GREMLIN Database
PANC - Pantothenate synthetase
UniProt: P31663 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11746
Length: 283 (276)
Sequences: 3543 (2523)
Seq/√Len: 151.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_A51_V3.5541.00
182_D198_R3.1661.00
79_C90_V2.9141.00
135_S168_F2.8511.00
156_L174_G2.7301.00
75_L92_A2.6481.00
43_E47_R2.5381.00
239_R268_W2.4961.00
48_A147_C2.4381.00
41_V82_L2.3981.00
39_K175_V2.3971.00
42_D85_R2.3691.00
180_A186_L2.3131.00
110_D128_R2.2761.00
43_E46_A2.2711.00
202_P205_Y2.2091.00
47_R147_C2.2061.00
25_A48_A2.1191.00
17_L50_V2.0951.00
45_K88_D2.0851.00
142_Q169_D2.0841.00
41_V53_V2.0831.00
4_I89_L2.0761.00
108_Y128_R2.0011.00
138_F170_I1.9871.00
205_Y209_S1.9781.00
26_L54_S1.9701.00
150_E176_P1.9701.00
145_I171_E1.9641.00
48_A145_I1.9591.00
247_D250_T1.9321.00
13_Q89_L1.9111.00
74_T77_E1.9091.00
53_V87_V1.8681.00
238_F269_L1.8591.00
212_A216_Q1.8571.00
147_C175_V1.8531.00
197_Q270_G1.8531.00
35_D42_D1.8521.00
38_M81_K1.8441.00
245_I263_I1.8381.00
77_E81_K1.8261.00
32_N74_T1.8121.00
22_K50_V1.8021.00
5_E75_L1.7701.00
6_T9_L1.7471.00
56_F95_V1.7391.00
150_E279_M1.7341.00
139_N168_F1.7141.00
197_Q271_D1.6931.00
10_L14_I1.6831.00
153_F262_V1.6621.00
211_I225_I1.6451.00
192_Y272_A1.6371.00
194_T197_Q1.6321.00
52_V141_V1.6161.00
7_L140_L1.5311.00
23_R49_D1.5111.00
134_V159_I1.5101.00
53_V82_L1.4971.00
135_S162_M1.4951.00
211_I263_I1.4931.00
214_K228_I1.4751.00
254_V261_A1.4611.00
7_L97_E1.4581.00
229_A243_I1.4561.00
114_L158_L1.4561.00
200_I237_G1.4491.00
210_S232_E1.4431.00
26_L141_V1.4421.00
3_I79_C1.4411.00
122_S241_D1.4381.00
43_E175_V1.4371.00
2_L13_Q1.4231.00
14_I18_R1.4191.00
47_R145_I1.4161.00
10_L140_L1.4151.00
80_E84_K1.4081.00
230_G234_N1.4021.00
6_T97_E1.3971.00
4_I10_L1.3861.00
146_A172_I1.3491.00
41_V87_V1.3491.00
4_I13_Q1.3441.00
131_S158_L1.3311.00
163_V172_I1.3221.00
65_P69_A1.3161.00
13_Q17_L1.3091.00
25_A147_C1.3091.00
38_M85_R1.3071.00
111_V131_S1.2811.00
109_V135_S1.2781.00
160_R174_G1.2761.00
226_I230_G1.2721.00
119_E264_L1.2701.00
63_D125_G1.2621.00
244_Q253_E1.2611.00
64_R192_Y1.2571.00
11_R142_Q1.2561.00
215_L280_V1.2541.00
204_L265_V1.2501.00
150_E156_L1.2451.00
66_E192_Y1.2431.00
150_E174_G1.2211.00
219_E224_E1.2191.00
91_F140_L1.1951.00
138_F146_A1.1891.00
209_S212_A1.1761.00
135_S166_M1.1751.00
211_I243_I1.1711.00
80_E83_N1.1701.00
99_Y133_I1.1651.00
63_D66_E1.1611.00
262_V279_M1.1531.00
182_D202_P1.1521.00
157_A160_R1.1521.00
227_T231_Q1.1351.00
63_D192_Y1.1241.00
24_V52_V1.1221.00
145_I173_V1.1210.99
136_K167_G1.1170.99
47_R173_V1.1020.99
150_E262_V1.1000.99
115_S158_L1.0990.99
35_D186_L1.0880.99
17_L22_K1.0730.99
207_V211_I1.0710.99
32_N191_G1.0670.99
101_N164_A1.0640.99
22_K49_D1.0610.99
75_L79_C1.0600.99
241_D268_W1.0590.99
119_E244_Q1.0570.99
82_L87_V1.0460.99
7_L11_R1.0430.99
206_K232_E1.0410.99
94_S97_E1.0390.99
28_P54_S1.0390.99
107_T165_D1.0340.99
42_D46_A1.0270.99
60_M103_T1.0250.99
43_E147_C1.0240.99
18_R144_D1.0240.99
45_K51_V1.0220.99
159_I172_I1.0190.99
25_A44_A1.0120.99
192_Y271_D1.0090.99
203_G206_K1.0080.99
221_D224_E1.0060.99
38_M41_V1.0010.99
246_R264_L0.9960.99
39_K178_M0.9940.99
266_A275_I0.9930.99
79_C92_A0.9870.99
111_V115_S0.9870.99
202_P269_L0.9870.99
98_I140_L0.9860.99
180_A198_R0.9820.99
32_N77_E0.9730.99
156_L172_I0.9710.99
7_L167_G0.9670.99
50_V88_D0.9650.98
240_A267_A0.9580.98
38_M82_L0.9420.98
131_S162_M0.9380.98
15_R144_D0.9370.98
223_D227_T0.9350.98
5_E92_A0.9350.98
247_D259_K0.9340.98
231_Q235_E0.9320.98
197_Q272_A0.9300.98
238_F267_A0.9170.98
54_S141_V0.9140.98
14_I24_V0.9100.98
98_I136_K0.9020.98
140_L167_G0.8920.97
243_I265_V0.8860.97
226_I244_Q0.8840.97
15_R142_Q0.8790.97
118_L246_R0.8770.97
138_F148_F0.8740.97
212_A278_K0.8740.97
226_I245_I0.8740.97
33_L41_V0.8740.97
76_Q80_E0.8710.97
70_R192_Y0.8690.97
118_L264_L0.8670.97
150_E153_F0.8670.97
234_N240_A0.8620.97
203_G207_V0.8590.97
70_R271_D0.8590.97
7_L91_F0.8590.97
211_I229_A0.8580.97
200_I269_L0.8460.97
199_K202_P0.8450.96
228_I231_Q0.8430.96
214_K219_E0.8370.96
248_A262_V0.8340.96
16_R20_E0.8310.96
55_I90_V0.8270.96
2_L9_L0.8260.96
163_V170_I0.8230.96
77_E80_E0.8210.96
111_V128_R0.8210.96
25_A47_R0.8110.96
210_S213_D0.8100.96
214_K218_G0.8070.95
226_I243_I0.8060.95
79_C83_N0.8040.95
14_I52_V0.8040.95
230_G240_A0.8030.95
3_I75_L0.8030.95
60_M132_T0.8010.95
196_E199_K0.8010.95
77_E191_G0.7970.95
18_R21_G0.7950.95
39_K42_D0.7950.95
57_V73_R0.7900.95
10_L141_V0.7810.95
43_E173_V0.7780.94
4_I140_L0.7740.94
17_L89_L0.7720.94
200_I203_G0.7690.94
33_L55_I0.7670.94
117_M246_R0.7660.94
15_R169_D0.7530.93
161_K164_A0.7510.93
247_D258_S0.7510.93
25_A145_I0.7490.93
65_P192_Y0.7480.93
153_F246_R0.7450.93
210_S214_K0.7450.93
125_G128_R0.7440.93
114_L117_M0.7420.93
50_V89_L0.7410.93
39_K43_E0.7410.93
117_M252_L0.7400.93
213_D217_A0.7370.93
82_L86_K0.7350.93
233_L240_A0.7340.93
113_G252_L0.7340.93
205_Y278_K0.7340.93
135_S139_N0.7310.92
147_C173_V0.7280.92
23_R145_I0.7270.92
114_L161_K0.7260.92
91_F97_E0.7240.92
134_V162_M0.7150.92
116_T125_G0.7150.92
104_E161_K0.7090.91
114_L251_L0.7080.91
5_E94_S0.7060.91
208_L278_K0.7060.91
26_L137_L0.7040.91
178_M186_L0.7030.91
249_D260_R0.7030.91
222_L226_I0.7020.91
203_G232_E0.7010.91
207_V233_L0.6990.91
82_L90_V0.6980.91
14_I144_D0.6980.91
245_I261_A0.6970.91
63_D126_H0.6960.90
226_I229_A0.6950.90
215_L261_A0.6950.90
14_I89_L0.6900.90
38_M84_K0.6900.90
23_R48_A0.6890.90
243_I263_I0.6830.90
161_K165_D0.6820.90
180_A202_P0.6810.90
246_R251_L0.6740.89
4_I9_L0.6730.89
200_I238_F0.6720.89
121_A125_G0.6710.89
118_L244_Q0.6700.89
196_E200_I0.6700.89
153_F251_L0.6690.89
41_V51_V0.6660.88
115_S131_S0.6660.88
207_V210_S0.6640.88
3_I90_V0.6620.88
207_V232_E0.6580.88
107_T166_M0.6580.88
119_E242_D0.6560.88
203_G238_F0.6530.87
14_I50_V0.6500.87
248_A279_M0.6500.87
52_V89_L0.6480.87
153_F279_M0.6480.87
8_P97_E0.6460.87
11_R14_I0.6460.87
222_L245_I0.6440.87
38_M42_D0.6440.87
66_E69_A0.6400.86
157_A251_L0.6400.86
100_P103_T0.6350.86
128_R132_T0.6340.86
263_I280_V0.6340.86
110_D116_T0.6330.86
14_I17_L0.6320.86
163_V168_F0.6300.86
35_D38_M0.6260.85
38_M55_I0.6260.85
25_A49_D0.6250.85
139_N142_Q0.6240.85
59_P95_V0.6240.85
44_A147_C0.6220.85
64_R272_A0.6190.85
153_F157_A0.6160.84
131_S135_S0.6140.84
64_R68_L0.6140.84
120_G125_G0.6130.84
210_S228_I0.6130.84
4_I14_I0.6130.84
229_A263_I0.6120.84
229_A265_V0.6110.84
174_G177_I0.6090.84
112_P115_S0.6080.84
164_A249_D0.6070.83
207_V229_A0.6050.83
221_D256_E0.6040.83
45_K85_R0.6010.83
223_D226_I0.6000.83
13_Q16_R0.5980.82
107_T161_K0.5980.82
53_V90_V0.5980.82
240_A243_I0.5980.82
23_R144_D0.5960.82
162_M168_F0.5960.82
202_P206_K0.5950.82
194_T272_A0.5950.82
200_I236_K0.5950.82
109_V132_T0.5940.82
215_L225_I0.5940.82
117_M253_E0.5930.82
74_T191_G0.5930.82
153_F248_A0.5910.82
264_L279_M0.5870.81
248_A261_A0.5870.81
222_L225_I0.5870.81
130_V138_F0.5860.81
28_P138_F0.5810.81
5_E9_L0.5790.80
16_R19_M0.5790.80
119_E122_S0.5790.80
209_S213_D0.5790.80
63_D119_E0.5790.80
60_M126_H0.5780.80
209_S278_K0.5770.80
13_Q50_V0.5760.80
70_R272_A0.5740.80
182_D191_G0.5720.80
117_M264_L0.5700.79
148_F172_I0.5700.79
244_Q264_L0.5690.79
10_L52_V0.5680.79
136_K139_N0.5650.79
194_T270_G0.5650.79
109_V131_S0.5620.78
134_V148_F0.5610.78
28_P137_L0.5610.78
107_T110_D0.5610.78
273_R277_N0.5510.77
227_T230_G0.5500.77
180_A205_Y0.5500.77
138_F172_I0.5470.77
114_L157_A0.5470.77
268_W271_D0.5460.76
246_R262_V0.5440.76
130_V158_L0.5440.76
8_P12_Q0.5440.76
266_A273_R0.5440.76
213_D216_Q0.5430.76
134_V137_L0.5430.76
23_R171_E0.5430.76
81_K85_R0.5430.76
24_V50_V0.5430.76
118_L243_I0.5430.76
232_E235_E0.5420.76
247_D261_A0.5410.76
153_F264_L0.5370.75
117_M120_G0.5370.75
146_A163_V0.5310.74
214_K217_A0.5300.74
163_V169_D0.5300.74
2_L16_R0.5290.74
118_L251_L0.5290.74
233_L269_L0.5280.74
9_L12_Q0.5260.74
102_G164_A0.5260.74
133_I136_K0.5260.74
18_R142_Q0.5250.74
126_H130_V0.5250.74
137_L141_V0.5240.74
42_D45_K0.5230.73
91_F136_K0.5220.73
55_I75_L0.5200.73
114_L120_G0.5190.73
138_F162_M0.5180.73
60_M125_G0.5170.73
134_V138_F0.5170.73
138_F141_V0.5140.72
82_L85_R0.5130.72
197_Q200_I0.5110.72
214_K225_I0.5100.72
26_L90_V0.5100.72
246_R250_T0.5080.71
119_E266_A0.5070.71
11_R169_D0.5050.71
242_D273_R0.5040.71
143_P170_I0.5000.70
134_V146_A0.5000.70
231_Q234_N0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v8fA 4 0.9682 100 0.022 Contact Map
3innA 4 0.9929 100 0.062 Contact Map
3mxtA 2 0.9894 100 0.062 Contact Map
3q12A 2 1 100 0.105 Contact Map
2ejcA 2 0.9859 100 0.192 Contact Map
3ag6A 2 0.9929 100 0.197 Contact Map
3uk2A 2 0.9682 100 0.201 Contact Map
3covA 2 0.9753 100 0.237 Contact Map
3n8hA 2 0.9081 100 0.243 Contact Map
2x0kA 5 0.8375 99.6 0.854 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0097 seconds.