GREMLIN Database
YHGA - Uncharacterized protein YhgA
UniProt: P31667 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11750
Length: 292 (263)
Sequences: 1537 (1269)
Seq/√Len: 78.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
246_I250_L5.0241.00
242_S246_I4.9061.00
258_K262_I4.1231.00
262_I266_M3.7061.00
251_R257_S3.4271.00
256_Q260_L3.3811.00
260_L264_K3.0521.00
259_A263_A3.0031.00
247_A250_L2.9711.00
266_M269_S2.7921.00
255_E259_A2.7571.00
244_M250_L2.6971.00
255_E258_K2.6251.00
262_I265_I2.6191.00
266_M270_G2.5951.00
247_A251_R2.5951.00
84_Q94_R2.5861.00
272_P275_D2.5191.00
266_M272_P2.5081.00
248_E252_Q2.4921.00
242_S250_L2.4691.00
266_M274_A2.4671.00
46_K67_S2.4351.00
249_R253_E2.3241.00
255_E261_H2.2251.00
263_A266_M2.2241.00
268_E272_P2.2081.00
259_A262_I2.1911.00
265_I269_S2.1451.00
244_M252_Q2.1151.00
247_A253_E2.0931.00
259_A265_I2.0631.00
242_S245_T2.0611.00
243_L249_R2.0491.00
252_Q256_Q2.0231.00
241_E246_I1.9331.00
264_K268_E1.9221.00
244_M247_A1.9191.00
271_V275_D1.9051.00
266_M271_V1.8931.00
255_E263_A1.8791.00
245_T249_R1.8671.00
245_T250_L1.8611.00
84_Q91_I1.8561.00
243_L246_I1.8371.00
93_F107_L1.8221.00
266_M273_L1.7771.00
250_L254_G1.7731.00
251_R255_E1.7681.00
263_A267_L1.7591.00
91_I94_R1.7541.00
257_S261_H1.7481.00
256_Q264_K1.7461.00
260_L263_A1.7361.00
246_I249_R1.6151.00
259_A267_L1.5921.00
177_E180_Q1.5791.00
261_H265_I1.5660.99
163_P166_E1.5510.99
252_Q260_L1.5510.99
254_G258_K1.5210.99
269_S275_D1.4870.99
258_K263_A1.4710.99
174_A178_L1.4680.99
241_E244_M1.4540.99
243_L247_A1.4350.99
243_L251_R1.4340.99
231_G235_R1.4270.99
240_K246_I1.4230.99
260_L268_E1.4220.99
242_S247_A1.4110.99
245_T253_E1.4110.99
158_D161_V1.3860.99
96_M100_I1.3170.98
25_R29_A1.3170.98
258_K261_H1.3110.98
245_T248_E1.2670.98
241_E249_R1.2590.98
267_L271_V1.2580.98
263_A269_S1.2520.97
47_L66_W1.2390.97
264_K272_P1.2370.97
267_L270_G1.2220.97
258_K266_M1.2160.97
244_M248_E1.2060.97
103_M117_V1.2050.97
44_T69_K1.1880.96
178_L181_K1.1840.96
236_S239_H1.1780.96
101_A104_Q1.1710.96
253_E257_S1.1550.96
263_A270_G1.1380.96
90_L139_C1.1380.96
269_S274_A1.1300.95
62_S65_L1.1270.95
256_Q259_A1.1230.95
243_L250_L1.1160.95
248_E256_Q1.1110.95
270_G273_L1.1020.95
270_G274_A1.1000.95
230_D233_A1.0940.94
259_A266_M1.0890.94
113_T141_A1.0850.94
263_A271_V1.0810.94
226_N230_D1.0790.94
97_R104_Q1.0780.94
269_S273_L1.0580.93
15_K51_S1.0540.93
41_D44_T1.0490.93
270_G275_D1.0400.93
247_A255_E1.0300.92
52_F65_L1.0300.92
11_D15_K1.0290.92
80_L119_P1.0270.92
174_A180_Q1.0270.92
261_H269_S1.0260.92
262_I272_P1.0250.92
176_L179_I1.0220.92
262_I273_L1.0180.92
266_M275_D1.0140.92
231_G239_H1.0100.92
69_K74_P1.0070.92
259_A264_K0.9990.91
106_H115_P0.9960.91
269_S272_P0.9950.91
176_L180_Q0.9940.91
173_M177_E0.9890.91
241_E245_T0.9790.90
135_C151_A0.9740.90
248_E251_R0.9580.89
135_C153_A0.9500.89
227_D231_G0.9490.89
271_V274_A0.9430.89
265_I273_L0.9370.88
264_K269_S0.9370.88
99_A119_P0.9360.88
267_L273_L0.9360.88
93_F100_I0.9340.88
70_T73_G0.9340.88
65_L76_Y0.9300.88
235_R239_H0.9300.88
268_E273_L0.9300.88
259_A271_V0.9290.88
263_A272_P0.9120.87
67_S74_P0.9070.87
240_K243_L0.9060.87
268_E274_A0.9010.86
95_M119_P0.8990.86
177_E181_K0.8940.86
87_S132_Y0.8930.86
132_Y154_F0.8900.86
29_A37_H0.8850.85
133_S138_D0.8720.84
14_F83_H0.8690.84
240_K244_M0.8680.84
85_S124_H0.8670.84
268_E271_V0.8640.84
99_A103_M0.8580.84
261_H264_K0.8550.83
164_D182_H0.8470.83
54_D57_L0.8420.82
99_A117_V0.8410.82
65_L102_A0.8410.82
60_S101_A0.8390.82
265_I268_E0.8390.82
24_A66_W0.8330.82
228_F231_G0.8280.81
28_L79_C0.8260.81
227_D230_D0.8250.81
137_L151_A0.8230.81
241_E247_A0.8200.81
258_K265_I0.8190.81
12_A59_E0.8120.80
263_A273_L0.8030.79
118_V155_P0.8020.79
241_E250_L0.7950.79
257_S268_E0.7910.78
82_E98_Y0.7910.78
229_I233_A0.7900.78
129_P234_E0.7870.78
253_E256_Q0.7840.78
60_S97_R0.7820.77
93_F157_I0.7820.77
179_I182_H0.7820.77
262_I267_L0.7650.76
256_Q261_H0.7650.76
252_Q255_E0.7600.75
262_I269_S0.7550.75
253_E261_H0.7520.75
179_I183_I0.7510.75
21_P66_W0.7470.74
125_G130_Y0.7390.73
81_I92_A0.7370.73
264_K270_G0.7360.73
262_I274_A0.7350.73
80_L95_M0.7340.73
244_M256_Q0.7330.73
96_M150_Y0.7310.73
245_T251_R0.7310.73
243_L248_E0.7310.73
166_E169_Q0.7300.72
39_L141_A0.7280.72
130_Y133_S0.7260.72
135_C138_D0.7230.72
247_A259_A0.7200.71
100_I103_M0.7200.71
257_S265_I0.7200.71
129_P161_V0.7140.71
263_A268_E0.7080.70
250_L253_E0.7070.70
75_G105_N0.7020.69
262_I271_V0.7010.69
260_L265_I0.6940.69
239_H242_S0.6890.68
209_I216_I0.6890.68
178_L182_H0.6860.68
138_D141_A0.6850.68
147_R153_A0.6820.67
27_F31_H0.6820.67
148_Q155_P0.6780.67
89_K132_Y0.6780.67
246_I251_R0.6770.67
240_K248_E0.6750.66
52_F102_A0.6710.66
175_L182_H0.6710.66
243_L253_E0.6710.66
99_A152_S0.6660.65
149_L153_A0.6650.65
80_L99_A0.6650.65
18_L24_A0.6650.65
17_F212_L0.6650.65
36_I118_V0.6640.65
18_L81_I0.6620.65
21_P25_R0.6610.65
231_G234_E0.6590.65
106_H122_F0.6580.64
208_Q212_L0.6570.64
260_L272_P0.6570.64
175_L180_Q0.6550.64
239_H245_T0.6550.64
20_Q102_A0.6550.64
267_L272_P0.6520.64
225_F249_R0.6500.64
244_M249_R0.6480.63
230_D234_E0.6480.63
225_F228_F0.6480.63
33_P36_I0.6460.63
232_V235_R0.6450.63
232_V239_H0.6450.63
25_R40_C0.6430.63
134_L137_L0.6420.63
259_A268_E0.6410.62
95_M121_L0.6380.62
245_T257_S0.6380.62
86_T94_R0.6360.62
227_D235_R0.6360.62
176_L181_K0.6360.62
247_A252_Q0.6340.62
58_R81_I0.6320.61
47_L105_N0.6300.61
26_D29_A0.6300.61
193_E197_C0.6270.61
265_I271_V0.6220.60
13_L140_F0.6180.60
127_E235_R0.6160.59
205_N208_Q0.6110.59
13_L84_Q0.6110.59
239_H250_L0.6110.59
240_K247_A0.6100.59
17_F23_T0.6090.59
20_Q23_T0.6090.59
264_K275_D0.6070.58
259_A270_G0.6030.58
240_K245_T0.6000.57
68_V168_M0.5990.57
24_A32_L0.5980.57
28_L120_L0.5940.57
26_D30_F0.5930.57
177_E182_H0.5910.56
251_R256_Q0.5910.56
209_I213_F0.5900.56
249_R252_Q0.5900.56
177_E184_R0.5900.56
35_P38_A0.5900.56
25_R42_M0.5900.56
165_D194_Q0.5870.56
134_L153_A0.5870.56
175_L178_L0.5860.56
91_I121_L0.5860.56
243_L255_E0.5850.56
236_S242_S0.5840.55
54_D122_F0.5830.55
167_I176_L0.5810.55
97_R100_I0.5810.55
125_G158_D0.5810.55
112_K267_L0.5800.55
226_N253_E0.5710.54
255_E265_I0.5710.54
15_K23_T0.5700.54
83_H123_Y0.5700.54
265_I272_P0.5690.54
209_I219_T0.5680.53
225_F229_I0.5680.53
102_A117_V0.5670.53
18_L30_F0.5670.53
247_A263_A0.5660.53
261_H273_L0.5630.53
164_D181_K0.5630.53
51_S80_L0.5620.53
28_L203_Y0.5620.53
193_E232_V0.5610.52
121_L156_L0.5600.52
30_F173_M0.5590.52
62_S66_W0.5590.52
48_E51_S0.5570.52
122_F125_G0.5560.52
121_L130_Y0.5550.52
210_K214_N0.5550.52
130_Y148_Q0.5520.51
51_S197_C0.5520.51
225_F235_R0.5520.51
10_H14_F0.5510.51
218_Q221_D0.5500.51
48_E54_D0.5480.51
41_D69_K0.5470.51
192_V219_T0.5470.51
54_D61_Y0.5450.50
43_K217_L0.5440.50
247_A256_Q0.5430.50
163_P253_E0.5430.50
16_L108_D0.5420.50
15_K80_L0.5410.50
136_W139_C0.5410.50
225_F232_V0.5410.50
242_S249_R0.5390.50
262_I270_G0.5380.50
103_M106_H0.5380.50
32_L36_I0.5380.50
18_L83_H0.5340.49
97_R101_A0.5340.49
258_K273_L0.5330.49
21_P64_V0.5330.49
35_P39_L0.5320.49
262_I268_E0.5310.49
26_D172_R0.5300.49
268_E275_D0.5290.48
259_A269_S0.5280.48
99_A150_Y0.5270.48
228_F233_A0.5270.48
27_F120_L0.5250.48
18_L66_W0.5250.48
237_P240_K0.5250.48
88_N100_I0.5240.48
192_V195_M0.5220.47
51_S58_R0.5200.47
136_W152_S0.5200.47
42_M54_D0.5200.47
165_D196_A0.5190.47
253_E265_I0.5190.47
117_V184_R0.5180.47
212_L216_I0.5160.47
204_A212_L0.5160.47
81_I94_R0.5160.47
174_A181_K0.5150.47
28_L172_R0.5150.47
60_S94_R0.5150.47
191_L195_M0.5140.46
33_P244_M0.5140.46
24_A62_S0.5130.46
10_H53_I0.5130.46
138_D264_K0.5130.46
164_D167_I0.5120.46
68_V108_D0.5110.46
215_Y219_T0.5110.46
27_F201_S0.5100.46
124_H180_Q0.5100.46
247_A257_S0.5090.46
29_A36_I0.5090.46
17_F177_E0.5090.46
48_E145_L0.5080.46
84_Q124_H0.5070.46
65_L95_M0.5070.46
226_N236_S0.5060.45
27_F136_W0.5050.45
103_M136_W0.5050.45
176_L191_L0.5050.45
226_N229_I0.5040.45
83_H124_H0.5040.45
96_M152_S0.5030.45
187_D190_G0.5030.45
36_I62_S0.5030.45
181_K184_R0.5020.45
265_I275_D0.5010.45
47_L91_I0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dyqA 5 0.1404 57.3 0.941 Contact Map
1jkoC 1 0.1473 35.3 0.949 Contact Map
3c1dA 2 0.3733 31.9 0.95 Contact Map
3frwA 2 0.2603 30.4 0.95 Contact Map
2lfwA 1 0.4486 30.1 0.95 Contact Map
2jpcA 1 0.1199 30.1 0.95 Contact Map
2h8rA 2 0.226 29.7 0.951 Contact Map
1ic8A 2 0.2226 26.3 0.952 Contact Map
1tc3C 1 0.1473 25.4 0.952 Contact Map
3e3vA 1 0.3425 25 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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