CHAA - ECOLI - GREMLIN Contacts

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CHAA - Sodium/proton antiporter ChaA

UniProt:	P31801	Sequences: MSNAQEAVKTRHKETSLIFPVLALVVLFLWGSSQTLPVVIAINLLALIGILSSAFSVVRHADVLAHRLGEPYGSLILSLSVVILEVSLISALMATGDAAPTLMRDTLYSIIMIVTGGLVGFSLLLGGRKFATQYMNLFGIKQYLIALFPLAIIVLVFPMALPAANFSTGQALLVALISAAMYGVFLLIQTKTHQSLFVYEHEDDSDDDDPHHGKPSAHSSLWHAIWLIIHLIAVIAVTKMNASSLETLLDSMNAPVAFTGFLVALLILSPEGLGALKAVLNNQVQRAMNLFFGSVLATISLTVPVVTLIAFMTGNELQFALGAPEMVVMVASLVLCHISFSTGRTNVLNGAAHLALFAAYLMTIFA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11753
Length:	366 (339)
Sequences:	2082 (1247)
Seq/√Len:	67.7

ECOLI - CHAA
BACSU - CHAA
SULSO - Q97U31

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
184_V	351_A	5.292	1.00
126_G	133_Q	4.084	1.00
308_L	312_M	3.850	1.00
177_I	355_A	3.822	1.00
40_I	44_L	3.780	1.00
32_S	37_P	3.412	1.00
310_A	317_L	3.258	1.00
264_A	267_I	3.227	1.00
132_T	344_R	3.210	1.00
29_L	46_A	3.193	1.00
173_L	362_M	3.068	1.00
133_Q	282_N	2.678	1.00
23_A	26_V	2.653	1.00
221_L	225_I	2.636	1.00
249_L	259_T	2.624	1.00
65_A	73_G	2.538	1.00
39_V	247_T	2.524	1.00
98_A	315_N	2.404	1.00
193_H	197_F	2.324	1.00
130_F	282_N	2.221	1.00
41_A	45_L	2.216	1.00
65_A	70_E	2.214	1.00
129_K	280_L	2.169	1.00
124_L	354_L	2.097	1.00
235_I	239_K	2.082	1.00
110_I	268_L	2.078	1.00
85_E	271_E	2.076	1.00
32_S	45_L	2.027	1.00
225_I	229_I	2.027	1.00
181_M	355_A	2.024	1.00
271_E	294_S	2.014	1.00
28_F	31_G	2.008	1.00
28_F	32_S	2.005	1.00
124_L	184_V	1.985	1.00
342_T	349_N	1.968	1.00
298_T	302_T	1.968	1.00
24_L	28_F	1.967	1.00
188_I	192_T	1.916	1.00
159_M	326_M	1.904	1.00
220_S	224_A	1.900	1.00
310_A	315_N	1.860	1.00
278_A	286_R	1.830	1.00
124_L	128_R	1.808	1.00
211_H	214_K	1.797	1.00
30_W	34_Q	1.789	1.00
125_L	280_L	1.787	1.00
68_L	72_Y	1.772	1.00
274_G	278_A	1.771	1.00
207_D	211_H	1.745	1.00
29_L	237_V	1.738	1.00
74_S	78_S	1.721	1.00
30_W	33_S	1.694	1.00
62_D	65_A	1.689	0.99
107_L	303_V	1.667	0.99
126_G	282_N	1.640	0.99
116_G	332_S	1.601	0.99
23_A	27_L	1.592	0.99
28_F	37_P	1.591	0.99
263_V	267_I	1.583	0.99
133_Q	345_T	1.582	0.99
25_V	28_F	1.577	0.99
192_T	197_F	1.577	0.99
209_D	212_H	1.572	0.99
176_L	180_A	1.571	0.99
30_W	236_A	1.569	0.99
263_V	266_L	1.561	0.99
23_A	30_W	1.555	0.99
24_L	31_G	1.548	0.99
127_G	133_Q	1.548	0.99
109_S	116_G	1.538	0.99
58_V	272_G	1.528	0.99
32_S	42_I	1.496	0.99
184_V	347_V	1.489	0.99
176_L	308_L	1.484	0.99
27_L	49_G	1.479	0.99
206_D	210_P	1.472	0.99
305_V	309_I	1.465	0.99
188_I	193_H	1.453	0.98
130_F	133_Q	1.453	0.98
110_I	118_L	1.443	0.98
101_T	104_R	1.423	0.98
232_I	236_A	1.394	0.98
31_G	35_T	1.394	0.98
64_L	220_S	1.391	0.98
28_F	45_L	1.375	0.98
226_W	229_I	1.354	0.98
172_L	311_F	1.346	0.97
63_V	122_S	1.346	0.97
188_I	347_V	1.345	0.97
193_H	196_L	1.340	0.97
203_D	206_D	1.337	0.97
291_F	295_V	1.337	0.97
151_A	299_I	1.333	0.97
195_S	228_I	1.332	0.97
181_M	351_A	1.317	0.97
186_L	190_T	1.314	0.97
31_G	34_Q	1.314	0.97
206_D	209_D	1.314	0.97
50_I	54_A	1.310	0.97
121_F	354_L	1.307	0.97
218_H	222_W	1.295	0.97
268_L	272_G	1.291	0.97
100_P	317_L	1.287	0.97
263_V	360_Y	1.285	0.97
116_G	353_H	1.285	0.97
205_S	208_D	1.280	0.97
79_L	297_A	1.277	0.96
274_G	290_L	1.271	0.96
209_D	213_G	1.267	0.96
96_G	313_T	1.264	0.96
310_A	314_G	1.263	0.96
160_A	321_L	1.261	0.96
119_V	336_C	1.261	0.96
180_A	351_A	1.260	0.96
181_M	352_A	1.257	0.96
58_V	241_N	1.253	0.96
32_S	35_T	1.248	0.96
104_R	318_Q	1.244	0.96
82_V	294_S	1.244	0.96
64_L	68_L	1.244	0.96
203_D	208_D	1.240	0.96
265_L	310_A	1.238	0.96
99_A	256_V	1.237	0.96
210_P	229_I	1.229	0.96
69_G	88_L	1.203	0.95
30_W	240_M	1.199	0.95
138_F	142_Q	1.187	0.95
21_V	25_V	1.186	0.95
115_T	241_N	1.178	0.94
282_N	345_T	1.172	0.94
38_V	248_L	1.169	0.94
83_I	89_I	1.168	0.94
189_Q	289_N	1.164	0.94
49_G	54_A	1.158	0.94
24_L	27_L	1.158	0.94
99_A	246_E	1.157	0.94
102_L	245_L	1.137	0.93
67_R	238_T	1.124	0.93
324_P	363_T	1.119	0.93
46_A	49_G	1.118	0.93
20_P	25_V	1.111	0.93
208_D	211_H	1.107	0.92
322_G	325_E	1.099	0.92
76_I	228_I	1.096	0.92
261_F	364_I	1.091	0.92
264_A	296_L	1.090	0.92
229_I	233_A	1.086	0.92
222_W	225_I	1.077	0.91
114_V	272_G	1.073	0.91
145_I	263_V	1.058	0.91
294_S	297_A	1.055	0.90
65_A	75_L	1.052	0.90
129_K	282_N	1.049	0.90
234_V	260_G	1.049	0.90
22_L	25_V	1.049	0.90
196_L	332_S	1.047	0.90
124_L	351_A	1.046	0.90
118_L	268_L	1.044	0.90
265_L	324_P	1.041	0.90
203_D	207_D	1.034	0.90
245_L	248_L	1.031	0.89
32_S	36_L	1.030	0.89
243_S	246_E	1.015	0.89
205_S	209_D	1.009	0.88
105_D	303_V	1.007	0.88
23_A	29_L	1.006	0.88
66_H	214_K	1.003	0.88
176_L	235_I	1.002	0.88
112_M	329_M	0.995	0.88
265_L	348_L	0.994	0.88
54_A	279_V	0.992	0.87
89_I	293_G	0.991	0.87
134_Y	344_R	0.989	0.87
187_L	334_V	0.986	0.87
261_F	360_Y	0.984	0.87
126_G	130_F	0.982	0.87
81_V	268_L	0.979	0.87
204_D	228_I	0.976	0.87
81_V	114_V	0.975	0.87
77_L	80_S	0.968	0.86
113_I	268_L	0.965	0.86
156_V	329_M	0.960	0.86
54_A	57_V	0.947	0.85
244_S	251_S	0.941	0.85
294_S	298_T	0.939	0.84
128_R	131_A	0.933	0.84
244_S	247_T	0.926	0.84
102_L	106_T	0.921	0.83
206_D	213_G	0.916	0.83
51_L	245_L	0.914	0.83
313_T	316_E	0.911	0.83
132_T	282_N	0.909	0.82
187_L	191_K	0.907	0.82
41_A	308_L	0.903	0.82
27_L	31_G	0.900	0.82
263_V	314_G	0.900	0.82
106_T	242_A	0.900	0.82
84_L	238_T	0.896	0.82
135_M	345_T	0.895	0.81
134_Y	205_S	0.895	0.81
268_L	297_A	0.888	0.81
68_L	76_I	0.888	0.81
205_S	210_P	0.887	0.81
45_L	219_S	0.887	0.81
128_R	134_Y	0.884	0.81
58_V	268_L	0.883	0.81
77_L	290_L	0.883	0.81
113_I	357_F	0.880	0.80
61_A	77_L	0.876	0.80
310_A	352_A	0.876	0.80
333_L	337_H	0.876	0.80
283_Q	286_R	0.873	0.80
346_N	349_N	0.873	0.80
151_A	254_A	0.872	0.80
352_A	355_A	0.869	0.80
126_G	132_T	0.866	0.79
357_F	360_Y	0.862	0.79
22_L	26_V	0.861	0.79
47_L	55_F	0.859	0.79
122_S	245_L	0.857	0.79
82_V	268_L	0.856	0.79
108_Y	321_L	0.855	0.78
106_T	239_K	0.849	0.78
78_S	231_L	0.840	0.77
180_A	217_A	0.839	0.77
173_L	359_A	0.839	0.77
157_F	363_T	0.837	0.77
47_L	263_V	0.837	0.77
21_V	24_L	0.835	0.77
169_G	362_M	0.834	0.77
347_V	357_F	0.834	0.77
25_V	49_G	0.833	0.77
20_P	23_A	0.832	0.77
54_A	62_D	0.831	0.76
309_I	312_M	0.831	0.76
158_P	161_L	0.830	0.76
123_L	345_T	0.829	0.76
51_L	332_S	0.829	0.76
169_G	305_V	0.825	0.76
238_T	296_L	0.823	0.76
257_A	322_G	0.821	0.76
92_L	354_L	0.820	0.75
144_L	352_A	0.820	0.75
88_L	253_N	0.819	0.75
287_A	294_S	0.818	0.75
206_D	212_H	0.817	0.75
63_V	220_S	0.816	0.75
114_V	268_L	0.813	0.75
26_V	29_L	0.811	0.75
25_V	41_A	0.810	0.75
149_P	334_V	0.807	0.74
268_L	298_T	0.805	0.74
208_D	212_H	0.802	0.74
245_L	249_L	0.801	0.74
110_I	272_G	0.800	0.74
148_F	154_V	0.798	0.73
69_G	82_V	0.797	0.73
155_L	329_M	0.791	0.73
262_L	265_L	0.789	0.73
72_Y	224_A	0.788	0.73
76_I	133_Q	0.788	0.73
113_I	118_L	0.788	0.73
125_L	276_L	0.787	0.72
142_Q	359_A	0.785	0.72
185_F	189_Q	0.785	0.72
190_T	193_H	0.785	0.72
50_I	274_G	0.784	0.72
38_V	41_A	0.781	0.72
79_L	82_V	0.779	0.72
153_I	356_L	0.776	0.71
71_P	289_N	0.776	0.71
54_A	258_F	0.774	0.71
25_V	35_T	0.774	0.71
92_L	124_L	0.771	0.71
261_F	333_L	0.769	0.71
328_V	360_Y	0.766	0.70
154_V	161_L	0.766	0.70
207_D	358_A	0.762	0.70
84_L	248_L	0.762	0.70
175_A	308_L	0.760	0.70
37_P	148_F	0.756	0.69
25_V	29_L	0.756	0.69
100_P	315_N	0.754	0.69
204_D	210_P	0.750	0.69
141_K	363_T	0.750	0.69
57_V	234_V	0.748	0.69
239_K	290_L	0.745	0.68
214_K	225_I	0.744	0.68
80_S	83_I	0.742	0.68
111_I	299_I	0.742	0.68
29_L	42_I	0.741	0.68
118_L	272_G	0.736	0.67
136_N	317_L	0.735	0.67
323_A	326_M	0.735	0.67
144_L	153_I	0.734	0.67
321_L	326_M	0.734	0.67
237_V	240_M	0.729	0.67
275_A	291_F	0.725	0.66
88_L	92_L	0.724	0.66
278_A	290_L	0.721	0.66
267_I	270_P	0.721	0.66
70_E	331_A	0.719	0.66
185_F	197_F	0.716	0.65
183_G	187_L	0.715	0.65
34_Q	41_A	0.715	0.65
161_L	166_F	0.713	0.65
150_L	156_V	0.712	0.65
231_L	235_I	0.712	0.65
60_H	80_S	0.711	0.65
20_P	27_L	0.710	0.65
326_M	330_V	0.705	0.64
100_P	265_L	0.705	0.64
192_T	196_L	0.702	0.64
26_V	153_I	0.701	0.64
109_S	360_Y	0.701	0.64
262_L	267_I	0.697	0.63
180_A	205_S	0.696	0.63
38_V	225_I	0.695	0.63
75_L	293_G	0.694	0.63
180_A	183_G	0.692	0.63
61_A	294_S	0.690	0.62
281_N	317_L	0.686	0.62
22_L	27_L	0.685	0.62
28_F	39_V	0.683	0.62
171_A	307_T	0.679	0.61
270_P	275_A	0.678	0.61
66_H	209_D	0.677	0.61
23_A	31_G	0.675	0.61
38_V	44_L	0.674	0.61
269_S	272_G	0.674	0.61
198_V	210_P	0.673	0.60
42_I	53_S	0.672	0.60
121_F	124_L	0.669	0.60
96_G	264_A	0.666	0.60
215_P	236_A	0.665	0.59
35_T	253_N	0.665	0.59
62_D	293_G	0.664	0.59
122_S	341_S	0.664	0.59
207_D	212_H	0.664	0.59
69_G	92_L	0.661	0.59
304_P	319_F	0.660	0.59
183_G	233_A	0.660	0.59
141_K	337_H	0.659	0.59
28_F	48_I	0.658	0.59
342_T	348_L	0.655	0.58
101_T	325_E	0.655	0.58
127_G	345_T	0.655	0.58
157_F	163_A	0.654	0.58
130_F	340_F	0.652	0.58
34_Q	40_I	0.652	0.58
162_P	320_A	0.651	0.58
207_D	215_P	0.650	0.58
188_I	357_F	0.645	0.57
248_L	255_P	0.644	0.57
41_A	209_D	0.643	0.57
98_A	258_F	0.643	0.57
244_S	248_L	0.642	0.57
93_M	238_T	0.641	0.57
294_S	302_T	0.640	0.57
181_M	310_A	0.640	0.57
177_I	318_Q	0.638	0.56
210_P	213_G	0.634	0.56
68_L	112_M	0.632	0.56
260_G	326_M	0.630	0.55
92_L	309_I	0.629	0.55
189_Q	197_F	0.629	0.55
141_K	329_M	0.626	0.55
307_T	310_A	0.626	0.55
225_I	308_L	0.625	0.55
173_L	177_I	0.624	0.55
206_D	225_I	0.622	0.54
133_Q	347_V	0.621	0.54
196_L	347_V	0.620	0.54
89_I	234_V	0.619	0.54
168_T	172_L	0.618	0.54
91_A	162_P	0.617	0.54
231_L	268_L	0.615	0.54
188_I	196_L	0.613	0.53
173_L	248_L	0.613	0.53
340_F	348_L	0.613	0.53
248_L	323_A	0.611	0.53
38_V	251_S	0.611	0.53
26_V	31_G	0.610	0.53
354_L	365_F	0.609	0.53
26_V	53_S	0.606	0.53
204_D	207_D	0.605	0.52
295_V	298_T	0.604	0.52
149_P	153_I	0.603	0.52
64_L	283_Q	0.602	0.52
90_S	239_K	0.601	0.52
107_L	152_I	0.601	0.52
191_K	195_S	0.601	0.52
33_S	36_L	0.600	0.52
205_S	212_H	0.600	0.52
46_A	237_V	0.600	0.52
339_S	353_H	0.599	0.52
126_G	275_A	0.598	0.52
148_F	338_I	0.597	0.51
234_V	294_S	0.597	0.51
178_S	188_I	0.597	0.51
62_D	73_G	0.596	0.51
204_D	208_D	0.596	0.51
39_V	323_A	0.595	0.51
241_N	249_L	0.594	0.51
350_G	353_H	0.593	0.51
115_T	332_S	0.593	0.51
50_I	246_E	0.592	0.51
115_T	230_H	0.592	0.51
57_V	223_H	0.591	0.51
296_L	351_A	0.591	0.51
174_V	359_A	0.590	0.51
141_K	333_L	0.586	0.50
213_G	217_A	0.583	0.50
62_D	83_I	0.583	0.50
205_S	217_A	0.581	0.50
261_F	287_A	0.580	0.49
168_T	250_D	0.579	0.49
54_A	271_E	0.579	0.49
127_G	350_G	0.577	0.49
206_D	211_H	0.577	0.49
212_H	228_I	0.576	0.49
212_H	358_A	0.576	0.49
21_V	26_V	0.576	0.49
342_T	347_V	0.574	0.49
209_D	229_I	0.574	0.49
46_A	53_S	0.573	0.49
335_L	356_L	0.573	0.49
238_T	301_L	0.570	0.48
43_N	47_L	0.570	0.48
205_S	221_L	0.569	0.48
232_I	263_V	0.569	0.48
195_S	224_A	0.569	0.48
36_L	180_A	0.567	0.48
60_H	117_G	0.566	0.48
56_S	226_W	0.565	0.48
24_L	212_H	0.562	0.47
106_T	272_G	0.561	0.47
244_S	259_T	0.561	0.47
122_S	290_L	0.560	0.47
137_L	140_I	0.559	0.47
184_V	301_L	0.557	0.47
157_F	358_A	0.557	0.47
57_V	61_A	0.555	0.46
180_A	358_A	0.554	0.46
304_P	350_G	0.552	0.46
76_I	243_S	0.551	0.46
63_V	348_L	0.546	0.45
42_I	45_L	0.545	0.45
81_V	298_T	0.544	0.45
73_G	293_G	0.544	0.45
25_V	42_I	0.544	0.45
78_S	85_E	0.543	0.45
108_Y	326_M	0.541	0.45
35_T	41_A	0.541	0.45
93_M	96_G	0.537	0.44
144_L	339_S	0.536	0.44
46_A	240_M	0.536	0.44
160_A	320_A	0.536	0.44
62_D	111_I	0.536	0.44
69_G	260_G	0.534	0.44
27_L	262_L	0.534	0.44
78_S	298_T	0.533	0.44
28_F	183_G	0.532	0.44
172_L	176_L	0.532	0.44
188_I	197_F	0.528	0.43
27_L	94_A	0.527	0.43
189_Q	193_H	0.527	0.43
88_L	285_Q	0.526	0.43
211_H	217_A	0.526	0.43
275_A	284_V	0.525	0.43
108_Y	261_F	0.525	0.43
237_V	296_L	0.524	0.43
211_H	220_S	0.523	0.43
33_S	219_S	0.520	0.42
181_M	320_A	0.520	0.42
145_I	339_S	0.518	0.42
140_I	340_F	0.518	0.42
102_L	148_F	0.517	0.42
66_H	216_S	0.516	0.42
100_P	262_L	0.516	0.42
30_W	237_V	0.513	0.42
77_L	297_A	0.513	0.42
22_L	33_S	0.512	0.41
136_N	139_G	0.511	0.41
181_M	348_L	0.511	0.41
182_Y	293_G	0.510	0.41
31_G	221_L	0.510	0.41
21_V	38_V	0.510	0.41
34_Q	236_A	0.509	0.41
223_H	268_L	0.509	0.41
249_L	260_G	0.508	0.41
54_A	61_A	0.507	0.41
149_P	355_A	0.507	0.41
26_V	30_W	0.507	0.41
344_R	349_N	0.506	0.41
109_S	357_F	0.506	0.41
242_A	270_P	0.506	0.41
181_M	339_S	0.505	0.41
327_V	345_T	0.505	0.41
108_Y	130_F	0.505	0.41
191_K	194_Q	0.504	0.41
248_L	252_M	0.504	0.41
249_L	277_K	0.503	0.40
29_L	33_S	0.501	0.40
135_M	279_V	0.501	0.40
135_M	227_L	0.501	0.40
77_L	81_V	0.501	0.40
185_F	293_G	0.500	0.40

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4k1cA	4	0.9836	100	0.291	Contact Map
4kjrA	3	0.8716	100	0.402	Contact Map
4kppA	1	0.9262	100	0.548	Contact Map
3v5uA	1	0.7923	100	0.578	Contact Map
3zuxA	1	0.4918	54.7	0.96	Contact Map
4mndA	2	0.459	34.1	0.964	Contact Map
4j05A	3	0.5137	23.5	0.967	Contact Map
4n7wA	2	0.5027	19.6	0.968	Contact Map
4czbA	2	0.5	11.3	0.971	Contact Map
3giaA	1	0.4809	10.1	0.972	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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