GREMLIN Database
FIMC - Chaperone protein FimC
UniProt: P31697 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10310
Length: 241 (212)
Sequences: 2853 (2159)
Seq/√Len: 148.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
105_D108_N3.1911.00
73_V149_L3.1691.00
187_T202_L3.1311.00
185_Y204_P3.0041.00
48_P51_Q2.9641.00
179_I208_E2.9581.00
118_L202_L2.9221.00
115_R206_M2.8641.00
40_L147_I2.7921.00
204_P207_G2.7501.00
168_R179_I2.7091.00
111_L119_F2.6841.00
45_V54_E2.5171.00
177_T210_T2.5081.00
169_F178_L2.4971.00
67_Y125_A2.4841.00
177_T208_E2.4561.00
50_G154_A2.4161.00
45_V103_I2.4081.00
150_Y202_L2.3561.00
162_Q165_E2.3411.00
45_V121_M2.3161.00
178_L211_V2.1971.00
227_N233_T2.1781.00
66_T94_K2.1111.00
150_Y185_Y2.0961.00
74_E146_R2.0371.00
170_R177_T1.9901.00
72_W122_N1.9211.00
124_K144_I1.8991.00
167_L178_L1.8831.00
71_S101_L1.8421.00
48_P54_E1.8221.00
156_L184_Y1.7841.00
66_T92_A1.7731.00
84_F103_I1.7281.00
86_V101_L1.7081.00
112_P117_S1.7011.00
74_E122_N1.6501.00
40_L123_V1.6151.00
175_S210_T1.6101.00
94_K97_K1.5991.00
163_A186_L1.5811.00
166_K182_T1.5731.00
167_L186_L1.5411.00
73_V82_G1.5371.00
190_E224_R1.5361.00
122_N146_R1.5261.00
186_L225_T1.5151.00
227_N231_A1.4821.00
159_P162_Q1.4741.00
163_A225_T1.4701.00
172_S177_T1.4521.00
118_L150_Y1.4441.00
56_L121_M1.4131.00
69_I91_F1.4051.00
167_L188_V1.3761.00
84_F149_L1.3501.00
170_R179_I1.3411.00
47_Y54_E1.3351.00
57_A98_E1.3291.00
105_D109_N1.3171.00
53_Q102_R1.3151.00
203_V209_S1.2941.00
49_A113_Q1.2841.00
169_F223_Y1.2801.00
86_V103_I1.2481.00
64_N96_K1.2441.00
118_L187_T1.2251.00
160_P163_A1.2191.00
58_V93_M1.2131.00
192_N222_T1.2101.00
45_V147_I1.2081.00
62_D125_A1.2081.00
112_P115_R1.2061.00
172_S175_S1.2031.00
75_N79_V1.1951.00
175_S212_K1.1921.00
49_A154_A1.1851.00
187_T225_T1.1721.00
183_P206_M1.1641.00
77_D80_K1.1461.00
189_T232_L1.1431.00
164_A186_L1.1431.00
105_D110_Q1.1361.00
130_D138_T1.1230.99
121_M149_L1.1090.99
105_D151_Y1.1060.99
74_E78_G1.0920.99
19_L24_M1.0890.99
176_L213_L1.0840.99
40_L56_L1.0810.99
225_T233_T1.0730.99
72_W146_R1.0620.99
192_N197_V1.0560.99
103_I149_L1.0480.99
192_N195_T1.0440.99
130_D140_Q1.0380.99
39_A42_A1.0270.99
38_V93_M1.0270.99
41_G57_A1.0200.99
158_L184_Y1.0100.99
120_W146_R1.0090.99
91_F99_N0.9960.99
47_Y104_L0.9920.99
188_V203_V0.9850.99
42_A56_L0.9820.99
72_W124_K0.9810.99
49_A151_Y0.9760.98
166_K181_P0.9690.98
125_A143_I0.9680.98
99_N124_K0.9680.98
38_V69_I0.9680.98
37_G125_A0.9580.98
59_T98_E0.9400.98
101_L121_M0.9400.98
188_V225_T0.9320.98
224_R232_L0.9320.98
20_A28_M0.9270.98
93_M98_E0.9210.98
164_A223_Y0.9190.98
40_L58_V0.9060.98
74_E120_W0.9050.98
101_L123_V0.9010.97
58_V69_I0.9000.97
196_R216_D0.9000.97
62_D67_Y0.8930.97
99_N125_A0.8890.97
41_G98_E0.8850.97
142_A169_F0.8560.97
44_R152_R0.8550.96
148_K226_I0.8500.96
73_V86_V0.8440.96
179_I206_M0.8360.96
62_D65_S0.8340.96
120_W124_K0.8310.96
71_S86_V0.8280.96
169_F191_L0.8270.96
171_R174_N0.8250.96
86_V121_M0.8220.96
20_A23_L0.8200.96
171_R175_S0.8130.95
47_Y84_F0.8070.95
114_D206_M0.8040.95
119_F151_Y0.8040.95
172_S210_T0.8030.95
24_M27_A0.8020.95
45_V56_L0.8010.95
71_S123_V0.8000.95
93_M99_N0.7990.95
176_L191_L0.7920.95
155_K158_L0.7850.94
185_Y205_P0.7830.94
188_V231_A0.7830.94
194_G219_S0.7820.94
160_P164_A0.7600.93
162_Q166_K0.7590.93
69_I93_M0.7560.93
21_G29_M0.7480.93
23_L26_M0.7480.93
37_G67_Y0.7450.93
39_A145_S0.7440.93
123_V147_I0.7440.93
111_L115_R0.7440.93
67_Y124_K0.7420.93
118_L185_Y0.7400.92
193_A221_I0.7400.92
122_N144_I0.7400.92
44_R148_K0.7320.92
42_A45_V0.7300.92
158_L163_A0.7250.92
158_L162_Q0.7230.92
169_F176_L0.7220.91
122_N148_K0.7220.91
37_G61_N0.7200.91
70_Q124_K0.7200.91
191_L211_V0.7190.91
189_T226_I0.7180.91
164_A225_T0.7150.91
39_A61_N0.7110.91
75_N82_G0.7060.91
114_D152_R0.7040.90
93_M97_K0.7040.90
76_A120_W0.7040.90
115_R153_P0.7040.90
91_F101_L0.7030.90
187_T200_N0.7010.90
168_R181_P0.6960.90
116_E152_R0.6930.90
75_N81_D0.6910.90
171_R217_A0.6890.89
67_Y71_S0.6870.89
90_L98_E0.6850.89
61_N128_S0.6850.89
25_F32_G0.6840.89
148_K187_T0.6840.89
73_V126_I0.6800.89
19_L26_M0.6760.89
113_Q155_K0.6750.89
160_P186_L0.6750.89
200_N211_V0.6720.88
57_A90_L0.6720.88
22_I25_F0.6710.88
24_M35_E0.6710.88
44_R153_P0.6700.88
117_S151_Y0.6660.88
114_D117_S0.6620.88
40_L61_N0.6590.87
76_A118_L0.6540.87
143_I200_N0.6510.87
120_W148_K0.6490.87
131_K134_L0.6480.86
84_F117_S0.6460.86
125_A144_I0.6430.86
46_I152_R0.6430.86
38_V67_Y0.6420.86
125_A142_A0.6380.86
176_L221_I0.6370.85
47_Y105_D0.6280.85
36_A39_A0.6270.85
32_G234_P0.6270.85
102_R127_P0.6270.85
89_P126_I0.6260.84
164_A167_L0.6250.84
120_W187_T0.6240.84
66_T128_S0.6200.84
47_Y51_Q0.6170.84
47_Y52_K0.6130.83
43_T152_R0.6120.83
104_L205_P0.6120.83
111_L117_S0.6120.83
148_K152_R0.6100.83
21_G210_T0.6050.82
51_Q109_N0.6020.82
22_I135_T0.6020.82
175_S213_L0.5990.82
20_A24_M0.5990.82
19_L31_A0.5990.82
120_W223_Y0.5960.82
176_L210_T0.5950.81
30_V34_A0.5900.81
35_E176_L0.5870.81
84_F151_Y0.5850.80
68_L124_K0.5840.80
68_L184_Y0.5840.80
71_S99_N0.5830.80
111_L114_D0.5820.80
73_V119_F0.5800.80
48_P150_Y0.5800.80
25_F28_M0.5790.80
131_K168_R0.5780.80
71_S91_F0.5780.80
55_Q141_L0.5770.79
25_F30_V0.5770.79
32_G35_E0.5720.79
21_G24_M0.5710.79
224_R234_P0.5710.79
31_A35_E0.5650.78
40_L68_L0.5640.78
103_I121_M0.5640.78
104_L107_T0.5620.78
62_D124_K0.5620.78
213_L216_D0.5610.77
127_P142_A0.5610.77
107_T110_Q0.5590.77
164_A182_T0.5590.77
67_Y93_M0.5590.77
22_I172_S0.5580.77
192_N224_R0.5570.77
76_A146_R0.5530.76
161_D165_E0.5520.76
139_L146_R0.5520.76
143_I146_R0.5500.76
110_Q113_Q0.5500.76
164_A181_P0.5490.76
159_P166_K0.5470.76
223_Y233_T0.5470.76
159_P164_A0.5470.76
26_M31_A0.5460.76
203_V207_G0.5450.75
193_A220_N0.5450.75
57_A141_L0.5440.75
126_I143_I0.5430.75
125_A187_T0.5390.75
31_A34_A0.5390.75
153_P205_P0.5370.74
178_L203_V0.5330.74
125_A223_Y0.5330.74
85_I104_L0.5320.74
27_A30_V0.5320.74
201_A211_V0.5320.74
169_F202_L0.5290.73
57_A124_K0.5290.73
74_E141_L0.5270.73
169_F221_I0.5270.73
191_L213_L0.5250.73
195_T222_T0.5240.73
44_R228_D0.5230.72
226_I233_T0.5220.72
152_R156_L0.5200.72
154_A157_A0.5190.72
54_E147_I0.5190.72
162_Q234_P0.5160.71
30_V33_R0.5120.71
20_A77_D0.5110.71
120_W123_V0.5090.70
64_N197_V0.5090.70
167_L225_T0.5070.70
68_L92_A0.5070.70
120_W144_I0.5070.70
209_S212_K0.5060.70
113_Q154_A0.5060.70
32_G215_S0.5060.70
72_W120_W0.5050.70
70_Q102_R0.5030.70
29_M197_V0.5020.69
170_R196_R0.5010.69
27_A199_E0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1klfA 1 0.8465 100 0.146 Contact Map
2co7B 1 0.8133 100 0.155 Contact Map
1l4iA 2 0.7884 100 0.155 Contact Map
3q48A 1 0.7635 100 0.196 Contact Map
2xg5A 1 0.8174 100 0.197 Contact Map
4djmA 1 0.8299 100 0.201 Contact Map
4ay0A 2 0.7801 100 0.201 Contact Map
3gfuC 1 0.8008 100 0.209 Contact Map
4ncdA 2 0.7718 100 0.285 Contact Map
1mspA 3 0.4689 89.7 0.922 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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