GREMLIN Database
PQQL - Probable zinc protease PqqL
UniProt: P31828 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11744
Length: 931 (858)
Sequences: 4161 (3371)
Seq/√Len: 115.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
378_A382_D6.6141.00
356_N359_D5.3531.00
853_E857_N5.3181.00
210_A214_Q5.2901.00
370_T374_H5.2131.00
74_N211_Q4.4501.00
795_N799_Q4.2581.00
634_D638_A4.2511.00
581_S584_S4.0501.00
367_E370_T4.0251.00
92_T141_A3.8561.00
239_L243_K3.7581.00
234_D237_E3.7051.00
91_K149_A3.7021.00
369_A373_Q3.6361.00
36_I236_K3.6131.00
240_A244_D3.5801.00
852_S855_E3.4891.00
908_N911_T3.4801.00
853_E906_V3.3101.00
82_V152_F3.2001.00
558_P561_Q3.1741.00
441_Q445_E3.0671.00
362_N366_A2.9361.00
211_Q214_Q2.9181.00
907_E911_T2.9151.00
209_P213_R2.9051.00
214_Q218_R2.8451.00
905_T908_N2.8451.00
79_A215_F2.6441.00
137_Q241_L2.6371.00
906_V910_N2.6131.00
229_V242_I2.5921.00
64_I225_M2.5781.00
609_V619_G2.5751.00
783_A904_M2.5111.00
448_Q453_N2.4991.00
372_D448_Q2.4791.00
578_G629_H2.4781.00
911_T915_Q2.4761.00
475_A479_A2.4611.00
645_I682_A2.4521.00
907_E910_N2.3681.00
548_A705_F2.3591.00
531_R704_T2.3361.00
625_Q629_H2.3231.00
831_R834_E2.3221.00
214_Q217_Q2.3101.00
116_Y123_V2.3091.00
844_V848_A2.2901.00
93_W141_A2.2781.00
895_T899_Q2.2741.00
471_A475_A2.2691.00
68_S197_P2.2401.00
680_Q687_A2.2381.00
494_F497_R2.2301.00
561_Q695_Q2.2281.00
45_R226_T2.2261.00
92_T145_E2.2131.00
506_D509_A2.1791.00
687_A691_A2.1431.00
297_E433_R2.1301.00
896_E899_Q2.1151.00
265_E268_L2.1051.00
80_H83_E2.0951.00
48_I235_S2.0911.00
755_N758_V2.0751.00
868_D898_E2.0691.00
580_L625_Q2.0691.00
246_L249_L2.0561.00
63_Q123_V2.0441.00
513_S517_L2.0391.00
48_I233_I2.0381.00
308_M376_F2.0361.00
892_A896_E2.0321.00
39_Q45_R2.0271.00
494_F498_N2.0261.00
36_I235_S2.0051.00
237_E240_A2.0011.00
677_Q680_Q1.9891.00
864_Q902_K1.9861.00
615_N618_P1.9841.00
80_H84_H1.9661.00
62_L227_F1.9641.00
350_V364_L1.9621.00
791_D855_E1.9551.00
837_T841_E1.9501.00
758_V761_V1.9491.00
680_Q683_Q1.9421.00
676_L680_Q1.9401.00
468_A472_L1.9231.00
534_L711_V1.9081.00
784_F913_V1.9061.00
369_A372_D1.8931.00
685_T688_D1.8921.00
780_A904_M1.8721.00
899_Q903_Q1.8651.00
777_T915_Q1.8601.00
618_P621_Q1.8421.00
845_K849_K1.8391.00
36_I239_L1.8331.00
592_N615_N1.8271.00
382_D385_K1.8161.00
260_W263_K1.8121.00
81_F157_V1.8091.00
73_D195_R1.8061.00
478_L482_K1.8051.00
874_V877_L1.8041.00
133_K237_E1.8021.00
223_N251_A1.8011.00
440_V444_A1.8001.00
157_V209_P1.7921.00
712_A715_K1.7761.00
624_N726_S1.7671.00
86_M150_A1.7541.00
203_T206_T1.7521.00
233_I238_A1.7491.00
116_Y121_E1.7441.00
873_S877_L1.7441.00
154_K158_D1.7321.00
213_R217_Q1.7261.00
230_V408_T1.7251.00
896_E900_L1.7201.00
226_T415_S1.7181.00
856_L906_V1.7151.00
101_T138_Q1.7141.00
297_E437_Q1.6971.00
686_A690_L1.6961.00
265_E269_R1.6951.00
715_K718_A1.6931.00
295_N298_Q1.6731.00
638_A641_Q1.6731.00
467_A471_A1.6551.00
714_D717_V1.6541.00
580_L588_W1.6531.00
680_Q684_F1.6511.00
279_R353_R1.6481.00
168_W198_I1.6441.00
237_E241_L1.6391.00
442_S445_E1.6331.00
780_A912_A1.6281.00
181_A184_P1.6231.00
592_N618_P1.6221.00
784_F909_V1.6181.00
473_S476_A1.6111.00
61_W412_A1.6091.00
833_D837_T1.6071.00
316_R380_E1.6011.00
243_K247_S1.5991.00
136_L238_A1.5931.00
834_E837_T1.5931.00
550_S703_I1.5931.00
611_A619_G1.5921.00
363_A367_E1.5871.00
43_G251_A1.5751.00
378_A440_V1.5711.00
373_Q448_Q1.5681.00
533_I704_T1.5591.00
785_N808_S1.5561.00
637_W686_A1.5541.00
560_Q688_D1.5401.00
774_N777_T1.5351.00
377_S380_E1.5311.00
317_L364_L1.5291.00
38_G46_Y1.5281.00
503_V507_P1.5281.00
201_M205_A1.5251.00
857_N861_Q1.5111.00
838_L841_E1.5101.00
485_A488_K1.5001.00
287_Y365_M1.4971.00
546_I707_I1.4961.00
358_Q362_N1.4931.00
757_P760_Q1.4931.00
491_A495_P1.4911.00
708_V878_A1.4861.00
359_D362_N1.4841.00
445_E449_Q1.4781.00
480_L484_Y1.4771.00
717_V721_T1.4761.00
137_Q245_N1.4751.00
546_I609_V1.4731.00
83_E167_E1.4671.00
578_G631_T1.4611.00
157_V212_L1.4601.00
44_L227_F1.4591.00
873_S876_Q1.4571.00
516_T903_Q1.4561.00
617_E719_L1.4531.00
153_E156_E1.4531.00
787_A909_V1.4471.00
227_F246_L1.4401.00
241_L244_D1.4371.00
320_R367_E1.4341.00
561_Q688_D1.4331.00
85_M212_L1.4321.00
617_E621_Q1.4281.00
776_P908_N1.4251.00
81_F212_L1.4251.00
47_M411_L1.4241.00
348_F364_L1.4231.00
228_I408_T1.4061.00
579_E629_H1.4041.00
680_Q686_A1.4001.00
86_M90_T1.3991.00
857_N860_Q1.3931.00
328_T331_G1.3901.00
779_M900_L1.3881.00
500_S504_D1.3851.00
319_E323_S1.3841.00
255_A258_R1.3701.00
548_A703_I1.3681.00
637_W641_Q1.3671.00
84_H117_T1.3661.00
145_E149_A1.3651.00
783_A909_V1.3611.00
513_S516_T1.3531.00
713_E717_V1.3501.00
64_I147_S1.3501.00
62_L225_M1.3491.00
114_N797_R1.3451.00
486_N489_L1.3431.00
77_G199_G1.3431.00
479_A482_K1.3421.00
217_Q252_N1.3381.00
721_T725_G1.3271.00
754_Q758_V1.3261.00
490_A494_F1.3261.00
115_A160_E1.3231.00
579_E625_Q1.3211.00
756_E761_V1.3211.00
776_P900_L1.3201.00
544_L709_G1.3201.00
634_D686_A1.3191.00
678_E682_A1.3191.00
794_V799_Q1.3171.00
60_L67_G1.3161.00
758_V763_Q1.3161.00
264_A267_H1.3141.00
469_K472_L1.3111.00
137_Q244_D1.3101.00
497_R501_L1.3041.00
691_A695_Q1.3031.00
718_A721_T1.3021.00
899_Q902_K1.3021.00
841_E844_V1.3011.00
439_T442_S1.2991.00
326_L329_I1.2920.99
325_E356_N1.2920.99
75_E203_T1.2910.99
41_D243_K1.2910.99
90_T150_A1.2910.99
327_K330_S1.2850.99
599_K606_L1.2810.99
564_L688_D1.2810.99
864_Q898_E1.2770.99
558_P695_Q1.2760.99
856_L860_Q1.2760.99
80_H804_Y1.2730.99
371_I376_F1.2710.99
114_N117_T1.2680.99
389_L393_K1.2670.99
544_L613_T1.2650.99
568_A692_A1.2650.99
171_H198_I1.2620.99
863_V901_L1.2610.99
126_V139_V1.2580.99
83_E117_T1.2540.99
80_H117_T1.2530.99
152_F209_P1.2500.99
526_L529_G1.2500.99
117_T167_E1.2490.99
366_A370_T1.2480.99
180_Q184_P1.2480.99
83_E804_Y1.2470.99
48_I238_A1.2440.99
867_L901_L1.2420.99
853_E907_E1.2420.99
841_E845_K1.2390.99
620_F719_L1.2380.99
645_I649_K1.2350.99
707_I716_L1.2330.99
911_T914_K1.2310.99
117_T797_R1.2290.99
461_M464_N1.2280.99
152_F213_R1.2230.99
797_R804_Y1.2180.99
149_A249_L1.2170.99
585_L626_R1.2150.99
84_H167_E1.2140.99
913_V917_L1.2120.99
105_M135_N1.2040.99
684_F687_A1.2010.99
551_N555_L1.2010.99
182_R286_Y1.1940.99
210_A217_Q1.1940.99
484_Y492_Y1.1930.99
63_Q412_A1.1920.99
557_F561_Q1.1910.99
84_H804_Y1.1880.99
365_M369_A1.1870.99
577_V625_Q1.1840.99
83_E114_N1.1830.99
165_T201_M1.1810.99
617_E722_R1.1810.99
296_D299_S1.1800.99
475_A478_L1.1740.99
154_K209_P1.1740.99
80_H167_E1.1720.99
128_L139_V1.1720.99
120_D193_L1.1710.99
115_A167_E1.1710.99
756_E760_Q1.1690.99
501_L505_A1.1660.99
568_A693_D1.1630.99
617_E715_K1.1630.99
61_W123_V1.1610.99
780_A908_N1.1570.99
842_V845_K1.1560.99
564_L692_A1.1550.99
59_N408_T1.1540.99
92_T149_A1.1530.99
544_L711_V1.1520.99
748_S752_K1.1520.99
474_P478_L1.1500.99
117_T160_E1.1460.99
84_H114_N1.1440.99
523_S531_R1.1430.99
690_L694_R1.1410.99
200_L203_T1.1390.99
84_H115_A1.1350.99
144_S148_N1.1350.99
66_T215_F1.1320.99
116_Y125_Q1.1290.99
262_T268_L1.1290.99
76_L200_L1.1220.99
143_F146_W1.1220.99
796_I803_A1.1210.99
285_L361_A1.1160.99
793_R798_E1.1150.99
60_L229_V1.1140.99
498_N501_L1.1120.98
50_P235_S1.1090.98
787_A851_I1.1070.98
165_T205_A1.1070.98
298_Q449_Q1.1070.98
776_P780_A1.1060.98
88_N798_E1.1040.98
441_Q444_A1.1040.98
241_L245_N1.1030.98
487_K490_A1.1020.98
102_F113_V1.1010.98
80_H114_N1.1000.98
114_N160_E1.0990.98
520_N523_S1.0980.98
119_Y197_P1.0960.98
881_I886_I1.0950.98
847_L914_K1.0920.98
114_N199_G1.0900.98
114_N804_Y1.0900.98
83_E115_A1.0890.98
327_K331_G1.0870.98
428_Y432_K1.0860.98
530_A724_L1.0800.98
160_E167_E1.0760.98
754_Q757_P1.0720.98
675_L678_E1.0710.98
320_R370_T1.0700.98
826_T835_L1.0670.98
687_A690_L1.0660.98
86_M216_Y1.0650.98
75_E211_Q1.0640.98
262_T265_E1.0630.98
102_F105_M1.0600.98
302_E450_L1.0550.98
681_I684_F1.0520.98
76_L211_Q1.0510.98
571_A637_W1.0500.98
90_T152_F1.0500.98
505_A509_A1.0480.98
221_Q224_N1.0370.98
229_V233_I1.0370.98
185_F458_W1.0360.98
281_N354_D1.0330.98
690_L693_D1.0330.98
499_L503_V1.0320.98
86_M146_W1.0320.98
881_I885_L1.0280.97
488_K491_A1.0240.97
784_F912_A1.0230.97
856_L909_V1.0230.97
641_Q681_I1.0230.97
154_K210_A1.0230.97
488_K493_V1.0210.97
463_N466_V1.0200.97
189_N194_D1.0190.97
65_H226_T1.0170.97
481_E484_Y1.0170.97
503_V506_D1.0150.97
84_H797_R1.0140.97
80_H160_E1.0140.97
860_Q901_L1.0120.97
588_W618_P1.0110.97
168_W171_H1.0100.97
462_V465_E1.0080.97
850_G910_N1.0070.97
493_V496_G1.0060.97
100_E104_S1.0060.97
385_K435_W1.0010.97
432_K436_Q1.0010.97
80_H115_A0.9990.97
117_T804_Y0.9980.97
81_F164_I0.9980.97
471_A474_P0.9970.97
758_V762_S0.9970.97
711_V716_L0.9970.97
298_Q450_L0.9960.97
84_H160_E0.9950.97
90_T146_W0.9930.97
48_I239_L0.9930.97
301_I442_S0.9930.97
318_Q582_S0.9920.97
914_K918_S0.9920.97
877_L881_I0.9850.97
331_G334_A0.9850.97
187_L343_Y0.9840.97
649_K652_D0.9820.97
82_V212_L0.9810.97
368_L372_D0.9810.97
433_R437_Q0.9810.97
691_A694_R0.9770.97
429_Q432_K0.9770.97
75_E195_R0.9760.97
140_M241_L0.9760.97
681_I686_A0.9740.96
170_A198_I0.9730.96
677_Q681_I0.9710.96
115_A797_R0.9700.96
63_Q121_E0.9690.96
547_I608_S0.9670.96
60_L139_V0.9670.96
654_R657_E0.9670.96
91_K151_T0.9670.96
202_D469_K0.9660.96
641_Q645_I0.9660.96
91_K249_L0.9650.96
900_L903_Q0.9630.96
361_A457_F0.9590.96
845_K850_G0.9590.96
472_L481_E0.9560.96
329_I332_G0.9540.96
787_A859_Y0.9500.96
516_T519_E0.9500.96
138_Q142_I0.9490.96
910_N914_K0.9480.96
645_I678_E0.9480.96
93_W142_I0.9480.96
550_S605_T0.9470.96
675_L679_N0.9460.96
484_Y489_L0.9460.96
792_L839_A0.9440.96
49_Y230_V0.9430.96
636_I639_S0.9420.96
137_Q238_A0.9410.96
83_E797_R0.9410.96
78_V82_V0.9380.96
792_L806_V0.9380.96
521_L526_L0.9360.96
156_E159_A0.9360.96
363_A366_A0.9360.96
596_M623_I0.9360.96
561_Q564_L0.9330.96
124_Y220_Y0.9310.95
457_F463_N0.9300.95
662_Q665_E0.9300.95
385_K389_L0.9290.95
513_S518_A0.9260.95
441_Q448_Q0.9250.95
580_L629_H0.9240.95
381_L440_V0.9230.95
802_G835_L0.9230.95
683_Q687_A0.9220.95
491_A494_F0.9220.95
809_R822_L0.9220.95
897_Q901_L0.9210.95
140_M242_I0.9190.95
223_N254_A0.9180.95
165_T169_R0.9180.95
270_F274_N0.9170.95
236_K240_A0.9160.95
784_F917_L0.9160.95
780_A909_V0.9150.95
844_V847_L0.9130.95
445_E448_Q0.9130.95
574_G636_I0.9130.95
854_Q858_E0.9130.95
754_Q759_A0.9120.95
85_M88_N0.9120.95
478_L481_E0.9120.95
265_E275_D0.9110.95
485_A489_L0.9090.95
496_G499_L0.9090.95
564_L689_A0.9090.95
484_Y488_K0.9060.95
823_L839_A0.9060.95
582_S636_I0.9050.95
114_N167_E0.9040.95
758_V764_W0.9040.95
514_K517_L0.9020.95
662_Q666_T0.9010.95
52_A232_D0.9010.95
88_N156_E0.9010.95
326_L331_G0.9000.95
160_E804_Y0.8990.95
150_A216_Y0.8980.94
874_V878_A0.8980.94
490_A493_V0.8970.94
141_A145_E0.8970.94
249_L258_R0.8970.94
613_T710_N0.8970.94
524_L720_I0.8970.94
632_I690_L0.8960.94
208_T211_Q0.8940.94
749_V752_K0.8940.94
783_A901_L0.8940.94
825_F839_A0.8940.94
256_E259_V0.8920.94
76_L203_T0.8910.94
544_L707_I0.8890.94
447_W452_K0.8890.94
477_I485_A0.8880.94
326_L350_V0.8870.94
48_I229_V0.8850.94
683_Q686_A0.8850.94
145_E148_N0.8850.94
426_E429_Q0.8840.94
229_V238_A0.8840.94
580_L585_L0.8830.94
684_F688_D0.8830.94
352_A360_A0.8830.94
761_V764_W0.8820.94
755_N761_V0.8810.94
425_E428_Y0.8810.94
828_Q831_R0.8790.94
585_L589_S0.8790.94
718_A722_R0.8770.94
425_E429_Q0.8760.94
270_F361_A0.8750.94
731_D734_L0.8750.94
598_S607_L0.8750.94
577_V630_S0.8740.94
325_E328_T0.8740.94
522_T713_E0.8740.94
624_N628_T0.8720.94
827_C835_L0.8710.94
167_E797_R0.8680.93
851_I856_L0.8670.93
245_N249_L0.8670.93
678_E681_I0.8670.93
544_L616_P0.8660.93
860_Q902_K0.8660.93
638_A642_N0.8650.93
68_S198_I0.8640.93
486_N490_A0.8630.93
72_E75_E0.8630.93
909_V912_A0.8630.93
75_E218_R0.8610.93
99_I113_V0.8610.93
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883_N887_Q0.5440.65
258_R261_P0.5440.65
67_G123_V0.5440.65
541_E710_N0.5440.65
741_T745_D0.5430.65
242_I258_R0.5430.65
857_N902_K0.5430.65
154_K285_L0.5420.65
777_T911_T0.5420.65
620_F623_I0.5420.65
278_N282_G0.5410.65
58_V233_I0.5410.65
295_N442_S0.5400.65
695_Q732_S0.5400.65
83_E199_G0.5390.65
250_P254_A0.5390.65
796_I835_L0.5390.65
72_E218_R0.5380.65
102_F793_R0.5380.65
157_V164_I0.5380.65
165_T204_V0.5380.65
692_A696_L0.5380.65
247_S250_P0.5370.64
677_Q684_F0.5370.64
98_V126_V0.5370.64
407_L411_L0.5370.64
76_L197_P0.5370.64
138_Q141_A0.5360.64
644_Q648_L0.5360.64
715_K719_L0.5350.64
792_L808_S0.5350.64
42_N246_L0.5350.64
574_G639_S0.5350.64
345_S349_R0.5340.64
679_N774_N0.5340.64
75_E157_V0.5330.64
77_G114_N0.5330.64
705_F724_L0.5330.64
319_E363_A0.5330.64
159_A798_E0.5320.64
524_L717_V0.5320.64
486_N493_V0.5310.64
771_T775_L0.5300.63
321_I328_T0.5300.63
79_A83_E0.5300.63
586_K640_L0.5300.63
379_E588_W0.5290.63
83_E164_I0.5290.63
42_N48_I0.5290.63
621_Q719_L0.5290.63
89_G151_T0.5290.63
96_N790_K0.5280.63
377_S382_D0.5280.63
85_M102_F0.5280.63
182_R185_F0.5270.63
88_N146_W0.5270.63
491_A498_N0.5270.63
521_L848_A0.5260.63
81_F89_G0.5250.63
100_E103_E0.5250.63
834_E838_L0.5250.63
299_S303_Q0.5240.63
469_K476_A0.5230.62
143_F150_A0.5230.62
87_F114_N0.5230.62
365_M457_F0.5220.62
657_E661_Q0.5220.62
694_R698_S0.5220.62
637_W684_F0.5210.62
586_K596_M0.5210.62
750_T758_V0.5210.62
202_D206_T0.5210.62
285_L477_I0.5210.62
752_K755_N0.5200.62
531_R537_S0.5200.62
281_N463_N0.5200.62
488_K492_Y0.5200.62
794_V798_E0.5200.62
368_L447_W0.5190.62
97_K102_F0.5190.62
477_I488_K0.5190.62
746_N754_Q0.5190.62
89_G145_E0.5180.62
525_T532_V0.5180.62
60_L136_L0.5180.62
221_Q254_A0.5180.62
146_W150_A0.5170.62
873_S881_I0.5160.61
549_V882_V0.5160.61
342_D345_S0.5160.61
637_W642_N0.5160.61
630_S693_D0.5150.61
667_R670_D0.5150.61
594_V619_G0.5150.61
897_Q900_L0.5130.61
297_E823_L0.5130.61
114_N122_T0.5130.61
304_A381_L0.5130.61
479_A488_K0.5120.61
372_D447_W0.5110.61
66_T418_N0.5110.61
268_L273_I0.5110.61
609_V705_F0.5110.61
468_A474_P0.5100.61
89_G94_P0.5100.61
516_T895_T0.5090.60
144_S246_L0.5090.60
61_W64_I0.5090.60
684_F918_S0.5080.60
458_W464_N0.5080.60
664_Y811_S0.5080.60
113_V126_V0.5080.60
334_A347_F0.5080.60
285_L365_M0.5070.60
186_L456_A0.5070.60
73_D202_D0.5070.60
79_A122_T0.5060.60
198_I203_T0.5060.60
98_V105_M0.5060.60
140_M238_A0.5060.60
760_Q763_Q0.5050.60
429_Q433_R0.5050.60
283_I350_V0.5040.60
150_A213_R0.5040.60
82_V169_R0.5040.60
65_H224_N0.5030.59
93_W101_T0.5030.59
638_A670_D0.5030.59
66_T219_W0.5020.59
93_W145_E0.5020.59
122_T215_F0.5020.59
51_H404_L0.5010.59
290_P450_L0.5010.59
102_F790_K0.5010.59
78_V203_T0.5010.59
325_E331_G0.5010.59
383_D587_R0.5000.59
68_S216_Y0.5000.59
133_K241_L0.5000.59
156_E163_V0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1q2lA 1 0.9495 100 0.302 Contact Map
3cwwA 3 0.9495 100 0.324 Contact Map
2fgeA 1 0.9517 100 0.375 Contact Map
4l3tA 1 0.9044 100 0.384 Contact Map
3s5mA 1 0.9431 100 0.409 Contact Map
3eoqA 2 0.435 100 0.62 Contact Map
3amiA 2 0.4447 100 0.624 Contact Map
4nnzA 2 0.42 100 0.631 Contact Map
1hr6B 1 0.4597 100 0.639 Contact Map
1pp9A 1 0.464 100 0.643 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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