GREMLIN Database
CHAA - Sodium/proton antiporter ChaA
UniProt: P31801 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11753
Length: 366 (339)
Sequences: 2082 (1247)
Seq/√Len: 67.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
184_V351_A5.2921.00
126_G133_Q4.0841.00
308_L312_M3.8501.00
177_I355_A3.8221.00
40_I44_L3.7801.00
32_S37_P3.4121.00
310_A317_L3.2581.00
264_A267_I3.2271.00
132_T344_R3.2101.00
29_L46_A3.1931.00
173_L362_M3.0681.00
133_Q282_N2.6781.00
23_A26_V2.6531.00
221_L225_I2.6361.00
249_L259_T2.6241.00
65_A73_G2.5381.00
39_V247_T2.5241.00
98_A315_N2.4041.00
193_H197_F2.3241.00
130_F282_N2.2211.00
41_A45_L2.2161.00
65_A70_E2.2141.00
129_K280_L2.1691.00
124_L354_L2.0971.00
235_I239_K2.0821.00
110_I268_L2.0781.00
85_E271_E2.0761.00
32_S45_L2.0271.00
225_I229_I2.0271.00
181_M355_A2.0241.00
271_E294_S2.0141.00
28_F31_G2.0081.00
28_F32_S2.0051.00
124_L184_V1.9851.00
342_T349_N1.9681.00
298_T302_T1.9681.00
24_L28_F1.9671.00
188_I192_T1.9161.00
159_M326_M1.9041.00
220_S224_A1.9001.00
310_A315_N1.8601.00
278_A286_R1.8301.00
124_L128_R1.8081.00
211_H214_K1.7971.00
30_W34_Q1.7891.00
125_L280_L1.7871.00
68_L72_Y1.7721.00
274_G278_A1.7711.00
207_D211_H1.7451.00
29_L237_V1.7381.00
74_S78_S1.7211.00
30_W33_S1.6941.00
62_D65_A1.6890.99
107_L303_V1.6670.99
126_G282_N1.6400.99
116_G332_S1.6010.99
23_A27_L1.5920.99
28_F37_P1.5910.99
263_V267_I1.5830.99
133_Q345_T1.5820.99
25_V28_F1.5770.99
192_T197_F1.5770.99
209_D212_H1.5720.99
176_L180_A1.5710.99
30_W236_A1.5690.99
263_V266_L1.5610.99
23_A30_W1.5550.99
24_L31_G1.5480.99
127_G133_Q1.5480.99
109_S116_G1.5380.99
58_V272_G1.5280.99
32_S42_I1.4960.99
184_V347_V1.4890.99
176_L308_L1.4840.99
27_L49_G1.4790.99
206_D210_P1.4720.99
305_V309_I1.4650.99
188_I193_H1.4530.98
130_F133_Q1.4530.98
110_I118_L1.4430.98
101_T104_R1.4230.98
232_I236_A1.3940.98
31_G35_T1.3940.98
64_L220_S1.3910.98
28_F45_L1.3750.98
226_W229_I1.3540.98
172_L311_F1.3460.97
63_V122_S1.3460.97
188_I347_V1.3450.97
193_H196_L1.3400.97
203_D206_D1.3370.97
291_F295_V1.3370.97
151_A299_I1.3330.97
195_S228_I1.3320.97
181_M351_A1.3170.97
186_L190_T1.3140.97
31_G34_Q1.3140.97
206_D209_D1.3140.97
50_I54_A1.3100.97
121_F354_L1.3070.97
218_H222_W1.2950.97
268_L272_G1.2910.97
100_P317_L1.2870.97
263_V360_Y1.2850.97
116_G353_H1.2850.97
205_S208_D1.2800.97
79_L297_A1.2770.96
274_G290_L1.2710.96
209_D213_G1.2670.96
96_G313_T1.2640.96
310_A314_G1.2630.96
160_A321_L1.2610.96
119_V336_C1.2610.96
180_A351_A1.2600.96
181_M352_A1.2570.96
58_V241_N1.2530.96
32_S35_T1.2480.96
104_R318_Q1.2440.96
82_V294_S1.2440.96
64_L68_L1.2440.96
203_D208_D1.2400.96
265_L310_A1.2380.96
99_A256_V1.2370.96
210_P229_I1.2290.96
69_G88_L1.2030.95
30_W240_M1.1990.95
138_F142_Q1.1870.95
21_V25_V1.1860.95
115_T241_N1.1780.94
282_N345_T1.1720.94
38_V248_L1.1690.94
83_I89_I1.1680.94
189_Q289_N1.1640.94
49_G54_A1.1580.94
24_L27_L1.1580.94
99_A246_E1.1570.94
102_L245_L1.1370.93
67_R238_T1.1240.93
324_P363_T1.1190.93
46_A49_G1.1180.93
20_P25_V1.1110.93
208_D211_H1.1070.92
322_G325_E1.0990.92
76_I228_I1.0960.92
261_F364_I1.0910.92
264_A296_L1.0900.92
229_I233_A1.0860.92
222_W225_I1.0770.91
114_V272_G1.0730.91
145_I263_V1.0580.91
294_S297_A1.0550.90
65_A75_L1.0520.90
129_K282_N1.0490.90
234_V260_G1.0490.90
22_L25_V1.0490.90
196_L332_S1.0470.90
124_L351_A1.0460.90
118_L268_L1.0440.90
265_L324_P1.0410.90
203_D207_D1.0340.90
245_L248_L1.0310.89
32_S36_L1.0300.89
243_S246_E1.0150.89
205_S209_D1.0090.88
105_D303_V1.0070.88
23_A29_L1.0060.88
66_H214_K1.0030.88
176_L235_I1.0020.88
112_M329_M0.9950.88
265_L348_L0.9940.88
54_A279_V0.9920.87
89_I293_G0.9910.87
134_Y344_R0.9890.87
187_L334_V0.9860.87
261_F360_Y0.9840.87
126_G130_F0.9820.87
81_V268_L0.9790.87
204_D228_I0.9760.87
81_V114_V0.9750.87
77_L80_S0.9680.86
113_I268_L0.9650.86
156_V329_M0.9600.86
54_A57_V0.9470.85
244_S251_S0.9410.85
294_S298_T0.9390.84
128_R131_A0.9330.84
244_S247_T0.9260.84
102_L106_T0.9210.83
206_D213_G0.9160.83
51_L245_L0.9140.83
313_T316_E0.9110.83
132_T282_N0.9090.82
187_L191_K0.9070.82
41_A308_L0.9030.82
27_L31_G0.9000.82
263_V314_G0.9000.82
106_T242_A0.9000.82
84_L238_T0.8960.82
135_M345_T0.8950.81
134_Y205_S0.8950.81
268_L297_A0.8880.81
68_L76_I0.8880.81
205_S210_P0.8870.81
45_L219_S0.8870.81
128_R134_Y0.8840.81
58_V268_L0.8830.81
77_L290_L0.8830.81
113_I357_F0.8800.80
61_A77_L0.8760.80
310_A352_A0.8760.80
333_L337_H0.8760.80
283_Q286_R0.8730.80
346_N349_N0.8730.80
151_A254_A0.8720.80
352_A355_A0.8690.80
126_G132_T0.8660.79
357_F360_Y0.8620.79
22_L26_V0.8610.79
47_L55_F0.8590.79
122_S245_L0.8570.79
82_V268_L0.8560.79
108_Y321_L0.8550.78
106_T239_K0.8490.78
78_S231_L0.8400.77
180_A217_A0.8390.77
173_L359_A0.8390.77
157_F363_T0.8370.77
47_L263_V0.8370.77
21_V24_L0.8350.77
169_G362_M0.8340.77
347_V357_F0.8340.77
25_V49_G0.8330.77
20_P23_A0.8320.77
54_A62_D0.8310.76
309_I312_M0.8310.76
158_P161_L0.8300.76
123_L345_T0.8290.76
51_L332_S0.8290.76
169_G305_V0.8250.76
238_T296_L0.8230.76
257_A322_G0.8210.76
92_L354_L0.8200.75
144_L352_A0.8200.75
88_L253_N0.8190.75
287_A294_S0.8180.75
206_D212_H0.8170.75
63_V220_S0.8160.75
114_V268_L0.8130.75
26_V29_L0.8110.75
25_V41_A0.8100.75
149_P334_V0.8070.74
268_L298_T0.8050.74
208_D212_H0.8020.74
245_L249_L0.8010.74
110_I272_G0.8000.74
148_F154_V0.7980.73
69_G82_V0.7970.73
155_L329_M0.7910.73
262_L265_L0.7890.73
72_Y224_A0.7880.73
76_I133_Q0.7880.73
113_I118_L0.7880.73
125_L276_L0.7870.72
142_Q359_A0.7850.72
185_F189_Q0.7850.72
190_T193_H0.7850.72
50_I274_G0.7840.72
38_V41_A0.7810.72
79_L82_V0.7790.72
153_I356_L0.7760.71
71_P289_N0.7760.71
54_A258_F0.7740.71
25_V35_T0.7740.71
92_L124_L0.7710.71
261_F333_L0.7690.71
328_V360_Y0.7660.70
154_V161_L0.7660.70
207_D358_A0.7620.70
84_L248_L0.7620.70
175_A308_L0.7600.70
37_P148_F0.7560.69
25_V29_L0.7560.69
100_P315_N0.7540.69
204_D210_P0.7500.69
141_K363_T0.7500.69
57_V234_V0.7480.69
239_K290_L0.7450.68
214_K225_I0.7440.68
80_S83_I0.7420.68
111_I299_I0.7420.68
29_L42_I0.7410.68
118_L272_G0.7360.67
136_N317_L0.7350.67
323_A326_M0.7350.67
144_L153_I0.7340.67
321_L326_M0.7340.67
237_V240_M0.7290.67
275_A291_F0.7250.66
88_L92_L0.7240.66
278_A290_L0.7210.66
267_I270_P0.7210.66
70_E331_A0.7190.66
185_F197_F0.7160.65
183_G187_L0.7150.65
34_Q41_A0.7150.65
161_L166_F0.7130.65
150_L156_V0.7120.65
231_L235_I0.7120.65
60_H80_S0.7110.65
20_P27_L0.7100.65
326_M330_V0.7050.64
100_P265_L0.7050.64
192_T196_L0.7020.64
26_V153_I0.7010.64
109_S360_Y0.7010.64
262_L267_I0.6970.63
180_A205_S0.6960.63
38_V225_I0.6950.63
75_L293_G0.6940.63
180_A183_G0.6920.63
61_A294_S0.6900.62
281_N317_L0.6860.62
22_L27_L0.6850.62
28_F39_V0.6830.62
171_A307_T0.6790.61
270_P275_A0.6780.61
66_H209_D0.6770.61
23_A31_G0.6750.61
38_V44_L0.6740.61
269_S272_G0.6740.61
198_V210_P0.6730.60
42_I53_S0.6720.60
121_F124_L0.6690.60
96_G264_A0.6660.60
215_P236_A0.6650.59
35_T253_N0.6650.59
62_D293_G0.6640.59
122_S341_S0.6640.59
207_D212_H0.6640.59
69_G92_L0.6610.59
304_P319_F0.6600.59
183_G233_A0.6600.59
141_K337_H0.6590.59
28_F48_I0.6580.59
342_T348_L0.6550.58
101_T325_E0.6550.58
127_G345_T0.6550.58
157_F163_A0.6540.58
130_F340_F0.6520.58
34_Q40_I0.6520.58
162_P320_A0.6510.58
207_D215_P0.6500.58
188_I357_F0.6450.57
248_L255_P0.6440.57
41_A209_D0.6430.57
98_A258_F0.6430.57
244_S248_L0.6420.57
93_M238_T0.6410.57
294_S302_T0.6400.57
181_M310_A0.6400.57
177_I318_Q0.6380.56
210_P213_G0.6340.56
68_L112_M0.6320.56
260_G326_M0.6300.55
92_L309_I0.6290.55
189_Q197_F0.6290.55
141_K329_M0.6260.55
307_T310_A0.6260.55
225_I308_L0.6250.55
173_L177_I0.6240.55
206_D225_I0.6220.54
133_Q347_V0.6210.54
196_L347_V0.6200.54
89_I234_V0.6190.54
168_T172_L0.6180.54
91_A162_P0.6170.54
231_L268_L0.6150.54
188_I196_L0.6130.53
173_L248_L0.6130.53
340_F348_L0.6130.53
248_L323_A0.6110.53
38_V251_S0.6110.53
26_V31_G0.6100.53
354_L365_F0.6090.53
26_V53_S0.6060.53
204_D207_D0.6050.52
295_V298_T0.6040.52
149_P153_I0.6030.52
64_L283_Q0.6020.52
90_S239_K0.6010.52
107_L152_I0.6010.52
191_K195_S0.6010.52
33_S36_L0.6000.52
205_S212_H0.6000.52
46_A237_V0.6000.52
339_S353_H0.5990.52
126_G275_A0.5980.52
148_F338_I0.5970.51
234_V294_S0.5970.51
178_S188_I0.5970.51
62_D73_G0.5960.51
204_D208_D0.5960.51
39_V323_A0.5950.51
241_N249_L0.5940.51
350_G353_H0.5930.51
115_T332_S0.5930.51
50_I246_E0.5920.51
115_T230_H0.5920.51
57_V223_H0.5910.51
296_L351_A0.5910.51
174_V359_A0.5900.51
141_K333_L0.5860.50
213_G217_A0.5830.50
62_D83_I0.5830.50
205_S217_A0.5810.50
261_F287_A0.5800.49
168_T250_D0.5790.49
54_A271_E0.5790.49
127_G350_G0.5770.49
206_D211_H0.5770.49
212_H228_I0.5760.49
212_H358_A0.5760.49
21_V26_V0.5760.49
342_T347_V0.5740.49
209_D229_I0.5740.49
46_A53_S0.5730.49
335_L356_L0.5730.49
238_T301_L0.5700.48
43_N47_L0.5700.48
205_S221_L0.5690.48
232_I263_V0.5690.48
195_S224_A0.5690.48
36_L180_A0.5670.48
60_H117_G0.5660.48
56_S226_W0.5650.48
24_L212_H0.5620.47
106_T272_G0.5610.47
244_S259_T0.5610.47
122_S290_L0.5600.47
137_L140_I0.5590.47
184_V301_L0.5570.47
157_F358_A0.5570.47
57_V61_A0.5550.46
180_A358_A0.5540.46
304_P350_G0.5520.46
76_I243_S0.5510.46
63_V348_L0.5460.45
42_I45_L0.5450.45
81_V298_T0.5440.45
73_G293_G0.5440.45
25_V42_I0.5440.45
78_S85_E0.5430.45
108_Y326_M0.5410.45
35_T41_A0.5410.45
93_M96_G0.5370.44
144_L339_S0.5360.44
46_A240_M0.5360.44
160_A320_A0.5360.44
62_D111_I0.5360.44
69_G260_G0.5340.44
27_L262_L0.5340.44
78_S298_T0.5330.44
28_F183_G0.5320.44
172_L176_L0.5320.44
188_I197_F0.5280.43
27_L94_A0.5270.43
189_Q193_H0.5270.43
88_L285_Q0.5260.43
211_H217_A0.5260.43
275_A284_V0.5250.43
108_Y261_F0.5250.43
237_V296_L0.5240.43
211_H220_S0.5230.43
33_S219_S0.5200.42
181_M320_A0.5200.42
145_I339_S0.5180.42
140_I340_F0.5180.42
102_L148_F0.5170.42
66_H216_S0.5160.42
100_P262_L0.5160.42
30_W237_V0.5130.42
77_L297_A0.5130.42
22_L33_S0.5120.41
136_N139_G0.5110.41
181_M348_L0.5110.41
182_Y293_G0.5100.41
31_G221_L0.5100.41
21_V38_V0.5100.41
34_Q236_A0.5090.41
223_H268_L0.5090.41
249_L260_G0.5080.41
54_A61_A0.5070.41
149_P355_A0.5070.41
26_V30_W0.5070.41
344_R349_N0.5060.41
109_S357_F0.5060.41
242_A270_P0.5060.41
181_M339_S0.5050.41
327_V345_T0.5050.41
108_Y130_F0.5050.41
191_K194_Q0.5040.41
248_L252_M0.5040.41
249_L277_K0.5030.40
29_L33_S0.5010.40
135_M279_V0.5010.40
135_M227_L0.5010.40
77_L81_V0.5010.40
185_F293_G0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k1cA 4 0.9836 100 0.291 Contact Map
4kjrA 3 0.8716 100 0.402 Contact Map
4kppA 1 0.9262 100 0.548 Contact Map
3v5uA 1 0.7923 100 0.578 Contact Map
3zuxA 1 0.4918 54.7 0.96 Contact Map
4mndA 2 0.459 34.1 0.964 Contact Map
4j05A 3 0.5137 23.5 0.967 Contact Map
4n7wA 2 0.5027 19.6 0.968 Contact Map
4czbA 2 0.5 11.3 0.971 Contact Map
3giaA 1 0.4809 10.1 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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