FIMC - ECOLI - GREMLIN Contacts

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FIMC - Chaperone protein FimC

UniProt:	P31697	Sequences: MSNKNVNVRKSQEITFCLLAGILMFMAMMVAGRAEAGVALGATRVIYPAGQKQEQLAVTNNDENSTYLIQSWVENADGVKDGRFIVTPPLFAMKGKKENTLRILDATNNQLPQDRESLFWMNVKAIPSMDKSKLTENTLQLAIISRIKLYYRPAKLALPPDQAAEKLRFRRSANSLTLINPTPYYLTVTELNAGTRVLENALVPPMGESTVKLPSDAGSNITYRTINDYGALTPKMTGVME	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10310
Length:	241 (212)
Sequences:	2853 (2159)
Seq/√Len:	148.3

ECOLI - FIMC YRAI SFMC ELFD YBGP YFCS YCBF YEHC YHCA YADV YQIH

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
105_D	108_N	3.191	1.00
73_V	149_L	3.169	1.00
187_T	202_L	3.131	1.00
185_Y	204_P	3.004	1.00
48_P	51_Q	2.964	1.00
179_I	208_E	2.958	1.00
118_L	202_L	2.922	1.00
115_R	206_M	2.864	1.00
40_L	147_I	2.792	1.00
204_P	207_G	2.750	1.00
168_R	179_I	2.709	1.00
111_L	119_F	2.684	1.00
45_V	54_E	2.517	1.00
177_T	210_T	2.508	1.00
169_F	178_L	2.497	1.00
67_Y	125_A	2.484	1.00
177_T	208_E	2.456	1.00
50_G	154_A	2.416	1.00
45_V	103_I	2.408	1.00
150_Y	202_L	2.356	1.00
162_Q	165_E	2.341	1.00
45_V	121_M	2.316	1.00
178_L	211_V	2.197	1.00
227_N	233_T	2.178	1.00
66_T	94_K	2.111	1.00
150_Y	185_Y	2.096	1.00
74_E	146_R	2.037	1.00
170_R	177_T	1.990	1.00
72_W	122_N	1.921	1.00
124_K	144_I	1.899	1.00
167_L	178_L	1.883	1.00
71_S	101_L	1.842	1.00
48_P	54_E	1.822	1.00
156_L	184_Y	1.784	1.00
66_T	92_A	1.773	1.00
84_F	103_I	1.728	1.00
86_V	101_L	1.708	1.00
112_P	117_S	1.701	1.00
74_E	122_N	1.650	1.00
40_L	123_V	1.615	1.00
175_S	210_T	1.610	1.00
94_K	97_K	1.599	1.00
163_A	186_L	1.581	1.00
166_K	182_T	1.573	1.00
167_L	186_L	1.541	1.00
73_V	82_G	1.537	1.00
190_E	224_R	1.536	1.00
122_N	146_R	1.526	1.00
186_L	225_T	1.515	1.00
227_N	231_A	1.482	1.00
159_P	162_Q	1.474	1.00
163_A	225_T	1.470	1.00
172_S	177_T	1.452	1.00
118_L	150_Y	1.444	1.00
56_L	121_M	1.413	1.00
69_I	91_F	1.405	1.00
167_L	188_V	1.376	1.00
84_F	149_L	1.350	1.00
170_R	179_I	1.341	1.00
47_Y	54_E	1.335	1.00
57_A	98_E	1.329	1.00
105_D	109_N	1.317	1.00
53_Q	102_R	1.315	1.00
203_V	209_S	1.294	1.00
49_A	113_Q	1.284	1.00
169_F	223_Y	1.280	1.00
86_V	103_I	1.248	1.00
64_N	96_K	1.244	1.00
118_L	187_T	1.225	1.00
160_P	163_A	1.219	1.00
58_V	93_M	1.213	1.00
192_N	222_T	1.210	1.00
45_V	147_I	1.208	1.00
62_D	125_A	1.208	1.00
112_P	115_R	1.206	1.00
172_S	175_S	1.203	1.00
75_N	79_V	1.195	1.00
175_S	212_K	1.192	1.00
49_A	154_A	1.185	1.00
187_T	225_T	1.172	1.00
183_P	206_M	1.164	1.00
77_D	80_K	1.146	1.00
189_T	232_L	1.143	1.00
164_A	186_L	1.143	1.00
105_D	110_Q	1.136	1.00
130_D	138_T	1.123	0.99
121_M	149_L	1.109	0.99
105_D	151_Y	1.106	0.99
74_E	78_G	1.092	0.99
19_L	24_M	1.089	0.99
176_L	213_L	1.084	0.99
40_L	56_L	1.081	0.99
225_T	233_T	1.073	0.99
72_W	146_R	1.062	0.99
192_N	197_V	1.056	0.99
103_I	149_L	1.048	0.99
192_N	195_T	1.044	0.99
130_D	140_Q	1.038	0.99
39_A	42_A	1.027	0.99
38_V	93_M	1.027	0.99
41_G	57_A	1.020	0.99
158_L	184_Y	1.010	0.99
120_W	146_R	1.009	0.99
91_F	99_N	0.996	0.99
47_Y	104_L	0.992	0.99
188_V	203_V	0.985	0.99
42_A	56_L	0.982	0.99
72_W	124_K	0.981	0.99
49_A	151_Y	0.976	0.98
166_K	181_P	0.969	0.98
125_A	143_I	0.968	0.98
99_N	124_K	0.968	0.98
38_V	69_I	0.968	0.98
37_G	125_A	0.958	0.98
59_T	98_E	0.940	0.98
101_L	121_M	0.940	0.98
188_V	225_T	0.932	0.98
224_R	232_L	0.932	0.98
20_A	28_M	0.927	0.98
93_M	98_E	0.921	0.98
164_A	223_Y	0.919	0.98
40_L	58_V	0.906	0.98
74_E	120_W	0.905	0.98
101_L	123_V	0.901	0.97
58_V	69_I	0.900	0.97
196_R	216_D	0.900	0.97
62_D	67_Y	0.893	0.97
99_N	125_A	0.889	0.97
41_G	98_E	0.885	0.97
142_A	169_F	0.856	0.97
44_R	152_R	0.855	0.96
148_K	226_I	0.850	0.96
73_V	86_V	0.844	0.96
179_I	206_M	0.836	0.96
62_D	65_S	0.834	0.96
120_W	124_K	0.831	0.96
71_S	86_V	0.828	0.96
169_F	191_L	0.827	0.96
171_R	174_N	0.825	0.96
86_V	121_M	0.822	0.96
20_A	23_L	0.820	0.96
171_R	175_S	0.813	0.95
47_Y	84_F	0.807	0.95
114_D	206_M	0.804	0.95
119_F	151_Y	0.804	0.95
172_S	210_T	0.803	0.95
24_M	27_A	0.802	0.95
45_V	56_L	0.801	0.95
71_S	123_V	0.800	0.95
93_M	99_N	0.799	0.95
176_L	191_L	0.792	0.95
155_K	158_L	0.785	0.94
185_Y	205_P	0.783	0.94
188_V	231_A	0.783	0.94
194_G	219_S	0.782	0.94
160_P	164_A	0.760	0.93
162_Q	166_K	0.759	0.93
69_I	93_M	0.756	0.93
21_G	29_M	0.748	0.93
23_L	26_M	0.748	0.93
37_G	67_Y	0.745	0.93
39_A	145_S	0.744	0.93
123_V	147_I	0.744	0.93
111_L	115_R	0.744	0.93
67_Y	124_K	0.742	0.93
118_L	185_Y	0.740	0.92
193_A	221_I	0.740	0.92
122_N	144_I	0.740	0.92
44_R	148_K	0.732	0.92
42_A	45_V	0.730	0.92
158_L	163_A	0.725	0.92
158_L	162_Q	0.723	0.92
169_F	176_L	0.722	0.91
122_N	148_K	0.722	0.91
37_G	61_N	0.720	0.91
70_Q	124_K	0.720	0.91
191_L	211_V	0.719	0.91
189_T	226_I	0.718	0.91
164_A	225_T	0.715	0.91
39_A	61_N	0.711	0.91
75_N	82_G	0.706	0.91
114_D	152_R	0.704	0.90
93_M	97_K	0.704	0.90
76_A	120_W	0.704	0.90
115_R	153_P	0.704	0.90
91_F	101_L	0.703	0.90
187_T	200_N	0.701	0.90
168_R	181_P	0.696	0.90
116_E	152_R	0.693	0.90
75_N	81_D	0.691	0.90
171_R	217_A	0.689	0.89
67_Y	71_S	0.687	0.89
90_L	98_E	0.685	0.89
61_N	128_S	0.685	0.89
25_F	32_G	0.684	0.89
148_K	187_T	0.684	0.89
73_V	126_I	0.680	0.89
19_L	26_M	0.676	0.89
113_Q	155_K	0.675	0.89
160_P	186_L	0.675	0.89
200_N	211_V	0.672	0.88
57_A	90_L	0.672	0.88
22_I	25_F	0.671	0.88
24_M	35_E	0.671	0.88
44_R	153_P	0.670	0.88
117_S	151_Y	0.666	0.88
114_D	117_S	0.662	0.88
40_L	61_N	0.659	0.87
76_A	118_L	0.654	0.87
143_I	200_N	0.651	0.87
120_W	148_K	0.649	0.87
131_K	134_L	0.648	0.86
84_F	117_S	0.646	0.86
125_A	144_I	0.643	0.86
46_I	152_R	0.643	0.86
38_V	67_Y	0.642	0.86
125_A	142_A	0.638	0.86
176_L	221_I	0.637	0.85
47_Y	105_D	0.628	0.85
36_A	39_A	0.627	0.85
32_G	234_P	0.627	0.85
102_R	127_P	0.627	0.85
89_P	126_I	0.626	0.84
164_A	167_L	0.625	0.84
120_W	187_T	0.624	0.84
66_T	128_S	0.620	0.84
47_Y	51_Q	0.617	0.84
47_Y	52_K	0.613	0.83
43_T	152_R	0.612	0.83
104_L	205_P	0.612	0.83
111_L	117_S	0.612	0.83
148_K	152_R	0.610	0.83
21_G	210_T	0.605	0.82
51_Q	109_N	0.602	0.82
22_I	135_T	0.602	0.82
175_S	213_L	0.599	0.82
20_A	24_M	0.599	0.82
19_L	31_A	0.599	0.82
120_W	223_Y	0.596	0.82
176_L	210_T	0.595	0.81
30_V	34_A	0.590	0.81
35_E	176_L	0.587	0.81
84_F	151_Y	0.585	0.80
68_L	124_K	0.584	0.80
68_L	184_Y	0.584	0.80
71_S	99_N	0.583	0.80
111_L	114_D	0.582	0.80
73_V	119_F	0.580	0.80
48_P	150_Y	0.580	0.80
25_F	28_M	0.579	0.80
131_K	168_R	0.578	0.80
71_S	91_F	0.578	0.80
55_Q	141_L	0.577	0.79
25_F	30_V	0.577	0.79
32_G	35_E	0.572	0.79
21_G	24_M	0.571	0.79
224_R	234_P	0.571	0.79
31_A	35_E	0.565	0.78
40_L	68_L	0.564	0.78
103_I	121_M	0.564	0.78
104_L	107_T	0.562	0.78
62_D	124_K	0.562	0.78
213_L	216_D	0.561	0.77
127_P	142_A	0.561	0.77
107_T	110_Q	0.559	0.77
164_A	182_T	0.559	0.77
67_Y	93_M	0.559	0.77
22_I	172_S	0.558	0.77
192_N	224_R	0.557	0.77
76_A	146_R	0.553	0.76
161_D	165_E	0.552	0.76
139_L	146_R	0.552	0.76
143_I	146_R	0.550	0.76
110_Q	113_Q	0.550	0.76
164_A	181_P	0.549	0.76
159_P	166_K	0.547	0.76
223_Y	233_T	0.547	0.76
159_P	164_A	0.547	0.76
26_M	31_A	0.546	0.76
203_V	207_G	0.545	0.75
193_A	220_N	0.545	0.75
57_A	141_L	0.544	0.75
126_I	143_I	0.543	0.75
125_A	187_T	0.539	0.75
31_A	34_A	0.539	0.75
153_P	205_P	0.537	0.74
178_L	203_V	0.533	0.74
125_A	223_Y	0.533	0.74
85_I	104_L	0.532	0.74
27_A	30_V	0.532	0.74
201_A	211_V	0.532	0.74
169_F	202_L	0.529	0.73
57_A	124_K	0.529	0.73
74_E	141_L	0.527	0.73
169_F	221_I	0.527	0.73
191_L	213_L	0.525	0.73
195_T	222_T	0.524	0.73
44_R	228_D	0.523	0.72
226_I	233_T	0.522	0.72
152_R	156_L	0.520	0.72
154_A	157_A	0.519	0.72
54_E	147_I	0.519	0.72
162_Q	234_P	0.516	0.71
30_V	33_R	0.512	0.71
20_A	77_D	0.511	0.71
120_W	123_V	0.509	0.70
64_N	197_V	0.509	0.70
167_L	225_T	0.507	0.70
68_L	92_A	0.507	0.70
120_W	144_I	0.507	0.70
209_S	212_K	0.506	0.70
113_Q	154_A	0.506	0.70
32_G	215_S	0.506	0.70
72_W	120_W	0.505	0.70
70_Q	102_R	0.503	0.70
29_M	197_V	0.502	0.69
170_R	196_R	0.501	0.69
27_A	199_E	0.500	0.69

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1klfA	1	0.8465	100	0.146	Contact Map
2co7B	1	0.8133	100	0.155	Contact Map
1l4iA	2	0.7884	100	0.155	Contact Map
3q48A	1	0.7635	100	0.196	Contact Map
2xg5A	1	0.8174	100	0.197	Contact Map
4djmA	1	0.8299	100	0.201	Contact Map
4ay0A	2	0.7801	100	0.201	Contact Map
3gfuC	1	0.8008	100	0.209	Contact Map
4ncdA	2	0.7718	100	0.285	Contact Map
1mspA	3	0.4689	89.7	0.922	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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