GREMLIN Database
CAID - Carnitinyl-CoA dehydratase
UniProt: P31551 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11557
Length: 261 (246)
Sequences: 30049 (19718)
Seq/√Len: 1257.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
126_S164_R3.2081.00
123_D181_S3.1991.00
178_R188_N3.0961.00
121_C176_V2.9731.00
99_A116_A2.8641.00
188_N191_E2.7901.00
15_E190_R2.6751.00
39_L89_E2.5141.00
42_R94_D2.4791.00
163_R195_Q2.3431.00
6_H19_D2.3101.00
124_N182_Q2.2171.00
169_E172_R2.2141.00
218_P221_E2.2111.00
9_R14_L2.1921.00
166_G169_E2.1841.00
157_E163_R2.1561.00
133_K199_S2.0961.00
154_I173_W2.0941.00
15_E53_T2.0461.00
123_D168_E2.0411.00
9_R44_D2.0021.00
159_V207_L1.9911.00
100_A189_A1.9641.00
12_S48_R1.9241.00
7_L14_L1.9211.00
35_G89_E1.8951.00
106_F128_A1.8801.00
100_A186_M1.8791.00
19_D55_A1.8531.00
29_K33_E1.8491.00
17_T55_A1.8471.00
245_E254_R1.8451.00
248_L252_E1.8201.00
120_V180_V1.8121.00
184_E187_D1.8061.00
157_E177_N1.7671.00
14_L41_F1.7621.00
17_T53_T1.7601.00
156_N212_R1.7571.00
40_N44_D1.7391.00
190_R194_Q1.6931.00
117_D208_K1.6861.00
152_P156_N1.6551.00
169_E173_W1.6531.00
50_A93_L1.6381.00
123_D182_Q1.6161.00
14_L47_L1.5971.00
32_F82_G1.5561.00
168_E172_R1.5461.00
120_V192_L1.5441.00
184_E188_N1.5361.00
157_E178_R1.5361.00
121_C127_F1.5261.00
41_F50_A1.5181.00
119_I153_A1.4981.00
180_V188_N1.4921.00
57_E102_N1.4851.00
113_A119_I1.4691.00
119_I149_I1.4611.00
42_R89_E1.4591.00
10_N190_R1.4551.00
16_I37_V1.4541.00
156_N211_Y1.4411.00
11_G194_Q1.4371.00
7_L41_F1.4311.00
49_V193_A1.4301.00
122_A182_Q1.4151.00
156_N160_M1.3981.00
88_T92_N1.3951.00
171_L179_V1.3951.00
101_V113_A1.3821.00
6_H55_A1.3791.00
53_T102_N1.3761.00
88_T220_E1.3641.00
102_N122_A1.3571.00
10_N194_Q1.3491.00
102_N124_N1.3461.00
90_I97_V1.3421.00
38_F93_L1.3391.00
163_R169_E1.3351.00
91_F145_R1.3291.00
101_V105_A1.3201.00
35_G39_L1.3191.00
158_M165_M1.3091.00
154_I157_E1.3081.00
206_A236_S1.3061.00
110_F129_L1.3021.00
10_N15_E1.2951.00
28_A68_A1.2561.00
15_E186_M1.2471.00
27_D30_T1.2471.00
128_A164_R1.2391.00
153_A177_N1.2331.00
18_L30_T1.2291.00
53_T186_M1.2281.00
35_G85_A1.2271.00
209_E213_T1.2091.00
104_Y126_S1.2081.00
42_R93_L1.2011.00
185_L189_A1.1861.00
199_S204_I1.1841.00
154_I169_E1.1831.00
132_A162_G1.1831.00
33_E37_V1.1821.00
243_A247_P1.1791.00
217_M221_E1.1721.00
122_A185_L1.1601.00
186_M190_R1.1591.00
58_K104_Y1.1381.00
111_E142_G1.1331.00
9_R46_Q1.1161.00
23_A67_K1.1161.00
8_T17_T1.1141.00
167_A179_V1.1131.00
9_R40_N1.0941.00
165_M173_W1.0831.00
151_P154_I1.0821.00
18_L61_S1.0791.00
61_S109_G1.0681.00
186_M189_A1.0671.00
92_N220_E1.0491.00
8_T15_E1.0481.00
20_R23_A1.0471.00
213_T225_Y1.0421.00
33_E36_E1.0371.00
202_L242_D1.0331.00
28_A32_F1.0331.00
193_A197_V1.0261.00
118_F192_L1.0221.00
181_S184_E1.0201.00
36_E40_N1.0171.00
50_A95_K1.0171.00
97_V116_A1.0151.00
83_G140_S1.0121.00
6_H17_T1.0001.00
217_M225_Y0.9891.00
56_G102_N0.9801.00
20_R65_D0.9761.00
187_D191_E0.9591.00
123_D179_V0.9551.00
37_V40_N0.9501.00
51_I189_A0.9481.00
150_L154_I0.9481.00
171_L176_V0.9461.00
94_D205_A0.9441.00
53_T100_A0.9301.00
168_E171_L0.9271.00
15_E51_I0.9191.00
149_I153_A0.9151.00
110_F127_F0.9131.00
13_I49_V0.9111.00
102_N185_L0.9091.00
244_I248_L0.9081.00
50_A97_V0.9081.00
47_L95_K0.9071.00
144_L222_A0.9011.00
201_P205_A0.9001.00
132_A207_L0.8951.00
221_E224_R0.8881.00
31_S86_G0.8851.00
126_S166_G0.8831.00
100_A185_L0.8801.00
45_P95_K0.8761.00
101_V127_F0.8761.00
209_E233_H0.8681.00
206_A209_E0.8631.00
73_E76_D0.8631.00
152_P215_S0.8631.00
143_V226_I0.8471.00
190_R193_A0.8371.00
122_A183_A0.8291.00
118_F177_N0.8251.00
101_V119_I0.8241.00
9_R47_L0.8231.00
137_V237_V0.8201.00
191_E195_Q0.8201.00
225_Y228_S0.8191.00
206_A233_H0.8191.00
35_G82_G0.8181.00
171_L178_R0.8121.00
198_N255_D0.8081.00
38_F90_I0.8071.00
39_L43_D0.7891.00
158_M173_W0.7881.00
106_F164_R0.7881.00
67_K251_A0.7861.00
111_E131_E0.7851.00
146_L150_L0.7851.00
16_I50_A0.7831.00
42_R95_K0.7821.00
159_V211_Y0.7801.00
178_R192_L0.7761.00
39_L85_A0.7751.00
150_L158_M0.7711.00
41_F47_L0.7691.00
35_G86_G0.7671.00
133_K164_R0.7651.00
206_A237_V0.7651.00
20_R27_D0.7631.00
28_A82_G0.7621.00
189_A193_A0.7601.00
200_A242_D0.7591.00
210_I233_H0.7571.00
151_P155_V0.7501.00
32_F36_E0.7501.00
107_G130_P0.7481.00
77_A81_P0.7461.00
94_D209_E0.7451.00
157_E161_T0.7431.00
26_I30_T0.7421.00
87_L115_A0.7381.00
48_R201_P0.7381.00
196_L204_I0.7371.00
52_I116_A0.7351.00
241_E244_I0.7321.00
167_A176_V0.7311.00
170_A175_I0.7251.00
247_P251_A0.7191.00
27_D68_A0.7161.00
233_H236_S0.7161.00
114_L175_I0.7141.00
219_V223_Y0.7131.00
144_L147_P0.7121.00
180_V185_L0.7121.00
191_E194_Q0.7111.00
187_D190_R0.7081.00
20_R25_A0.7071.00
188_N192_L0.7011.00
93_L97_V0.6911.00
81_P85_A0.6901.00
13_I51_I0.6901.00
7_L37_V0.6881.00
131_E139_D0.6831.00
161_T192_L0.6831.00
195_Q199_S0.6791.00
176_V179_V0.6761.00
101_V125_A0.6761.00
120_V178_R0.6731.00
202_L240_S0.6721.00
7_L40_N0.6641.00
51_I190_R0.6621.00
29_K32_F0.6611.00
44_D47_L0.6591.00
127_F176_V0.6561.00
194_Q198_N0.6541.00
213_T217_M0.6541.00
152_P212_R0.6521.00
225_Y233_H0.6491.00
120_V189_A0.6491.00
41_F95_K0.6491.00
137_V210_I0.6481.00
51_I100_A0.6461.00
129_L142_G0.6451.00
131_E138_P0.6441.00
106_F130_P0.6391.00
12_S46_Q0.6381.00
58_K102_N0.6371.00
37_V41_F0.6341.00
52_I97_V0.6331.00
93_L96_P0.6331.00
54_G57_E0.6301.00
120_V188_N0.6281.00
30_T33_E0.6261.00
210_I225_Y0.6241.00
44_D95_K0.6231.00
102_N182_Q0.6221.00
120_V185_L0.6221.00
9_R12_S0.6221.00
70_A248_L0.6221.00
138_P207_L0.6201.00
224_R228_S0.6191.00
128_A162_G0.6181.00
154_I171_L0.6141.00
39_L42_R0.6131.00
121_C125_A0.6131.00
152_P211_Y0.6091.00
81_P227_R0.6071.00
64_W69_A0.6051.00
111_E139_D0.6031.00
98_I193_A0.6031.00
13_I193_A0.6021.00
36_E39_L0.6021.00
168_E179_V0.6021.00
220_E224_R0.6001.00
99_A119_I0.5991.00
49_V98_I0.5961.00
227_R235_P0.5961.00
34_M86_G0.5911.00
49_V197_V0.5891.00
7_L16_I0.5891.00
13_I190_R0.5881.00
192_L195_Q0.5881.00
77_A228_S0.5861.00
104_Y164_R0.5861.00
132_A199_S0.5841.00
165_M170_A0.5841.00
150_L155_V0.5811.00
131_E234_Y0.5791.00
144_L148_K0.5761.00
149_I177_N0.5741.00
136_I243_A0.5721.00
242_D246_G0.5701.00
202_L237_V0.5681.00
207_L210_I0.5641.00
78_D82_G0.5641.00
16_I52_I0.5641.00
246_G249_A0.5621.00
248_L251_A0.5601.00
156_N208_K0.5571.00
23_A65_D0.5571.00
77_A235_P0.5551.00
161_T196_L0.5551.00
160_M204_I0.5531.00
25_A62_A0.5521.00
245_E248_L0.5521.00
122_A125_A0.5521.00
245_E252_E0.5521.00
16_I38_F0.5511.00
38_F89_E0.5501.00
157_E169_E0.5501.00
85_A89_E0.5501.00
113_A116_A0.5491.00
228_S236_S0.5481.00
224_R227_R0.5481.00
118_F196_L0.5481.00
129_L159_V0.5461.00
47_L50_A0.5461.00
245_E249_A0.5461.00
110_F175_I0.5451.00
241_E245_E0.5451.00
85_A88_T0.5441.00
166_G172_R0.5441.00
48_R197_V0.5431.00
163_R178_R0.5411.00
150_L173_W0.5401.00
147_P214_T0.5391.00
111_E129_L0.5381.00
167_A171_L0.5371.00
29_K68_A0.5351.00
161_T195_Q0.5351.00
115_A145_R0.5321.00
132_A204_I0.5291.00
154_I172_R0.5281.00
147_P150_L0.5281.00
124_N167_A0.5241.00
26_I108_G0.5241.00
157_E192_L0.5241.00
107_G129_L0.5221.00
31_S35_G0.5211.00
108_G140_S0.5191.00
66_L134_L0.5191.00
38_F97_V0.5161.00
135_G200_A0.5151.00
137_V207_L0.5151.00
237_V240_S0.5141.00
82_G85_A0.5091.00
105_A110_F0.5091.00
100_A193_A0.5081.00
184_E191_E0.5081.00
102_N125_A0.5081.00
111_E145_R0.5071.00
70_A251_A0.5071.00
5_L37_V0.5071.00
51_I186_M0.5051.00
64_W108_G0.5051.00
129_L146_L0.5031.00
38_F50_A0.5011.00
243_A246_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3peaA 3 0.977 100 0.082 Contact Map
2ej5A 3 0.9579 100 0.083 Contact Map
1nzyA 4 0.9808 100 0.083 Contact Map
4lk5A 3 0.9502 100 0.085 Contact Map
4olqA 3 0.9732 100 0.086 Contact Map
3sllA 6 0.9655 100 0.086 Contact Map
4jfcA 3 0.9655 100 0.087 Contact Map
3kqfA 3 0.977 100 0.087 Contact Map
3qxzA 3 0.977 100 0.088 Contact Map
3swxA 3 0.9732 100 0.088 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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