GREMLIN Database
FIXB - Protein FixB
UniProt: P31574 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11563
Length: 313 (300)
Sequences: 4096 (2484)
Seq/√Len: 143.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
298_G303_I5.0311.00
289_F295_G3.6171.00
259_V280_I3.4371.00
196_R254_E3.4211.00
200_S261_I3.2811.00
86_L96_A3.1331.00
51_H166_H2.6971.00
198_V251_L2.6461.00
201_V211_I2.5981.00
259_V304_L2.5971.00
23_G26_A2.5901.00
45_I163_G2.5581.00
220_A308_T2.4341.00
22_N155_A2.3261.00
75_I84_V2.3061.00
51_H164_E2.2431.00
25_Q29_N2.2161.00
212_A215_E2.1821.00
238_M242_R2.1461.00
212_A216_Q2.0791.00
268_M291_Y2.0741.00
38_D56_N2.0631.00
227_C238_M2.0561.00
201_V214_A2.0361.00
216_Q308_T2.0181.00
276_T294_Y1.9931.00
197_L223_A1.9561.00
255_L278_F1.9391.00
279_A292_A1.9371.00
259_V300_A1.9251.00
20_L85_L1.9221.00
116_V121_A1.9161.00
215_E225_L1.9161.00
217_L308_T1.9101.00
41_G167_T1.8921.00
210_N301_V1.8711.00
38_D60_D1.8301.00
228_S261_I1.8291.00
205_I214_A1.8111.00
38_D58_K1.7961.00
124_K133_I1.7881.00
113_T124_K1.7621.00
200_S258_A1.7511.00
279_A288_I1.7401.00
254_E275_Q1.7361.00
111_A145_L1.7351.00
68_A102_R1.7331.00
256_Y267_H1.7221.00
214_A259_V1.7181.00
217_L304_L1.7131.00
72_A102_R1.7111.00
11_S18_P1.7031.00
191_D194_K1.6861.00
200_S244_V1.6731.00
306_A309_A1.6701.00
72_A99_L1.6631.00
251_L271_A1.6031.00
198_V226_A1.5791.00
192_L198_V1.5771.00
271_A274_S1.5741.00
217_L221_I1.5621.00
199_V217_L1.5561.00
96_A146_T1.5531.00
85_L145_L1.5521.00
53_W166_H1.5311.00
63_M66_D1.5291.00
64_I94_L1.5051.00
20_L87_P1.5031.00
72_A76_R1.4961.00
77_Q168_V1.4821.00
239_E242_R1.4791.00
28_A32_N1.4751.00
39_A56_N1.4751.00
211_I225_L1.4731.00
30_Q115_S1.4701.00
25_Q50_N1.4241.00
115_S124_K1.3981.00
215_E219_K1.3751.00
73_D77_Q1.3721.00
227_C231_V1.3401.00
189_S219_K1.3371.00
73_D76_R1.3351.00
108_S138_I1.3301.00
7_V24_A1.3281.00
213_L304_L1.3171.00
12_D89_T1.3101.00
220_A311_L1.3101.00
112_S124_K1.2931.00
71_M99_L1.2831.00
296_I303_I1.2781.00
258_A267_H1.2701.00
258_A261_I1.2611.00
216_Q220_A1.2601.00
61_D182_T1.2561.00
205_I300_A1.2451.00
32_N50_N1.2421.00
302_K306_A1.2421.00
53_W168_V1.2311.00
45_I52_V1.2301.00
10_F95_L1.2261.00
53_W78_H1.2191.00
306_A310_A1.2171.00
99_L144_V1.2131.00
43_Q46_Q1.2121.00
226_A244_V1.2121.00
55_L70_V1.2091.00
227_C232_A1.2081.00
193_D249_L1.2071.00
8_W74_T1.2071.00
19_E150_G1.2071.00
67_Y95_L1.2051.00
46_Q157_P1.1971.00
213_L216_Q1.1971.00
11_S44_A1.1961.00
81_D142_Y1.1931.00
110_D148_S1.1891.00
122_T135_E1.1891.00
205_I210_N1.1871.00
43_Q157_P1.1791.00
54_K167_T1.1701.00
40_D56_N1.1661.00
40_D54_K1.1611.00
207_S237_W1.1571.00
41_G56_N1.1510.99
201_V231_V1.1480.99
111_A147_I1.1450.99
112_S133_I1.1410.99
28_A31_I1.1290.99
56_N167_T1.1270.99
200_S251_L1.1260.99
228_S244_V1.1250.99
289_F297_V1.1230.99
71_M95_L1.1110.99
11_S33_T1.1100.99
46_Q158_D1.1060.99
36_L67_Y1.1000.99
74_T168_V1.0980.99
127_V132_A1.0970.99
173_P176_A1.0900.99
304_L308_T1.0880.99
211_I231_V1.0800.99
232_A243_Y1.0750.99
172_A175_V1.0740.99
10_F71_M1.0680.99
121_A143_A1.0630.99
208_K238_M1.0620.99
36_L70_V1.0500.99
244_V258_A1.0480.99
26_A113_T1.0460.99
209_E212_A1.0450.99
68_A99_L1.0450.99
121_A137_R1.0370.99
52_V163_G1.0240.99
42_A46_Q1.0220.99
300_A305_P1.0200.99
115_S135_E1.0180.99
103_L144_V1.0130.99
62_R67_Y1.0120.99
230_P235_E1.0070.99
68_A98_K1.0070.99
201_V205_I1.0040.99
213_L308_T1.0010.99
96_A107_V0.9990.99
219_K222_G0.9990.99
200_S226_A0.9980.99
200_S228_S0.9980.99
298_G302_K0.9940.98
9_V21_M0.9880.98
108_S111_A0.9870.98
204_G237_W0.9870.98
218_C225_L0.9810.98
107_V144_V0.9810.98
206_G301_V0.9780.98
47_L156_Q0.9770.98
224_E242_R0.9640.98
226_A242_R0.9610.98
77_Q166_H0.9610.98
179_R182_T0.9590.98
45_I158_D0.9580.98
7_V31_I0.9550.98
27_L85_L0.9530.98
34_F71_M0.9510.98
75_I80_A0.9470.98
21_M49_A0.9410.98
252_K273_A0.9340.98
257_L280_I0.9320.98
105_A144_V0.9290.98
75_I103_L0.9250.98
76_R79_G0.9160.97
231_V238_M0.9130.97
201_V238_M0.9110.97
231_V237_W0.9090.97
214_A225_L0.9030.97
69_G73_D0.9020.97
72_A103_L0.9010.97
107_V146_T0.8960.97
149_S250_M0.8870.97
210_N213_L0.8860.97
211_I238_M0.8860.97
93_K110_D0.8840.97
45_I165_T0.8820.97
172_A177_I0.8750.97
211_I214_A0.8640.96
37_N56_N0.8610.96
192_L226_A0.8600.96
53_W74_T0.8580.96
106_A138_I0.8570.96
9_V85_L0.8550.96
111_A114_V0.8510.96
124_K135_E0.8480.96
216_Q225_L0.8470.96
88_N92_G0.8470.96
160_S163_G0.8470.96
280_I303_I0.8470.96
21_M155_A0.8420.96
172_A176_A0.8390.96
32_N78_H0.8370.96
43_Q47_L0.8350.96
123_V145_L0.8330.96
98_K102_R0.8270.95
86_L146_T0.8260.95
81_D141_P0.8260.95
213_L305_P0.8240.95
253_P274_S0.8230.95
106_A140_T0.8190.95
75_I142_Y0.8170.95
207_S210_N0.8170.95
25_Q47_L0.8160.95
88_N110_D0.8160.95
114_V123_V0.8140.95
62_R94_L0.8110.95
205_I211_I0.8110.95
46_Q160_S0.8050.95
213_L259_V0.8010.94
9_V20_L0.8000.94
6_Q32_N0.8000.94
69_G174_A0.7970.94
64_I98_K0.7930.94
65_E176_A0.7920.94
15_S40_D0.7880.94
78_H166_H0.7880.94
42_A45_I0.7860.94
122_T137_R0.7850.94
11_S35_V0.7840.94
205_I208_K0.7830.94
111_A123_V0.7770.94
117_Q121_A0.7720.93
100_G107_V0.7660.93
123_V143_A0.7640.93
19_E154_A0.7640.93
204_G208_K0.7640.93
92_G95_L0.7630.93
204_G210_N0.7630.93
198_V224_E0.7610.93
30_Q50_N0.7610.93
34_F74_T0.7580.93
126_M148_S0.7550.93
121_A145_L0.7530.92
257_L278_F0.7490.92
205_I301_V0.7470.92
192_L249_L0.7450.92
271_A291_Y0.7420.92
208_K237_W0.7390.92
73_D171_Q0.7390.92
10_F84_V0.7330.91
76_R103_L0.7320.91
73_D169_E0.7320.91
158_D162_T0.7320.91
207_S301_V0.7260.91
86_L92_G0.7230.91
138_I143_A0.7220.91
205_I213_L0.7210.91
41_G54_K0.7200.91
74_T78_H0.7090.90
62_R95_L0.7020.90
46_Q159_A0.7010.89
234_N243_Y0.6960.89
208_K215_E0.6950.89
103_L142_Y0.6940.89
129_G148_S0.6920.89
23_G152_F0.6900.89
14_P17_L0.6880.89
201_V227_C0.6870.89
258_A288_I0.6850.88
153_D156_Q0.6840.88
205_I237_W0.6830.88
8_W78_H0.6800.88
268_M290_Q0.6780.88
10_F86_L0.6750.88
288_I295_G0.6750.88
199_V225_L0.6730.88
203_R230_P0.6720.87
303_I306_A0.6690.87
67_Y91_R0.6660.87
96_A99_L0.6650.87
228_S268_M0.6650.87
24_A28_A0.6640.87
76_R142_Y0.6640.87
178_T182_T0.6630.87
9_V24_A0.6580.86
71_M75_I0.6550.86
8_W84_V0.6510.86
22_N25_Q0.6480.85
204_G213_L0.6470.85
8_W34_F0.6470.85
211_I246_I0.6430.85
251_L274_S0.6420.85
24_A85_L0.6410.85
111_A116_V0.6400.85
208_K212_A0.6390.85
61_D179_R0.6380.85
69_G175_V0.6370.85
220_A223_A0.6370.85
197_L222_G0.6360.84
47_L157_P0.6300.84
276_T293_D0.6300.84
59_P172_A0.6280.84
116_V137_R0.6270.84
25_Q31_I0.6260.83
200_S267_H0.6250.83
173_P177_I0.6250.83
44_A52_V0.6230.83
10_F67_Y0.6230.83
228_S258_A0.6210.83
217_L220_A0.6160.82
199_V304_L0.6150.82
16_R41_G0.6100.82
69_G173_P0.6100.82
84_V142_Y0.6100.82
256_Y261_I0.6090.82
86_L99_L0.6070.82
299_D302_K0.6030.81
211_I227_C0.6030.81
287_P290_Q0.6030.81
55_L168_V0.6020.81
210_N216_Q0.5990.81
78_H168_V0.5990.81
191_D249_L0.5980.81
68_A72_A0.5970.81
70_V73_D0.5950.80
244_V271_A0.5950.80
32_N51_H0.5920.80
240_H244_V0.5920.80
125_H266_Q0.5920.80
123_V147_I0.5910.80
190_V224_E0.5900.80
91_R95_L0.5890.80
74_T77_Q0.5880.80
23_G147_I0.5870.79
221_I257_L0.5860.79
284_K287_P0.5860.79
7_V27_L0.5860.79
189_S192_L0.5860.79
138_I141_P0.5860.79
98_K101_Y0.5850.79
62_R91_R0.5840.79
185_R284_K0.5840.79
247_S265_I0.5840.79
66_D173_P0.5830.79
277_I291_Y0.5830.79
46_Q156_Q0.5820.79
148_S246_I0.5810.79
225_L242_R0.5810.79
30_Q33_T0.5810.79
279_A289_F0.5800.79
33_T36_L0.5780.78
268_M271_A0.5720.78
294_Y301_V0.5720.78
7_V85_L0.5710.78
201_V225_L0.5710.78
6_Q33_T0.5710.78
210_N300_A0.5690.77
55_L74_T0.5690.77
160_S164_E0.5670.77
69_G171_Q0.5650.77
28_A33_T0.5640.77
75_I144_V0.5640.77
108_S136_E0.5630.77
301_V305_P0.5620.76
200_S256_Y0.5610.76
57_G169_E0.5600.76
205_I304_L0.5580.76
35_V54_K0.5560.76
265_I293_D0.5540.75
205_I231_V0.5540.75
107_V111_A0.5530.75
10_F13_T0.5520.75
7_V30_Q0.5500.75
108_S223_A0.5500.75
40_D60_D0.5500.75
215_E223_A0.5480.75
229_R243_Y0.5470.74
125_H136_E0.5470.74
66_D69_G0.5460.74
59_P174_A0.5450.74
65_E68_A0.5450.74
22_N156_Q0.5440.74
189_S215_E0.5440.74
33_T81_D0.5430.74
204_G300_A0.5420.74
201_V259_V0.5420.74
215_E242_R0.5420.74
251_L291_Y0.5410.74
69_G102_R0.5410.74
105_A143_A0.5400.74
204_G297_V0.5390.73
45_I49_A0.5390.73
55_L73_D0.5380.73
93_K109_N0.5380.73
108_S123_V0.5370.73
66_D177_I0.5360.73
83_L143_A0.5350.73
50_N53_W0.5330.73
197_L254_E0.5300.72
190_V198_V0.5300.72
227_C235_E0.5290.72
106_A134_G0.5290.72
127_V134_G0.5280.72
116_V122_T0.5270.72
204_G228_S0.5270.72
66_D175_V0.5250.71
100_G144_V0.5220.71
35_V52_V0.5210.71
197_L221_I0.5210.71
76_R186_Q0.5180.70
210_N237_W0.5170.70
279_A295_G0.5170.70
261_I274_S0.5160.70
228_S269_V0.5160.70
83_L121_A0.5140.70
236_K243_Y0.5140.70
199_V220_A0.5140.70
271_A288_I0.5110.69
36_L71_M0.5090.69
123_V138_I0.5080.69
207_S231_V0.5080.69
66_D174_A0.5070.69
206_G217_L0.5060.69
11_S49_A0.5060.69
6_Q51_H0.5050.69
147_I152_F0.5050.69
220_A306_A0.5050.69
38_D57_G0.5050.69
123_V152_F0.5040.68
115_S122_T0.5030.68
104_K140_T0.5020.68
227_C243_Y0.5010.68
38_D41_G0.5010.68
111_A136_E0.5010.68
13_T35_V0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l2iA 1 0.9904 100 0.045 Contact Map
1efvA 1 0.9649 100 0.064 Contact Map
1o97D 1 0.9521 100 0.073 Contact Map
1efpA 1 0.9457 100 0.082 Contact Map
3ih5A 6 0.5911 100 0.673 Contact Map
3fetA 2 0.5272 99.9 0.73 Contact Map
1efvB 1 0.655 99.9 0.766 Contact Map
1efpB 1 0.6358 99.9 0.768 Contact Map
4l2iB 1 0.6965 99.9 0.771 Contact Map
1o97C 1 0.6454 99.8 0.778 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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