METI - ECOLI - GREMLIN Contacts

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METI - D-methionine transport system permease protein MetI

UniProt:	P31547	Sequences: MSEPMMWLLVRGVWETLAMTFVSGFFGFVIGLPVGVLLYVTRPGQIIANAKLYRTVSAIVNIFRSIPFIILLVWMIPFTRVIVGTSIGLQAAIVPLTVGAAPFIARMVENALLEIPTGLIEASRAMGATPMQIVRKVLLPEALPGLVNAATITLITLVGYSAMGGAVGAGGLGQIGYQYGYIGYNATVMNTVLVLLVILVYLIQFAGDRIVRAVTRK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11737
Length:	217 (197)
Sequences:	75489 (45936)
Seq/√Len:	3272.8

ECOLI - METI YEHY YECS MALF PSTC POTH MODB POTB YDCV CYST POTC YDCU THIP CYSW YCJO PSTA TAUC YEHW YCJP PROW SSUC POTI GLNP UGPA YNJC PHNE MALG UGPE HISM HISQ ARTQ GLTJ GLTK YHDY ARTM
BACSU - METP TCYB YXEN GANP ARAP MDXF TCYL ARTQ OPUCB YTEP OPUAB AMYD LPLB OPUBD YQGI OPUBB OPUCD YURN YQGH YTLD SSUC GANQ YURM AMYC YVGM YCKA MDXG YESQ GLNP YESP ARAQ YTCP GLNM LPLC TCYM
HALSA - Q9HML6 Q9HS11 Q9HP02 Q9HNI9 Q9HMT4 Q9HR05 Q9HP01 Q9HPK3 Q9HHQ7 Q9HHQ6 Q9HS12 Q9HML7
SULSO - Q97UZ0 Q97UF3 Q97YY2 Q97ZC1 Q97VC0 Q97UY9 Q97YY3 Q97UF4 Q97ZT6 Q97ZC2 Q97Z98 Q97ZT7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
124_R	133_I	3.422	1.00
14_W	18_A	3.369	1.00
132_Q	136_K	3.294	1.00
123_S	133_I	2.827	1.00
26_F	97_T	2.594	1.00
129_T	132_Q	2.593	1.00
130_P	133_I	2.470	1.00
22_V	93_I	2.424	1.00
109_E	113_L	2.364	1.00
131_M	135_R	2.359	1.00
120_I	138_L	2.203	1.00
111_A	145_G	2.165	1.00
119_L	141_E	2.152	1.00
10_V	14_W	2.134	1.00
120_I	133_I	2.110	1.00
11_R	14_W	2.110	1.00
50_A	53_Y	1.960	1.00
92_A	164_G	1.936	1.00
205_F	209_R	1.903	1.00
18_A	89_L	1.897	1.00
120_I	124_R	1.841	1.00
132_Q	135_R	1.785	1.00
108_V	146_L	1.781	1.00
11_R	15_E	1.776	1.00
128_A	132_Q	1.757	1.00
39_Y	113_L	1.734	1.00
84_G	87_I	1.724	1.00
175_I	178_Q	1.705	1.00
151_T	207_G	1.664	1.00
32_L	142_A	1.643	1.00
32_L	108_V	1.638	1.00
34_V	105_A	1.631	1.00
15_E	18_A	1.621	1.00
18_A	22_V	1.601	1.00
29_V	33_P	1.589	1.00
123_S	128_A	1.588	1.00
57_S	109_E	1.582	1.00
104_I	153_T	1.570	1.00
24_G	150_A	1.565	1.00
82_I	85_T	1.561	1.00
124_R	130_P	1.557	1.00
174_Q	178_Q	1.550	1.00
31_G	104_I	1.544	1.00
12_G	175_I	1.510	1.00
175_I	179_Y	1.506	1.00
185_N	188_V	1.498	1.00
38_L	105_A	1.496	1.00
176_G	192_V	1.493	1.00
66_I	71_L	1.443	1.00
35_G	108_V	1.434	1.00
34_V	101_A	1.386	1.00
161_S	165_G	1.384	1.00
82_I	87_I	1.379	1.00
20_T	154_L	1.360	1.00
8_L	11_R	1.345	1.00
130_P	134_V	1.330	1.00
82_I	86_S	1.326	1.00
129_T	133_I	1.323	1.00
179_Y	183_G	1.321	1.00
148_N	152_I	1.301	1.00
51_K	54_R	1.289	1.00
28_F	150_A	1.287	1.00
123_S	137_V	1.286	1.00
104_I	149_A	1.283	1.00
112_L	142_A	1.274	1.00
117_T	120_I	1.273	1.00
39_Y	109_E	1.262	1.00
49_N	53_Y	1.260	1.00
117_T	121_E	1.218	1.00
25_F	29_V	1.201	1.00
174_Q	177_Y	1.198	1.00
51_K	55_T	1.192	1.00
26_F	93_I	1.184	1.00
118_G	121_E	1.175	1.00
39_Y	112_L	1.173	1.00
36_V	112_L	1.169	1.00
93_I	97_T	1.142	1.00
75_M	95_P	1.142	1.00
55_T	59_I	1.142	1.00
30_I	101_A	1.125	1.00
37_L	56_V	1.120	1.00
201_Y	205_F	1.114	1.00
178_Q	182_I	1.113	1.00
115_I	141_E	1.110	1.00
95_P	167_V	1.106	1.00
50_A	54_R	1.095	1.00
47_I	120_I	1.088	1.00
139_L	146_L	1.081	1.00
143_L	147_V	1.077	1.00
52_L	55_T	1.072	1.00
112_L	138_L	1.064	1.00
173_G	176_G	1.060	1.00
176_G	179_Y	1.055	1.00
22_V	25_F	1.049	1.00
55_T	58_A	1.047	1.00
96_L	157_L	1.043	1.00
182_I	185_N	1.042	1.00
108_V	149_A	1.038	1.00
87_I	90_Q	1.034	1.00
101_A	105_A	1.025	1.00
22_V	26_F	1.024	1.00
205_F	208_D	1.014	1.00
23_S	96_L	1.011	1.00
23_S	157_L	1.008	1.00
68_F	99_G	1.002	1.00
24_G	154_L	0.995	1.00
30_I	97_T	0.990	1.00
206_A	209_R	0.983	1.00
108_V	142_A	0.976	1.00
202_L	206_A	0.976	1.00
23_S	27_G	0.975	1.00
36_V	134_V	0.970	1.00
24_G	157_L	0.962	1.00
133_I	136_K	0.952	1.00
92_A	96_L	0.948	1.00
18_A	90_Q	0.946	1.00
128_A	136_K	0.939	1.00
187_T	190_N	0.939	1.00
141_E	144_P	0.935	1.00
33_P	37_L	0.931	1.00
49_N	54_R	0.927	1.00
104_I	108_V	0.922	1.00
27_G	153_T	0.917	1.00
25_F	150_A	0.915	1.00
35_G	112_L	0.911	1.00
145_G	149_A	0.910	1.00
35_G	39_Y	0.907	1.00
90_Q	94_V	0.907	1.00
27_G	104_I	0.905	1.00
27_G	100_A	0.901	1.00
89_L	93_I	0.895	1.00
90_Q	93_I	0.871	1.00
53_Y	57_S	0.865	1.00
26_F	29_V	0.862	1.00
60_V	105_A	0.862	1.00
180_G	186_A	0.861	1.00
28_F	108_V	0.860	1.00
28_F	146_L	0.855	1.00
95_P	163_M	0.853	1.00
180_G	189_M	0.852	1.00
32_L	134_V	0.850	1.00
53_Y	113_L	0.850	1.00
22_V	97_T	0.844	1.00
188_V	192_V	0.840	1.00
31_G	105_A	0.836	1.00
54_R	57_S	0.834	1.00
18_A	21_F	0.831	1.00
208_D	211_V	0.826	1.00
83_V	87_I	0.824	1.00
85_T	88_G	0.824	1.00
14_W	17_L	0.817	1.00
21_F	25_F	0.816	1.00
83_V	86_S	0.813	1.00
134_V	139_L	0.812	1.00
35_G	105_A	0.811	1.00
79_T	91_A	0.810	1.00
71_L	99_G	0.802	1.00
199_L	202_L	0.801	1.00
23_S	97_T	0.793	1.00
138_L	141_E	0.791	1.00
61_N	106_R	0.790	1.00
197_V	201_Y	0.790	1.00
10_V	13_V	0.788	1.00
32_L	146_L	0.785	1.00
183_G	186_A	0.781	1.00
135_R	138_L	0.781	1.00
162_A	165_G	0.780	1.00
107_M	149_A	0.780	1.00
19_M	96_L	0.778	1.00
128_A	133_I	0.773	1.00
100_A	153_T	0.771	1.00
200_V	204_Q	0.770	1.00
135_R	139_L	0.769	1.00
20_T	158_V	0.768	1.00
160_Y	164_G	0.767	1.00
16_T	158_V	0.766	1.00
199_L	204_Q	0.760	1.00
17_L	21_F	0.757	1.00
48_A	51_K	0.756	1.00
49_N	52_L	0.754	1.00
179_Y	185_N	0.752	1.00
175_I	192_V	0.752	1.00
15_E	169_A	0.752	1.00
134_V	138_L	0.748	1.00
180_G	183_G	0.730	1.00
202_L	205_F	0.728	1.00
68_F	162_A	0.725	1.00
54_R	58_A	0.721	1.00
170_G	178_Q	0.718	1.00
23_S	93_I	0.717	1.00
71_L	98_V	0.716	1.00
204_Q	208_D	0.715	1.00
30_I	33_P	0.704	1.00
56_V	60_V	0.703	1.00
153_T	157_L	0.700	1.00
13_V	199_L	0.697	1.00
133_I	138_L	0.693	1.00
188_V	191_T	0.693	1.00
190_N	194_V	0.688	1.00
207_G	211_V	0.688	1.00
122_A	125_A	0.688	1.00
173_G	177_Y	0.687	1.00
119_L	137_V	0.679	1.00
206_A	210_I	0.677	1.00
71_L	75_M	0.677	1.00
64_R	102_P	0.676	1.00
31_G	108_V	0.675	1.00
198_I	202_L	0.674	1.00
117_T	124_R	0.672	1.00
15_E	89_L	0.670	1.00
120_I	130_P	0.667	1.00
72_L	76_I	0.665	1.00
84_G	88_G	0.664	1.00
187_T	191_T	0.663	1.00
168_G	171_G	0.661	1.00
16_T	172_L	0.659	1.00
38_L	57_S	0.658	1.00
179_Y	188_V	0.657	1.00
59_I	63_F	0.650	1.00
38_L	109_E	0.647	1.00
12_G	15_E	0.645	1.00
143_L	146_L	0.644	1.00
190_N	193_L	0.644	1.00
160_Y	163_M	0.642	1.00
27_G	97_T	0.637	1.00
77_P	81_V	0.635	1.00
106_R	109_E	0.631	1.00
156_T	159_G	0.630	1.00
86_S	90_Q	0.628	1.00
142_A	145_G	0.622	1.00
191_T	195_L	0.621	1.00
99_G	163_M	0.620	1.00
161_S	177_Y	0.620	1.00
203_I	207_G	0.616	1.00
29_V	32_L	0.613	1.00
115_I	142_A	0.613	1.00
61_N	64_R	0.612	1.00
27_G	31_G	0.611	1.00
19_M	89_L	0.609	1.00
116_P	119_L	0.607	1.00
177_Y	181_Y	0.606	1.00
199_L	203_I	0.606	1.00
19_M	92_A	0.603	1.00
146_L	149_A	0.603	1.00
8_L	175_I	0.601	1.00
69_I	166_A	0.597	1.00
13_V	17_L	0.596	1.00
88_G	91_A	0.589	1.00
153_T	156_T	0.582	1.00
111_A	142_A	0.581	1.00
121_E	124_R	0.581	1.00
72_L	164_G	0.578	1.00
155_I	159_G	0.577	1.00
195_L	199_L	0.571	1.00
100_A	157_L	0.571	1.00
165_G	174_Q	0.570	1.00
96_L	164_G	0.569	1.00
122_A	126_M	0.568	1.00
11_R	18_A	0.567	1.00
170_G	174_Q	0.564	1.00
52_L	56_V	0.564	1.00
47_I	117_T	0.559	1.00
195_L	198_I	0.558	1.00
173_G	179_Y	0.558	1.00
31_G	35_G	0.554	1.00
48_A	53_Y	0.553	1.00
68_F	160_Y	0.552	1.00
108_V	112_L	0.551	1.00
91_A	95_P	0.549	1.00
149_A	153_T	0.548	1.00
177_Y	180_G	0.546	1.00
24_G	28_F	0.546	1.00
189_M	192_V	0.545	1.00
13_V	172_L	0.543	1.00
194_V	198_I	0.542	1.00
97_T	100_A	0.537	1.00
82_I	88_G	0.534	1.00
96_L	160_Y	0.533	1.00
133_I	137_V	0.531	1.00
96_L	100_A	0.529	1.00
75_M	78_F	0.524	1.00
24_G	104_I	0.524	1.00
189_M	193_L	0.523	1.00
34_V	37_L	0.522	1.00
172_L	179_Y	0.521	1.00
97_T	101_A	0.520	1.00
20_T	161_S	0.518	1.00
20_T	25_F	0.518	1.00
33_P	36_V	0.513	1.00
20_T	24_G	0.513	1.00
36_V	138_L	0.512	1.00
129_T	135_R	0.510	1.00
162_A	166_A	0.507	1.00
57_S	106_R	0.506	1.00
22_V	89_L	0.500	1.00
179_Y	192_V	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2onkC	2	0.9401	100	0.264	Contact Map
3rlfF	1	0.9124	100	0.274	Contact Map
3d31C	2	0.9217	100	0.275	Contact Map
3tuiA	2	0.9954	100	0.277	Contact Map
4tquM	1	0.9677	100	0.29	Contact Map
4ymuD	2	0.9585	100	0.328	Contact Map
3rlfG	1	0.9631	99.9	0.359	Contact Map
4tquN	1	0.9263	99.9	0.402	Contact Map
4mt1A	3	0.8203	11.8	0.932	Contact Map
3zdqA	2	0.4055	10.5	0.933	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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