GREMLIN Database
OTSA - Alpha,alpha-trehalose-phosphate synthase [UDP-forming]
UniProt: P31677 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11751
Length: 474 (450)
Sequences: 2328 (1446)
Seq/√Len: 68.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
224_Y450_D5.3691.00
278_E320_R4.3831.00
115_D144_R4.2811.00
282_E324_K3.9241.00
399_L419_M3.7291.00
356_L413_L3.7251.00
135_L177_L3.5481.00
258_I413_L3.4681.00
284_Y414_D3.4661.00
414_D418_T3.3881.00
185_F194_F3.3861.00
274_F321_I3.2651.00
282_E325_Y3.0131.00
397_S430_E2.9741.00
278_E324_K2.8741.00
171_D175_E2.8701.00
72_D108_R2.8481.00
405_D408_E2.7981.00
278_E325_Y2.6281.00
382_V419_M2.6041.00
116_K119_P2.5361.00
72_D112_L2.5321.00
277_Y293_Y2.4961.00
382_V399_L2.4791.00
139_H143_K2.4601.00
111_A115_D2.4351.00
423_E427_R2.4061.00
312_H316_N2.4041.00
354_V384_V2.3881.00
142_R150_I2.3851.00
111_A140_E2.3531.00
118_L141_L2.3171.00
80_F169_T2.3121.00
174_L202_T2.3091.00
280_L287_H2.2651.00
176_Q179_D2.2511.00
170_Y387_Q2.2351.00
274_F333_L2.1981.00
277_Y281_L2.1911.00
127_I148_N2.1451.00
395_L431_M2.1231.00
392_A400_I2.0971.00
260_S295_Q2.0941.00
442_H446_C2.0731.00
182_L224_Y2.0511.00
191_R221_T2.0221.00
399_L412_A2.0001.00
319_G323_G1.9931.00
111_A144_R1.9881.00
137_F141_L1.9521.00
174_L197_C1.9401.00
118_L144_R1.9291.00
397_S434_V1.9181.00
75_E105_G1.9171.00
71_Q75_E1.9171.00
107_L172_T1.8901.00
111_A143_K1.8891.00
287_H414_D1.8861.00
3_R125_D1.8731.00
369_K394_E1.8621.00
139_H175_E1.8621.00
305_Q309_D1.8521.00
151_G447_F1.8421.00
288_H325_Y1.8351.00
419_M423_E1.8301.00
283_K411_A1.8131.00
175_E202_T1.8051.00
195_L221_T1.8031.00
141_L148_N1.7941.00
354_V416_A1.7851.00
270_L314_L1.7731.00
88_A96_V1.7541.00
11_I41_G1.7421.00
277_Y291_I1.7241.00
184_G224_Y1.7211.00
89_F135_L1.7131.00
127_I145_G1.7061.00
258_I356_L1.6921.00
256_Q417_L1.6760.99
11_I65_S1.6700.99
234_A238_A1.6600.99
69_S72_D1.6590.99
121_L148_N1.6490.99
27_G226_I1.6450.99
89_F156_I1.6400.99
138_A180_Y1.6390.99
275_L320_R1.6320.99
375_Q424_R1.6180.99
428_H432_L1.6110.99
213_T216_G1.6050.99
145_G148_N1.5920.99
241_L347_K1.5860.99
275_L317_E1.5720.99
431_M435_I1.5520.99
211_S218_A1.5490.99
354_V417_L1.5470.99
7_V117_L1.5390.99
186_Q190_D1.5330.99
191_R223_V1.5200.99
246_A250_A1.4970.99
421_L425_I1.4910.99
256_Q353_D1.4890.99
89_F154_L1.4890.99
244_K247_Q1.4720.99
136_P176_Q1.4680.99
419_M427_R1.4590.99
64_A120_L1.4480.98
244_K344_L1.4420.98
192_L196_D1.4420.98
275_L278_E1.4380.98
178_C219_F1.4330.98
314_L318_A1.4100.98
257_N351_Y1.4070.98
245_L351_Y1.4030.98
277_Y333_L1.3850.98
243_P247_Q1.3830.98
162_E193_A1.3770.98
388_F402_N1.3690.98
213_T218_A1.3670.98
293_Y356_L1.3640.98
316_N320_R1.3550.98
425_I429_A1.3540.98
177_L183_L1.3370.97
204_V214_A1.3200.97
322_N333_L1.3160.97
43_S67_N1.3060.97
151_G451_L1.3030.97
291_I417_L1.3020.97
233_I346_M1.2970.97
280_L384_V1.2950.97
181_D217_K1.2950.97
283_K407_D1.2880.97
242_P350_R1.2850.97
105_G108_R1.2830.97
170_Y197_C1.2770.97
287_H418_T1.2760.97
75_E102_A1.2710.96
182_L451_L1.2700.96
284_Y287_H1.2680.96
175_E215_W1.2670.96
278_E317_E1.2670.96
380_P424_R1.2630.96
380_P425_I1.2590.96
172_T175_E1.2590.96
289_G330_W1.2520.96
276_A409_V1.2510.96
268_K365_N1.2470.96
245_L350_R1.2400.96
356_L409_V1.2390.96
70_E74_D1.2390.96
271_P313_Q1.2230.96
382_V424_R1.2200.95
114_A137_F1.2160.95
88_A167_L1.2100.95
233_I349_F1.2080.95
43_S65_S1.2060.95
152_F177_L1.2020.95
38_L64_A1.1990.95
91_Y361_R1.1960.95
82_N307_Y1.1900.95
56_V60_N1.1830.95
279_A282_E1.1810.95
315_E323_G1.1770.95
419_M424_R1.1660.94
248_L351_Y1.1660.94
375_Q380_P1.1660.94
279_A283_K1.1650.94
5_V117_L1.1620.94
355_G359_P1.1600.94
106_Y110_N1.1590.94
72_D105_G1.1550.94
107_L111_A1.1500.94
315_E319_G1.1480.94
255_V290_K1.1410.94
317_E320_R1.1390.93
118_L145_G1.1360.93
41_G65_S1.1350.93
65_S158_F1.1300.93
345_L349_F1.1260.93
160_T193_A1.1220.93
280_L413_L1.1210.93
311_R315_E1.1160.93
3_R122_Q1.1160.93
279_A410_A1.1140.93
79_Q102_A1.1140.93
271_P317_E1.1120.93
258_I291_I1.1080.93
193_A196_D1.1060.92
420_S423_E1.1010.92
74_D78_N1.0980.92
122_Q125_D1.0950.92
234_A436_V1.0950.92
21_A25_A1.0940.92
195_L212_H1.0860.92
42_W68_L1.0830.92
258_I277_Y1.0810.92
307_Y367_V1.0730.91
121_L145_G1.0720.91
377_P380_P1.0610.91
311_R335_Y1.0570.91
433_D437_K1.0570.91
432_L436_V1.0540.91
240_P243_P1.0520.90
129_I180_Y1.0500.90
280_L284_Y1.0470.90
289_G327_Q1.0430.90
263_R362_D1.0410.90
32_L37_G1.0410.90
235_K239_G1.0400.90
128_W151_G1.0380.90
445_E449_S1.0380.90
72_D109_V1.0340.90
233_I374_A1.0280.89
268_K307_Y1.0280.89
205_T213_T1.0270.89
206_T212_H1.0270.89
410_A414_D1.0200.89
82_N301_R1.0140.89
265_D268_K1.0120.89
22_G25_A1.0070.88
198_L202_T1.0050.88
264_L335_Y1.0040.88
261_V345_L1.0010.88
52_P55_K0.9990.88
315_E337_N0.9970.88
279_A407_D0.9890.88
434_V438_N0.9880.87
40_F66_F0.9820.87
152_F183_L0.9730.87
278_E333_L0.9680.86
228_I233_I0.9640.86
230_P436_V0.9620.86
82_N367_V0.9610.86
273_R295_Q0.9610.86
289_G329_G0.9560.86
51_Q54_K0.9500.85
22_G82_N0.9470.85
380_P421_L0.9370.85
358_T409_V0.9360.84
84_V102_A0.9330.84
27_G227_G0.9320.84
263_R307_Y0.9320.84
183_L219_F0.9320.84
194_F198_L0.9290.84
140_E179_D0.9290.84
112_L116_K0.9250.84
395_L434_V0.9240.84
93_L166_A0.9200.83
285_P411_A0.9190.83
154_L158_F0.9150.83
78_N303_D0.9140.83
401_V409_V0.9140.83
225_P265_D0.9070.83
9_N22_G0.9060.82
262_E273_R0.9050.82
230_P439_D0.9050.82
141_L144_R0.9030.82
10_R23_G0.9020.82
23_G307_Y0.9020.82
429_A433_D0.9010.82
82_N86_W0.9000.82
274_F318_A0.8920.81
399_L416_A0.8910.81
188_E192_L0.8900.81
103_W169_T0.8900.81
174_L201_L0.8890.81
5_V40_F0.8880.81
230_P435_I0.8870.81
49_E52_P0.8870.81
91_Y193_A0.8860.81
117_L141_L0.8840.81
77_Y86_W0.8810.81
262_E270_L0.8810.81
266_Y307_Y0.8790.81
396_T430_E0.8780.80
50_D53_L0.8780.80
76_Y113_L0.8770.80
41_G44_G0.8740.80
394_E434_V0.8700.80
178_C198_L0.8690.80
165_N387_Q0.8670.80
68_L76_Y0.8670.80
123_D147_N0.8670.80
82_N300_S0.8620.79
162_E176_Q0.8610.79
104_D108_R0.8590.79
117_L137_F0.8590.79
9_N77_Y0.8580.79
288_H330_W0.8490.78
116_K120_L0.8470.78
359_P389_A0.8440.78
138_A176_Q0.8420.78
268_K362_D0.8390.77
362_D367_V0.8380.77
263_R266_Y0.8350.77
31_A173_L0.8310.77
128_W447_F0.8290.76
40_F120_L0.8280.76
81_S133_H0.8270.76
77_Y133_H0.8270.76
270_L273_R0.8230.76
135_L152_F0.8190.76
438_N442_H0.8190.76
9_N301_R0.8160.75
241_L343_K0.8160.75
16_E40_F0.8150.75
87_P269_G0.8130.75
346_M350_R0.8120.75
140_E143_K0.8110.75
236_Q342_R0.8080.75
258_I417_L0.8060.74
77_Y82_N0.8050.74
138_A353_D0.8040.74
212_H219_F0.8030.74
258_I354_V0.8030.74
301_R307_Y0.8030.74
108_R111_A0.8010.74
261_V349_F0.8010.74
186_Q364_M0.7990.74
268_K301_R0.7980.74
23_G39_W0.7970.74
82_N263_R0.7950.73
329_G334_Y0.7950.73
87_P128_W0.7940.73
140_E144_R0.7940.73
76_Y109_V0.7890.73
176_Q180_Y0.7880.73
10_R22_G0.7880.73
68_L109_V0.7860.73
350_R374_A0.7850.72
249_K353_D0.7820.72
394_E438_N0.7820.72
135_L180_Y0.7810.72
375_Q428_H0.7810.72
9_N82_N0.7790.72
189_N200_N0.7780.72
384_V401_V0.7780.72
135_L154_L0.7760.72
286_Q414_D0.7750.72
10_R307_Y0.7750.72
185_F198_L0.7750.72
276_A406_R0.7740.71
224_Y446_C0.7730.71
411_A415_R0.7700.71
241_L245_L0.7700.71
52_P56_V0.7690.71
91_Y163_I0.7680.71
161_P193_A0.7670.71
182_L220_R0.7650.71
342_R349_F0.7620.70
5_V121_L0.7580.70
154_L374_A0.7580.70
257_N292_R0.7560.70
126_I452_K0.7560.70
301_R304_V0.7550.70
362_D365_N0.7540.69
376_D432_L0.7530.69
161_P196_D0.7530.69
201_L387_Q0.7510.69
240_P246_A0.7510.69
66_F166_A0.7450.69
283_K414_D0.7440.68
313_Q316_N0.7430.68
82_N268_K0.7420.68
249_K351_Y0.7400.68
121_L124_D0.7390.68
278_E282_E0.7390.68
266_Y345_L0.7340.67
371_Y381_G0.7330.67
41_G262_E0.7300.67
23_G266_Y0.7260.67
174_L198_L0.7250.66
162_E189_N0.7230.66
267_S359_P0.7210.66
296_I340_F0.7200.66
119_P123_D0.7180.66
161_P197_C0.7180.66
82_N304_V0.7160.65
137_F144_R0.7160.65
42_W73_L0.7150.65
340_F345_L0.7150.65
85_L173_L0.7150.65
89_F152_F0.7120.65
306_A309_D0.7110.65
276_A401_V0.7080.65
86_W155_H0.7070.64
183_L241_L0.7060.64
399_L415_R0.7050.64
254_N258_I0.7040.64
255_V409_V0.7030.64
140_E176_Q0.7020.64
236_Q346_M0.7010.64
450_D453_Q0.7000.64
268_K367_V0.7000.64
326_G360_L0.7000.64
41_G128_W0.6990.64
80_F98_F0.6980.63
250_A253_K0.6980.63
124_D147_N0.6960.63
449_S452_K0.6950.63
331_T334_Y0.6940.63
41_G135_L0.6940.63
77_Y90_H0.6930.63
269_G295_Q0.6910.63
408_E412_A0.6900.63
199_S206_T0.6890.62
152_F180_Y0.6880.62
238_A422_A0.6870.62
186_Q295_Q0.6860.62
27_G30_G0.6860.62
22_G27_G0.6840.62
284_Y410_A0.6790.61
315_E335_Y0.6770.61
245_L248_L0.6770.61
267_S369_K0.6730.61
13_P17_H0.6730.61
86_W132_Y0.6710.60
323_G331_T0.6700.60
153_F184_G0.6690.60
64_A116_K0.6690.60
86_W363_G0.6690.60
126_I448_I0.6680.60
187_T223_V0.6680.60
86_W307_Y0.6670.60
129_I137_F0.6670.60
346_M374_A0.6670.60
371_Y441_N0.6660.60
40_F117_L0.6660.60
232_E342_R0.6650.60
262_E295_Q0.6640.60
6_V10_R0.6640.60
75_E101_P0.6630.60
294_T348_I0.6620.59
311_R337_N0.6600.59
318_A335_Y0.6590.59
127_I150_I0.6590.59
65_S154_L0.6580.59
9_N79_Q0.6570.59
82_N365_N0.6560.59
92_R95_L0.6540.58
283_K410_A0.6520.58
77_Y268_K0.6520.58
12_A170_Y0.6520.58
138_A146_V0.6520.58
131_D265_D0.6520.58
252_L294_T0.6500.58
297_A314_L0.6480.58
281_L293_Y0.6480.58
201_L228_I0.6470.58
263_R365_N0.6460.58
100_R407_D0.6460.58
297_A308_Q0.6460.58
87_P260_S0.6430.57
260_S306_A0.6430.57
263_R367_V0.6420.57
240_P274_F0.6390.57
266_Y367_V0.6370.56
3_R36_G0.6360.56
244_K248_L0.6340.56
36_G313_Q0.6340.56
22_G300_S0.6320.56
260_S269_G0.6320.56
418_T422_A0.6310.56
76_Y321_I0.6310.56
150_I180_Y0.6300.56
69_S108_R0.6300.56
388_F404_Y0.6290.56
295_Q388_F0.6290.56
422_A426_S0.6290.56
420_S424_R0.6280.55
99_Q102_A0.6280.55
85_L430_E0.6260.55
100_R104_D0.6250.55
242_P245_L0.6250.55
240_P249_K0.6240.55
289_G332_P0.6210.55
257_N352_S0.6210.55
8_S24_L0.6200.54
121_L127_I0.6170.54
103_W165_N0.6160.54
107_L136_P0.6150.54
362_D390_G0.6150.54
274_F317_E0.6140.54
170_Y174_L0.6140.54
277_Y326_G0.6140.54
439_D442_H0.6130.54
50_D54_K0.6110.53
109_V172_T0.6090.53
255_V292_R0.6080.53
77_Y301_R0.6070.53
366_L390_G0.6070.53
123_D145_G0.6070.53
9_N24_L0.6050.53
323_G335_Y0.6040.53
22_G26_V0.6030.52
287_H417_L0.6030.52
23_G82_N0.6020.52
41_G154_L0.6010.52
282_E326_G0.6010.52
178_C321_I0.6010.52
236_Q343_K0.5990.52
263_R268_K0.5980.52
111_A139_H0.5980.52
165_N201_L0.5980.52
398_A423_E0.5960.52
388_F403_P0.5960.52
237_A350_R0.5960.52
86_W268_K0.5960.52
287_H290_K0.5950.51
202_T214_A0.5950.51
368_A383_L0.5940.51
23_G268_K0.5940.51
155_H184_G0.5940.51
167_L356_L0.5930.51
384_V413_L0.5910.51
299_T337_N0.5910.51
133_H154_L0.5900.51
178_C194_F0.5900.51
105_G109_V0.5900.51
22_G301_R0.5900.51
44_G65_S0.5870.51
197_C201_L0.5860.50
205_T258_I0.5860.50
203_R207_R0.5850.50
160_T192_L0.5820.50
373_A381_G0.5820.50
165_N176_Q0.5800.50
66_F116_K0.5790.50
103_W172_T0.5780.49
432_L435_I0.5770.49
259_F355_G0.5770.49
231_K439_D0.5750.49
24_L447_F0.5750.49
53_L61_I0.5740.49
156_I168_P0.5740.49
22_G307_Y0.5730.49
233_I326_G0.5730.49
121_L125_D0.5730.49
204_V212_H0.5720.49
225_P390_G0.5720.49
178_C212_H0.5720.49
82_N133_H0.5710.49
80_F318_A0.5710.49
280_L414_D0.5690.48
375_Q432_L0.5690.48
269_G371_Y0.5690.48
9_N23_G0.5690.48
29_L61_I0.5680.48
298_P345_L0.5680.48
426_S446_C0.5680.48
73_L76_Y0.5670.48
251_E348_I0.5660.48
76_Y106_Y0.5660.48
103_W174_L0.5650.48
23_G156_I0.5650.48
275_L313_Q0.5650.48
167_L173_L0.5630.48
304_V307_Y0.5620.48
161_P165_N0.5620.48
103_W136_P0.5610.47
68_L73_L0.5600.47
22_G304_V0.5590.47
437_K442_H0.5580.47
117_L123_D0.5580.47
59_G70_E0.5580.47
248_L257_N0.5570.47
274_F314_L0.5560.47
81_S367_V0.5560.47
168_P299_T0.5560.47
166_A186_Q0.5550.47
340_F352_S0.5550.47
199_S205_T0.5540.47
440_I444_Q0.5540.47
259_F352_S0.5530.46
103_W162_E0.5510.46
224_Y447_F0.5510.46
129_I150_I0.5500.46
149_R352_S0.5500.46
433_D436_V0.5490.46
231_K235_K0.5480.46
106_Y228_I0.5470.46
92_R186_Q0.5460.46
303_D308_Q0.5450.46
58_K62_T0.5440.45
49_E53_L0.5420.45
82_N266_Y0.5420.45
336_L354_V0.5420.45
71_Q205_T0.5410.45
5_V38_L0.5410.45
23_G367_V0.5400.45
234_A432_L0.5400.45
32_L154_L0.5400.45
3_R38_L0.5400.45
21_A156_I0.5390.45
11_I66_F0.5390.45
255_V329_G0.5380.45
44_G310_I0.5380.45
187_T268_K0.5370.45
260_S435_I0.5370.45
130_H214_A0.5370.45
426_S430_E0.5370.45
114_A118_L0.5360.44
288_H332_P0.5350.44
296_I348_I0.5340.44
10_R39_W0.5340.44
70_E238_A0.5330.44
83_A97_Q0.5320.44
22_G263_R0.5320.44
54_K215_W0.5320.44
187_T332_P0.5290.44
124_D127_I0.5290.44
77_Y427_R0.5290.44
301_R367_V0.5290.44
216_G330_W0.5290.44
43_S154_L0.5290.44
247_Q329_G0.5270.43
30_G227_G0.5270.43
273_R300_S0.5260.43
86_W153_F0.5250.43
91_Y162_E0.5250.43
300_S307_Y0.5250.43
146_V176_Q0.5250.43
247_Q294_T0.5240.43
41_G447_F0.5240.43
281_L419_M0.5230.43
239_G343_K0.5220.43
230_P432_L0.5210.43
166_A404_Y0.5200.43
136_P140_E0.5190.42
246_A251_E0.5190.42
283_K446_C0.5190.42
344_L413_L0.5180.42
13_P357_V0.5180.42
29_L33_K0.5170.42
309_D399_L0.5170.42
189_N405_D0.5160.42
173_L221_T0.5160.42
35_A444_Q0.5150.42
76_Y79_Q0.5140.42
39_W366_L0.5140.42
41_G295_Q0.5130.42
280_L356_L0.5120.42
186_Q345_L0.5120.42
259_F345_L0.5120.42
135_L164_F0.5110.42
230_P237_A0.5100.41
203_R291_I0.5100.41
35_A445_E0.5100.41
82_N389_A0.5090.41
310_I315_E0.5080.41
261_V367_V0.5080.41
91_Y160_T0.5080.41
220_R450_D0.5070.41
128_W269_G0.5070.41
130_H155_H0.5070.41
237_A376_D0.5070.41
182_L339_H0.5070.41
68_L112_L0.5050.41
286_Q417_L0.5040.41
260_S297_A0.5040.41
122_Q145_G0.5040.41
384_V412_A0.5030.41
319_G359_P0.5030.41
113_L137_F0.5030.41
272_E360_L0.5030.41
144_R384_V0.5020.40
242_P255_V0.5020.40
112_L115_D0.5020.40
199_S203_R0.5020.40
234_A376_D0.5010.40
380_P432_L0.5010.40
124_D384_V0.5010.40
114_A144_R0.5000.40
438_N446_C0.5000.40
238_A246_A0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1uqtA 2 0.9536 100 0.359 Contact Map
3t5tA 2 0.9325 100 0.41 Contact Map
4qlbA 3 0.9325 99.9 0.842 Contact Map
4rbnA 3 0.9219 99.9 0.856 Contact Map
3nb0A 4 0.9325 99.9 0.859 Contact Map
3vueA 1 0.8376 99.8 0.869 Contact Map
2r60A 1 0.8439 99.8 0.869 Contact Map
4hlnA 1 0.8481 99.8 0.87 Contact Map
3froA 3 0.8333 99.8 0.875 Contact Map
3s28A 4 0.9198 99.8 0.876 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0122 seconds.