FIXB - ECOLI - GREMLIN Contacts

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FIXB - Protein FixB

UniProt:	P31574	Sequences: MNTFSQVWVFSDTPSRLPELMNGAQALANQINTFVLNDADGAQAIQLGANHVWKLNGKPDDRMIEDYAGVMADTIRQHGADGLVLLPNTRRGKLLAAKLGYRLKAAVSNDASTVSVQDGKATVKHMVYGGLAIGEERIATPYAVLTISSGTFDAAQPDASRTGETHTVEWQAPAVAITRTATQARQSNSVDLDKARLVVSVGRGIGSKENIALAEQLCKAIGAELACSRPVAENEKWMEHERYVGISNLMLKPELYLAVGISGQIQHMVGANASQTIFAINKDKNAPIFQYADYGIVGDAVKILPALTAALAR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11563
Length:	313 (300)
Sequences:	4096 (2484)
Seq/√Len:	143.4

ECOLI - FIXB YDIR YGCQ
BACSU - ETFA
HALSA - Q9HND2
SULSO - Q97V19 Q97V72

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
298_G	303_I	5.031	1.00
289_F	295_G	3.617	1.00
259_V	280_I	3.437	1.00
196_R	254_E	3.421	1.00
200_S	261_I	3.281	1.00
86_L	96_A	3.133	1.00
51_H	166_H	2.697	1.00
198_V	251_L	2.646	1.00
201_V	211_I	2.598	1.00
259_V	304_L	2.597	1.00
23_G	26_A	2.590	1.00
45_I	163_G	2.558	1.00
220_A	308_T	2.434	1.00
22_N	155_A	2.326	1.00
75_I	84_V	2.306	1.00
51_H	164_E	2.243	1.00
25_Q	29_N	2.216	1.00
212_A	215_E	2.182	1.00
238_M	242_R	2.146	1.00
212_A	216_Q	2.079	1.00
268_M	291_Y	2.074	1.00
38_D	56_N	2.063	1.00
227_C	238_M	2.056	1.00
201_V	214_A	2.036	1.00
216_Q	308_T	2.018	1.00
276_T	294_Y	1.993	1.00
197_L	223_A	1.956	1.00
255_L	278_F	1.939	1.00
279_A	292_A	1.937	1.00
259_V	300_A	1.925	1.00
20_L	85_L	1.922	1.00
116_V	121_A	1.916	1.00
215_E	225_L	1.916	1.00
217_L	308_T	1.910	1.00
41_G	167_T	1.892	1.00
210_N	301_V	1.871	1.00
38_D	60_D	1.830	1.00
228_S	261_I	1.829	1.00
205_I	214_A	1.811	1.00
38_D	58_K	1.796	1.00
124_K	133_I	1.788	1.00
113_T	124_K	1.762	1.00
200_S	258_A	1.751	1.00
279_A	288_I	1.740	1.00
254_E	275_Q	1.736	1.00
111_A	145_L	1.735	1.00
68_A	102_R	1.733	1.00
256_Y	267_H	1.722	1.00
214_A	259_V	1.718	1.00
217_L	304_L	1.713	1.00
72_A	102_R	1.711	1.00
11_S	18_P	1.703	1.00
191_D	194_K	1.686	1.00
200_S	244_V	1.673	1.00
306_A	309_A	1.670	1.00
72_A	99_L	1.663	1.00
251_L	271_A	1.603	1.00
198_V	226_A	1.579	1.00
192_L	198_V	1.577	1.00
271_A	274_S	1.574	1.00
217_L	221_I	1.562	1.00
199_V	217_L	1.556	1.00
96_A	146_T	1.553	1.00
85_L	145_L	1.552	1.00
53_W	166_H	1.531	1.00
63_M	66_D	1.529	1.00
64_I	94_L	1.505	1.00
20_L	87_P	1.503	1.00
72_A	76_R	1.496	1.00
77_Q	168_V	1.482	1.00
239_E	242_R	1.479	1.00
28_A	32_N	1.475	1.00
39_A	56_N	1.475	1.00
211_I	225_L	1.473	1.00
30_Q	115_S	1.470	1.00
25_Q	50_N	1.424	1.00
115_S	124_K	1.398	1.00
215_E	219_K	1.375	1.00
73_D	77_Q	1.372	1.00
227_C	231_V	1.340	1.00
189_S	219_K	1.337	1.00
73_D	76_R	1.335	1.00
108_S	138_I	1.330	1.00
7_V	24_A	1.328	1.00
213_L	304_L	1.317	1.00
12_D	89_T	1.310	1.00
220_A	311_L	1.310	1.00
112_S	124_K	1.293	1.00
71_M	99_L	1.283	1.00
296_I	303_I	1.278	1.00
258_A	267_H	1.270	1.00
258_A	261_I	1.261	1.00
216_Q	220_A	1.260	1.00
61_D	182_T	1.256	1.00
205_I	300_A	1.245	1.00
32_N	50_N	1.242	1.00
302_K	306_A	1.242	1.00
53_W	168_V	1.231	1.00
45_I	52_V	1.230	1.00
10_F	95_L	1.226	1.00
53_W	78_H	1.219	1.00
306_A	310_A	1.217	1.00
99_L	144_V	1.213	1.00
43_Q	46_Q	1.212	1.00
226_A	244_V	1.212	1.00
55_L	70_V	1.209	1.00
227_C	232_A	1.208	1.00
193_D	249_L	1.207	1.00
8_W	74_T	1.207	1.00
19_E	150_G	1.207	1.00
67_Y	95_L	1.205	1.00
46_Q	157_P	1.197	1.00
213_L	216_Q	1.197	1.00
11_S	44_A	1.196	1.00
81_D	142_Y	1.193	1.00
110_D	148_S	1.189	1.00
122_T	135_E	1.189	1.00
205_I	210_N	1.187	1.00
43_Q	157_P	1.179	1.00
54_K	167_T	1.170	1.00
40_D	56_N	1.166	1.00
40_D	54_K	1.161	1.00
207_S	237_W	1.157	1.00
41_G	56_N	1.151	0.99
201_V	231_V	1.148	0.99
111_A	147_I	1.145	0.99
112_S	133_I	1.141	0.99
28_A	31_I	1.129	0.99
56_N	167_T	1.127	0.99
200_S	251_L	1.126	0.99
228_S	244_V	1.125	0.99
289_F	297_V	1.123	0.99
71_M	95_L	1.111	0.99
11_S	33_T	1.110	0.99
46_Q	158_D	1.106	0.99
36_L	67_Y	1.100	0.99
74_T	168_V	1.098	0.99
127_V	132_A	1.097	0.99
173_P	176_A	1.090	0.99
304_L	308_T	1.088	0.99
211_I	231_V	1.080	0.99
232_A	243_Y	1.075	0.99
172_A	175_V	1.074	0.99
10_F	71_M	1.068	0.99
121_A	143_A	1.063	0.99
208_K	238_M	1.062	0.99
36_L	70_V	1.050	0.99
244_V	258_A	1.048	0.99
26_A	113_T	1.046	0.99
209_E	212_A	1.045	0.99
68_A	99_L	1.045	0.99
121_A	137_R	1.037	0.99
52_V	163_G	1.024	0.99
42_A	46_Q	1.022	0.99
300_A	305_P	1.020	0.99
115_S	135_E	1.018	0.99
103_L	144_V	1.013	0.99
62_R	67_Y	1.012	0.99
230_P	235_E	1.007	0.99
68_A	98_K	1.007	0.99
201_V	205_I	1.004	0.99
213_L	308_T	1.001	0.99
96_A	107_V	0.999	0.99
219_K	222_G	0.999	0.99
200_S	226_A	0.998	0.99
200_S	228_S	0.998	0.99
298_G	302_K	0.994	0.98
9_V	21_M	0.988	0.98
108_S	111_A	0.987	0.98
204_G	237_W	0.987	0.98
218_C	225_L	0.981	0.98
107_V	144_V	0.981	0.98
206_G	301_V	0.978	0.98
47_L	156_Q	0.977	0.98
224_E	242_R	0.964	0.98
226_A	242_R	0.961	0.98
77_Q	166_H	0.961	0.98
179_R	182_T	0.959	0.98
45_I	158_D	0.958	0.98
7_V	31_I	0.955	0.98
27_L	85_L	0.953	0.98
34_F	71_M	0.951	0.98
75_I	80_A	0.947	0.98
21_M	49_A	0.941	0.98
252_K	273_A	0.934	0.98
257_L	280_I	0.932	0.98
105_A	144_V	0.929	0.98
75_I	103_L	0.925	0.98
76_R	79_G	0.916	0.97
231_V	238_M	0.913	0.97
201_V	238_M	0.911	0.97
231_V	237_W	0.909	0.97
214_A	225_L	0.903	0.97
69_G	73_D	0.902	0.97
72_A	103_L	0.901	0.97
107_V	146_T	0.896	0.97
149_S	250_M	0.887	0.97
210_N	213_L	0.886	0.97
211_I	238_M	0.886	0.97
93_K	110_D	0.884	0.97
45_I	165_T	0.882	0.97
172_A	177_I	0.875	0.97
211_I	214_A	0.864	0.96
37_N	56_N	0.861	0.96
192_L	226_A	0.860	0.96
53_W	74_T	0.858	0.96
106_A	138_I	0.857	0.96
9_V	85_L	0.855	0.96
111_A	114_V	0.851	0.96
124_K	135_E	0.848	0.96
216_Q	225_L	0.847	0.96
88_N	92_G	0.847	0.96
160_S	163_G	0.847	0.96
280_I	303_I	0.847	0.96
21_M	155_A	0.842	0.96
172_A	176_A	0.839	0.96
32_N	78_H	0.837	0.96
43_Q	47_L	0.835	0.96
123_V	145_L	0.833	0.96
98_K	102_R	0.827	0.95
86_L	146_T	0.826	0.95
81_D	141_P	0.826	0.95
213_L	305_P	0.824	0.95
253_P	274_S	0.823	0.95
106_A	140_T	0.819	0.95
75_I	142_Y	0.817	0.95
207_S	210_N	0.817	0.95
25_Q	47_L	0.816	0.95
88_N	110_D	0.816	0.95
114_V	123_V	0.814	0.95
62_R	94_L	0.811	0.95
205_I	211_I	0.811	0.95
46_Q	160_S	0.805	0.95
213_L	259_V	0.801	0.94
9_V	20_L	0.800	0.94
6_Q	32_N	0.800	0.94
69_G	174_A	0.797	0.94
64_I	98_K	0.793	0.94
65_E	176_A	0.792	0.94
15_S	40_D	0.788	0.94
78_H	166_H	0.788	0.94
42_A	45_I	0.786	0.94
122_T	137_R	0.785	0.94
11_S	35_V	0.784	0.94
205_I	208_K	0.783	0.94
111_A	123_V	0.777	0.94
117_Q	121_A	0.772	0.93
100_G	107_V	0.766	0.93
123_V	143_A	0.764	0.93
19_E	154_A	0.764	0.93
204_G	208_K	0.764	0.93
92_G	95_L	0.763	0.93
204_G	210_N	0.763	0.93
198_V	224_E	0.761	0.93
30_Q	50_N	0.761	0.93
34_F	74_T	0.758	0.93
126_M	148_S	0.755	0.93
121_A	145_L	0.753	0.92
257_L	278_F	0.749	0.92
205_I	301_V	0.747	0.92
192_L	249_L	0.745	0.92
271_A	291_Y	0.742	0.92
208_K	237_W	0.739	0.92
73_D	171_Q	0.739	0.92
10_F	84_V	0.733	0.91
76_R	103_L	0.732	0.91
73_D	169_E	0.732	0.91
158_D	162_T	0.732	0.91
207_S	301_V	0.726	0.91
86_L	92_G	0.723	0.91
138_I	143_A	0.722	0.91
205_I	213_L	0.721	0.91
41_G	54_K	0.720	0.91
74_T	78_H	0.709	0.90
62_R	95_L	0.702	0.90
46_Q	159_A	0.701	0.89
234_N	243_Y	0.696	0.89
208_K	215_E	0.695	0.89
103_L	142_Y	0.694	0.89
129_G	148_S	0.692	0.89
23_G	152_F	0.690	0.89
14_P	17_L	0.688	0.89
201_V	227_C	0.687	0.89
258_A	288_I	0.685	0.88
153_D	156_Q	0.684	0.88
205_I	237_W	0.683	0.88
8_W	78_H	0.680	0.88
268_M	290_Q	0.678	0.88
10_F	86_L	0.675	0.88
288_I	295_G	0.675	0.88
199_V	225_L	0.673	0.88
203_R	230_P	0.672	0.87
303_I	306_A	0.669	0.87
67_Y	91_R	0.666	0.87
96_A	99_L	0.665	0.87
228_S	268_M	0.665	0.87
24_A	28_A	0.664	0.87
76_R	142_Y	0.664	0.87
178_T	182_T	0.663	0.87
9_V	24_A	0.658	0.86
71_M	75_I	0.655	0.86
8_W	84_V	0.651	0.86
22_N	25_Q	0.648	0.85
204_G	213_L	0.647	0.85
8_W	34_F	0.647	0.85
211_I	246_I	0.643	0.85
251_L	274_S	0.642	0.85
24_A	85_L	0.641	0.85
111_A	116_V	0.640	0.85
208_K	212_A	0.639	0.85
61_D	179_R	0.638	0.85
69_G	175_V	0.637	0.85
220_A	223_A	0.637	0.85
197_L	222_G	0.636	0.84
47_L	157_P	0.630	0.84
276_T	293_D	0.630	0.84
59_P	172_A	0.628	0.84
116_V	137_R	0.627	0.84
25_Q	31_I	0.626	0.83
200_S	267_H	0.625	0.83
173_P	177_I	0.625	0.83
44_A	52_V	0.623	0.83
10_F	67_Y	0.623	0.83
228_S	258_A	0.621	0.83
217_L	220_A	0.616	0.82
199_V	304_L	0.615	0.82
16_R	41_G	0.610	0.82
69_G	173_P	0.610	0.82
84_V	142_Y	0.610	0.82
256_Y	261_I	0.609	0.82
86_L	99_L	0.607	0.82
299_D	302_K	0.603	0.81
211_I	227_C	0.603	0.81
287_P	290_Q	0.603	0.81
55_L	168_V	0.602	0.81
210_N	216_Q	0.599	0.81
78_H	168_V	0.599	0.81
191_D	249_L	0.598	0.81
68_A	72_A	0.597	0.81
70_V	73_D	0.595	0.80
244_V	271_A	0.595	0.80
32_N	51_H	0.592	0.80
240_H	244_V	0.592	0.80
125_H	266_Q	0.592	0.80
123_V	147_I	0.591	0.80
190_V	224_E	0.590	0.80
91_R	95_L	0.589	0.80
74_T	77_Q	0.588	0.80
23_G	147_I	0.587	0.79
221_I	257_L	0.586	0.79
284_K	287_P	0.586	0.79
7_V	27_L	0.586	0.79
189_S	192_L	0.586	0.79
138_I	141_P	0.586	0.79
98_K	101_Y	0.585	0.79
62_R	91_R	0.584	0.79
185_R	284_K	0.584	0.79
247_S	265_I	0.584	0.79
66_D	173_P	0.583	0.79
277_I	291_Y	0.583	0.79
46_Q	156_Q	0.582	0.79
148_S	246_I	0.581	0.79
225_L	242_R	0.581	0.79
30_Q	33_T	0.581	0.79
279_A	289_F	0.580	0.79
33_T	36_L	0.578	0.78
268_M	271_A	0.572	0.78
294_Y	301_V	0.572	0.78
7_V	85_L	0.571	0.78
201_V	225_L	0.571	0.78
6_Q	33_T	0.571	0.78
210_N	300_A	0.569	0.77
55_L	74_T	0.569	0.77
160_S	164_E	0.567	0.77
69_G	171_Q	0.565	0.77
28_A	33_T	0.564	0.77
75_I	144_V	0.564	0.77
108_S	136_E	0.563	0.77
301_V	305_P	0.562	0.76
200_S	256_Y	0.561	0.76
57_G	169_E	0.560	0.76
205_I	304_L	0.558	0.76
35_V	54_K	0.556	0.76
265_I	293_D	0.554	0.75
205_I	231_V	0.554	0.75
107_V	111_A	0.553	0.75
10_F	13_T	0.552	0.75
7_V	30_Q	0.550	0.75
108_S	223_A	0.550	0.75
40_D	60_D	0.550	0.75
215_E	223_A	0.548	0.75
229_R	243_Y	0.547	0.74
125_H	136_E	0.547	0.74
66_D	69_G	0.546	0.74
59_P	174_A	0.545	0.74
65_E	68_A	0.545	0.74
22_N	156_Q	0.544	0.74
189_S	215_E	0.544	0.74
33_T	81_D	0.543	0.74
204_G	300_A	0.542	0.74
201_V	259_V	0.542	0.74
215_E	242_R	0.542	0.74
251_L	291_Y	0.541	0.74
69_G	102_R	0.541	0.74
105_A	143_A	0.540	0.74
204_G	297_V	0.539	0.73
45_I	49_A	0.539	0.73
55_L	73_D	0.538	0.73
93_K	109_N	0.538	0.73
108_S	123_V	0.537	0.73
66_D	177_I	0.536	0.73
83_L	143_A	0.535	0.73
50_N	53_W	0.533	0.73
197_L	254_E	0.530	0.72
190_V	198_V	0.530	0.72
227_C	235_E	0.529	0.72
106_A	134_G	0.529	0.72
127_V	134_G	0.528	0.72
116_V	122_T	0.527	0.72
204_G	228_S	0.527	0.72
66_D	175_V	0.525	0.71
100_G	144_V	0.522	0.71
35_V	52_V	0.521	0.71
197_L	221_I	0.521	0.71
76_R	186_Q	0.518	0.70
210_N	237_W	0.517	0.70
279_A	295_G	0.517	0.70
261_I	274_S	0.516	0.70
228_S	269_V	0.516	0.70
83_L	121_A	0.514	0.70
236_K	243_Y	0.514	0.70
199_V	220_A	0.514	0.70
271_A	288_I	0.511	0.69
36_L	71_M	0.509	0.69
123_V	138_I	0.508	0.69
207_S	231_V	0.508	0.69
66_D	174_A	0.507	0.69
206_G	217_L	0.506	0.69
11_S	49_A	0.506	0.69
6_Q	51_H	0.505	0.69
147_I	152_F	0.505	0.69
220_A	306_A	0.505	0.69
38_D	57_G	0.505	0.69
123_V	152_F	0.504	0.68
115_S	122_T	0.503	0.68
104_K	140_T	0.502	0.68
227_C	243_Y	0.501	0.68
38_D	41_G	0.501	0.68
111_A	136_E	0.501	0.68
13_T	35_V	0.500	0.68

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4l2iA	1	0.9904	100	0.045	Contact Map
1efvA	1	0.9649	100	0.064	Contact Map
1o97D	1	0.9521	100	0.073	Contact Map
1efpA	1	0.9457	100	0.082	Contact Map
3ih5A	6	0.5911	100	0.673	Contact Map
3fetA	2	0.5272	99.9	0.73	Contact Map
1efvB	1	0.655	99.9	0.766	Contact Map
1efpB	1	0.6358	99.9	0.768	Contact Map
4l2iB	1	0.6965	99.9	0.771	Contact Map
1o97C	1	0.6454	99.8	0.778	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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