GREMLIN Database
OTSB - Trehalose-6-phosphate phosphatase
UniProt: P31678 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11752
Length: 266 (234)
Sequences: 2566 (1756)
Seq/√Len: 114.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
196_L236_V5.0121.00
31_H34_Q4.1171.00
60_S67_L3.7531.00
107_S124_A3.5521.00
195_F205_G3.3951.00
219_I236_V3.2651.00
218_K222_G3.1261.00
232_G235_D2.8551.00
67_L78_L2.7331.00
231_A235_D2.7061.00
203_E224_T2.6051.00
162_G165_V2.4061.00
58_L71_A2.3781.00
130_A165_V2.3181.00
63_S66_E2.3041.00
66_E70_L2.2001.00
29_K35_V2.1831.00
230_L239_W2.1831.00
120_A136_A2.1341.00
210_N216_S2.1281.00
51_A54_G2.0611.00
60_S78_L2.0441.00
82_H201_T1.9981.00
121_E135_Q1.8911.00
19_F240_L1.8841.00
207_A225_Q1.8801.00
21_L70_L1.8791.00
86_R185_E1.8491.00
110_L168_I1.7551.00
68_D87_R1.7551.00
20_D198_D1.7411.00
30_P135_Q1.7401.00
19_F196_L1.7031.00
15_Y54_G1.6991.00
40_N241_E1.6571.00
28_I163_K1.6411.00
114_I122_L1.6381.00
216_S219_I1.6301.00
179_I205_G1.6031.00
86_R181_A1.5911.00
57_A77_P1.5861.00
80_G85_E1.5741.00
18_F179_I1.5601.00
21_L35_V1.5541.00
144_M148_Q1.4981.00
37_V42_L1.4861.00
27_E233_V1.4551.00
31_H135_Q1.4511.00
41_I237_W1.4301.00
16_A183_M1.4271.00
196_L217_V1.4081.00
59_I179_I1.4071.00
26_A41_I1.3831.00
17_W194_V1.3751.00
21_L26_A1.3591.00
38_P237_W1.3391.00
47_L245_T1.3371.00
107_S111_H1.3361.00
56_L76_F1.3261.00
71_A78_L1.3231.00
55_A191_R1.3101.00
81_V127_M1.3081.00
196_L239_W1.2930.99
47_L244_T1.2930.99
61_G82_H1.2890.99
180_A208_V1.2810.99
117_Y120_A1.2810.99
109_Q153_I1.2560.99
113_V146_L1.2470.99
179_I209_V1.2460.99
62_R132_H1.2380.99
131_L147_A1.2290.99
169_K204_S1.2250.99
114_I131_L1.2240.99
174_S204_S1.2110.99
125_K132_H1.1940.99
120_A143_L1.1920.99
47_L241_E1.1850.99
107_S129_F1.1820.99
209_V214_G1.1790.99
40_N238_S1.1780.99
158_A169_K1.1780.99
158_A172_G1.1760.99
21_L67_L1.1560.99
26_A35_V1.1540.99
203_E226_A1.1520.99
162_G199_D1.1460.99
141_D145_T1.1460.99
21_L58_L1.1340.99
119_G136_A1.1300.99
15_Y51_A1.1200.99
22_D62_R1.1190.99
32_P134_R1.1170.99
142_A145_T1.1110.98
81_V126_G1.1100.98
142_A146_L1.0980.98
23_G198_D1.0950.98
145_T149_R1.0920.98
222_G229_R1.0900.98
41_I44_G1.0900.98
62_R82_H1.0880.98
20_D23_G1.0840.98
117_Y136_A1.0810.98
91_G94_H1.0760.98
18_F182_F1.0560.98
159_L166_V1.0520.98
57_A182_F1.0440.98
151_T168_I1.0380.98
29_K34_Q1.0360.98
22_D132_H1.0250.97
85_E126_G1.0180.97
44_G244_T1.0140.97
131_L143_L1.0140.97
112_T115_A1.0110.97
175_K198_D1.0110.97
64_M80_G1.0080.97
123_E132_H1.0070.97
94_H97_H1.0070.97
114_I120_A1.0050.97
68_D78_L1.0040.97
140_E144_M1.0000.97
66_E69_A0.9980.97
44_G241_E0.9950.97
62_R198_D0.9900.97
183_M193_P0.9900.97
62_R125_K0.9850.97
161_Q200_L0.9830.97
90_N93_T0.9790.97
132_H165_V0.9780.97
38_P41_I0.9760.97
112_T116_Q0.9730.96
144_M161_Q0.9720.96
133_Y164_C0.9650.96
73_P76_F0.9580.96
31_H121_E0.9550.96
23_G125_K0.9450.96
40_N237_W0.9440.96
174_S177_E0.9390.96
81_V85_E0.9390.96
79_A178_A0.9340.96
49_A76_F0.9340.96
12_S191_R0.9310.95
215_M228_W0.9230.95
23_G62_R0.9210.95
26_A29_K0.9200.95
230_L235_D0.9180.95
176_G206_F0.9130.95
24_T195_F0.9130.95
175_K202_D0.9120.95
236_V239_W0.9090.95
106_I157_M0.9070.95
64_M85_E0.9030.95
122_L129_F0.8990.94
216_S227_S0.8940.94
101_A105_D0.8870.94
143_L146_L0.8830.94
160_Q169_K0.8820.94
24_T61_G0.8790.94
111_H122_L0.8770.94
210_N227_S0.8750.94
201_T204_S0.8680.93
17_W54_G0.8660.93
214_G217_V0.8640.93
32_P132_H0.8620.93
183_M212_L0.8600.93
204_S207_A0.8520.93
103_A124_A0.8520.93
22_D201_T0.8460.92
218_K229_R0.8450.92
156_Q171_R0.8440.92
41_I233_V0.8360.92
162_G167_E0.8350.92
219_I230_L0.8330.92
26_A71_A0.8310.92
44_G237_W0.8290.92
14_K191_R0.8290.92
144_M166_V0.8270.92
23_G134_R0.8250.92
48_L56_L0.8240.91
127_M130_A0.8210.91
46_Q75_R0.8140.91
125_K199_D0.8090.91
110_L122_L0.8080.91
187_P190_G0.8020.90
77_P182_F0.8000.90
17_W48_L0.8000.90
19_F45_L0.7970.90
143_L150_I0.7960.90
64_M78_L0.7950.90
125_K198_D0.7810.89
21_L37_V0.7810.89
81_V124_A0.7790.89
221_T229_R0.7770.89
20_D24_T0.7760.89
123_E134_R0.7750.89
214_G218_K0.7730.89
22_D125_K0.7720.89
105_D109_Q0.7630.88
27_E234_P0.7580.88
44_G240_L0.7540.87
116_Q146_L0.7530.87
81_V128_A0.7530.87
176_G208_V0.7500.87
125_K134_R0.7480.87
82_H199_D0.7410.87
193_P214_G0.7400.86
28_I32_P0.7380.86
167_E199_D0.7370.86
14_K55_A0.7370.86
147_A168_I0.7360.86
113_V131_L0.7250.85
20_D199_D0.7240.85
45_L179_I0.7210.85
113_V143_L0.7210.85
79_A182_F0.7170.85
116_Q120_A0.7160.85
22_D35_V0.7150.85
195_F209_V0.7100.84
216_S220_G0.7080.84
82_H125_K0.7070.84
32_P162_G0.7040.84
79_A86_R0.7000.83
47_L69_A0.6950.83
119_G142_A0.6940.83
239_W243_I0.6870.82
50_T213_G0.6830.82
242_M245_T0.6830.82
118_P142_A0.6830.82
17_W52_S0.6820.82
122_L151_T0.6820.82
224_T229_R0.6820.82
158_A161_Q0.6790.81
112_T146_L0.6720.81
54_G191_R0.6720.81
71_A133_Y0.6700.80
148_Q159_L0.6700.80
146_L149_R0.6630.80
220_G229_R0.6620.80
61_G198_D0.6620.80
194_V217_V0.6600.79
105_D108_V0.6570.79
37_V71_A0.6560.79
130_A160_Q0.6520.79
196_L230_L0.6470.78
176_G205_G0.6470.78
160_Q204_S0.6470.78
88_D185_E0.6440.78
133_Y166_V0.6430.78
181_A185_E0.6410.77
125_K167_E0.6400.77
125_K162_G0.6360.77
203_E206_F0.6350.77
134_R165_V0.6340.77
61_G201_T0.6310.76
230_L236_V0.6300.76
175_K199_D0.6270.76
142_A147_A0.6240.76
206_F224_T0.6240.76
224_T227_S0.6190.75
61_G176_G0.6170.75
61_G199_D0.6150.75
157_M168_I0.6150.75
218_K224_T0.6130.74
17_W243_I0.6120.74
20_D61_G0.6070.74
86_R178_A0.6030.73
110_L131_L0.6030.73
24_T198_D0.6020.73
102_I106_I0.6010.73
22_D82_H0.6000.73
47_L234_P0.6000.73
98_L211_R0.5980.72
184_Q207_A0.5970.72
55_A190_G0.5960.72
22_D198_D0.5950.72
122_L215_M0.5950.72
15_Y192_T0.5920.72
128_A200_L0.5920.72
72_K75_R0.5890.71
24_T129_F0.5890.71
151_T155_P0.5850.71
81_V84_A0.5830.71
30_P43_Q0.5790.70
10_E44_G0.5790.70
209_V212_L0.5760.70
16_A55_A0.5740.69
19_F25_L0.5730.69
49_A56_L0.5730.69
140_E148_Q0.5720.69
66_E205_G0.5710.69
37_V70_L0.5650.68
96_V99_P0.5640.68
37_V41_I0.5640.68
62_R123_E0.5640.68
82_H165_V0.5630.68
63_S126_G0.5630.68
221_T231_A0.5630.68
28_I132_H0.5630.68
163_K200_L0.5610.68
27_E35_V0.5550.67
84_A173_T0.5540.67
193_P196_L0.5520.66
39_D43_Q0.5510.66
64_M68_D0.5500.66
203_E218_K0.5470.66
99_P156_Q0.5470.66
199_D202_D0.5460.66
213_G227_S0.5450.65
198_D202_D0.5440.65
241_E244_T0.5410.65
27_E59_I0.5410.65
22_D28_I0.5390.65
59_I134_R0.5390.65
63_S130_A0.5390.65
22_D199_D0.5370.64
143_L147_A0.5360.64
117_Y139_H0.5340.64
128_A170_P0.5340.64
134_R167_E0.5330.64
174_S201_T0.5320.64
134_R198_D0.5310.63
125_K130_A0.5300.63
24_T202_D0.5300.63
86_R182_F0.5300.63
26_A38_P0.5280.63
82_H204_S0.5280.63
113_V117_Y0.5280.63
90_N100_D0.5270.63
78_L173_T0.5270.63
103_A109_Q0.5250.63
21_L71_A0.5240.62
62_R201_T0.5220.62
111_H211_R0.5220.62
148_Q152_Q0.5220.62
100_D227_S0.5210.62
43_Q241_E0.5190.62
97_H100_D0.5180.62
42_L58_L0.5170.61
79_A195_F0.5130.61
165_V206_F0.5120.61
71_A81_V0.5120.61
160_Q200_L0.5110.61
65_V68_D0.5090.60
28_I33_D0.5080.60
13_A166_V0.5080.60
176_G201_T0.5070.60
201_T217_V0.5070.60
166_V224_T0.5030.59
163_K199_D0.5030.59
11_L39_D0.5010.59
28_I164_C0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1u02A 1 0.8459 100 0.63 Contact Map
2b30A 2 0.8647 99.9 0.701 Contact Map
3daoA 1 0.8459 99.9 0.706 Contact Map
2amyA 1 0.7782 99.9 0.708 Contact Map
1l6rA 2 0.8045 99.8 0.71 Contact Map
3l7yA 1 0.8195 99.8 0.713 Contact Map
1nrwA 1 0.8308 99.8 0.715 Contact Map
1rlmA 1 0.8421 99.8 0.717 Contact Map
3pgvA 3 0.8271 99.8 0.72 Contact Map
1nf2A 4 0.8346 99.8 0.724 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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