GREMLIN Database
PRPC - 2-methylcitrate synthase
UniProt: P31660 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11756
Length: 389 (365)
Sequences: 4102 (2005)
Seq/√Len: 104.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
212_I225_G7.3841.00
163_E166_D5.3441.00
51_D381_P4.0811.00
209_S226_A3.9071.00
69_K75_E3.4141.00
73_R77_A3.3871.00
56_C382_F3.1671.00
171_G187_E3.1301.00
48_D51_D3.0921.00
183_S297_E2.9311.00
309_R312_T2.9221.00
54_K289_R2.8861.00
212_I229_A2.7541.00
168_S171_G2.7321.00
292_K308_D2.6361.00
72_T75_E2.6251.00
262_R267_E2.6211.00
217_S231_R2.6061.00
254_E257_A2.5471.00
204_A215_T2.5091.00
60_E76_L2.4341.00
186_W335_M2.4041.00
250_E254_E2.3811.00
247_Q333_N2.3601.00
256_E309_R2.3271.00
114_V227_I2.3181.00
211_V368_I2.2601.00
69_K380_R2.2371.00
172_H176_L2.1421.00
136_A355_A2.1351.00
208_T229_A2.1201.00
215_T229_A2.0531.00
170_G191_H2.0521.00
23_S366_K1.9931.00
289_R293_Q1.9611.00
147_L348_I1.8971.00
213_A222_A1.8891.00
95_T98_E1.8741.00
57_E76_L1.8731.00
62_A352_T1.8711.00
185_S297_E1.8591.00
307_A330_V1.8571.00
256_E313_V1.8541.00
63_H69_K1.8491.00
143_L351_V1.8251.00
309_R313_V1.8241.00
257_A261_K1.8141.00
167_D171_G1.7911.00
260_R264_E1.7851.00
337_V345_L1.7771.00
188_K191_H1.7751.00
247_Q339_T1.7711.00
152_H157_G1.7491.00
292_K296_Q1.7291.00
213_A358_I1.7271.00
47_Y380_R1.7181.00
193_S332_Y1.6791.00
240_E244_E1.6651.00
261_K265_N1.6431.00
301_L333_N1.6411.00
168_S187_E1.6381.00
177_L337_V1.6251.00
112_T115_S1.6191.00
50_L285_Q1.5951.00
111_R228_G1.5791.00
192_I290_V1.5721.00
128_T131_G1.5691.00
33_C199_E1.5481.00
77_A81_T1.5401.00
252_P309_R1.5371.00
183_S186_W1.5311.00
41_D48_D1.5281.00
66_I140_L1.5241.00
113_G146_I1.5181.00
163_E181_K1.5111.00
111_R115_S1.5061.00
261_K266_K1.4931.00
225_G229_A1.4691.00
91_A95_T1.4661.00
114_V143_L1.4511.00
109_V150_W1.4471.00
94_R149_Y1.4451.00
154_S340_E1.4411.00
74_D78_A1.4381.00
82_K137_D1.4201.00
188_K192_I1.4191.00
56_C195_V1.4131.00
184_Q188_K1.4101.00
95_T99_A1.4081.00
269_V314_M1.4051.00
63_H75_E1.4001.00
193_S287_I1.3991.00
59_E83_L1.3871.00
160_I176_L1.3851.00
204_A229_A1.3721.00
148_L173_F1.3691.00
61_V195_V1.3540.99
23_S275_P1.3430.99
208_T225_G1.3320.99
86_L138_K1.3300.99
201_E371_S1.3250.99
51_D55_H1.3240.99
230_L347_V1.3150.99
259_I314_M1.3120.99
96_V116_A1.3080.99
289_R292_K1.3050.99
291_A330_V1.3000.99
198_A352_T1.2970.99
208_T212_I1.2970.99
261_K267_E1.2890.99
272_F314_M1.2790.99
288_K311_E1.2770.99
65_L352_T1.2610.99
81_T85_A1.2570.99
217_S221_S1.2520.99
235_H238_A1.2500.99
139_L223_I1.2490.99
219_M355_A1.2440.99
280_A285_Q1.2400.99
131_G135_I1.2300.99
251_T302_K1.2240.99
296_Q301_L1.2120.99
249_Y262_R1.2100.99
221_S231_R1.2090.99
45_R68_G1.2080.99
135_I219_M1.2000.99
50_L286_V1.1990.99
208_T211_V1.1870.99
333_N339_T1.1760.99
37_K40_N1.1740.99
145_S162_P1.1730.99
29_N375_V1.1720.99
60_E382_F1.1710.99
162_P176_L1.1630.98
251_T254_E1.1540.98
163_E167_D1.1520.98
66_I355_A1.1520.98
107_M239_N1.1520.98
29_N373_N1.1510.98
209_S358_I1.1480.98
47_Y70_L1.1470.98
129_V363_Q1.1440.98
87_R169_I1.1330.98
77_A80_K1.1300.98
44_Y198_A1.1300.98
244_E339_T1.1290.98
110_M147_L1.1270.98
63_H67_H1.1240.98
288_K292_K1.1200.98
287_I331_S1.1100.98
31_A375_V1.0900.98
47_Y64_L1.0890.98
191_H195_V1.0880.98
290_V293_Q1.0830.98
97_L113_G1.0820.98
64_L70_L1.0760.97
78_A82_K1.0760.97
234_K268_V1.0740.97
178_H186_W1.0710.97
223_I355_A1.0710.97
49_I286_V1.0620.97
75_E78_A1.0590.97
89_L149_Y1.0540.97
82_K134_D1.0490.97
87_R164_T1.0490.97
58_F352_T1.0450.97
56_C60_E1.0420.97
252_P312_T1.0370.97
359_I363_Q1.0320.97
147_L344_P1.0260.97
134_D138_K1.0250.97
258_D262_R1.0200.96
86_L137_D1.0130.96
185_S293_Q1.0120.96
44_Y61_V1.0060.96
219_M358_I1.0040.96
94_R98_E1.0020.96
69_K72_T1.0010.96
80_K84_K1.0000.96
246_Q310_L0.9990.96
151_Y155_H0.9990.96
171_G184_Q0.9980.96
307_A329_A0.9960.96
249_Y258_D0.9870.96
105_H240_E0.9820.96
67_H133_R0.9790.96
51_D54_K0.9780.96
256_E260_R0.9770.95
210_R361_Q0.9740.95
74_D77_A0.9710.95
249_Y255_A0.9680.95
223_I351_V0.9610.95
172_H175_H0.9600.95
349_A352_T0.9590.95
57_E191_H0.9570.95
98_E158_E0.9570.95
43_H379_D0.9480.95
133_R359_I0.9480.95
245_I262_R0.9460.95
28_G202_F0.9450.95
111_R224_I0.9390.94
94_R161_Q0.9390.94
167_D172_H0.9350.94
288_K308_D0.9340.94
65_L198_A0.9340.94
188_K293_Q0.9300.94
238_A323_N0.9300.94
259_I313_V0.9280.94
57_E60_E0.9270.94
197_Y324_L0.9250.94
97_L153_Y0.9190.94
248_R267_E0.9130.94
252_P305_N0.9090.93
194_L348_I0.9040.93
308_D312_T0.9030.93
47_Y52_L0.9010.93
247_Q303_M0.9000.93
305_N308_D0.8980.93
135_I220_Y0.8900.93
217_S222_A0.8870.93
227_I347_V0.8820.92
215_T367_I0.8820.92
83_L137_D0.8820.92
200_H277_Y0.8770.92
255_A309_R0.8750.92
89_L146_I0.8720.92
205_S235_H0.8710.92
272_F322_P0.8690.92
307_A326_W0.8670.92
63_H79_Y0.8640.92
188_K290_V0.8630.91
126_G131_G0.8600.91
33_C201_E0.8590.91
202_F371_S0.8580.91
170_G187_E0.8560.91
250_E302_K0.8550.91
301_L305_N0.8530.91
291_A307_A0.8530.91
88_G161_Q0.8530.91
230_L236_G0.8510.91
34_T379_D0.8500.91
316_E319_K0.8490.91
59_E170_G0.8470.91
249_Y310_L0.8470.91
250_E253_D0.8430.91
136_A359_I0.8410.90
20_V364_D0.8360.90
52_L61_V0.8360.90
100_L116_A0.8350.90
32_L45_R0.8340.90
153_Y159_R0.8320.90
66_I352_T0.8320.90
236_G346_F0.8320.90
252_P306_I0.8320.90
115_S228_G0.8310.90
230_L346_F0.8310.90
34_T374_Y0.8250.90
132_A135_I0.8240.89
167_D187_E0.8230.89
96_V99_A0.8210.89
186_W294_L0.8210.89
216_G234_K0.8200.89
207_F368_I0.8180.89
239_N325_D0.8150.89
253_D257_A0.8120.89
82_K86_L0.8050.88
235_H325_D0.8040.88
207_F211_V0.8030.88
280_A288_K0.8020.88
170_G190_M0.8020.88
140_L169_I0.8010.88
241_V244_E0.7960.88
62_A140_L0.7900.87
145_S176_L0.7900.87
86_L134_D0.7890.87
257_A260_R0.7880.87
100_L119_C0.7860.87
160_I179_G0.7840.87
222_A358_I0.7830.87
76_L80_K0.7690.86
292_K304_Y0.7660.86
201_E372_A0.7650.86
242_S324_L0.7650.86
168_S191_H0.7640.86
58_F62_A0.7640.86
115_S224_I0.7610.85
52_L70_L0.7610.85
27_A207_F0.7590.85
162_P172_H0.7590.85
197_Y239_N0.7560.85
290_V331_S0.7550.85
156_N159_R0.7540.85
235_H346_F0.7540.85
44_Y64_L0.7520.85
242_S306_I0.7520.85
121_L138_K0.7510.85
141_A144_S0.7510.85
130_S134_D0.7490.85
92_N120_T0.7490.85
163_E175_H0.7470.84
131_G134_D0.7460.84
123_E134_D0.7420.84
185_S189_A0.7420.84
243_L342_F0.7390.84
86_L226_A0.7390.84
62_A79_Y0.7340.83
246_Q307_A0.7320.83
205_S236_G0.7280.83
123_E138_K0.7280.83
200_H236_G0.7260.83
88_G134_D0.7230.82
97_L150_W0.7170.82
239_N343_T0.7170.82
377_P380_R0.7170.82
53_A195_V0.7170.82
256_E259_I0.7170.82
39_G279_I0.7160.82
252_P256_E0.7150.82
197_Y328_S0.7150.82
260_R317_S0.7150.82
291_A331_S0.7150.82
148_L176_L0.7150.82
262_R265_N0.7130.81
212_I222_A0.7110.81
245_I258_D0.7090.81
170_G194_L0.7060.81
93_V97_L0.7040.81
42_L49_I0.7030.81
238_A273_G0.7000.80
248_R262_R0.6960.80
93_V113_G0.6950.80
36_G39_G0.6940.80
243_L339_T0.6930.80
287_I328_S0.6910.79
93_V116_A0.6880.79
60_E70_L0.6880.79
254_E261_K0.6870.79
244_E247_Q0.6840.79
242_S246_Q0.6840.79
255_A313_V0.6820.79
255_A306_I0.6820.79
58_F191_H0.6820.79
303_M333_N0.6800.78
96_V100_L0.6790.78
61_V198_A0.6770.78
347_V354_W0.6770.78
256_E316_E0.6760.78
249_Y259_I0.6760.78
92_N95_T0.6760.78
180_E186_W0.6760.78
136_A219_M0.6760.78
188_K195_V0.6760.78
82_K85_A0.6730.78
48_D381_P0.6730.78
98_E149_Y0.6710.77
19_S25_V0.6710.77
230_L239_N0.6690.77
218_D221_S0.6690.77
57_E188_K0.6680.77
206_T357_H0.6680.77
34_T37_K0.6640.77
30_T33_C0.6640.77
269_V318_K0.6640.77
160_I175_H0.6640.77
149_Y176_L0.6620.76
205_S325_D0.6610.76
93_V96_V0.6600.76
132_A362_R0.6600.76
216_G362_R0.6590.76
158_E161_Q0.6580.76
123_E126_G0.6560.76
304_Y308_D0.6560.76
47_Y69_K0.6560.76
305_N309_R0.6530.76
110_M227_I0.6530.76
78_A81_T0.6500.75
121_L135_I0.6490.75
252_P255_A0.6470.75
43_H48_D0.6450.75
194_L349_A0.6450.75
186_W298_G0.6430.74
182_P187_E0.6410.74
22_L25_V0.6410.74
37_K279_I0.6380.74
138_K142_S0.6380.74
192_I195_V0.6380.74
56_C191_H0.6360.74
337_V341_M0.6340.73
200_H346_F0.6330.73
167_D175_H0.6330.73
34_T39_G0.6320.73
275_P278_T0.6290.73
24_G207_F0.6290.73
83_L141_A0.6280.73
257_A264_E0.6280.73
200_H203_N0.6270.73
262_R266_K0.6260.72
152_H155_H0.6250.72
118_G218_D0.6230.72
59_E169_I0.6210.72
291_A304_Y0.6200.72
206_T343_T0.6160.71
91_A161_Q0.6150.71
295_S304_Y0.6140.71
196_L286_V0.6130.71
241_V270_I0.6130.71
273_G323_N0.6110.71
100_L104_S0.6100.70
49_I196_L0.6100.70
149_Y159_R0.6080.70
261_K264_E0.6070.70
357_H365_N0.6070.70
193_S197_Y0.6060.70
114_V139_L0.6060.70
26_P373_N0.6040.70
244_E248_R0.6030.70
311_E322_P0.6030.70
294_L331_S0.6000.69
97_L159_R0.6000.69
277_Y354_W0.5990.69
170_G174_L0.5990.69
203_N277_Y0.5980.69
157_G160_I0.5980.69
139_L219_M0.5970.69
205_S346_F0.5960.69
145_S172_H0.5950.69
197_Y325_D0.5950.69
351_V355_A0.5940.68
143_L146_I0.5940.68
36_G41_D0.5930.68
33_C43_H0.5910.68
62_A66_I0.5880.68
268_V367_I0.5880.68
324_L328_S0.5870.68
247_Q342_F0.5870.68
57_E80_K0.5860.67
218_D231_R0.5860.67
79_Y83_L0.5860.67
274_H346_F0.5850.67
57_E62_A0.5840.67
193_S345_L0.5820.67
216_G233_P0.5820.67
202_F210_R0.5800.67
30_T357_H0.5800.67
174_L187_E0.5800.67
259_I306_I0.5800.67
96_V112_T0.5790.67
280_A321_F0.5780.66
145_S148_L0.5780.66
243_L333_N0.5780.66
288_K327_F0.5770.66
152_H163_E0.5770.66
288_K304_Y0.5760.66
140_L355_A0.5730.66
45_R62_A0.5710.65
248_R252_P0.5710.65
89_L94_R0.5680.65
200_H205_S0.5680.65
118_G217_S0.5680.65
235_H273_G0.5680.65
191_H366_K0.5660.65
315_W319_K0.5660.65
201_E320_M0.5660.65
205_S230_L0.5660.65
323_N329_A0.5640.64
157_G161_Q0.5640.64
239_N342_F0.5620.64
47_Y51_D0.5620.64
273_G325_D0.5580.64
203_N346_F0.5570.64
315_W320_M0.5550.63
260_R263_V0.5550.63
203_N324_L0.5530.63
100_L112_T0.5530.63
149_Y153_Y0.5530.63
243_L307_A0.5520.63
243_L330_V0.5510.63
253_D256_E0.5490.62
140_L352_T0.5480.62
132_A136_A0.5470.62
86_L142_S0.5470.62
302_K305_N0.5450.62
262_R318_K0.5450.62
152_H160_I0.5450.62
132_A359_I0.5440.62
375_V378_E0.5440.62
315_W321_F0.5440.62
122_P138_K0.5440.62
332_Y342_F0.5440.62
22_L26_P0.5440.62
329_A346_F0.5440.62
73_R76_L0.5430.62
167_D182_P0.5420.61
28_G368_I0.5420.61
129_V359_I0.5420.61
121_L362_R0.5380.61
326_W342_F0.5370.61
34_T43_H0.5370.61
245_I249_Y0.5350.60
151_Y154_S0.5340.60
213_A362_R0.5330.60
156_N162_P0.5330.60
358_I372_A0.5330.60
18_K26_P0.5310.60
22_L207_F0.5300.60
260_R313_V0.5280.59
27_A211_V0.5280.59
292_K312_T0.5280.59
260_R316_E0.5270.59
189_A294_L0.5270.59
203_N274_H0.5260.59
52_L64_L0.5260.59
47_Y61_V0.5260.59
31_A363_Q0.5250.59
177_L341_M0.5250.59
203_N235_H0.5230.59
166_D181_K0.5220.59
113_G116_A0.5200.58
73_R184_Q0.5180.58
199_E355_A0.5180.58
324_L331_S0.5180.58
91_A166_D0.5160.58
210_R216_G0.5160.58
64_L198_A0.5150.58
47_Y55_H0.5150.58
174_L190_M0.5150.58
206_T210_R0.5140.57
142_S145_S0.5140.57
73_R180_E0.5110.57
33_C37_K0.5100.57
325_D346_F0.5100.57
199_E349_A0.5090.57
287_I332_Y0.5090.57
233_P238_A0.5090.57
294_L338_P0.5080.57
152_H156_N0.5070.56
24_G35_V0.5070.56
270_I320_M0.5060.56
210_R246_Q0.5050.56
376_G380_R0.5050.56
289_R312_T0.5040.56
80_K83_L0.5030.56
147_L227_I0.5010.56
36_G43_H0.5010.56
98_E153_Y0.5010.56
90_P101_P0.5010.56
148_L152_H0.5000.55
62_A210_R0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2h12A 4 0.9949 100 0.062 Contact Map
4xghA 5 0.91 100 0.063 Contact Map
2ibpA 2 0.9871 100 0.069 Contact Map
3o8jA 3 0.9357 100 0.07 Contact Map
1iomA 2 0.9512 100 0.076 Contact Map
4tvmA 2 0.8972 100 0.079 Contact Map
4jadA 5 0.9923 100 0.081 Contact Map
1o7xA 2 0.9357 100 0.082 Contact Map
3tqgA 2 0.9306 100 0.082 Contact Map
3hwkA 5 0.9434 100 0.083 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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