GREMLIN Database
HCHA - Molecular chaperone Hsp31 and glyoxalase 3
UniProt: P31658 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11755
Length: 283 (218)
Sequences: 2349 (1523)
Seq/√Len: 103.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
249_G268_A4.3791.00
198_D202_N3.9711.00
234_E237_K3.8991.00
258_L276_E3.3051.00
210_P242_I3.2221.00
212_A246_D3.1061.00
50_K91_E2.9641.00
272_L275_Q2.8331.00
211_D233_E2.8221.00
232_G236_K2.5841.00
93_E146_Y2.5321.00
151_V167_V2.5111.00
101_M128_R2.4961.00
205_S241_N2.4801.00
137_V145_E2.4111.00
243_I250_R2.3751.00
204_Y255_R2.3171.00
174_A179_R2.2691.00
132_K135_D2.2561.00
205_S243_I2.1621.00
199_N238_M2.0981.00
182_I273_A2.0321.00
251_V272_L1.9961.00
216_Q246_D1.9731.00
137_V144_S1.9691.00
180_F273_A1.9361.00
253_K276_E1.9341.00
234_E238_M1.9271.00
175_I256_K1.8931.00
51_I90_F1.8261.00
84_H271_K1.8231.00
253_K272_L1.7891.00
134_A166_D1.7101.00
143_D173_W1.6141.00
85_L273_A1.6041.00
90_F274_A1.5951.00
78_T94_V1.5911.00
109_M120_F1.5871.00
56_A156_G1.5681.00
148_A273_A1.5621.00
86_H92_F1.5451.00
163_E193_A1.5451.00
51_I148_A1.5431.00
151_V190_A1.5391.00
207_C242_I1.5211.00
215_K224_P1.5181.00
268_A272_L1.4951.00
169_A173_W1.4481.00
258_L269_L1.4151.00
83_Y87_A1.4091.00
248_T264_F1.3961.00
182_I258_L1.3741.00
267_N271_K1.3721.00
85_L270_G1.3400.99
192_L234_E1.3360.99
95_A133_L1.3170.99
208_A242_I1.2980.99
175_I204_Y1.2920.99
60_Y70_S1.2640.99
94_V126_L1.2620.99
50_K93_E1.2570.99
171_L194_L1.2530.99
178_D256_K1.2450.99
54_I167_V1.2440.99
172_Q176_K1.2360.99
232_G244_N1.2260.99
53_V92_F1.2200.99
58_E159_I1.2180.99
114_E117_M1.2060.99
231_F235_L1.2020.99
204_Y254_D1.1930.99
84_H274_A1.1770.98
171_L181_V1.1710.98
183_S191_F1.1640.98
51_I85_L1.1630.98
253_K258_L1.1590.98
193_A238_M1.1490.98
151_V171_L1.1280.98
183_S188_P1.1240.98
152_P161_L1.1210.98
166_D169_A1.1160.98
114_E118_P1.1100.98
81_P150_F1.1070.98
76_I266_A1.1010.98
195_R199_N1.0850.97
251_V268_A1.0800.97
76_I80_L1.0780.97
175_I200_P1.0760.97
131_K136_V1.0730.97
55_A78_T1.0720.97
131_K135_D1.0690.97
118_P122_Q1.0690.97
191_F257_L1.0680.97
144_S173_W1.0560.97
167_V190_A1.0540.97
86_H126_L1.0520.97
49_H90_F1.0480.97
125_S129_N1.0470.97
137_V143_D1.0440.97
157_A161_L1.0410.97
168_A172_Q1.0350.97
88_A274_A1.0270.96
189_A231_F1.0250.96
143_D174_A1.0230.96
216_Q247_I1.0220.96
73_N104_F1.0130.96
113_D116_V1.0080.96
206_I240_M1.0070.96
162_P193_A1.0060.96
100_L130_P0.9980.96
211_D230_Y0.9840.95
69_F107_W0.9830.95
95_A131_K0.9780.95
209_F247_I0.9770.95
97_I164_S0.9680.95
73_N102_T0.9660.95
55_A94_V0.9600.95
174_A181_V0.9560.95
189_A229_W0.9510.95
81_P266_A0.9510.95
75_P104_F0.9420.94
165_Q169_A0.9350.94
53_V269_L0.9320.94
85_L92_F0.9290.94
168_A194_L0.9260.94
61_L227_L0.9260.94
143_D170_A0.9260.94
215_K225_G0.9190.93
233_E236_K0.9140.93
85_L90_F0.9140.93
131_K146_Y0.9130.93
62_P66_G0.9070.93
53_V85_L0.9020.93
183_S259_T0.8980.93
144_S177_N0.8970.93
162_P189_A0.8950.93
212_A216_Q0.8930.92
206_I235_L0.8890.92
53_V78_T0.8890.92
271_K275_Q0.8800.92
189_A192_L0.8780.92
117_M121_E0.8720.92
117_M120_F0.8690.91
84_H267_N0.8660.91
55_A102_T0.8640.91
247_I264_F0.8570.91
83_Y118_P0.8550.91
213_A261_D0.8480.90
250_R253_K0.8460.90
80_L266_A0.8420.90
62_P159_I0.8400.90
55_A73_N0.8360.90
105_E108_A0.8350.90
82_L86_H0.8290.89
175_I181_V0.8230.89
157_A162_P0.8220.89
185_C263_P0.8190.89
205_S254_D0.8180.89
158_L229_W0.8170.89
243_I252_H0.8160.89
184_L269_L0.8140.88
80_L113_D0.8120.88
192_L231_F0.8020.88
115_K267_N0.7990.88
112_K116_V0.7970.87
113_D118_P0.7890.87
54_I95_A0.7750.86
96_T130_P0.7730.86
93_E131_K0.7720.86
162_P192_L0.7690.86
57_D100_L0.7680.85
230_Y233_E0.7670.85
212_A244_N0.7600.85
253_K275_Q0.7590.85
58_E61_L0.7580.85
102_T130_P0.7570.85
120_F124_K0.7560.85
251_V269_L0.7520.84
152_P157_A0.7520.84
54_I151_V0.7500.84
208_A240_M0.7450.84
102_T127_F0.7440.84
217_T223_M0.7430.83
179_R256_K0.7410.83
93_E126_L0.7400.83
52_L95_A0.7390.83
270_G274_A0.7360.83
134_A164_S0.7330.83
266_A270_G0.7310.83
158_L231_F0.7290.82
82_L94_V0.7280.82
205_S252_H0.7270.82
218_P224_P0.7260.82
180_F258_L0.7250.82
67_K226_H0.7220.82
83_Y115_K0.7170.81
187_G190_A0.7150.81
61_L159_I0.7060.80
168_A193_A0.7030.80
201_L235_L0.7020.80
87_A118_P0.7010.80
203_G241_N0.7010.80
180_F256_K0.7000.80
173_W177_N0.6990.80
75_P109_M0.6960.79
249_G271_K0.6960.79
224_P230_Y0.6960.79
124_K128_R0.6930.79
137_V170_A0.6930.79
272_L276_E0.6860.78
195_R238_M0.6830.78
74_H108_A0.6830.78
233_E237_K0.6800.78
133_L171_L0.6750.77
151_V161_L0.6730.77
85_L182_I0.6710.77
143_D177_N0.6710.77
149_I171_L0.6700.77
136_V146_Y0.6680.76
162_P229_W0.6640.76
191_F194_L0.6580.75
61_L68_L0.6570.75
90_F277_M0.6510.75
245_D250_R0.6480.74
77_E185_C0.6450.74
56_A103_K0.6450.74
57_D97_I0.6440.74
235_L240_M0.6440.74
71_T155_H0.6390.73
172_Q195_R0.6360.73
97_I133_L0.6360.73
231_F234_E0.6360.73
150_F184_L0.6350.73
150_F269_L0.6340.73
119_F123_H0.6320.72
170_A179_R0.6320.72
211_D215_K0.6310.72
180_F276_E0.6260.72
169_A172_Q0.6260.72
217_T247_I0.6240.72
175_I178_D0.6240.72
78_T124_K0.6240.72
96_T100_L0.6230.71
256_K273_A0.6220.71
111_H120_F0.6200.71
81_P85_L0.6190.71
53_V152_P0.6180.71
50_K145_E0.6180.71
149_I170_A0.6170.71
199_N206_I0.6140.70
82_L92_F0.6130.70
90_F278_L0.6100.70
167_V171_L0.6100.70
73_N152_P0.6090.70
73_N127_F0.6070.69
52_L136_V0.6070.69
116_V120_F0.6060.69
116_V119_F0.6050.69
210_P213_A0.6030.69
268_A271_K0.6020.69
54_I149_I0.6020.69
107_W110_P0.6020.69
83_Y119_F0.6000.69
242_I250_R0.5970.68
170_A174_A0.5950.68
71_T105_E0.5950.68
258_L273_A0.5930.68
119_F122_Q0.5930.68
199_N240_M0.5860.67
201_L206_I0.5860.67
60_Y68_L0.5850.67
208_A231_F0.5850.67
155_H263_P0.5780.66
208_A233_E0.5770.66
149_I152_P0.5770.66
111_H115_K0.5760.65
59_R103_K0.5750.65
206_I257_L0.5750.65
87_A274_A0.5730.65
133_L167_V0.5720.65
56_A155_H0.5680.64
184_L262_S0.5660.64
69_F110_P0.5660.64
132_K166_D0.5660.64
245_D248_T0.5640.64
90_F147_A0.5640.64
207_C245_D0.5620.64
94_V102_T0.5620.64
153_G161_L0.5590.63
126_L131_K0.5570.63
149_I169_A0.5540.62
113_D119_F0.5530.62
211_D236_K0.5520.62
181_V256_K0.5510.62
97_I157_A0.5500.62
100_L103_K0.5460.61
155_H227_L0.5460.61
129_N169_A0.5450.61
95_A166_D0.5450.61
182_I269_L0.5410.61
62_P67_K0.5390.60
207_C269_L0.5360.60
171_L179_R0.5340.60
112_K117_M0.5310.59
85_L148_A0.5290.59
210_P262_S0.5280.59
188_P259_T0.5280.59
203_G239_G0.5280.59
148_A277_M0.5250.58
59_R98_S0.5240.58
275_Q278_L0.5230.58
71_T223_M0.5210.58
96_T102_T0.5210.58
195_R200_P0.5210.58
184_L260_G0.5190.57
57_D96_T0.5170.57
125_S128_R0.5160.57
78_T152_P0.5150.57
172_Q200_P0.5120.56
206_I233_E0.5100.56
54_I179_R0.5090.56
79_L266_A0.5070.56
57_D98_S0.5040.55
94_V130_P0.5040.55
80_L267_N0.5040.55
158_L189_A0.5030.55
158_L227_L0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i4nA 2 0.9859 100 0.434 Contact Map
1n57A 2 0.9823 100 0.461 Contact Map
4p5pA 1 0.7739 100 0.536 Contact Map
3kklA 2 0.7456 100 0.546 Contact Map
4lruA 1 0.8057 100 0.547 Contact Map
4qyxA 2 0.7915 100 0.552 Contact Map
1u9cA 1 0.7668 100 0.554 Contact Map
3n7tA 2 0.8127 100 0.558 Contact Map
3l3bA 2 0.6996 100 0.642 Contact Map
1vhqA 2 0.6996 100 0.665 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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