CAIT - ECOLI - GREMLIN Contacts

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CAIT - L-carnitine/gamma-butyrobetaine antiporter

UniProt:	P31553	Sequences: MKNEKRKTGIEPKVFFPPLIIVGILCWLTVRDLDAANVVINAVFSYVTNVWGWAFEWYMVVMLFGWFWLVFGPYAKKRLGNEPPEFSTASWIFMMFASCTSAAVLFWGSIEIYYYISTPPFGLEPNSTGAKELGLAYSLFHWGPLPWATYSFLSVAFAYFFFVRKMEVIRPSSTLVPLVGEKHAKGLFGTIVDNFYLVALIFAMGTSLGLATPLVTECMQWLFGIPHTLQLDAIIITCWIILNAICVACGLQKGVRIASDVRSYLSFLMLGWVFIVSGASFIMNYFTDSVGMLLMYLPRMLFYTDPIAKGGFPQGWTVFYWAWWVIYAIQMSIFLARISRGRTVRELCFGMVLGLTASTWILWTVLGSNTLLLIDKNIINIPNLIEQYGVARAIIETWAALPLSTATMWGFFILCFIATVTLVNACSYTLAMSTCREVRDGEEPPLLVRIGWSILVGIIGIVLLALGGLKPIQTAIIAGGCPLFFVNIMVTLSFIKDAKQNWKD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11561
Length:	504 (486)
Sequences:	3373 (2041)
Seq/√Len:	92.6

ECOLI - CAIT BETT YEAV
BACSU - OPUD
HALSA - Q9HQN5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
78_R	83_P	4.460	1.00
197_L	434_T	3.861	1.00
54_A	484_F	3.500	1.00
27_W	31_R	3.376	1.00
272_W	407_T	3.354	1.00
272_W	276_V	3.279	1.00
82_E	340_R	3.195	1.00
374_I	380_N	3.067	1.00
233_A	461_I	2.863	1.00
127_S	130_A	2.832	1.00
19_L	451_G	2.676	1.00
372_L	376_K	2.664	1.00
230_Q	234_I	2.626	1.00
32_D	35_A	2.575	1.00
17_P	194_N	2.554	1.00
175_L	192_V	2.508	1.00
246_C	424_N	2.489	1.00
286_F	364_T	2.472	1.00
274_F	365_V	2.455	1.00
369_N	401_L	2.453	1.00
116_I	375_D	2.446	1.00
65_G	491_T	2.385	1.00
270_L	365_V	2.375	1.00
59_M	149_T	2.374	1.00
273_V	401_L	2.334	1.00
86_F	252_Q	2.331	1.00
344_V	498_A	2.317	1.00
47_V	481_C	2.310	1.00
274_F	283_M	2.304	1.00
249_C	257_I	2.268	1.00
28_L	35_A	2.247	1.00
70_V	348_C	2.233	1.00
179_V	184_A	2.214	1.00
61_V	488_I	2.213	1.00
90_S	260_D	2.207	1.00
380_N	383_N	2.171	1.00
70_V	349_F	2.168	1.00
245_I	249_C	2.141	1.00
416_F	420_V	2.140	1.00
139_L	360_W	2.129	1.00
423_V	456_V	2.118	1.00
181_E	185_K	2.109	1.00
240_I	457_G	2.083	1.00
68_W	495_I	2.078	1.00
396_E	399_A	2.047	1.00
65_G	495_I	2.045	1.00
43_V	46_Y	2.044	1.00
248_A	450_I	2.044	1.00
216_T	227_H	2.010	1.00
216_T	235_I	1.973	1.00
285_Y	368_S	1.937	1.00
244_A	248_A	1.912	1.00
481_C	485_F	1.905	1.00
186_G	189_G	1.899	1.00
113_Y	374_I	1.863	1.00
264_Y	268_L	1.856	1.00
30_V	462_V	1.854	1.00
87_S	90_S	1.849	1.00
176_V	185_K	1.836	1.00
166_M	176_V	1.822	1.00
286_F	361_I	1.820	1.00
326_I	476_I	1.817	1.00
43_V	478_A	1.814	1.00
187_L	191_I	1.806	1.00
58_Y	62_M	1.805	1.00
179_V	188_F	1.798	1.00
234_I	238_C	1.791	1.00
74_Y	499_K	1.782	1.00
421_T	425_A	1.782	1.00
266_S	418_A	1.782	1.00
73_P	76_K	1.771	1.00
295_M	299_R	1.765	1.00
244_A	453_S	1.761	1.00
124_E	127_S	1.754	1.00
62_M	487_N	1.740	1.00
60_V	302_F	1.737	1.00
398_W	411_F	1.737	1.00
485_F	489_M	1.729	1.00
229_L	465_A	1.724	1.00
216_T	231_L	1.724	1.00
93_F	97_A	1.720	1.00
13_K	190_T	1.709	1.00
398_W	407_T	1.701	1.00
311_G	315_G	1.694	1.00
174_T	490_V	1.691	1.00
13_K	17_P	1.680	1.00
427_S	453_S	1.679	1.00
64_F	68_W	1.676	1.00
58_Y	484_F	1.674	1.00
423_V	427_S	1.668	1.00
82_E	163_V	1.661	1.00
61_V	491_T	1.656	1.00
288_D	306_P	1.653	1.00
274_F	279_A	1.641	1.00
216_T	232_D	1.641	1.00
28_L	36_A	1.628	1.00
296_Y	299_R	1.621	1.00
373_L	400_A	1.620	1.00
107_W	110_I	1.617	1.00
278_G	282_I	1.616	1.00
97_A	417_I	1.606	1.00
72_G	75_A	1.600	1.00
68_W	72_G	1.597	1.00
381_I	385_I	1.589	1.00
237_T	461_I	1.573	1.00
225_I	231_L	1.572	1.00
57_W	287_T	1.565	1.00
220_Q	227_H	1.557	1.00
431_A	448_V	1.557	1.00
88_T	346_E	1.552	1.00
286_F	360_W	1.541	1.00
146_P	324_W	1.537	1.00
143_G	356_T	1.517	1.00
75_A	345_R	1.511	1.00
172_S	190_T	1.497	1.00
220_Q	226_P	1.488	1.00
63_L	67_F	1.470	1.00
257_I	261_V	1.457	1.00
107_W	390_V	1.454	1.00
261_V	264_Y	1.431	0.99
406_A	409_W	1.426	0.99
195_F	486_V	1.424	0.99
403_L	406_A	1.418	0.99
25_L	202_F	1.416	0.99
155_V	344_V	1.415	0.99
394_I	411_F	1.415	0.99
229_L	232_D	1.411	0.99
176_V	181_E	1.408	0.99
241_I	245_I	1.406	0.99
160_F	497_D	1.394	0.99
179_V	489_M	1.379	0.99
267_F	271_G	1.378	0.99
488_I	492_L	1.375	0.99
248_A	446_L	1.373	0.99
131_K	375_D	1.371	0.99
62_M	491_T	1.369	0.99
116_I	126_N	1.368	0.99
228_T	231_L	1.368	0.99
113_Y	381_I	1.360	0.99
90_S	256_R	1.358	0.99
71_F	349_F	1.356	0.99
41_N	45_S	1.353	0.99
136_A	296_Y	1.350	0.99
69_L	344_V	1.349	0.99
212_T	235_I	1.345	0.99
244_A	450_I	1.340	0.99
39_V	43_V	1.337	0.99
178_L	492_L	1.324	0.99
454_I	458_I	1.316	0.99
210_L	319_F	1.314	0.99
256_R	260_D	1.311	0.99
46_Y	50_V	1.301	0.99
377_N	380_N	1.297	0.99
356_T	360_W	1.297	0.99
28_L	32_D	1.296	0.99
153_L	490_V	1.292	0.99
136_A	292_M	1.291	0.99
35_A	39_V	1.289	0.99
22_V	201_I	1.286	0.99
60_V	145_L	1.280	0.99
374_I	379_I	1.269	0.99
187_L	190_T	1.268	0.99
219_M	231_L	1.265	0.99
164_R	497_D	1.264	0.99
16_F	20_I	1.264	0.99
427_S	456_V	1.263	0.99
414_L	417_I	1.253	0.99
382_P	386_E	1.253	0.99
136_A	300_M	1.251	0.99
150_Y	324_W	1.249	0.99
29_T	36_A	1.248	0.99
237_T	241_I	1.241	0.98
63_L	297_L	1.234	0.98
289_S	364_T	1.230	0.98
166_M	184_A	1.224	0.98
495_I	499_K	1.218	0.98
85_E	252_Q	1.218	0.98
71_F	345_R	1.216	0.98
446_L	449_R	1.207	0.98
238_C	242_L	1.206	0.98
480_G	484_F	1.203	0.98
369_N	397_T	1.203	0.98
62_M	152_F	1.202	0.98
38_V	42_A	1.202	0.98
24_I	28_L	1.200	0.98
422_L	425_A	1.199	0.98
470_K	473_Q	1.193	0.98
249_C	253_K	1.193	0.98
216_T	228_T	1.188	0.98
226_P	231_L	1.187	0.98
63_L	148_A	1.168	0.98
180_G	186_G	1.167	0.98
89_A	263_S	1.166	0.98
11_E	190_T	1.166	0.98
294_L	298_P	1.165	0.98
119_P	122_G	1.165	0.98
60_V	301_L	1.159	0.98
12_P	16_F	1.153	0.98
287_T	291_G	1.152	0.98
261_V	417_I	1.151	0.97
176_V	184_A	1.149	0.97
20_I	24_I	1.139	0.97
221_W	399_A	1.136	0.97
145_L	301_L	1.130	0.97
89_A	93_F	1.129	0.97
63_L	144_P	1.128	0.97
290_V	360_W	1.126	0.97
55_F	322_A	1.126	0.97
156_A	490_V	1.110	0.97
151_S	351_M	1.107	0.97
34_D	38_V	1.106	0.97
216_T	226_P	1.095	0.97
86_F	337_R	1.094	0.97
132_E	288_D	1.094	0.97
463_L	475_A	1.093	0.97
278_G	372_L	1.091	0.97
106_F	391_A	1.088	0.96
396_E	400_A	1.085	0.96
100_T	359_T	1.083	0.96
72_G	77_K	1.080	0.96
45_S	49_N	1.078	0.96
100_T	146_P	1.074	0.96
282_I	365_V	1.072	0.96
125_P	130_A	1.070	0.96
119_P	125_P	1.068	0.96
231_L	234_I	1.067	0.96
77_K	498_A	1.067	0.96
145_L	293_L	1.067	0.96
451_G	455_L	1.064	0.96
180_G	189_G	1.064	0.96
188_F	191_I	1.062	0.96
298_P	301_L	1.061	0.96
357_A	361_I	1.054	0.96
39_V	42_A	1.052	0.96
281_F	375_D	1.052	0.96
239_W	416_F	1.050	0.96
46_Y	51_W	1.047	0.96
229_L	233_A	1.047	0.96
182_K	186_G	1.043	0.96
50_V	280_S	1.043	0.96
156_A	494_F	1.042	0.95
328_A	487_N	1.035	0.95
78_R	343_T	1.035	0.95
109_S	393_A	1.032	0.95
129_G	133_L	1.032	0.95
195_F	479_G	1.031	0.95
374_I	377_N	1.031	0.95
219_M	223_F	1.029	0.95
63_L	145_L	1.029	0.95
283_M	287_T	1.025	0.95
271_G	275_I	1.023	0.95
144_P	352_V	1.022	0.95
172_S	243_N	1.022	0.95
285_Y	289_S	1.014	0.95
204_M	255_V	1.013	0.95
353_L	357_A	1.013	0.95
258_A	424_N	1.009	0.95
327_Y	422_L	1.005	0.95
74_Y	495_I	1.003	0.94
129_G	132_E	1.001	0.94
34_D	37_N	1.001	0.94
401_L	406_A	0.996	0.94
173_S	176_V	0.996	0.94
405_T	409_W	0.991	0.94
166_M	173_S	0.990	0.94
168_V	172_S	0.989	0.94
161_F	168_V	0.988	0.94
54_A	58_Y	0.987	0.94
37_N	41_N	0.987	0.94
67_F	71_F	0.984	0.94
218_C	395_I	0.982	0.94
247_V	453_S	0.981	0.94
126_N	130_A	0.981	0.94
247_V	251_L	0.977	0.94
450_I	454_I	0.974	0.94
92_I	354_G	0.974	0.94
242_L	420_V	0.970	0.93
36_A	40_I	0.968	0.93
177_P	180_G	0.967	0.93
392_R	396_E	0.966	0.93
52_G	318_V	0.942	0.92
237_T	454_I	0.941	0.92
221_W	392_R	0.938	0.92
164_R	501_N	0.938	0.92
483_L	486_V	0.935	0.92
243_N	453_S	0.935	0.92
58_Y	488_I	0.934	0.92
384_L	396_E	0.932	0.92
418_A	422_L	0.931	0.92
86_F	94_M	0.925	0.92
253_K	257_I	0.924	0.92
242_L	245_I	0.917	0.91
335_L	351_M	0.917	0.91
26_C	462_V	0.913	0.91
93_F	263_S	0.913	0.91
295_M	298_P	0.913	0.91
434_T	448_V	0.912	0.91
141_H	317_T	0.911	0.91
137_Y	300_M	0.911	0.91
430_L	456_V	0.908	0.91
110_I	312_F	0.907	0.91
233_A	237_T	0.904	0.91
60_V	298_P	0.900	0.91
70_V	75_A	0.899	0.90
144_P	148_A	0.899	0.90
204_M	426_C	0.898	0.90
154_S	347_L	0.898	0.90
88_T	92_I	0.896	0.90
374_I	378_I	0.893	0.90
148_A	151_S	0.889	0.90
108_G	363_W	0.889	0.90
404_S	408_M	0.884	0.90
107_W	210_L	0.884	0.90
236_I	460_G	0.883	0.90
126_N	129_G	0.883	0.90
13_K	16_F	0.883	0.90
100_T	104_V	0.882	0.90
289_S	292_M	0.881	0.90
21_I	198_V	0.876	0.89
220_Q	225_I	0.873	0.89
207_S	211_A	0.872	0.89
86_F	90_S	0.871	0.89
284_N	304_T	0.868	0.89
90_S	93_F	0.865	0.89
124_E	130_A	0.865	0.89
135_L	289_S	0.862	0.89
494_F	498_A	0.861	0.89
206_T	473_Q	0.859	0.88
440_D	444_P	0.859	0.88
102_A	207_S	0.859	0.88
321_W	324_W	0.858	0.88
381_I	386_E	0.855	0.88
102_A	211_A	0.854	0.88
374_I	382_P	0.849	0.88
115_Y	312_F	0.849	0.88
109_S	397_T	0.848	0.88
364_T	369_N	0.845	0.88
233_A	465_A	0.844	0.88
69_L	155_V	0.842	0.87
65_G	152_F	0.842	0.87
18_P	197_L	0.842	0.87
179_V	493_S	0.831	0.87
64_F	297_L	0.830	0.87
409_W	413_I	0.828	0.86
54_A	485_F	0.827	0.86
176_V	182_K	0.826	0.86
289_S	368_S	0.825	0.86
251_L	428_Y	0.824	0.86
139_L	289_S	0.822	0.86
206_T	472_I	0.821	0.86
143_G	146_P	0.821	0.86
351_M	354_G	0.820	0.86
38_V	41_N	0.819	0.86
60_V	297_L	0.819	0.86
258_A	417_I	0.817	0.86
154_S	297_L	0.817	0.86
240_I	243_N	0.815	0.86
288_D	292_M	0.812	0.85
249_C	252_Q	0.810	0.85
54_A	488_I	0.810	0.85
276_V	407_T	0.810	0.85
164_R	500_Q	0.808	0.85
43_V	47_V	0.808	0.85
257_I	260_D	0.801	0.85
432_M	444_P	0.799	0.84
219_M	225_I	0.799	0.84
178_L	188_F	0.798	0.84
51_W	481_C	0.798	0.84
456_V	460_G	0.798	0.84
95_M	422_L	0.795	0.84
160_F	166_M	0.795	0.84
267_F	358_S	0.790	0.84
403_L	407_T	0.790	0.84
384_L	388_Y	0.787	0.84
206_T	463_L	0.785	0.83
52_G	284_N	0.783	0.83
399_A	404_S	0.783	0.83
291_G	302_F	0.782	0.83
13_K	194_N	0.781	0.83
66_W	352_V	0.781	0.83
131_K	307_I	0.776	0.83
73_P	365_V	0.775	0.83
102_A	419_T	0.773	0.82
279_A	282_I	0.772	0.82
103_A	142_W	0.771	0.82
128_T	375_D	0.769	0.82
59_M	145_L	0.769	0.82
56_E	313_P	0.768	0.82
110_I	390_V	0.768	0.82
28_L	39_V	0.768	0.82
291_G	304_T	0.768	0.82
208_L	419_T	0.767	0.82
97_A	259_S	0.766	0.82
477_I	480_G	0.765	0.82
47_V	478_A	0.763	0.82
377_N	382_P	0.763	0.82
116_I	127_S	0.761	0.81
135_L	139_L	0.761	0.81
272_W	403_L	0.759	0.81
109_S	113_Y	0.755	0.81
296_Y	300_M	0.753	0.81
53_W	57_W	0.748	0.80
282_I	369_N	0.746	0.80
19_L	455_L	0.743	0.80
273_V	369_N	0.742	0.80
44_F	48_T	0.742	0.80
55_F	318_V	0.741	0.80
353_L	356_T	0.741	0.80
404_S	409_W	0.741	0.80
276_V	401_L	0.740	0.80
403_L	409_W	0.740	0.80
26_C	458_I	0.738	0.79
246_C	259_S	0.737	0.79
68_W	71_F	0.737	0.79
247_V	449_R	0.737	0.79
260_D	424_N	0.736	0.79
104_V	207_S	0.735	0.79
246_C	258_A	0.732	0.79
455_L	458_I	0.731	0.79
175_L	489_M	0.730	0.79
281_F	372_L	0.729	0.79
281_F	368_S	0.725	0.78
496_K	499_K	0.723	0.78
78_R	346_E	0.723	0.78
98_S	331_M	0.722	0.78
282_I	361_I	0.721	0.78
446_L	450_I	0.721	0.78
283_M	365_V	0.719	0.78
217_E	227_H	0.719	0.78
195_F	478_A	0.717	0.78
138_S	363_W	0.715	0.77
427_S	431_A	0.714	0.77
317_T	321_W	0.714	0.77
78_R	81_N	0.710	0.77
59_M	154_S	0.710	0.77
247_V	427_S	0.710	0.77
201_I	430_L	0.710	0.77
252_Q	257_I	0.709	0.77
108_G	362_L	0.708	0.77
325_V	486_V	0.706	0.76
389_G	392_R	0.706	0.76
122_G	133_L	0.704	0.76
141_H	321_W	0.703	0.76
184_A	189_G	0.703	0.76
66_W	150_Y	0.702	0.76
268_L	406_A	0.702	0.76
398_W	408_M	0.701	0.76
431_A	444_P	0.700	0.76
117_S	382_P	0.699	0.76
77_K	159_Y	0.699	0.76
385_I	389_G	0.699	0.76
82_E	85_E	0.698	0.76
441_G	444_P	0.698	0.76
55_F	481_C	0.697	0.76
65_G	69_L	0.695	0.75
272_W	398_W	0.694	0.75
281_F	285_Y	0.692	0.75
94_M	338_I	0.692	0.75
262_R	421_T	0.692	0.75
373_L	397_T	0.691	0.75
397_T	401_L	0.689	0.75
122_G	125_P	0.689	0.75
240_I	419_T	0.688	0.75
222_L	409_W	0.687	0.74
178_L	493_S	0.685	0.74
38_V	228_T	0.684	0.74
280_S	283_M	0.683	0.74
148_A	352_V	0.682	0.74
259_S	424_N	0.682	0.74
230_Q	233_A	0.681	0.74
243_N	426_C	0.679	0.74
159_Y	501_N	0.679	0.74
236_I	419_T	0.678	0.73
56_E	140_F	0.678	0.73
121_F	133_L	0.675	0.73
428_Y	449_R	0.675	0.73
369_N	420_V	0.674	0.73
147_W	339_S	0.674	0.73
220_Q	223_F	0.673	0.73
172_S	426_C	0.671	0.73
85_E	340_R	0.671	0.73
44_F	474_T	0.671	0.73
46_Y	49_N	0.668	0.72
208_L	211_A	0.668	0.72
213_P	232_D	0.667	0.72
330_Q	426_C	0.667	0.72
466_L	469_L	0.666	0.72
26_C	459_I	0.665	0.72
175_L	189_G	0.665	0.72
94_M	97_A	0.664	0.72
100_T	145_L	0.660	0.71
190_T	194_N	0.658	0.71
230_Q	237_T	0.658	0.71
222_L	415_C	0.657	0.71
385_I	388_Y	0.656	0.71
181_E	186_G	0.655	0.71
114_Y	118_T	0.653	0.71
159_Y	494_F	0.651	0.70
143_G	360_W	0.651	0.70
244_A	454_I	0.650	0.70
66_W	152_F	0.649	0.70
210_L	470_K	0.649	0.70
297_L	301_L	0.647	0.70
369_N	372_L	0.645	0.70
113_Y	393_A	0.644	0.70
15_F	120_P	0.643	0.70
29_T	40_I	0.642	0.69
268_L	272_W	0.642	0.69
347_L	355_L	0.639	0.69
211_A	214_L	0.639	0.69
225_I	234_I	0.637	0.69
246_C	262_R	0.635	0.69
110_I	113_Y	0.635	0.69
117_S	126_N	0.634	0.68
370_T	397_T	0.632	0.68
135_L	285_Y	0.631	0.68
17_P	20_I	0.630	0.68
240_I	456_V	0.629	0.68
305_D	311_G	0.629	0.68
330_Q	422_L	0.629	0.68
216_T	220_Q	0.628	0.68
222_L	408_M	0.628	0.68
291_G	294_L	0.627	0.68
161_F	165_K	0.626	0.67
148_A	152_F	0.625	0.67
243_N	431_A	0.623	0.67
305_D	308_A	0.623	0.67
154_S	159_Y	0.622	0.67
382_P	385_I	0.622	0.67
163_V	340_R	0.620	0.67
22_V	455_L	0.620	0.67
167_E	173_S	0.620	0.67
87_S	93_F	0.618	0.66
86_F	251_L	0.617	0.66
152_F	491_T	0.616	0.66
209_G	319_F	0.615	0.66
145_L	297_L	0.615	0.66
496_K	500_Q	0.614	0.66
175_L	199_A	0.611	0.66
159_Y	344_V	0.610	0.65
223_F	409_W	0.608	0.65
16_F	19_L	0.607	0.65
29_T	170_R	0.606	0.65
167_E	176_V	0.604	0.65
435_C	448_V	0.604	0.65
177_P	189_G	0.603	0.65
253_K	256_R	0.603	0.65
274_F	282_I	0.603	0.65
431_A	445_P	0.600	0.64
162_F	442_E	0.600	0.64
273_V	373_L	0.599	0.64
95_M	99_C	0.598	0.64
25_L	36_A	0.597	0.64
56_E	60_V	0.595	0.64
89_A	353_L	0.595	0.64
474_T	477_I	0.594	0.63
78_R	82_E	0.593	0.63
346_E	349_F	0.593	0.63
15_F	448_V	0.592	0.63
153_L	328_A	0.591	0.63
275_I	283_M	0.590	0.63
376_K	380_N	0.590	0.63
381_I	393_A	0.589	0.63
238_C	241_I	0.588	0.63
318_V	501_N	0.588	0.63
247_V	423_V	0.587	0.63
489_M	492_L	0.587	0.63
237_T	409_W	0.586	0.62
294_L	297_L	0.586	0.62
201_I	456_V	0.585	0.62
312_F	362_L	0.585	0.62
42_A	46_Y	0.585	0.62
111_E	316_W	0.584	0.62
244_A	457_G	0.582	0.62
67_F	352_V	0.581	0.62
125_P	129_G	0.581	0.62
177_P	193_D	0.579	0.61
72_G	348_C	0.577	0.61
158_A	347_L	0.577	0.61
92_I	358_S	0.577	0.61
404_S	407_T	0.577	0.61
27_W	67_F	0.577	0.61
162_F	366_L	0.575	0.61
109_S	370_T	0.575	0.61
157_F	333_I	0.574	0.61
99_C	332_S	0.574	0.61
101_S	104_V	0.573	0.61
270_L	358_S	0.573	0.61
236_I	461_I	0.573	0.61
100_T	320_Y	0.573	0.61
119_P	130_A	0.572	0.61
30_V	413_I	0.572	0.61
491_T	495_I	0.571	0.60
255_V	425_A	0.570	0.60
29_T	466_L	0.570	0.60
463_L	469_L	0.567	0.60
227_H	231_L	0.565	0.60
91_W	350_G	0.565	0.60
95_M	335_L	0.565	0.60
197_L	430_L	0.565	0.60
338_I	490_V	0.564	0.59
111_E	142_W	0.564	0.59
398_W	404_S	0.563	0.59
100_T	324_W	0.563	0.59
79_L	340_R	0.562	0.59
66_W	348_C	0.560	0.59
284_N	287_T	0.560	0.59
114_Y	390_V	0.559	0.59
24_I	27_W	0.559	0.59
118_T	125_P	0.559	0.59
146_P	150_Y	0.557	0.59
147_W	418_A	0.555	0.58
249_C	423_V	0.555	0.58
156_A	325_V	0.555	0.58
269_M	411_F	0.554	0.58
456_V	476_I	0.554	0.58
291_G	306_P	0.554	0.58
196_Y	205_G	0.553	0.58
69_L	498_A	0.553	0.58
327_Y	330_Q	0.553	0.58
146_P	359_T	0.552	0.58
230_Q	406_A	0.552	0.58
206_T	476_I	0.551	0.58
287_T	302_F	0.551	0.58
70_V	73_P	0.551	0.58
146_P	476_I	0.550	0.58
85_E	337_R	0.550	0.58
82_E	86_F	0.549	0.57
236_I	464_L	0.549	0.57
262_R	418_A	0.549	0.57
310_G	313_P	0.549	0.57
38_V	230_Q	0.548	0.57
14_V	18_P	0.548	0.57
389_G	396_E	0.547	0.57
79_L	163_V	0.547	0.57
107_W	312_F	0.546	0.57
131_K	281_F	0.545	0.57
63_L	352_V	0.545	0.57
158_A	162_F	0.545	0.57
93_F	260_D	0.544	0.57
48_T	314_Q	0.544	0.57
383_N	386_E	0.544	0.57
361_I	365_V	0.544	0.57
423_V	430_L	0.543	0.57
373_L	379_I	0.543	0.57
171_P	196_Y	0.541	0.56
243_N	457_G	0.541	0.56
455_L	459_I	0.539	0.56
79_L	159_Y	0.539	0.56
143_G	147_W	0.537	0.56
107_W	303_Y	0.536	0.56
327_Y	331_M	0.536	0.56
137_Y	322_A	0.535	0.56
281_F	376_K	0.535	0.56
260_D	264_Y	0.535	0.56
49_N	315_G	0.534	0.55
493_S	496_K	0.534	0.55
212_T	236_I	0.534	0.55
166_M	185_K	0.533	0.55
92_I	350_G	0.533	0.55
20_I	23_G	0.533	0.55
29_T	462_V	0.533	0.55
145_L	149_T	0.533	0.55
270_L	274_F	0.532	0.55
434_T	452_W	0.532	0.55
112_I	460_G	0.532	0.55
328_A	431_A	0.531	0.55
98_S	207_S	0.531	0.55
200_L	321_W	0.531	0.55
428_Y	432_M	0.529	0.55
68_W	76_K	0.529	0.55
368_S	372_L	0.529	0.55
56_E	105_L	0.528	0.55
373_L	378_I	0.528	0.55
272_W	402_P	0.527	0.54
199_A	326_I	0.526	0.54
251_L	446_L	0.526	0.54
356_T	359_T	0.525	0.54
337_R	449_R	0.523	0.54
116_I	131_K	0.523	0.54
132_E	292_M	0.523	0.54
268_L	271_G	0.523	0.54
60_V	64_F	0.523	0.54
103_A	324_W	0.522	0.54
265_L	348_C	0.521	0.54
40_I	478_A	0.521	0.54
171_P	483_L	0.521	0.54
243_N	456_V	0.520	0.53
282_I	364_T	0.520	0.53
46_Y	481_C	0.519	0.53
31_R	500_Q	0.518	0.53
343_T	346_E	0.517	0.53
110_I	114_Y	0.517	0.53
274_F	412_F	0.517	0.53
222_L	335_L	0.516	0.53
116_I	130_A	0.515	0.53
431_A	434_T	0.515	0.53
61_V	126_N	0.513	0.52
199_A	453_S	0.513	0.52
105_L	415_C	0.512	0.52
263_S	417_I	0.512	0.52
50_V	54_A	0.512	0.52
394_I	398_W	0.512	0.52
476_I	501_N	0.511	0.52
498_A	501_N	0.511	0.52
59_M	146_P	0.510	0.52
481_C	484_F	0.510	0.52
151_S	348_C	0.510	0.52
10_I	15_F	0.509	0.52
485_F	488_I	0.509	0.52
236_I	240_I	0.508	0.52
310_G	314_Q	0.507	0.52
282_I	368_S	0.507	0.52
191_I	194_N	0.507	0.52
107_W	393_A	0.506	0.51
159_Y	163_V	0.505	0.51
250_G	424_N	0.504	0.51
200_L	330_Q	0.504	0.51
274_F	361_I	0.504	0.51
265_L	294_L	0.503	0.51
144_P	290_V	0.503	0.51
319_F	326_I	0.502	0.51
177_P	493_S	0.502	0.51
255_V	444_P	0.502	0.51
81_N	226_P	0.502	0.51
135_L	371_L	0.501	0.51
57_W	61_V	0.501	0.51
447_L	451_G	0.501	0.51
267_F	380_N	0.500	0.51

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2wswA	3	0.996	100	0.022	Contact Map
4c7rA	3	0.9643	100	0.051	Contact Map
2xq2A	2	0.7738	97.6	0.952	Contact Map
3dh4A	3	0.7242	97.2	0.956	Contact Map
3l1lA	2	0.6766	96.7	0.959	Contact Map
3giaA	1	0.6885	96.4	0.96	Contact Map
4djkA	2	0.6687	92.8	0.967	Contact Map
4us3A	1	0.6845	91.1	0.969	Contact Map
2jlnA	1	0.6726	79.8	0.974	Contact Map
4wgvA	2	0.6627	36.7	0.98	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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