THIP - ECOLI - GREMLIN Contacts

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THIP - Thiamine transport system permease protein ThiP

UniProt:	P31549	Sequences: MATRRQPLIPGWLIPGVSATTLVVAVALAAFLALWWNAPQDDWVAVWQDSYLWHVVRFSFWQAFLSALLSVIPAIFLARALYRRRFPGRLALLRLCAMTLILPVLVAVFGILSVYGRQGWLATLCQSLGLEWTFSPYGLQGILLAHVFFNLPMASRLLLQALENIPGEQRQLAAQLGMRSWHFFRFVEWPWLRRQIPPVAALIFMLCFASFATVLSLGGGPQATTIELAIYQALSYDYDPARAAMLALLQMVCCLGLVLLSQRLSKAIAPGTTLLQGWRDPDDRLHSRICDTVLIVLALLLLLPPLLAVIVDGVNRQLPEVLAQPVLWQALWTSLRIALAAGVLCVVLTMMLLWSSRELRARQKMLAGQVLEMSGMLILAMPGIVLATGFFLLLNNTIGLPQSADGIVIFTNALMAIPYALKVLENPMRDITARYSMLCQSLGIEGWSRLKVVELRALKRPLAQALAFACVLSIGDFGVVALFGNDDFRTLPFYLYQQIGSYRSQDGAVTALILLLLCFLLFTVIEKLPGRNVKTD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11573
Length:	536 (503)
Sequences:	4214 (3115)
Seq/√Len:	138.9

ECOLI - THIP YNJC
HALSA - Q9HMT4 Q9HR05
SULSO - Q97VC0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
439_C	449_R	5.899	1.00
313_G	318_L	5.160	1.00
175_Q	441_S	4.696	1.00
69_L	147_V	4.512	1.00
173_A	183_F	4.198	1.00
284_R	288_R	4.141	1.00
448_S	451_K	3.997	1.00
284_R	287_S	3.884	1.00
65_L	143_L	3.742	1.00
181_W	185_R	3.673	1.00
332_W	336_R	3.496	1.00
67_A	200_A	3.478	1.00
427_P	461_P	3.366	1.00
182_H	186_F	3.334	1.00
35_W	43_W	3.301	1.00
65_L	139_L	3.268	1.00
344_L	413_A	2.971	1.00
448_S	452_V	2.921	1.00
334_S	474_I	2.918	1.00
57_R	61_W	2.873	1.00
176_L	442_L	2.806	1.00
343_V	466_L	2.795	1.00
74_A	154_A	2.772	1.00
91_A	95_L	2.771	1.00
444_I	448_S	2.746	1.00
444_I	452_V	2.691	1.00
179_R	182_H	2.608	1.00
283_D	287_S	2.600	1.00
342_G	466_L	2.521	1.00
316_R	319_P	2.497	1.00
284_R	289_I	2.459	1.00
83_R	170_R	2.425	1.00
445_E	448_S	2.413	1.00
259_L	263_R	2.381	1.00
71_V	200_A	2.341	1.00
282_D	286_H	2.339	1.00
171_Q	437_M	2.322	1.00
340_A	409_I	2.207	1.00
178_M	444_I	2.203	1.00
154_A	203_I	2.168	1.00
61_W	139_L	2.162	1.00
211_F	231_Y	2.147	1.00
139_L	143_L	2.135	1.00
182_H	185_R	2.109	1.00
178_M	186_F	2.067	1.00
154_A	158_L	2.057	1.00
285_L	289_I	2.049	1.00
186_F	452_V	2.037	1.00
365_M	368_G	2.036	1.00
53_W	57_R	2.005	1.00
173_A	187_V	2.005	1.00
63_A	204_F	2.003	1.00
177_G	443_G	1.997	1.00
284_R	290_C	1.986	1.00
305_P	309_V	1.932	1.00
299_L	303_L	1.919	1.00
350_M	462_L	1.891	1.00
75_I	158_L	1.886	1.00
283_D	286_H	1.880	1.00
74_A	158_L	1.872	1.00
336_R	340_A	1.855	1.00
285_L	288_R	1.847	1.00
154_A	199_V	1.815	1.00
439_C	444_I	1.806	1.00
27_A	31_F	1.795	1.00
54_H	57_R	1.779	1.00
75_I	192_L	1.769	1.00
85_R	89_R	1.767	1.00
337_I	409_I	1.767	1.00
297_L	301_L	1.755	1.00
170_R	188_E	1.717	1.00
43_W	46_V	1.705	1.00
341_A	473_S	1.697	1.00
161_A	195_Q	1.691	1.00
239_D	242_R	1.686	1.00
178_M	182_H	1.669	1.00
180_S	183_F	1.665	1.00
26_V	393_L	1.663	1.00
338_A	342_G	1.661	1.00
336_R	339_L	1.637	1.00
282_D	287_S	1.624	1.00
353_L	428_M	1.612	1.00
310_I	512_L	1.609	1.00
349_T	420_A	1.601	1.00
55_V	229_A	1.593	1.00
80_A	290_C	1.590	1.00
431_I	458_L	1.585	1.00
514_L	518_C	1.573	1.00
143_L	147_V	1.560	1.00
21_T	25_A	1.549	1.00
27_A	32_L	1.547	1.00
65_L	147_V	1.522	1.00
511_A	514_L	1.512	1.00
70_S	147_V	1.507	1.00
339_L	343_V	1.505	1.00
31_F	389_G	1.502	1.00
256_G	260_L	1.491	1.00
174_A	440_Q	1.488	1.00
41_D	44_V	1.487	1.00
517_L	521_L	1.484	1.00
338_A	474_I	1.483	1.00
62_Q	139_L	1.483	1.00
28_L	32_L	1.475	1.00
111_I	145_A	1.466	1.00
446_G	449_R	1.464	1.00
305_P	313_G	1.450	1.00
310_I	314_V	1.440	1.00
508_A	511_A	1.436	1.00
290_C	294_L	1.428	1.00
172_L	438_L	1.425	1.00
174_A	183_F	1.421	1.00
43_W	248_L	1.415	1.00
503_R	506_D	1.408	1.00
170_R	183_F	1.403	1.00
59_S	208_F	1.399	1.00
263_R	266_K	1.398	1.00
293_V	297_L	1.390	1.00
402_Q	407_I	1.380	1.00
447_W	451_K	1.377	1.00
252_V	256_G	1.373	1.00
436_S	454_E	1.367	1.00
225_T	228_L	1.367	1.00
518_C	521_L	1.364	1.00
282_D	288_R	1.356	1.00
514_L	521_L	1.353	1.00
37_N	40_Q	1.349	1.00
72_I	76_F	1.347	1.00
434_R	437_M	1.346	1.00
372_E	422_K	1.340	1.00
295_I	299_L	1.331	1.00
124_L	127_S	1.330	1.00
480_V	490_T	1.326	1.00
140_Q	144_L	1.326	1.00
283_D	289_I	1.325	1.00
328_W	332_W	1.324	1.00
70_S	203_I	1.321	1.00
424_L	465_A	1.316	1.00
301_L	305_P	1.316	1.00
289_I	292_T	1.314	1.00
230_I	246_L	1.307	1.00
81_L	155_S	1.297	1.00
35_W	248_L	1.297	1.00
62_Q	66_S	1.283	1.00
358_E	436_S	1.280	1.00
476_D	480_V	1.280	1.00
304_P	307_L	1.279	1.00
290_C	293_V	1.275	1.00
61_W	65_L	1.264	1.00
107_A	149_F	1.262	1.00
93_L	155_S	1.257	1.00
43_W	47_W	1.249	1.00
192_L	195_Q	1.239	1.00
69_L	73_P	1.236	1.00
69_L	143_L	1.232	1.00
71_V	154_A	1.230	1.00
504_S	511_A	1.230	1.00
291_D	295_I	1.230	1.00
449_R	453_V	1.225	1.00
435_Y	457_A	1.216	1.00
75_I	196_I	1.205	1.00
185_R	189_W	1.205	1.00
411_T	479_V	1.203	1.00
88_G	91_A	1.189	1.00
508_A	514_L	1.188	1.00
510_T	514_L	1.186	1.00
510_T	518_C	1.183	1.00
439_C	452_V	1.168	0.99
423_V	465_A	1.168	0.99
412_N	480_V	1.167	0.99
514_L	517_L	1.164	0.99
412_N	473_S	1.160	0.99
158_L	196_I	1.158	0.99
317_Q	320_E	1.157	0.99
282_D	290_C	1.157	0.99
329_Q	332_W	1.157	0.99
142_I	214_V	1.156	0.99
333_T	488_F	1.152	0.99
307_L	311_V	1.151	0.99
61_W	143_L	1.149	0.99
310_I	313_G	1.149	0.99
173_A	178_M	1.148	0.99
52_L	56_V	1.144	0.99
424_L	458_L	1.141	0.99
60_F	64_F	1.141	0.99
183_F	187_V	1.140	0.99
420_A	469_A	1.135	0.99
287_S	290_C	1.133	0.99
148_F	301_L	1.131	0.99
341_A	413_A	1.128	0.99
282_D	285_L	1.122	0.99
345_C	413_A	1.115	0.99
508_A	515_L	1.113	0.99
319_P	323_A	1.105	0.99
345_C	469_A	1.101	0.99
112_L	137_Y	1.099	0.99
504_S	508_A	1.091	0.99
288_R	291_D	1.088	0.99
29_A	33_A	1.085	0.99
27_A	35_W	1.083	0.99
520_L	524_V	1.080	0.99
76_F	80_A	1.080	0.99
146_H	210_S	1.079	0.99
65_L	69_L	1.079	0.99
44_V	48_Q	1.076	0.99
61_W	64_F	1.076	0.99
170_R	174_A	1.074	0.99
66_S	146_H	1.073	0.99
302_L	305_P	1.070	0.99
511_A	517_L	1.066	0.99
523_T	527_K	1.059	0.99
494_Y	497_Q	1.058	0.99
511_A	515_L	1.057	0.99
279_R	282_D	1.051	0.99
158_L	192_L	1.051	0.99
283_D	288_R	1.049	0.99
504_S	514_L	1.048	0.99
420_A	465_A	1.047	0.99
129_G	132_W	1.045	0.99
77_L	151_L	1.045	0.99
148_F	300_L	1.044	0.99
387_A	478_G	1.039	0.99
484_G	493_F	1.038	0.99
455_L	462_L	1.037	0.99
343_V	347_V	1.035	0.99
169_Q	191_W	1.031	0.99
62_Q	142_I	1.031	0.99
23_V	27_A	1.028	0.99
30_A	34_L	1.028	0.99
79_R	184_F	1.022	0.99
337_I	405_D	1.019	0.99
331_L	491_L	1.019	0.99
320_E	323_A	1.017	0.99
309_V	313_G	1.016	0.99
229_A	232_Q	1.016	0.99
157_L	199_V	1.015	0.99
319_P	322_L	1.010	0.98
438_L	441_S	1.008	0.98
286_H	290_C	1.008	0.98
233_A	239_D	1.005	0.98
45_A	48_Q	1.003	0.98
25_A	29_A	1.001	0.98
93_L	159_L	0.995	0.98
299_L	304_P	0.992	0.98
55_V	59_S	0.989	0.98
248_L	252_V	0.987	0.98
42_D	45_A	0.986	0.98
263_R	267_A	0.986	0.98
150_N	207_C	0.983	0.98
303_L	307_L	0.983	0.98
408_V	412_N	0.982	0.98
41_D	45_A	0.981	0.98
511_A	521_L	0.980	0.98
336_R	405_D	0.977	0.98
288_R	292_T	0.976	0.98
440_Q	449_R	0.974	0.98
317_Q	322_L	0.970	0.98
292_T	296_V	0.967	0.98
518_C	522_F	0.966	0.98
77_L	96_C	0.965	0.98
383_G	415_M	0.964	0.98
208_F	250_Q	0.958	0.98
311_V	315_N	0.957	0.98
40_Q	44_V	0.957	0.98
439_C	453_V	0.956	0.98
106_V	511_A	0.952	0.98
179_R	183_F	0.949	0.98
328_W	331_L	0.949	0.98
513_I	517_L	0.948	0.98
404_A	407_I	0.946	0.98
333_T	336_R	0.946	0.98
198_P	422_K	0.945	0.98
458_L	461_P	0.944	0.98
158_L	162_L	0.942	0.98
224_T	229_A	0.942	0.98
427_P	458_L	0.939	0.98
470_C	521_L	0.939	0.98
349_T	421_L	0.939	0.98
308_A	312_D	0.937	0.98
397_T	400_L	0.937	0.98
66_S	70_S	0.936	0.98
511_A	518_C	0.934	0.97
34_L	392_L	0.932	0.97
431_I	457_A	0.931	0.97
41_D	68_L	0.931	0.97
309_V	314_V	0.930	0.97
338_A	473_S	0.926	0.97
85_R	282_D	0.924	0.97
73_P	147_V	0.923	0.97
416_A	469_A	0.922	0.97
495_L	511_A	0.921	0.97
331_L	517_L	0.920	0.97
110_G	218_G	0.917	0.97
428_M	458_L	0.913	0.97
192_L	196_I	0.911	0.97
57_R	60_F	0.909	0.97
521_L	525_I	0.906	0.97
353_L	424_L	0.906	0.97
151_L	155_S	0.905	0.97
39_P	42_D	0.901	0.97
489_R	497_Q	0.900	0.97
174_A	180_S	0.896	0.97
29_A	32_L	0.895	0.97
342_G	346_V	0.893	0.97
509_V	512_L	0.892	0.97
289_I	293_V	0.891	0.97
295_I	303_L	0.885	0.97
332_W	335_L	0.881	0.96
164_N	430_D	0.881	0.96
261_S	265_S	0.878	0.96
345_C	420_A	0.877	0.96
318_L	322_L	0.872	0.96
112_L	216_S	0.871	0.96
70_S	154_A	0.868	0.96
352_L	421_L	0.867	0.96
165_I	192_L	0.866	0.96
66_S	207_C	0.865	0.96
498_Q	510_T	0.863	0.96
273_T	276_Q	0.862	0.96
320_E	324_Q	0.861	0.96
445_E	449_R	0.860	0.96
338_A	341_A	0.860	0.96
334_S	492_P	0.859	0.96
281_P	286_H	0.858	0.96
159_L	163_E	0.856	0.96
93_L	163_E	0.854	0.96
380_A	383_G	0.854	0.96
27_A	34_L	0.853	0.96
124_L	128_L	0.852	0.96
74_A	155_S	0.851	0.96
514_L	522_F	0.850	0.96
53_W	56_V	0.849	0.96
59_S	227_E	0.847	0.96
280_D	286_H	0.847	0.96
403_S	407_I	0.847	0.96
281_P	284_R	0.847	0.96
162_L	188_E	0.844	0.95
182_H	448_S	0.842	0.95
405_D	409_I	0.842	0.95
354_W	428_M	0.841	0.95
280_D	283_D	0.840	0.95
412_N	476_D	0.840	0.95
513_I	516_L	0.837	0.95
334_S	338_A	0.833	0.95
354_W	358_E	0.831	0.95
230_I	250_Q	0.831	0.95
270_P	273_T	0.830	0.95
142_I	218_G	0.830	0.95
495_L	514_L	0.829	0.95
87_P	288_R	0.828	0.95
485_N	488_F	0.828	0.95
311_V	314_V	0.827	0.95
233_A	236_Y	0.826	0.95
450_L	454_E	0.824	0.95
504_S	518_C	0.824	0.95
211_F	215_L	0.824	0.95
344_L	409_I	0.823	0.95
484_G	489_R	0.823	0.95
285_L	290_C	0.822	0.95
366_L	369_Q	0.821	0.95
224_T	232_Q	0.821	0.95
518_C	523_T	0.821	0.95
510_T	521_L	0.819	0.95
27_A	30_A	0.818	0.95
287_S	291_D	0.814	0.94
64_F	200_A	0.813	0.94
449_R	452_V	0.812	0.94
229_A	233_A	0.807	0.94
394_L	407_I	0.807	0.94
20_T	24_V	0.807	0.94
507_G	510_T	0.807	0.94
224_T	228_L	0.805	0.94
56_V	253_C	0.805	0.94
78_A	82_Y	0.791	0.94
225_T	229_A	0.790	0.94
67_A	204_F	0.790	0.94
180_S	184_F	0.789	0.93
67_A	71_V	0.789	0.93
278_W	283_D	0.787	0.93
90_L	93_L	0.786	0.93
353_L	357_R	0.785	0.93
505_Q	510_T	0.783	0.93
162_L	192_L	0.782	0.93
62_Q	146_H	0.782	0.93
80_A	84_R	0.780	0.93
233_A	242_R	0.780	0.93
337_I	408_V	0.780	0.93
63_A	208_F	0.780	0.93
107_A	148_F	0.779	0.93
108_V	212_A	0.777	0.93
506_D	511_A	0.776	0.93
92_L	295_I	0.775	0.93
145_A	213_T	0.775	0.93
519_F	523_T	0.770	0.93
212_A	383_G	0.769	0.93
445_E	451_K	0.768	0.93
274_L	277_G	0.767	0.92
210_S	475_G	0.767	0.92
338_A	470_C	0.767	0.92
510_T	522_F	0.766	0.92
330_A	494_Y	0.764	0.92
105_L	210_S	0.764	0.92
43_W	245_M	0.762	0.92
19_A	27_A	0.762	0.92
517_L	523_T	0.762	0.92
280_D	285_L	0.758	0.92
347_V	520_L	0.757	0.92
284_R	305_P	0.756	0.92
364_K	369_Q	0.755	0.92
73_P	151_L	0.753	0.92
364_K	368_G	0.752	0.92
75_I	154_A	0.752	0.92
424_L	462_L	0.751	0.92
37_N	293_V	0.750	0.92
340_A	344_L	0.750	0.92
79_R	162_L	0.750	0.92
58_F	61_W	0.749	0.92
375_G	421_L	0.748	0.92
294_L	298_A	0.747	0.91
298_A	301_L	0.746	0.91
370_V	374_S	0.739	0.91
172_L	175_Q	0.739	0.91
19_A	23_V	0.738	0.91
281_P	285_L	0.738	0.91
346_V	466_L	0.737	0.91
504_S	509_V	0.736	0.91
211_F	496_Y	0.734	0.91
298_A	302_L	0.734	0.91
391_F	395_N	0.732	0.91
126_Q	129_G	0.732	0.91
58_F	228_L	0.728	0.90
161_A	192_L	0.728	0.90
391_F	397_T	0.727	0.90
199_V	203_I	0.724	0.90
352_L	375_G	0.723	0.90
210_S	383_G	0.723	0.90
281_P	287_S	0.722	0.90
63_A	67_A	0.722	0.90
50_S	54_H	0.722	0.90
396_N	400_L	0.718	0.90
506_D	518_C	0.715	0.90
508_A	517_L	0.715	0.90
338_A	356_S	0.712	0.89
77_L	217_L	0.712	0.89
18_S	22_L	0.712	0.89
282_D	289_I	0.709	0.89
476_D	490_T	0.708	0.89
103_P	212_A	0.708	0.89
504_S	510_T	0.707	0.89
42_D	241_A	0.704	0.89
285_L	291_D	0.703	0.89
294_L	297_L	0.701	0.89
195_Q	199_V	0.701	0.89
18_S	21_T	0.699	0.89
167_G	170_R	0.698	0.88
451_K	455_L	0.696	0.88
212_A	476_D	0.695	0.88
69_L	72_I	0.694	0.88
121_L	124_L	0.693	0.88
206_L	209_A	0.693	0.88
130_L	133_T	0.691	0.88
259_L	516_L	0.690	0.88
436_S	449_R	0.688	0.88
316_R	323_A	0.684	0.87
334_S	341_A	0.681	0.87
211_F	386_L	0.681	0.87
187_V	453_V	0.681	0.87
114_V	308_A	0.680	0.87
355_S	359_L	0.679	0.87
397_T	401_P	0.679	0.87
317_Q	321_V	0.678	0.87
247_A	338_A	0.678	0.87
508_A	518_C	0.675	0.87
301_L	304_P	0.674	0.87
511_A	522_F	0.674	0.87
272_T	275_L	0.674	0.87
102_L	107_A	0.672	0.87
81_L	89_R	0.671	0.86
337_I	412_N	0.670	0.86
369_Q	429_R	0.669	0.86
113_S	308_A	0.669	0.86
461_P	465_A	0.667	0.86
506_D	522_F	0.667	0.86
341_A	412_N	0.666	0.86
22_L	27_A	0.665	0.86
16_G	19_A	0.663	0.86
158_L	199_V	0.662	0.86
46_V	52_L	0.662	0.86
125_C	130_L	0.661	0.86
206_L	379_L	0.661	0.86
234_L	388_T	0.660	0.86
128_L	132_W	0.659	0.85
149_F	475_G	0.659	0.85
352_L	417_I	0.657	0.85
386_L	495_L	0.657	0.85
408_V	479_V	0.656	0.85
346_V	462_L	0.656	0.85
308_A	311_V	0.656	0.85
210_S	478_G	0.656	0.85
104_V	107_A	0.653	0.85
165_I	188_E	0.653	0.85
206_L	472_L	0.652	0.85
75_I	184_F	0.652	0.85
256_G	259_L	0.652	0.85
514_L	523_T	0.649	0.85
116_G	137_Y	0.649	0.85
215_L	496_Y	0.649	0.85
510_T	517_L	0.647	0.84
305_P	312_D	0.645	0.84
129_G	133_T	0.645	0.84
343_V	348_L	0.644	0.84
85_R	283_D	0.643	0.84
111_I	477_F	0.642	0.84
21_T	29_A	0.641	0.84
506_D	510_T	0.641	0.84
184_F	189_W	0.640	0.84
265_S	268_I	0.640	0.84
237_D	240_P	0.638	0.84
82_Y	162_L	0.638	0.84
335_L	339_L	0.638	0.84
329_Q	333_T	0.636	0.83
74_A	77_L	0.636	0.83
481_A	490_T	0.636	0.83
475_G	492_P	0.634	0.83
42_D	46_V	0.632	0.83
346_V	465_A	0.629	0.83
342_G	345_C	0.629	0.83
51_Y	55_V	0.628	0.83
85_R	90_L	0.628	0.83
77_L	81_L	0.625	0.82
517_L	522_F	0.624	0.82
105_L	478_G	0.623	0.82
458_L	462_L	0.623	0.82
56_V	60_F	0.622	0.82
350_M	424_L	0.622	0.82
86_F	89_R	0.621	0.82
296_V	411_T	0.620	0.82
24_V	468_F	0.619	0.82
334_S	473_S	0.618	0.82
81_L	84_R	0.616	0.81
107_A	172_L	0.616	0.81
46_V	245_M	0.615	0.81
258_V	411_T	0.614	0.81
419_Y	472_L	0.613	0.81
336_R	516_L	0.613	0.81
113_S	312_D	0.613	0.81
110_G	308_A	0.613	0.81
343_V	346_V	0.612	0.81
142_I	213_T	0.612	0.81
58_F	62_Q	0.612	0.81
406_G	409_I	0.612	0.81
358_E	433_A	0.612	0.81
121_L	125_C	0.611	0.81
205_M	209_A	0.610	0.81
72_I	256_G	0.610	0.81
481_A	484_G	0.609	0.81
60_F	521_L	0.609	0.81
316_R	325_P	0.609	0.81
60_F	181_W	0.609	0.81
71_V	199_V	0.608	0.81
523_T	526_E	0.607	0.81
479_V	483_F	0.607	0.81
146_H	214_V	0.606	0.80
158_L	195_Q	0.606	0.80
279_R	347_V	0.605	0.80
412_N	415_M	0.605	0.80
15_P	347_V	0.604	0.80
100_L	153_M	0.604	0.80
365_M	369_Q	0.603	0.80
381_M	385_V	0.602	0.80
74_A	78_A	0.601	0.80
27_A	36_W	0.601	0.80
18_S	364_K	0.599	0.80
460_R	483_F	0.599	0.80
96_C	151_L	0.598	0.80
243_A	389_G	0.598	0.80
505_Q	509_V	0.597	0.79
270_P	276_Q	0.596	0.79
320_E	325_P	0.596	0.79
31_F	36_W	0.596	0.79
300_L	305_P	0.596	0.79
307_L	310_I	0.595	0.79
283_D	290_C	0.595	0.79
122_A	130_L	0.595	0.79
85_R	281_P	0.594	0.79
319_P	324_Q	0.592	0.79
481_A	493_F	0.592	0.79
209_A	479_V	0.591	0.79
15_P	21_T	0.591	0.79
291_D	294_L	0.591	0.79
70_S	143_L	0.590	0.79
76_F	293_V	0.588	0.78
108_V	389_G	0.588	0.78
250_Q	382_P	0.587	0.78
227_E	250_Q	0.587	0.78
314_V	447_W	0.585	0.78
44_V	47_W	0.585	0.78
346_V	424_L	0.584	0.78
31_F	35_W	0.583	0.78
216_S	498_Q	0.582	0.78
104_V	213_T	0.579	0.77
199_V	476_D	0.579	0.77
390_F	410_F	0.579	0.77
316_R	366_L	0.579	0.77
450_L	455_L	0.578	0.77
350_M	390_F	0.577	0.77
235_S	388_T	0.576	0.77
262_Q	266_K	0.576	0.77
390_F	411_T	0.576	0.77
32_L	36_W	0.575	0.77
225_T	496_Y	0.575	0.77
491_L	502_Y	0.575	0.77
105_L	477_F	0.574	0.77
506_D	509_V	0.574	0.77
32_L	248_L	0.574	0.77
201_A	258_V	0.572	0.76
91_A	298_A	0.572	0.76
162_L	382_P	0.571	0.76
481_A	496_Y	0.571	0.76
75_I	79_R	0.571	0.76
178_M	183_F	0.570	0.76
474_I	517_L	0.570	0.76
480_V	492_P	0.570	0.76
469_A	473_S	0.569	0.76
116_G	218_G	0.569	0.76
206_L	478_G	0.569	0.76
76_F	294_L	0.569	0.76
84_R	291_D	0.568	0.76
120_W	124_L	0.568	0.76
31_F	34_L	0.568	0.76
68_L	71_V	0.568	0.76
302_L	307_L	0.567	0.76
306_L	309_V	0.567	0.76
109_F	238_Y	0.565	0.76
280_D	289_I	0.564	0.75
290_C	307_L	0.564	0.75
313_G	512_L	0.563	0.75
85_R	285_L	0.563	0.75
489_R	493_F	0.563	0.75
75_I	162_L	0.562	0.75
112_L	116_G	0.562	0.75
279_R	284_R	0.561	0.75
64_F	396_N	0.560	0.75
36_W	42_D	0.560	0.75
80_A	86_F	0.559	0.75
77_L	155_S	0.559	0.75
359_L	364_K	0.557	0.75
440_Q	458_L	0.557	0.75
408_V	480_V	0.556	0.74
428_M	454_E	0.555	0.74
345_C	349_T	0.555	0.74
73_P	294_L	0.553	0.74
477_F	490_T	0.553	0.74
206_L	380_A	0.552	0.74
472_L	475_G	0.552	0.74
196_I	262_Q	0.552	0.74
385_V	415_M	0.551	0.74
115_Y	492_P	0.551	0.74
207_C	492_P	0.550	0.74
228_L	232_Q	0.550	0.74
271_G	277_G	0.550	0.74
256_G	339_L	0.548	0.73
317_Q	323_A	0.548	0.73
367_A	370_V	0.547	0.73
388_T	482_L	0.545	0.73
515_L	521_L	0.545	0.73
162_L	190_P	0.544	0.73
415_M	476_D	0.544	0.73
322_L	325_P	0.544	0.73
22_L	25_A	0.543	0.73
153_M	199_V	0.543	0.73
105_L	475_G	0.543	0.73
505_Q	514_L	0.543	0.73
340_A	343_V	0.542	0.73
225_T	491_L	0.542	0.73
70_S	151_L	0.542	0.73
509_V	518_C	0.541	0.72
292_T	295_I	0.541	0.72
293_V	300_L	0.541	0.72
210_S	213_T	0.541	0.72
321_V	325_P	0.539	0.72
172_L	178_M	0.539	0.72
438_L	444_I	0.538	0.72
72_I	451_K	0.538	0.72
255_L	259_L	0.537	0.72
150_N	210_S	0.536	0.72
318_L	321_V	0.536	0.72
32_L	35_W	0.536	0.72
247_A	385_V	0.536	0.72
36_W	61_W	0.534	0.71
150_N	206_L	0.534	0.71
524_V	527_K	0.534	0.71
97_A	522_F	0.533	0.71
202_L	472_L	0.532	0.71
468_F	511_A	0.532	0.71
278_W	281_P	0.532	0.71
272_T	277_G	0.532	0.71
30_A	33_A	0.530	0.71
52_L	225_T	0.529	0.71
142_I	219_G	0.529	0.71
22_L	401_P	0.529	0.71
152_P	383_G	0.528	0.71
271_G	433_A	0.528	0.71
185_R	447_W	0.527	0.70
281_P	288_R	0.527	0.70
191_W	194_R	0.527	0.70
230_I	243_A	0.527	0.70
29_A	347_V	0.526	0.70
142_I	217_L	0.525	0.70
391_F	402_Q	0.524	0.70
379_L	475_G	0.524	0.70
204_F	214_V	0.523	0.70
128_L	131_E	0.523	0.70
179_R	185_R	0.523	0.70
146_H	150_N	0.521	0.70
225_T	490_T	0.521	0.70
219_G	482_L	0.520	0.69
302_L	306_L	0.520	0.69
455_L	458_L	0.519	0.69
305_P	476_D	0.519	0.69
482_L	495_L	0.519	0.69
394_L	414_L	0.518	0.69
504_S	517_L	0.518	0.69
504_S	515_L	0.517	0.69
142_I	228_L	0.517	0.69
211_F	228_L	0.517	0.69
61_W	68_L	0.516	0.69
28_L	36_W	0.516	0.69
152_P	385_V	0.515	0.69
412_N	490_T	0.515	0.69
309_V	315_N	0.515	0.69
105_L	383_G	0.515	0.69
278_W	284_R	0.514	0.69
141_G	338_A	0.513	0.68
81_L	92_L	0.512	0.68
276_Q	453_V	0.512	0.68
319_P	335_L	0.512	0.68
243_A	475_G	0.512	0.68
280_D	284_R	0.510	0.68
18_S	371_L	0.510	0.68
353_L	425_E	0.509	0.68
294_L	301_L	0.509	0.68
390_F	414_L	0.509	0.68
304_P	308_A	0.508	0.68
326_V	329_Q	0.507	0.68
137_Y	204_F	0.507	0.68
62_Q	207_C	0.507	0.68
450_L	524_V	0.506	0.67
287_S	299_L	0.505	0.67
331_L	335_L	0.504	0.67
49_D	52_L	0.503	0.67
73_P	297_L	0.502	0.67
21_T	26_V	0.502	0.67
41_D	296_V	0.501	0.67
82_Y	159_L	0.500	0.67

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2onkC	2	0.4683	100	0.654	Contact Map
3d31C	2	0.4627	100	0.662	Contact Map
4tquM	1	0.5	100	0.666	Contact Map
3rlfF	1	0.4795	100	0.697	Contact Map
3rlfG	1	0.4813	100	0.699	Contact Map
4tquN	1	0.4608	100	0.712	Contact Map
4ymuD	2	0.3993	100	0.761	Contact Map
3tuiA	2	0.3955	99.9	0.782	Contact Map
4xtrG	1	0.041	11.1	0.976	Contact Map
2kluA	1	0.069	11	0.976	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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