GREMLIN Database
CAIB - L-carnitine CoA-transferase
UniProt: P31572 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11559
Length: 405 (370)
Sequences: 10529 (7127)
Seq/√Len: 370.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
107_T110_V3.7061.00
39_E67_H3.5881.00
30_G93_I3.2531.00
303_H307_E3.1601.00
121_A180_A2.9921.00
185_H188_R2.9261.00
75_K78_G2.9181.00
121_A176_A2.8981.00
83_L114_H2.7581.00
87_E114_H2.7551.00
111_L118_L2.7091.00
102_A107_T2.6971.00
342_Q350_T2.6011.00
241_C305_I2.5881.00
79_R83_L2.5151.00
303_H308_V2.4871.00
71_L82_F2.4831.00
16_R39_E2.4451.00
242_A304_T2.4191.00
108_D112_W2.3631.00
304_T307_E2.3571.00
186_K194_E2.3231.00
303_H311_R2.3121.00
240_K301_A2.2701.00
80_E84_K2.2391.00
84_K87_E2.1961.00
375_G378_T2.1791.00
81_A387_Y2.1311.00
20_S82_F2.0961.00
91_I180_A2.0621.00
299_W302_T2.0611.00
342_Q352_K1.9661.00
288_Y291_L1.9441.00
377_D380_A1.9411.00
378_T382_L1.9231.00
112_W192_K1.9161.00
16_R88_T1.9151.00
294_E298_A1.8911.00
18_V86_M1.8781.00
128_Q197_D1.8761.00
67_H380_A1.8631.00
168_A204_M1.8251.00
178_T181_L1.8211.00
110_V113_Q1.8181.00
344_Q350_T1.8101.00
101_F106_I1.8051.00
36_W182_A1.7861.00
265_L299_W1.7841.00
186_K190_T1.7811.00
186_K362_N1.7651.00
295_K298_A1.7631.00
324_T327_E1.7601.00
72_N75_K1.7591.00
18_V89_T1.7281.00
15_L184_L1.7231.00
10_G13_A1.7231.00
134_Y331_N1.7121.00
137_L313_A1.7051.00
237_G293_E1.7021.00
92_F118_L1.6801.00
156_D159_Q1.6751.00
373_S376_M1.6731.00
86_M111_L1.6701.00
19_F30_G1.6671.00
67_H384_N1.6641.00
306_A310_E1.6491.00
134_Y137_L1.6471.00
265_L268_L1.6471.00
34_A65_N1.6251.00
186_K192_K1.6221.00
71_L78_G1.6101.00
146_A247_V1.6011.00
108_D120_I1.5871.00
202_E337_R1.5851.00
76_D79_R1.5761.00
296_L300_L1.5661.00
273_E291_L1.5551.00
122_H195_S1.5351.00
86_M115_N1.5191.00
299_W308_V1.5141.00
262_D311_R1.5101.00
148_S204_M1.4931.00
71_L81_A1.4801.00
279_Q282_H1.4721.00
305_I327_E1.4701.00
276_E279_Q1.4671.00
310_E314_E1.4661.00
69_L378_T1.4651.00
201_Y334_Y1.4611.00
194_E361_K1.4491.00
155_G224_R1.4491.00
370_G376_M1.4441.00
35_E64_R1.4441.00
265_L295_K1.4381.00
240_K297_D1.4321.00
241_C246_I1.4291.00
69_L381_I1.4091.00
261_K266_A1.4061.00
379_A383_K1.3731.00
330_S335_V1.3631.00
84_K387_Y1.3601.00
119_V187_V1.3591.00
258_E261_K1.3521.00
275_P279_Q1.3501.00
179_A358_P1.3471.00
291_L294_E1.3411.00
171_F207_M1.3361.00
372_P377_D1.3351.00
257_E270_G1.3301.00
259_C263_I1.3281.00
307_E311_R1.3281.00
192_K362_N1.3281.00
268_L295_K1.3271.00
333_Q336_A1.3251.00
300_L308_V1.3251.00
239_Y293_E1.3211.00
85_L385_I1.3181.00
123_L176_A1.3051.00
305_I321_K1.3031.00
94_E122_H1.3011.00
83_L106_I1.2901.00
83_L110_V1.2801.00
117_K187_V1.2721.00
194_E363_N1.2661.00
240_K245_Y1.2641.00
17_V91_I1.2611.00
15_L185_H1.2581.00
261_K269_L1.2521.00
134_Y147_F1.2521.00
108_D195_S1.2501.00
326_P330_S1.2211.00
77_E80_E1.2191.00
141_N145_Q1.2051.00
256_I260_F1.1921.00
20_S92_F1.1911.00
185_H189_E1.1841.00
340_I352_K1.1821.00
262_D315_L1.1801.00
254_T258_E1.1751.00
263_I299_W1.1691.00
181_L185_H1.1631.00
81_A385_I1.1561.00
205_L334_Y1.1541.00
240_K300_L1.1461.00
100_A103_R1.1391.00
253_I257_E1.1301.00
29_A177_T1.1281.00
246_I308_V1.1281.00
199_A202_E1.1251.00
175_T206_R1.1221.00
65_N369_R1.1191.00
68_A372_P1.1141.00
46_V70_S1.1111.00
70_S378_T1.1101.00
65_N368_W1.1041.00
86_M114_H1.0991.00
309_K319_C1.0991.00
145_Q168_A1.0871.00
323_L331_N1.0841.00
184_L188_R1.0841.00
101_F120_I1.0771.00
257_E261_K1.0751.00
73_I104_R1.0741.00
307_E310_E1.0731.00
139_A200_M1.0711.00
244_G305_I1.0661.00
345_T349_R1.0511.00
205_L328_L1.0481.00
111_L120_I1.0461.00
18_V82_F1.0441.00
345_T348_G1.0391.00
126_F147_F1.0381.00
74_F104_R1.0381.00
16_R41_I1.0361.00
250_L259_C1.0351.00
131_T336_A1.0351.00
183_A194_E1.0311.00
246_I300_L1.0271.00
221_M326_P1.0261.00
32_M178_T1.0251.00
190_T362_N1.0231.00
131_T333_Q1.0151.00
90_D187_V1.0101.00
139_A144_A1.0101.00
147_F331_N1.0081.00
369_R377_D1.0001.00
208_G325_V0.9981.00
11_P360_F0.9971.00
273_E288_Y0.9961.00
291_L295_K0.9951.00
306_A309_K0.9931.00
298_A302_T0.9911.00
29_A176_A0.9831.00
91_I119_V0.9831.00
221_M324_T0.9801.00
274_I288_Y0.9791.00
12_L181_L0.9791.00
179_A196_I0.9771.00
117_K188_R0.9751.00
194_E362_N0.9711.00
82_F106_I0.9711.00
309_K321_K0.9691.00
240_K244_G0.9631.00
94_E101_F0.9621.00
16_R89_T0.9591.00
21_G26_G0.9581.00
81_A84_K0.9571.00
236_C249_E0.9571.00
44_E53_R0.9561.00
229_K289_G0.9551.00
20_S101_F0.9541.00
332_P336_A0.9471.00
83_L87_E0.9451.00
34_A40_V0.9381.00
259_C296_L0.9371.00
87_E115_N0.9371.00
177_T181_L0.9341.00
92_F111_L0.9331.00
311_R314_E0.9241.00
343_W353_G0.9191.00
14_G185_H0.9191.00
108_D193_G0.9181.00
142_T249_E0.9181.00
79_R106_I0.9171.00
16_R67_H0.9151.00
310_E313_A0.9111.00
160_P245_Y0.9111.00
312_F319_C0.9101.00
187_V190_T0.9001.00
31_Q64_R0.8961.00
31_Q35_E0.8961.00
10_G368_W0.8951.00
323_L327_E0.8941.00
261_K315_L0.8911.00
277_G281_I0.8881.00
335_V352_K0.8851.00
129_Y135_T0.8831.00
274_I291_L0.8831.00
146_A320_A0.8831.00
186_K363_N0.8811.00
76_D80_E0.8761.00
23_E140_Y0.8761.00
306_A321_K0.8761.00
154_N164_F0.8731.00
256_I280_L0.8721.00
175_T203_V0.8721.00
128_Q195_S0.8701.00
372_P376_M0.8701.00
80_E83_L0.8681.00
380_A384_N0.8641.00
81_A382_L0.8641.00
125_G139_A0.8631.00
129_Y336_A0.8591.00
43_I82_F0.8581.00
305_I309_K0.8521.00
202_E339_S0.8481.00
82_F86_M0.8471.00
120_I195_S0.8471.00
39_E380_A0.8451.00
96_S100_A0.8441.00
184_L187_V0.8431.00
246_I305_I0.8361.00
59_P63_R0.8361.00
297_D301_A0.8361.00
247_V320_A0.8351.00
88_T384_N0.8301.00
345_T373_S0.8291.00
311_R315_L0.8281.00
78_G81_A0.8271.00
246_I309_K0.8261.00
49_A374_H0.8241.00
215_Y221_M0.8221.00
33_F180_A0.8221.00
297_D300_L0.8211.00
91_I184_L0.8201.00
178_T185_H0.8191.00
21_G30_G0.8171.00
124_S127_G0.8171.00
28_F32_M0.8161.00
142_T247_V0.8161.00
92_F101_F0.8151.00
63_R66_L0.8121.00
36_W178_T0.8101.00
70_S374_H0.8051.00
341_T355_N0.8031.00
92_F120_I0.8011.00
356_I365_G0.8001.00
82_F92_F0.8001.00
257_E269_L0.7991.00
83_L86_M0.7981.00
25_A123_L0.7961.00
295_K299_W0.7961.00
304_T308_V0.7951.00
215_Y326_P0.7911.00
107_T120_I0.7911.00
258_E262_D0.7901.00
83_L115_N0.7901.00
69_L81_A0.7891.00
49_A53_R0.7891.00
333_Q337_R0.7881.00
147_F323_L0.7851.00
109_E112_W0.7811.00
43_I69_L0.7811.00
152_I324_T0.7771.00
78_G382_L0.7761.00
234_A289_G0.7751.00
68_A375_G0.7741.00
94_E128_Q0.7711.00
130_G333_Q0.7701.00
238_L247_V0.7691.00
197_D337_R0.7671.00
144_A168_A0.7651.00
156_D161_M0.7651.00
153_Q208_G0.7651.00
339_S359_K0.7611.00
121_A196_I0.7611.00
264_G311_R0.7601.00
97_K100_A0.7571.00
78_G82_F0.7571.00
18_V92_F0.7561.00
158_D224_R0.7551.00
347_D373_S0.7541.00
242_A302_T0.7531.00
79_R105_G0.7481.00
102_A109_E0.7471.00
100_A104_R0.7461.00
110_V114_H0.7461.00
272_P275_P0.7441.00
19_F26_G0.7441.00
258_E315_L0.7421.00
242_A307_E0.7371.00
108_D118_L0.7351.00
174_L178_T0.7341.00
253_I280_L0.7321.00
146_A151_L0.7311.00
41_I381_I0.7311.00
102_A122_H0.7241.00
309_K313_A0.7231.00
234_A293_E0.7231.00
12_L15_L0.7201.00
24_I62_S0.7151.00
27_P169_D0.7121.00
355_N359_K0.7121.00
238_L322_V0.7121.00
134_Y333_Q0.7110.99
47_A70_S0.7110.99
79_R104_R0.7110.99
69_L382_L0.7100.99
42_W50_D0.7090.99
119_V183_A0.7080.99
263_I296_L0.7080.99
334_Y340_I0.7050.99
99_P102_A0.7040.99
338_E359_K0.7040.99
313_A319_C0.7040.99
212_M329_E0.7030.99
18_V88_T0.7030.99
39_E384_N0.7030.99
114_H117_K0.7010.99
78_G387_Y0.6990.99
334_Y339_S0.6980.99
43_I71_L0.6980.99
147_F321_K0.6950.99
205_L339_S0.6940.99
274_I295_K0.6930.99
60_Q371_M0.6930.99
70_S375_G0.6920.99
178_T182_A0.6910.99
42_W49_A0.6900.99
11_P363_N0.6890.99
237_G297_D0.6890.99
290_P294_E0.6870.99
29_A93_I0.6870.99
84_K88_T0.6860.99
294_E297_D0.6830.99
194_E360_F0.6820.99
156_D237_G0.6820.99
293_E297_D0.6750.99
19_F22_I0.6750.99
248_M300_L0.6740.99
168_A172_S0.6730.99
117_K190_T0.6720.99
143_I320_A0.6710.99
172_S203_V0.6710.99
150_Y163_A0.6690.99
302_T308_V0.6660.99
81_A386_G0.6660.99
331_N334_Y0.6640.99
292_V296_L0.6630.99
73_I82_F0.6620.99
119_V185_H0.6590.99
246_I319_C0.6590.99
88_T385_I0.6580.99
80_E114_H0.6570.99
153_Q325_V0.6550.99
67_H369_R0.6530.99
215_Y219_G0.6500.99
86_M106_I0.6500.99
361_K364_P0.6490.99
186_K189_E0.6490.99
140_Y318_A0.6450.99
173_G177_T0.6440.99
35_E65_N0.6420.99
94_E99_P0.6410.99
129_Y359_K0.6410.99
171_F174_L0.6400.99
341_T367_I0.6390.99
22_I51_T0.6360.99
329_E340_I0.6360.99
140_Y252_G0.6350.99
147_F320_A0.6320.99
36_W360_F0.6320.99
298_A301_A0.6320.99
109_E113_Q0.6310.99
321_K327_E0.6290.99
138_P316_N0.6260.99
212_M216_F0.6260.99
68_A376_M0.6240.99
97_K138_P0.6240.99
369_R380_A0.6230.99
32_M177_T0.6230.99
241_C244_G0.6220.99
41_I89_T0.6220.99
99_P136_N0.6220.99
124_S197_D0.6210.99
84_K385_I0.6210.99
252_G255_Q0.6200.99
102_A110_V0.6190.99
234_A292_V0.6180.99
33_F177_T0.6180.99
278_T282_H0.6170.99
127_G197_D0.6120.98
142_T236_C0.6100.98
65_N367_I0.6090.98
255_Q318_A0.6090.98
296_L299_W0.6080.98
117_K192_K0.6080.98
68_A374_H0.6060.98
28_F170_Y0.6060.98
24_I166_Y0.6060.98
41_I88_T0.6050.98
228_G235_G0.6050.98
248_M319_C0.6030.98
234_A281_I0.6020.98
344_Q349_R0.6020.98
71_L382_L0.6000.98
109_E195_S0.6000.98
129_Y337_R0.6000.98
171_F203_V0.6000.98
266_A269_L0.6000.98
176_A180_A0.5990.98
115_N118_L0.5980.98
108_D122_H0.5970.98
258_E316_N0.5970.98
150_Y204_M0.5950.98
18_V85_L0.5950.98
369_R376_M0.5950.98
260_F266_A0.5930.98
198_I203_V0.5920.98
241_C308_V0.5920.98
346_M373_S0.5900.98
28_F206_R0.5890.98
102_A195_S0.5890.98
10_G363_N0.5880.98
150_Y208_G0.5860.98
176_A198_I0.5850.98
172_S200_M0.5850.98
99_P107_T0.5850.98
91_I187_V0.5850.98
23_E51_T0.5820.98
50_D53_R0.5820.98
328_L334_Y0.5810.98
274_I292_V0.5810.98
360_F364_P0.5780.98
148_S201_Y0.5780.98
246_I312_F0.5770.98
15_L187_V0.5770.98
201_Y333_Q0.5740.98
282_H288_Y0.5730.98
45_N70_S0.5720.98
243_D306_A0.5720.98
30_G66_L0.5680.98
11_P36_W0.5670.98
25_A172_S0.5660.98
83_L105_G0.5660.98
140_Y143_I0.5640.97
102_A128_Q0.5610.97
229_K293_E0.5600.97
26_G93_I0.5570.97
170_Y209_Q0.5560.97
259_C312_F0.5550.97
346_M376_M0.5530.97
214_D232_Y0.5530.97
360_F363_N0.5520.97
86_M92_F0.5510.97
168_A200_M0.5490.97
94_E120_I0.5490.97
360_F365_G0.5490.97
183_A196_I0.5490.97
136_N313_A0.5470.97
127_G130_G0.5470.97
248_M259_C0.5460.97
262_D317_I0.5440.97
216_F352_K0.5430.97
30_G40_V0.5420.97
279_Q288_Y0.5420.97
68_A377_D0.5410.97
144_A200_M0.5410.97
53_R59_P0.5400.97
177_T182_A0.5400.97
97_K316_N0.5380.97
114_H118_L0.5360.97
242_A301_A0.5360.97
243_D305_I0.5350.97
383_K388_S0.5350.97
122_H128_Q0.5340.96
14_G39_E0.5340.96
126_F143_I0.5340.96
123_L172_S0.5330.96
380_A383_K0.5310.96
231_P237_G0.5310.96
98_G124_S0.5300.96
172_S198_I0.5300.96
338_E341_T0.5300.96
41_I385_I0.5290.96
338_E355_N0.5260.96
161_M228_G0.5230.96
241_C300_L0.5210.96
98_G128_Q0.5200.96
196_I360_F0.5190.96
28_F173_G0.5190.96
62_S170_Y0.5180.96
99_P103_R0.5180.96
229_K237_G0.5170.96
20_S73_I0.5160.96
376_M380_A0.5160.96
44_E68_A0.5160.96
163_A167_T0.5140.96
381_I384_N0.5120.96
91_I181_L0.5120.96
29_A173_G0.5110.95
75_K79_R0.5110.95
13_A189_E0.5100.95
15_L91_I0.5090.95
34_A369_R0.5080.95
273_E295_K0.5070.95
78_G386_G0.5050.95
16_R385_I0.5050.95
70_S81_A0.5040.95
267_H295_K0.5030.95
182_A185_H0.5020.95
60_Q345_T0.5020.95
229_K290_P0.5010.95
378_T381_I0.5010.95
14_G189_E0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xk7A 2 0.9877 100 0.042 Contact Map
1q7eA 2 0.9358 100 0.047 Contact Map
3ubmA 2 0.9531 100 0.049 Contact Map
2vjqA 2 0.9481 100 0.055 Contact Map
4ed9A 2 0.8988 100 0.093 Contact Map
4hl6A 2 0.9062 100 0.102 Contact Map
2yimA 2 0.8642 100 0.145 Contact Map
2g04A 2 0.8568 100 0.175 Contact Map
1vl6A 4 0.5111 93.7 0.95 Contact Map
2a9fA 2 0.4765 91.3 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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