GREMLIN Database
TRMN6 - tRNA1(Val) (adenine(37)-N6)-methyltransferase
UniProt: P31825 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11538
Length: 245 (189)
Sequences: 6636 (5292)
Seq/√Len: 384.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_F87_E3.0341.00
59_A74_A2.9711.00
79_S102_T2.8131.00
117_D160_T2.7441.00
73_D101_H2.7431.00
73_D116_F2.5511.00
152_L181_A2.5011.00
89_I100_V2.4881.00
155_A165_F2.4331.00
59_A72_I2.4321.00
103_A108_W2.4071.00
10_R17_Q2.3581.00
49_L116_F2.3481.00
193_D199_A2.1991.00
53_A85_A2.1851.00
23_D80_E2.1171.00
62_L120_I2.1091.00
82_A100_V2.0861.00
47_R71_M2.0261.00
16_K65_R1.9611.00
16_K64_Q1.8781.00
30_G33_G1.8661.00
89_I98_I1.8481.00
19_F91_Q1.8391.00
76_E82_A1.7811.00
53_A59_A1.7751.00
12_G17_Q1.7671.00
63_A72_I1.7481.00
167_V181_A1.7321.00
74_A100_V1.7271.00
71_M99_N1.7261.00
14_T65_R1.7201.00
174_G191_R1.7181.00
18_F61_M1.6721.00
128_Q140_A1.6561.00
159_I163_G1.6221.00
82_A102_T1.6201.00
104_D107_Q1.5441.00
118_L166_C1.5221.00
178_T191_R1.5131.00
38_A42_V1.5091.00
60_L94_W1.4711.00
23_D84_Q1.4671.00
77_L137_R1.4641.00
152_L180_L1.4591.00
104_D150_S1.4581.00
66_T70_V1.4491.00
59_A98_I1.4321.00
73_D99_N1.4261.00
21_A84_Q1.4221.00
149_P180_L1.4141.00
153_T184_M1.3961.00
16_K61_M1.3801.00
179_E183_S1.3621.00
106_Q158_C1.3441.00
136_Q140_A1.3251.00
24_R55_S1.3061.00
12_G15_F1.3021.00
174_G199_A1.2881.00
74_A98_I1.2761.00
171_E198_E1.2741.00
37_G41_P1.2721.00
53_A76_E1.2671.00
51_I105_I1.2661.00
82_A86_Q1.2621.00
105_I148_H1.2421.00
137_R141_R1.2401.00
154_C157_E1.2391.00
48_C70_V1.2381.00
127_Q172_Q1.2211.00
121_S167_V1.2071.00
179_E182_L1.2041.00
21_A87_E1.1961.00
36_L39_W1.1961.00
78_E81_A1.1941.00
47_R73_D1.1891.00
178_T182_L1.1881.00
169_L177_F1.1781.00
66_T69_S1.1671.00
85_A100_V1.1531.00
48_C72_I1.1481.00
47_R116_F1.1471.00
50_D59_A1.1401.00
60_L89_I1.1321.00
31_T34_I1.1261.00
150_S154_C1.1061.00
86_Q90_N1.1031.00
143_T149_P1.0991.00
63_A98_I1.0681.00
144_T149_P1.0671.00
115_R160_T1.0661.00
169_L174_G1.0661.00
58_L120_I1.0601.00
156_A186_W1.0501.00
39_W42_V1.0381.00
90_N95_A1.0381.00
10_R91_Q1.0291.00
105_I150_S1.0281.00
155_A186_W1.0241.00
132_C137_R1.0151.00
52_G105_I1.0051.00
106_Q150_S1.0041.00
142_Y147_D0.9971.00
51_I151_L0.9951.00
52_G121_S0.9931.00
36_L40_A0.9931.00
75_V103_A0.9861.00
60_L92_S0.9751.00
47_R114_V0.9741.00
64_Q94_W0.9591.00
40_A166_C0.9581.00
24_R27_M0.9481.00
75_V109_I0.9451.00
175_N179_E0.9331.00
138_E142_Y0.9281.00
46_K70_V0.9151.00
18_F60_L0.9021.00
159_I165_F0.9001.00
27_M30_G0.8931.00
87_E90_N0.8891.00
39_W192_T0.8841.00
79_S83_A0.8811.00
135_P138_E0.8791.00
151_L165_F0.8731.00
174_G178_T0.8701.00
173_I176_G0.8681.00
127_Q130_V0.8681.00
118_L164_F0.8671.00
48_C118_L0.8661.00
181_A186_W0.8621.00
59_A63_A0.8601.00
103_A107_Q0.8411.00
83_A86_Q0.8351.00
87_E91_Q0.8221.00
149_P183_S0.8191.00
154_C158_C0.8131.00
116_F119_I0.7991.00
150_S153_T0.7991.00
152_L184_M0.7951.00
146_L176_G0.7941.00
153_T156_A0.7901.00
89_I94_W0.7891.00
49_L119_I0.7871.00
130_V172_Q0.7861.00
59_A120_I0.7841.00
14_T61_M0.7841.00
48_C62_L0.7831.00
33_G195_A0.7821.00
170_P173_I0.7811.00
18_F57_L0.7781.00
192_T201_L0.7781.00
36_L42_V0.7741.00
106_Q154_C0.7651.00
45_V71_M0.7651.00
132_C141_R0.7631.00
105_I154_C0.7561.00
78_E137_R0.7541.00
138_E141_R0.7511.00
149_P184_M0.7511.00
131_E135_P0.7491.00
167_V177_F0.7481.00
86_Q89_I0.7411.00
156_A184_M0.7411.00
169_L191_R0.7381.00
30_G34_I0.7351.00
18_F94_W0.7341.00
126_Y170_P0.7331.00
53_A100_V0.7321.00
50_D53_A0.7291.00
61_M65_R0.7281.00
128_Q142_Y0.7281.00
147_D150_S0.7211.00
131_E138_E0.7171.00
135_P141_R0.7131.00
131_E141_R0.7111.00
165_F181_A0.7071.00
146_L151_L0.7071.00
137_R140_A0.7051.00
133_S137_R0.7041.00
43_A46_K0.7011.00
53_A74_A0.6991.00
119_I158_C0.6981.00
72_I98_I0.6910.99
34_I37_G0.6910.99
20_V24_R0.6900.99
50_D120_I0.6900.99
49_L75_V0.6890.99
31_T58_L0.6870.99
148_H167_V0.6820.99
73_D114_V0.6810.99
74_A85_A0.6760.99
33_G37_G0.6690.99
138_E144_T0.6690.99
64_Q92_S0.6660.99
37_G192_T0.6650.99
57_L61_M0.6620.99
75_V101_H0.6580.99
51_I106_Q0.6550.99
99_N114_V0.6530.99
47_R160_T0.6520.99
63_A89_I0.6500.99
17_Q91_Q0.6440.99
121_S151_L0.6440.99
36_L166_C0.6410.99
77_L139_Q0.6400.99
24_R28_K0.6400.99
193_D197_N0.6380.99
133_S140_A0.6380.99
132_C142_Y0.6370.99
20_V84_Q0.6340.99
48_C66_T0.6280.99
144_T147_D0.6270.99
152_L167_V0.6260.99
83_A87_E0.6260.99
113_T157_E0.6240.99
46_K117_D0.6220.99
174_G198_E0.6200.99
180_L184_M0.6200.99
194_V200_R0.6180.99
119_I159_I0.6150.99
141_R148_H0.6140.99
139_Q145_T0.6110.99
46_K69_S0.6110.99
105_I151_L0.6100.99
149_P153_T0.6090.99
36_L41_P0.6060.99
15_F64_Q0.6040.99
44_G69_S0.5990.98
197_N200_R0.5980.98
30_G196_E0.5940.98
28_K31_T0.5930.98
182_L187_H0.5900.98
176_G179_E0.5870.98
32_D36_L0.5860.98
173_I177_F0.5830.98
45_V69_S0.5820.98
132_C140_A0.5820.98
39_W166_C0.5770.98
84_Q88_N0.5760.98
132_C135_P0.5740.98
25_C84_Q0.5730.98
119_I165_F0.5700.98
52_G148_H0.5640.98
171_E174_G0.5610.98
131_E142_Y0.5600.98
182_L189_R0.5580.98
10_R19_F0.5570.98
146_L180_L0.5530.97
63_A95_A0.5520.97
24_R84_Q0.5520.97
46_K66_T0.5510.97
61_M64_Q0.5470.97
23_D26_A0.5430.97
60_L64_Q0.5430.97
25_C28_K0.5380.97
180_L183_S0.5380.97
80_E83_A0.5380.97
47_R117_D0.5370.97
178_T189_R0.5310.97
67_D70_V0.5310.97
136_Q141_R0.5260.97
133_S141_R0.5260.97
26_A81_A0.5240.96
132_C136_Q0.5240.96
63_A94_W0.5240.96
51_I158_C0.5230.96
127_Q176_G0.5210.96
127_Q173_I0.5200.96
17_Q92_S0.5200.96
39_W43_A0.5200.96
40_A120_I0.5190.96
12_G19_F0.5190.96
133_S138_E0.5180.96
62_L70_V0.5180.96
116_F158_C0.5160.96
49_L109_I0.5140.96
152_L177_F0.5110.96
168_V194_V0.5110.96
21_A24_R0.5090.96
43_A164_F0.5080.96
60_L88_N0.5050.96
78_E82_A0.5030.96
141_R147_D0.5030.96
89_I92_S0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lpmA 2 0.8816 100 0.387 Contact Map
2ozvA 2 0.7878 100 0.43 Contact Map
2b3tA 1 0.8286 100 0.527 Contact Map
1nv8A 1 0.8041 100 0.548 Contact Map
3evzA 1 0.751 100 0.585 Contact Map
4dzrA 2 0.6204 99.9 0.618 Contact Map
2ih2A 1 0.8408 99.9 0.637 Contact Map
4dcmA 1 0.7388 99.9 0.638 Contact Map
3v97A 1 0.7755 99.9 0.639 Contact Map
2h00A 1 0.7592 99.9 0.644 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0083 seconds.