.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_N56_D3.9131.00
252_F278_A3.8641.00
151_T168_E3.7461.00
55_K74_S3.6411.00
334_N422_G3.5721.00
159_N164_G3.4911.00
183_E204_P3.3901.00
271_R306_D3.2691.00
158_K166_D3.2291.00
237_Q245_A3.1671.00
88_L187_I3.1011.00
29_Y34_G3.0901.00
411_A419_F2.8211.00
30_R39_R2.8121.00
285_L331_H2.7481.00
46_S49_E2.6581.00
363_W366_K2.6161.00
53_Q233_V2.6081.00
127_R170_F2.5821.00
35_Y110_H2.5671.00
128_G167_F2.5601.00
301_T414_Y2.5591.00
231_N235_W2.5551.00
183_E203_F2.5261.00
144_R148_A2.4471.00
416_R420_E2.4361.00
84_I126_Y2.4181.00
285_L332_E2.4071.00
56_D234_E2.3621.00
385_E416_R2.3331.00
132_L143_L2.2081.00
235_W238_N2.1321.00
50_I121_F2.1181.00
89_C116_M2.0901.00
26_L153_A2.0301.00
83_N212_K2.0271.00
307_L317_A1.9701.00
56_D233_V1.9371.00
255_R333_I1.9361.00
74_S78_K1.9241.00
69_T217_N1.9111.00
292_P319_S1.9041.00
227_A235_W1.9021.00
38_A117_L1.8891.00
140_A173_T1.8851.00
27_D153_A1.8831.00
310_E313_S1.8651.00
48_D77_P1.8341.00
87_L119_S1.8131.00
116_M128_G1.7971.00
301_T304_H1.7861.00
55_K71_L1.7511.00
53_Q56_D1.7371.00
378_P424_K1.7351.00
286_K302_E1.7261.00
288_K418_E1.7081.00
37_G229_L1.6901.00
113_V169_L1.6831.00
187_I216_V1.6681.00
27_D30_R1.6271.00
76_M215_C1.6141.00
30_R153_A1.6091.00
119_S222_L1.5891.00
144_R171_V1.5891.00
89_C222_L1.5711.00
130_I143_L1.5631.00
120_A167_F1.5601.00
364_S384_L1.5451.00
417_E420_E1.5361.00
385_E413_K1.5301.00
421_A425_Q1.5271.00
30_R155_L1.5201.00
41_A50_I1.4960.99
148_A151_T1.4960.99
249_L261_L1.4930.99
75_L205_A1.4880.99
120_A128_G1.4850.99
204_P216_V1.4820.99
40_K45_L1.4750.99
233_V237_Q1.4630.99
243_K312_E1.4620.99
147_I171_V1.4600.99
227_A231_N1.4520.99
49_E52_N1.4510.99
24_V142_N1.4490.99
41_A45_L1.4410.99
48_D52_N1.4380.99
52_N55_K1.4370.99
91_A219_V1.4370.99
379_G382_E1.4350.99
69_T221_T1.4320.99
160_I166_D1.4320.99
37_G230_A1.4320.99
33_N36_E1.4270.99
383_T386_Q1.4160.99
54_V122_A1.4130.99
420_E424_K1.4010.99
269_T272_E1.3980.99
33_N230_A1.3940.99
56_D237_Q1.3920.99
148_A152_E1.3910.99
158_K168_E1.3880.99
257_K284_G1.3800.99
51_V122_A1.3770.99
369_R373_R1.3730.99
75_L203_F1.3640.99
234_E238_N1.3570.99
287_F305_L1.3570.99
190_L209_A1.3370.99
128_G169_L1.3260.99
54_V225_V1.3250.99
304_H414_Y1.3210.99
353_W397_F1.3130.99
105_M112_L1.3130.99
36_E39_R1.2970.98
105_M143_L1.2950.98
123_L215_C1.2920.98
377_Q423_I1.2900.98
129_Y170_F1.2870.98
145_R149_E1.2850.98
155_L161_M1.2840.98
247_T263_E1.2840.98
340_R369_R1.2790.98
127_R168_E1.2650.98
132_L140_A1.2600.98
329_V333_I1.2530.98
257_K282_R1.2450.98
286_K331_H1.2420.98
71_L74_S1.2380.98
57_A69_T1.2330.98
126_Y166_D1.2310.98
393_P409_Q1.2310.98
151_T169_L1.2290.98
183_E216_V1.2290.98
121_F165_F1.2250.98
271_R275_E1.2200.98
50_I122_A1.2190.98
361_L404_A1.2170.98
241_K244_D1.2120.98
91_A105_M1.2080.97
110_H149_E1.2030.97
329_V338_L1.2010.97
188_N193_R1.1980.97
227_A233_V1.1970.97
273_I309_M1.1940.97
220_E248_K1.1930.97
163_T166_D1.1900.97
25_W28_E1.1850.97
187_I204_P1.1840.97
112_L223_C1.1770.97
38_A161_M1.1750.97
88_L186_L1.1740.97
370_A375_E1.1730.97
289_A335_M1.1720.97
399_A402_P1.1690.97
37_G41_A1.1630.97
257_K283_D1.1560.97
55_K70_G1.1550.97
111_L227_A1.1530.97
188_N198_R1.1500.97
382_E385_E1.1420.96
113_V147_I1.1420.96
53_Q234_E1.1420.96
295_A346_F1.1390.96
255_R330_D1.1370.96
26_L30_R1.1310.96
372_E422_G1.1310.96
45_L53_Q1.1290.96
39_R43_T1.1270.96
84_I127_R1.1190.96
40_K229_L1.1160.96
274_L280_G1.1160.96
371_L423_I1.1140.96
21_K28_E1.1130.96
60_K66_G1.1100.96
207_S211_G1.1090.96
304_H317_A1.1060.96
138_E142_N1.1050.96
252_F256_V1.1000.96
76_M123_L1.0990.96
376_G380_D1.0970.96
60_K312_E1.0970.96
26_L155_L1.0920.95
408_L412_I1.0850.95
95_E100_K1.0830.95
174_G189_S1.0790.95
201_P204_P1.0730.95
86_Y212_K1.0730.95
51_V77_P1.0710.95
370_A377_Q1.0660.95
250_M273_I1.0650.95
271_R302_E1.0600.95
100_K220_E1.0590.95
58_G245_A1.0570.95
281_M287_F1.0560.94
300_L317_A1.0550.94
340_R372_E1.0540.94
117_L156_L1.0510.94
180_C189_S1.0440.94
81_S84_I1.0400.94
75_L183_E1.0380.94
183_E205_A1.0380.94
28_E32_K1.0360.94
108_L111_L1.0340.94
224_N236_Y1.0250.94
47_P121_F1.0150.93
79_D206_T1.0130.93
307_L313_S1.0130.93
242_S245_A1.0060.93
220_E224_N1.0060.93
71_L75_L1.0050.93
370_A380_D1.0000.93
20_D32_K0.9980.93
75_L206_T0.9970.93
347_A365_V0.9830.92
365_V369_R0.9820.92
40_K43_T0.9760.92
106_E138_E0.9710.92
288_K335_M0.9700.92
22_Q25_W0.9650.91
269_T308_P0.9640.91
371_L376_G0.9620.91
50_I229_L0.9540.91
256_V328_A0.9490.91
131_F189_S0.9440.90
337_S372_E0.9420.90
183_E202_P0.9400.90
88_L214_T0.9350.90
147_I151_T0.9310.90
159_N162_G0.9310.90
47_P77_P0.9280.90
385_E412_I0.9270.90
377_Q383_T0.9240.89
183_E201_P0.9230.89
45_L49_E0.9220.89
54_V70_G0.9220.89
87_L123_L0.9210.89
184_T204_P0.9200.89
95_E346_F0.9190.89
106_E139_A0.9180.89
91_A130_I0.9160.89
385_E389_R0.9100.89
117_L155_L0.9030.88
87_L128_G0.9010.88
183_E187_I0.9000.88
58_G237_Q0.8990.88
160_I165_F0.8900.88
400_H404_A0.8900.88
262_W273_I0.8890.88
299_F411_A0.8890.88
271_R305_L0.8880.88
59_L228_I0.8860.87
283_D286_K0.8860.87
92_D133_R0.8860.87
132_L173_T0.8840.87
102_R106_E0.8810.87
405_V409_Q0.8800.87
347_A361_L0.8790.87
268_T272_E0.8790.87
91_A143_L0.8780.87
149_E152_E0.8760.87
391_L395_K0.8730.87
243_K316_K0.8690.86
334_N337_S0.8660.86
24_V145_R0.8650.86
191_E198_R0.8630.86
157_G162_G0.8630.86
126_Y168_E0.8590.86
343_E346_F0.8580.86
313_S316_K0.8560.86
333_I338_L0.8560.86
45_L229_L0.8520.85
34_G111_L0.8500.85
45_L50_I0.8490.85
339_V411_A0.8490.85
340_R365_V0.8490.85
422_G426_P0.8460.85
397_F402_P0.8450.85
393_P406_E0.8430.85
117_L150_A0.8430.85
53_Q229_L0.8410.85
264_L268_T0.8390.84
160_I163_T0.8370.84
103_L107_Q0.8360.84
264_L273_I0.8330.84
36_E230_A0.8330.84
131_F174_G0.8310.84
144_R151_T0.8280.84
275_E281_M0.8280.84
143_L171_V0.8240.83
300_L319_S0.8230.83
258_N262_W0.8220.83
385_E409_Q0.8220.83
399_A403_G0.8200.83
23_P28_E0.8200.83
143_L147_I0.8140.83
303_A414_Y0.8130.82
340_R344_E0.8130.82
88_L190_L0.8130.82
244_D312_E0.8120.82
292_P326_A0.8100.82
140_A144_R0.8080.82
35_Y150_A0.8080.82
71_L204_P0.8080.82
412_I416_R0.8060.82
367_I370_A0.8050.82
391_L408_L0.8040.82
394_G402_P0.8040.82
274_L281_M0.8030.82
65_A68_S0.8000.81
37_G118_I0.7970.81
99_Y253_S0.7970.81
245_A311_F0.7970.81
390_F395_K0.7970.81
132_L171_V0.7940.81
119_S215_C0.7910.81
110_H150_A0.7860.80
133_R136_Y0.7850.80
105_M139_A0.7850.80
287_F290_W0.7850.80
371_L374_G0.7850.80
105_M130_I0.7850.80
378_P382_E0.7850.80
188_N194_R0.7840.80
287_F328_A0.7810.80
344_E369_R0.7810.80
304_H307_L0.7790.80
112_L143_L0.7780.80
92_D174_G0.7770.80
295_A342_L0.7750.79
257_K281_M0.7750.79
200_K203_F0.7740.79
187_I209_A0.7730.79
241_K245_A0.7730.79
417_E421_A0.7720.79
273_I326_A0.7720.79
22_Q28_E0.7710.79
347_A362_P0.7690.79
87_L222_L0.7670.79
315_G320_R0.7660.79
113_V130_I0.7660.79
92_D135_E0.7640.78
84_I212_K0.7640.78
37_G40_K0.7610.78
272_E275_E0.7570.78
51_V55_K0.7560.78
396_T402_P0.7560.78
48_D74_S0.7550.78
343_E368_L0.7550.78
250_M264_L0.7530.77
59_L69_T0.7510.77
364_S408_L0.7480.77
117_L169_L0.7480.77
159_N163_T0.7460.77
422_G425_Q0.7450.77
256_V278_A0.7420.76
190_L210_W0.7410.76
402_P405_V0.7400.76
239_I245_A0.7380.76
70_G233_V0.7360.76
215_C222_L0.7360.76
299_F335_M0.7350.76
117_L161_M0.7290.75
43_T163_T0.7280.75
259_P262_W0.7260.75
319_S326_A0.7260.75
80_E83_N0.7250.75
379_G383_T0.7240.75
411_A415_F0.7240.75
396_T401_A0.7240.75
203_F206_T0.7230.74
20_D28_E0.7230.74
211_G216_V0.7230.74
40_K53_Q0.7200.74
264_L277_Y0.7190.74
87_L125_A0.7170.74
359_D363_W0.7160.74
73_W217_N0.7160.74
145_R148_A0.7100.73
318_G413_K0.7070.73
26_L110_H0.7060.73
71_L183_E0.7050.73
126_Y165_F0.7020.72
401_A405_V0.7010.72
274_L328_A0.7010.72
287_F302_E0.7010.72
133_R175_A0.7000.72
157_G165_F0.6980.72
138_E141_V0.6960.72
178_Y346_F0.6930.71
262_W277_Y0.6900.71
141_V145_R0.6880.71
104_L249_L0.6880.71
251_G325_L0.6790.70
114_E226_P0.6790.70
256_V259_P0.6780.70
157_G160_I0.6770.70
382_E386_Q0.6770.70
104_L223_C0.6760.69
95_E98_T0.6750.69
314_I320_R0.6710.69
314_I319_S0.6700.69
308_P313_S0.6690.69
74_S77_P0.6690.69
92_D176_G0.6680.69
87_L112_L0.6670.68
129_Y209_A0.6660.68
268_T273_I0.6650.68
253_S327_M0.6640.68
128_G156_L0.6640.68
350_S357_C0.6610.68
281_M305_L0.6600.68
221_T248_K0.6590.68
94_M179_I0.6570.67
340_R368_L0.6560.67
395_K402_P0.6550.67
296_G323_T0.6540.67
75_L204_P0.6480.66
54_V118_I0.6470.66
140_A171_V0.6460.66
49_E53_Q0.6450.66
79_D83_N0.6440.66
184_T203_F0.6430.66
389_R394_G0.6430.66
59_L225_V0.6420.65
42_L117_L0.6420.65
41_A122_A0.6400.65
180_C195_A0.6400.65
216_V222_L0.6390.65
403_G406_E0.6390.65
39_R161_M0.6380.65
103_L261_L0.6370.65
26_L149_E0.6370.65
47_P51_V0.6360.65
87_L116_M0.6340.65
32_K36_E0.6320.64
270_A307_L0.6320.64
119_S123_L0.6310.64
46_S50_I0.6270.64
334_N426_P0.6270.64
285_L330_D0.6260.64
146_A149_E0.6250.63
27_D152_E0.6240.63
290_W326_A0.6240.63
36_E152_E0.6230.63
362_P366_K0.6210.63
148_A168_E0.6200.63
378_P420_E0.6200.63
110_H117_L0.6190.63
69_T73_W0.6190.63
319_S327_M0.6180.63
101_D266_F0.6170.62
48_D78_K0.6140.62
113_V150_A0.6120.62
297_T320_R0.6110.62
415_F418_E0.6110.62
28_E31_S0.6100.62
154_G157_G0.6090.61
100_K341_N0.6070.61
355_T359_D0.6070.61
116_M120_A0.6050.61
65_A312_E0.6040.61
393_P405_V0.6040.61
244_D266_F0.6040.61
31_S36_E0.6030.61
40_K158_K0.6020.61
388_C405_V0.5990.60
252_F260_G0.5980.60
120_A169_L0.5980.60
248_K324_A0.5970.60
81_S212_K0.5950.60
297_T401_A0.5950.60
37_G115_G0.5950.60
282_R330_D0.5910.59
22_Q31_S0.5880.59
69_T203_F0.5870.59
344_E365_V0.5860.58
309_M321_L0.5860.58
239_I265_P0.5850.58
388_C391_L0.5830.58
394_G403_G0.5830.58
39_R153_A0.5830.58
85_R124_K0.5830.58
57_A228_I0.5820.58
377_Q382_E0.5820.58
159_N166_D0.5810.58
87_L215_C0.5790.58
108_L175_A0.5790.58
151_T170_F0.5770.57
67_F203_F0.5770.57
269_T306_D0.5760.57
21_K25_W0.5750.57
77_P124_K0.5750.57
307_L314_I0.5740.57
248_K266_F0.5730.57
367_I387_L0.5730.57
312_E316_K0.5730.57
57_A70_G0.5720.57
144_R173_T0.5710.57
335_M339_V0.5700.56
251_G261_L0.5700.56
240_S246_G0.5690.56
239_I247_T0.5690.56
64_G72_K0.5690.56
104_L112_L0.5680.56
320_R324_A0.5680.56
414_Y418_E0.5680.56
111_L230_A0.5680.56
130_I171_V0.5670.56
292_P314_I0.5660.56
30_R36_E0.5660.56
398_C410_S0.5660.56
88_L216_V0.5650.56
92_D180_C0.5640.56
108_L143_L0.5640.56
217_N222_L0.5640.56
129_Y190_L0.5630.55
288_K331_H0.5630.55
156_L167_F0.5620.55
270_A326_A0.5600.55
302_E305_L0.5600.55
39_R155_L0.5600.55
23_P107_Q0.5590.55
231_N238_N0.5590.55
320_R399_A0.5590.55
64_G67_F0.5570.55
173_T319_S0.5560.55
95_E341_N0.5560.55
156_L160_I0.5550.54
224_N248_K0.5550.54
81_S85_R0.5540.54
334_N374_G0.5530.54
227_A230_A0.5510.54
402_P406_E0.5500.54
27_D31_S0.5500.54
238_N242_S0.5480.54
317_A320_R0.5480.54
116_M125_A0.5470.53
203_F216_V0.5460.53
43_T161_M0.5450.53
343_E361_L0.5420.53
187_I203_F0.5420.53
20_D31_S0.5410.53
114_E150_A0.5410.53
98_T346_F0.5400.52
221_T224_N0.5390.52
120_A222_L0.5370.52
73_W119_S0.5360.52
42_L160_I0.5360.52
282_R285_L0.5360.52
257_K279_G0.5350.52
116_M167_F0.5340.52
133_R176_G0.5330.52
188_N216_V0.5330.52
275_E284_G0.5310.51
334_N418_E0.5300.51
367_I384_L0.5280.51
247_T265_P0.5280.51
116_M222_L0.5270.51
41_A118_I0.5270.51
241_K272_E0.5260.51
71_L78_K0.5260.51
67_F183_E0.5240.50
50_I225_V0.5230.50
177_R189_S0.5210.50
52_N74_S0.5200.50
172_H190_L0.5190.50
380_D383_T0.5190.50
91_A132_L0.5180.50
97_G327_M0.5180.50
245_A268_T0.5170.49
139_A261_L0.5170.49
364_S388_C0.5170.49
157_G166_D0.5160.49
300_L415_F0.5140.49
200_K205_A0.5130.49
92_D349_E0.5120.49
157_G163_T0.5120.49
334_N425_Q0.5120.49
395_K399_A0.5110.49
43_T46_S0.5110.49
400_H403_G0.5110.49
58_G241_K0.5100.48
249_L263_E0.5090.48
87_L120_A0.5090.48
409_Q412_I0.5080.48
288_K417_E0.5080.48
115_G120_A0.5080.48
262_W278_A0.5070.48
46_S121_F0.5070.48
147_I169_L0.5060.48
114_E230_A0.5050.48
177_R195_A0.5050.48
292_P297_T0.5050.48
255_R329_V0.5050.48
396_T405_V0.5050.48
112_L130_I0.5050.48
396_T400_H0.5050.48
183_E200_K0.5040.48
132_L190_L0.5040.48
228_I235_W0.5030.48
99_Y260_G0.5030.48
416_R423_I0.5000.47
299_F329_V0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3i9v1 1 0.9663 100 0.216 Contact Map
4p6vA 1 0.7124 100 0.592 Contact Map
4u9oA 1 0.5236 100 0.639 Contact Map
3c8yA 1 0.364 96 0.956 Contact Map
4r0vA 1 0.1573 91.9 0.964 Contact Map
2bs2B 1 0.4337 84.4 0.968 Contact Map
1jb0C 1 0.1798 84.4 0.968 Contact Map
1kf6B 1 0.4494 75.5 0.971 Contact Map
2wdqB 1 0.4674 70.5 0.972 Contact Map
1hfeL 2 0.3303 68.2 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.012 seconds.