GREMLIN Database
METI - D-methionine transport system permease protein MetI
UniProt: P31547 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11737
Length: 217 (197)
Sequences: 75489 (45936)
Seq/√Len: 3272.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
124_R133_I3.4221.00
14_W18_A3.3691.00
132_Q136_K3.2941.00
123_S133_I2.8271.00
26_F97_T2.5941.00
129_T132_Q2.5931.00
130_P133_I2.4701.00
22_V93_I2.4241.00
109_E113_L2.3641.00
131_M135_R2.3591.00
120_I138_L2.2031.00
111_A145_G2.1651.00
119_L141_E2.1521.00
10_V14_W2.1341.00
120_I133_I2.1101.00
11_R14_W2.1101.00
50_A53_Y1.9601.00
92_A164_G1.9361.00
205_F209_R1.9031.00
18_A89_L1.8971.00
120_I124_R1.8411.00
132_Q135_R1.7851.00
108_V146_L1.7811.00
11_R15_E1.7761.00
128_A132_Q1.7571.00
39_Y113_L1.7341.00
84_G87_I1.7241.00
175_I178_Q1.7051.00
151_T207_G1.6641.00
32_L142_A1.6431.00
32_L108_V1.6381.00
34_V105_A1.6311.00
15_E18_A1.6211.00
18_A22_V1.6011.00
29_V33_P1.5891.00
123_S128_A1.5881.00
57_S109_E1.5821.00
104_I153_T1.5701.00
24_G150_A1.5651.00
82_I85_T1.5611.00
124_R130_P1.5571.00
174_Q178_Q1.5501.00
31_G104_I1.5441.00
12_G175_I1.5101.00
175_I179_Y1.5061.00
185_N188_V1.4981.00
38_L105_A1.4961.00
176_G192_V1.4931.00
66_I71_L1.4431.00
35_G108_V1.4341.00
34_V101_A1.3861.00
161_S165_G1.3841.00
82_I87_I1.3791.00
20_T154_L1.3601.00
8_L11_R1.3451.00
130_P134_V1.3301.00
82_I86_S1.3261.00
129_T133_I1.3231.00
179_Y183_G1.3211.00
148_N152_I1.3011.00
51_K54_R1.2891.00
28_F150_A1.2871.00
123_S137_V1.2861.00
104_I149_A1.2831.00
112_L142_A1.2741.00
117_T120_I1.2731.00
39_Y109_E1.2621.00
49_N53_Y1.2601.00
117_T121_E1.2181.00
25_F29_V1.2011.00
174_Q177_Y1.1981.00
51_K55_T1.1921.00
26_F93_I1.1841.00
118_G121_E1.1751.00
39_Y112_L1.1731.00
36_V112_L1.1691.00
93_I97_T1.1421.00
75_M95_P1.1421.00
55_T59_I1.1421.00
30_I101_A1.1251.00
37_L56_V1.1201.00
201_Y205_F1.1141.00
178_Q182_I1.1131.00
115_I141_E1.1101.00
95_P167_V1.1061.00
50_A54_R1.0951.00
47_I120_I1.0881.00
139_L146_L1.0811.00
143_L147_V1.0771.00
52_L55_T1.0721.00
112_L138_L1.0641.00
173_G176_G1.0601.00
176_G179_Y1.0551.00
22_V25_F1.0491.00
55_T58_A1.0471.00
96_L157_L1.0431.00
182_I185_N1.0421.00
108_V149_A1.0381.00
87_I90_Q1.0341.00
101_A105_A1.0251.00
22_V26_F1.0241.00
205_F208_D1.0141.00
23_S96_L1.0111.00
23_S157_L1.0081.00
68_F99_G1.0021.00
24_G154_L0.9951.00
30_I97_T0.9901.00
206_A209_R0.9831.00
108_V142_A0.9761.00
202_L206_A0.9761.00
23_S27_G0.9751.00
36_V134_V0.9701.00
24_G157_L0.9621.00
133_I136_K0.9521.00
92_A96_L0.9481.00
18_A90_Q0.9461.00
128_A136_K0.9391.00
187_T190_N0.9391.00
141_E144_P0.9351.00
33_P37_L0.9311.00
49_N54_R0.9271.00
104_I108_V0.9221.00
27_G153_T0.9171.00
25_F150_A0.9151.00
35_G112_L0.9111.00
145_G149_A0.9101.00
35_G39_Y0.9071.00
90_Q94_V0.9071.00
27_G104_I0.9051.00
27_G100_A0.9011.00
89_L93_I0.8951.00
90_Q93_I0.8711.00
53_Y57_S0.8651.00
26_F29_V0.8621.00
60_V105_A0.8621.00
180_G186_A0.8611.00
28_F108_V0.8601.00
28_F146_L0.8551.00
95_P163_M0.8531.00
180_G189_M0.8521.00
32_L134_V0.8501.00
53_Y113_L0.8501.00
22_V97_T0.8441.00
188_V192_V0.8401.00
31_G105_A0.8361.00
54_R57_S0.8341.00
18_A21_F0.8311.00
208_D211_V0.8261.00
83_V87_I0.8241.00
85_T88_G0.8241.00
14_W17_L0.8171.00
21_F25_F0.8161.00
83_V86_S0.8131.00
134_V139_L0.8121.00
35_G105_A0.8111.00
79_T91_A0.8101.00
71_L99_G0.8021.00
199_L202_L0.8011.00
23_S97_T0.7931.00
138_L141_E0.7911.00
61_N106_R0.7901.00
197_V201_Y0.7901.00
10_V13_V0.7881.00
32_L146_L0.7851.00
183_G186_A0.7811.00
135_R138_L0.7811.00
162_A165_G0.7801.00
107_M149_A0.7801.00
19_M96_L0.7781.00
128_A133_I0.7731.00
100_A153_T0.7711.00
200_V204_Q0.7701.00
135_R139_L0.7691.00
20_T158_V0.7681.00
160_Y164_G0.7671.00
16_T158_V0.7661.00
199_L204_Q0.7601.00
17_L21_F0.7571.00
48_A51_K0.7561.00
49_N52_L0.7541.00
179_Y185_N0.7521.00
175_I192_V0.7521.00
15_E169_A0.7521.00
134_V138_L0.7481.00
180_G183_G0.7301.00
202_L205_F0.7281.00
68_F162_A0.7251.00
54_R58_A0.7211.00
170_G178_Q0.7181.00
23_S93_I0.7171.00
71_L98_V0.7161.00
204_Q208_D0.7151.00
30_I33_P0.7041.00
56_V60_V0.7031.00
153_T157_L0.7001.00
13_V199_L0.6971.00
133_I138_L0.6931.00
188_V191_T0.6931.00
190_N194_V0.6881.00
207_G211_V0.6881.00
122_A125_A0.6881.00
173_G177_Y0.6871.00
119_L137_V0.6791.00
206_A210_I0.6771.00
71_L75_M0.6771.00
64_R102_P0.6761.00
31_G108_V0.6751.00
198_I202_L0.6741.00
117_T124_R0.6721.00
15_E89_L0.6701.00
120_I130_P0.6671.00
72_L76_I0.6651.00
84_G88_G0.6641.00
187_T191_T0.6631.00
168_G171_G0.6611.00
16_T172_L0.6591.00
38_L57_S0.6581.00
179_Y188_V0.6571.00
59_I63_F0.6501.00
38_L109_E0.6471.00
12_G15_E0.6451.00
143_L146_L0.6441.00
190_N193_L0.6441.00
160_Y163_M0.6421.00
27_G97_T0.6371.00
77_P81_V0.6351.00
106_R109_E0.6311.00
156_T159_G0.6301.00
86_S90_Q0.6281.00
142_A145_G0.6221.00
191_T195_L0.6211.00
99_G163_M0.6201.00
161_S177_Y0.6201.00
203_I207_G0.6161.00
29_V32_L0.6131.00
115_I142_A0.6131.00
61_N64_R0.6121.00
27_G31_G0.6111.00
19_M89_L0.6091.00
116_P119_L0.6071.00
177_Y181_Y0.6061.00
199_L203_I0.6061.00
19_M92_A0.6031.00
146_L149_A0.6031.00
8_L175_I0.6011.00
69_I166_A0.5971.00
13_V17_L0.5961.00
88_G91_A0.5891.00
153_T156_T0.5821.00
111_A142_A0.5811.00
121_E124_R0.5811.00
72_L164_G0.5781.00
155_I159_G0.5771.00
195_L199_L0.5711.00
100_A157_L0.5711.00
165_G174_Q0.5701.00
96_L164_G0.5691.00
122_A126_M0.5681.00
11_R18_A0.5671.00
170_G174_Q0.5641.00
52_L56_V0.5641.00
47_I117_T0.5591.00
195_L198_I0.5581.00
173_G179_Y0.5581.00
31_G35_G0.5541.00
48_A53_Y0.5531.00
68_F160_Y0.5521.00
108_V112_L0.5511.00
91_A95_P0.5491.00
149_A153_T0.5481.00
177_Y180_G0.5461.00
24_G28_F0.5461.00
189_M192_V0.5451.00
13_V172_L0.5431.00
194_V198_I0.5421.00
97_T100_A0.5371.00
82_I88_G0.5341.00
96_L160_Y0.5331.00
133_I137_V0.5311.00
96_L100_A0.5291.00
75_M78_F0.5241.00
24_G104_I0.5241.00
189_M193_L0.5231.00
34_V37_L0.5221.00
172_L179_Y0.5211.00
97_T101_A0.5201.00
20_T161_S0.5181.00
20_T25_F0.5181.00
33_P36_V0.5131.00
20_T24_G0.5131.00
36_V138_L0.5121.00
129_T135_R0.5101.00
162_A166_A0.5071.00
57_S106_R0.5061.00
22_V89_L0.5001.00
179_Y192_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2onkC 2 0.9401 100 0.264 Contact Map
3rlfF 1 0.9124 100 0.274 Contact Map
3d31C 2 0.9217 100 0.275 Contact Map
3tuiA 2 0.9954 100 0.277 Contact Map
4tquM 1 0.9677 100 0.29 Contact Map
4ymuD 2 0.9585 100 0.328 Contact Map
3rlfG 1 0.9631 99.9 0.359 Contact Map
4tquN 1 0.9263 99.9 0.402 Contact Map
4mt1A 3 0.8203 11.8 0.932 Contact Map
3zdqA 2 0.4055 10.5 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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