HCHA - ECOLI - GREMLIN Contacts

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HCHA - Molecular chaperone Hsp31 and glyoxalase 3

UniProt:	P31658	Sequences: MTVQTSKNPQVDIAEDNAFFPSEYSLSQYTSPVSDLDGVDYPKPYRGKHKILVIAADERYLPTDNGKLFSTGNHPIETLLPLYHLHAAGFEFEVATISGLMTKFEYWAMPHKDEKVMPFFEQHKSLFRNPKKLADVVASLNADSEYAAIFVPGGHGALIGLPESQDVAAALQWAIKNDRFVISLCHGPAAFLALRHGDNPLNGYSICAFPDAADKQTPEIGYMPGHLTWYFGEELKKMGMNIINDDITGRVHKDRKLLTGDSPFAANALGKLAAQEMLAAYAG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11755
Length:	283 (218)
Sequences:	2349 (1523)
Seq/√Len:	103.2

ECOLI - HCHA
HALSA - Q9HRT2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
249_G	268_A	4.379	1.00
198_D	202_N	3.971	1.00
234_E	237_K	3.899	1.00
258_L	276_E	3.305	1.00
210_P	242_I	3.222	1.00
212_A	246_D	3.106	1.00
50_K	91_E	2.964	1.00
272_L	275_Q	2.833	1.00
211_D	233_E	2.822	1.00
232_G	236_K	2.584	1.00
93_E	146_Y	2.532	1.00
151_V	167_V	2.511	1.00
101_M	128_R	2.496	1.00
205_S	241_N	2.480	1.00
137_V	145_E	2.411	1.00
243_I	250_R	2.375	1.00
204_Y	255_R	2.317	1.00
174_A	179_R	2.269	1.00
132_K	135_D	2.256	1.00
205_S	243_I	2.162	1.00
199_N	238_M	2.098	1.00
182_I	273_A	2.032	1.00
251_V	272_L	1.996	1.00
216_Q	246_D	1.973	1.00
137_V	144_S	1.969	1.00
180_F	273_A	1.936	1.00
253_K	276_E	1.934	1.00
234_E	238_M	1.927	1.00
175_I	256_K	1.893	1.00
51_I	90_F	1.826	1.00
84_H	271_K	1.823	1.00
253_K	272_L	1.789	1.00
134_A	166_D	1.710	1.00
143_D	173_W	1.614	1.00
85_L	273_A	1.604	1.00
90_F	274_A	1.595	1.00
78_T	94_V	1.591	1.00
109_M	120_F	1.587	1.00
56_A	156_G	1.568	1.00
148_A	273_A	1.562	1.00
86_H	92_F	1.545	1.00
163_E	193_A	1.545	1.00
51_I	148_A	1.543	1.00
151_V	190_A	1.539	1.00
207_C	242_I	1.521	1.00
215_K	224_P	1.518	1.00
268_A	272_L	1.495	1.00
169_A	173_W	1.448	1.00
258_L	269_L	1.415	1.00
83_Y	87_A	1.409	1.00
248_T	264_F	1.396	1.00
182_I	258_L	1.374	1.00
267_N	271_K	1.372	1.00
85_L	270_G	1.340	0.99
192_L	234_E	1.336	0.99
95_A	133_L	1.317	0.99
208_A	242_I	1.298	0.99
175_I	204_Y	1.292	0.99
60_Y	70_S	1.264	0.99
94_V	126_L	1.262	0.99
50_K	93_E	1.257	0.99
171_L	194_L	1.253	0.99
178_D	256_K	1.245	0.99
54_I	167_V	1.244	0.99
172_Q	176_K	1.236	0.99
232_G	244_N	1.226	0.99
53_V	92_F	1.220	0.99
58_E	159_I	1.218	0.99
114_E	117_M	1.206	0.99
231_F	235_L	1.202	0.99
204_Y	254_D	1.193	0.99
84_H	274_A	1.177	0.98
171_L	181_V	1.171	0.98
183_S	191_F	1.164	0.98
51_I	85_L	1.163	0.98
253_K	258_L	1.159	0.98
193_A	238_M	1.149	0.98
151_V	171_L	1.128	0.98
183_S	188_P	1.124	0.98
152_P	161_L	1.121	0.98
166_D	169_A	1.116	0.98
114_E	118_P	1.110	0.98
81_P	150_F	1.107	0.98
76_I	266_A	1.101	0.98
195_R	199_N	1.085	0.97
251_V	268_A	1.080	0.97
76_I	80_L	1.078	0.97
175_I	200_P	1.076	0.97
131_K	136_V	1.073	0.97
55_A	78_T	1.072	0.97
131_K	135_D	1.069	0.97
118_P	122_Q	1.069	0.97
191_F	257_L	1.068	0.97
144_S	173_W	1.056	0.97
167_V	190_A	1.054	0.97
86_H	126_L	1.052	0.97
49_H	90_F	1.048	0.97
125_S	129_N	1.047	0.97
137_V	143_D	1.044	0.97
157_A	161_L	1.041	0.97
168_A	172_Q	1.035	0.97
88_A	274_A	1.027	0.96
189_A	231_F	1.025	0.96
143_D	174_A	1.023	0.96
216_Q	247_I	1.022	0.96
73_N	104_F	1.013	0.96
113_D	116_V	1.008	0.96
206_I	240_M	1.007	0.96
162_P	193_A	1.006	0.96
100_L	130_P	0.998	0.96
211_D	230_Y	0.984	0.95
69_F	107_W	0.983	0.95
95_A	131_K	0.978	0.95
209_F	247_I	0.977	0.95
97_I	164_S	0.968	0.95
73_N	102_T	0.966	0.95
55_A	94_V	0.960	0.95
174_A	181_V	0.956	0.95
189_A	229_W	0.951	0.95
81_P	266_A	0.951	0.95
75_P	104_F	0.942	0.94
165_Q	169_A	0.935	0.94
53_V	269_L	0.932	0.94
85_L	92_F	0.929	0.94
168_A	194_L	0.926	0.94
61_L	227_L	0.926	0.94
143_D	170_A	0.926	0.94
215_K	225_G	0.919	0.93
233_E	236_K	0.914	0.93
85_L	90_F	0.914	0.93
131_K	146_Y	0.913	0.93
62_P	66_G	0.907	0.93
53_V	85_L	0.902	0.93
183_S	259_T	0.898	0.93
144_S	177_N	0.897	0.93
162_P	189_A	0.895	0.93
212_A	216_Q	0.893	0.92
206_I	235_L	0.889	0.92
53_V	78_T	0.889	0.92
271_K	275_Q	0.880	0.92
189_A	192_L	0.878	0.92
117_M	121_E	0.872	0.92
117_M	120_F	0.869	0.91
84_H	267_N	0.866	0.91
55_A	102_T	0.864	0.91
247_I	264_F	0.857	0.91
83_Y	118_P	0.855	0.91
213_A	261_D	0.848	0.90
250_R	253_K	0.846	0.90
80_L	266_A	0.842	0.90
62_P	159_I	0.840	0.90
55_A	73_N	0.836	0.90
105_E	108_A	0.835	0.90
82_L	86_H	0.829	0.89
175_I	181_V	0.823	0.89
157_A	162_P	0.822	0.89
185_C	263_P	0.819	0.89
205_S	254_D	0.818	0.89
158_L	229_W	0.817	0.89
243_I	252_H	0.816	0.89
184_L	269_L	0.814	0.88
80_L	113_D	0.812	0.88
192_L	231_F	0.802	0.88
115_K	267_N	0.799	0.88
112_K	116_V	0.797	0.87
113_D	118_P	0.789	0.87
54_I	95_A	0.775	0.86
96_T	130_P	0.773	0.86
93_E	131_K	0.772	0.86
162_P	192_L	0.769	0.86
57_D	100_L	0.768	0.85
230_Y	233_E	0.767	0.85
212_A	244_N	0.760	0.85
253_K	275_Q	0.759	0.85
58_E	61_L	0.758	0.85
102_T	130_P	0.757	0.85
120_F	124_K	0.756	0.85
251_V	269_L	0.752	0.84
152_P	157_A	0.752	0.84
54_I	151_V	0.750	0.84
208_A	240_M	0.745	0.84
102_T	127_F	0.744	0.84
217_T	223_M	0.743	0.83
179_R	256_K	0.741	0.83
93_E	126_L	0.740	0.83
52_L	95_A	0.739	0.83
270_G	274_A	0.736	0.83
134_A	164_S	0.733	0.83
266_A	270_G	0.731	0.83
158_L	231_F	0.729	0.82
82_L	94_V	0.728	0.82
205_S	252_H	0.727	0.82
218_P	224_P	0.726	0.82
180_F	258_L	0.725	0.82
67_K	226_H	0.722	0.82
83_Y	115_K	0.717	0.81
187_G	190_A	0.715	0.81
61_L	159_I	0.706	0.80
168_A	193_A	0.703	0.80
201_L	235_L	0.702	0.80
87_A	118_P	0.701	0.80
203_G	241_N	0.701	0.80
180_F	256_K	0.700	0.80
173_W	177_N	0.699	0.80
75_P	109_M	0.696	0.79
249_G	271_K	0.696	0.79
224_P	230_Y	0.696	0.79
124_K	128_R	0.693	0.79
137_V	170_A	0.693	0.79
272_L	276_E	0.686	0.78
195_R	238_M	0.683	0.78
74_H	108_A	0.683	0.78
233_E	237_K	0.680	0.78
133_L	171_L	0.675	0.77
151_V	161_L	0.673	0.77
85_L	182_I	0.671	0.77
143_D	177_N	0.671	0.77
149_I	171_L	0.670	0.77
136_V	146_Y	0.668	0.76
162_P	229_W	0.664	0.76
191_F	194_L	0.658	0.75
61_L	68_L	0.657	0.75
90_F	277_M	0.651	0.75
245_D	250_R	0.648	0.74
77_E	185_C	0.645	0.74
56_A	103_K	0.645	0.74
57_D	97_I	0.644	0.74
235_L	240_M	0.644	0.74
71_T	155_H	0.639	0.73
172_Q	195_R	0.636	0.73
97_I	133_L	0.636	0.73
231_F	234_E	0.636	0.73
150_F	184_L	0.635	0.73
150_F	269_L	0.634	0.73
119_F	123_H	0.632	0.72
170_A	179_R	0.632	0.72
211_D	215_K	0.631	0.72
180_F	276_E	0.626	0.72
169_A	172_Q	0.626	0.72
217_T	247_I	0.624	0.72
175_I	178_D	0.624	0.72
78_T	124_K	0.624	0.72
96_T	100_L	0.623	0.71
256_K	273_A	0.622	0.71
111_H	120_F	0.620	0.71
81_P	85_L	0.619	0.71
53_V	152_P	0.618	0.71
50_K	145_E	0.618	0.71
149_I	170_A	0.617	0.71
199_N	206_I	0.614	0.70
82_L	92_F	0.613	0.70
90_F	278_L	0.610	0.70
167_V	171_L	0.610	0.70
73_N	152_P	0.609	0.70
73_N	127_F	0.607	0.69
52_L	136_V	0.607	0.69
116_V	120_F	0.606	0.69
116_V	119_F	0.605	0.69
210_P	213_A	0.603	0.69
268_A	271_K	0.602	0.69
54_I	149_I	0.602	0.69
107_W	110_P	0.602	0.69
83_Y	119_F	0.600	0.69
242_I	250_R	0.597	0.68
170_A	174_A	0.595	0.68
71_T	105_E	0.595	0.68
258_L	273_A	0.593	0.68
119_F	122_Q	0.593	0.68
199_N	240_M	0.586	0.67
201_L	206_I	0.586	0.67
60_Y	68_L	0.585	0.67
208_A	231_F	0.585	0.67
155_H	263_P	0.578	0.66
208_A	233_E	0.577	0.66
149_I	152_P	0.577	0.66
111_H	115_K	0.576	0.65
59_R	103_K	0.575	0.65
206_I	257_L	0.575	0.65
87_A	274_A	0.573	0.65
133_L	167_V	0.572	0.65
56_A	155_H	0.568	0.64
184_L	262_S	0.566	0.64
69_F	110_P	0.566	0.64
132_K	166_D	0.566	0.64
245_D	248_T	0.564	0.64
90_F	147_A	0.564	0.64
207_C	245_D	0.562	0.64
94_V	102_T	0.562	0.64
153_G	161_L	0.559	0.63
126_L	131_K	0.557	0.63
149_I	169_A	0.554	0.62
113_D	119_F	0.553	0.62
211_D	236_K	0.552	0.62
181_V	256_K	0.551	0.62
97_I	157_A	0.550	0.62
100_L	103_K	0.546	0.61
155_H	227_L	0.546	0.61
129_N	169_A	0.545	0.61
95_A	166_D	0.545	0.61
182_I	269_L	0.541	0.61
62_P	67_K	0.539	0.60
207_C	269_L	0.536	0.60
171_L	179_R	0.534	0.60
112_K	117_M	0.531	0.59
85_L	148_A	0.529	0.59
210_P	262_S	0.528	0.59
188_P	259_T	0.528	0.59
203_G	239_G	0.528	0.59
148_A	277_M	0.525	0.58
59_R	98_S	0.524	0.58
275_Q	278_L	0.523	0.58
71_T	223_M	0.521	0.58
96_T	102_T	0.521	0.58
195_R	200_P	0.521	0.58
184_L	260_G	0.519	0.57
57_D	96_T	0.517	0.57
125_S	128_R	0.516	0.57
78_T	152_P	0.515	0.57
172_Q	200_P	0.512	0.56
206_I	233_E	0.510	0.56
54_I	179_R	0.509	0.56
79_L	266_A	0.507	0.56
57_D	98_S	0.504	0.55
94_V	130_P	0.504	0.55
80_L	267_N	0.504	0.55
158_L	189_A	0.503	0.55
158_L	227_L	0.500	0.55

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4i4nA	2	0.9859	100	0.434	Contact Map
1n57A	2	0.9823	100	0.461	Contact Map
4p5pA	1	0.7739	100	0.536	Contact Map
3kklA	2	0.7456	100	0.546	Contact Map
4lruA	1	0.8057	100	0.547	Contact Map
4qyxA	2	0.7915	100	0.552	Contact Map
1u9cA	1	0.7668	100	0.554	Contact Map
3n7tA	2	0.8127	100	0.558	Contact Map
3l3bA	2	0.6996	100	0.642	Contact Map
1vhqA	2	0.6996	100	0.665	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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