GREMLIN Database
EFEB - Deferrochelatase/peroxidase EfeB
UniProt: P31545 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11735
Length: 423 (388)
Sequences: 1531 (1030)
Seq/√Len: 52.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
414_D418_S6.4711.00
345_M382_V5.8361.00
83_D86_D4.9171.00
78_D207_R4.8851.00
328_S331_R4.3551.00
138_V406_L3.9761.00
62_A102_T3.7051.00
136_L416_F3.6211.00
200_T204_L3.6041.00
307_Q311_D3.5861.00
77_F197_I3.4791.00
57_Y99_A3.4431.00
305_G323_V3.1661.00
138_V417_G3.0301.00
268_S371_Y2.9701.00
297_D300_T2.8771.00
270_Q369_V2.7971.00
87_L142_L2.7341.00
54_Q62_A2.7091.00
75_V206_V2.6161.00
231_L277_F2.4731.00
278_R281_F2.3921.00
79_V87_L2.3501.00
264_T404_F2.3291.00
28_G31_P2.2881.00
158_Q376_E2.2781.00
308_H311_D2.2531.00
414_D419_A2.2131.00
79_V142_L2.2011.00
383_Q386_L2.1921.00
91_F421_L2.1921.00
175_G403_F2.1841.00
60_H266_G2.1761.00
313_P330_I2.1691.00
182_C350_Y2.1451.00
79_V147_F2.1241.00
183_A189_V2.1111.00
72_M367_L2.0591.00
278_R396_K2.0521.00
274_L398_I2.0091.00
54_Q131_N1.9861.00
59_E266_G1.9831.00
91_F138_V1.9411.00
30_C33_A1.9160.99
292_T325_A1.8850.99
406_L416_F1.8610.99
254_V264_T1.8520.99
18_L26_L1.8480.99
409_V416_F1.8310.99
131_N184_N1.8220.99
84_K88_E1.8090.99
139_G143_F1.7780.99
262_A265_I1.7700.99
74_L369_V1.7620.99
272_V367_L1.7460.99
272_V369_V1.7450.99
76_A175_G1.7400.99
380_L402_Y1.7370.99
345_M370_C1.7260.99
318_D321_G1.7250.99
29_S34_H1.7120.99
95_T416_F1.6970.99
64_I268_S1.6720.99
139_G142_L1.6400.98
21_I24_L1.6240.98
156_K374_D1.6200.98
138_V142_L1.6060.98
160_M163_F1.6050.98
64_I405_A1.5950.98
252_V345_M1.5880.98
270_Q371_Y1.5820.98
181_I189_V1.5660.98
163_F383_Q1.5480.98
315_Y330_I1.5390.97
391_L395_V1.5350.97
285_T289_E1.5320.97
305_G311_D1.5290.97
210_R274_L1.5250.97
96_Q99_A1.5250.97
141_S146_R1.5020.97
304_L324_I1.5000.97
165_N397_P1.4950.97
29_S32_V1.4890.97
374_D377_K1.4860.97
230_L277_F1.4850.97
271_A370_C1.4840.97
69_Q350_Y1.4810.97
95_T409_V1.4760.97
25_A29_S1.4630.97
325_A390_A1.4630.97
25_A33_A1.4580.96
167_S396_K1.4440.96
181_I193_L1.4320.96
178_L270_Q1.4310.96
42_P45_L1.4240.96
24_L28_G1.3940.95
16_R19_K1.3810.95
294_F328_S1.3770.95
410_K413_N1.3720.95
30_C34_H1.3710.95
27_A30_C1.3550.95
88_E421_L1.3450.94
375_L402_Y1.3420.94
98_F136_L1.3320.94
48_D51_N1.3270.94
87_L147_F1.3140.94
172_L274_L1.3130.94
333_A386_L1.3100.94
20_V26_L1.2970.93
144_D153_M1.2900.93
373_H378_G1.2780.93
99_A413_N1.2730.93
169_D172_L1.2690.92
97_R199_H1.2640.92
294_F349_G1.2620.92
43_G47_P1.2570.92
372_Q378_G1.2550.92
313_P324_I1.2370.92
132_L135_T1.2340.91
274_L352_Y1.2340.91
21_I25_A1.2260.91
138_V416_F1.2000.90
271_A375_L1.1880.90
333_A382_V1.1720.89
16_R25_A1.1690.89
411_D414_D1.1560.88
229_N277_F1.1500.88
276_Q363_D1.1500.88
72_M178_L1.1450.88
174_H403_F1.1450.88
238_A313_P1.1440.88
315_Y328_S1.1420.88
345_M372_Q1.1420.88
96_Q100_F1.1400.88
77_F179_L1.1270.87
249_Q255_T1.1210.87
21_I29_S1.1200.87
72_M350_Y1.1200.87
90_L177_V1.1180.87
407_P419_A1.1160.87
88_E92_R1.0960.86
98_F416_F1.0960.86
263_W267_G1.0890.85
66_T182_C1.0820.85
210_R354_L1.0790.85
247_L250_K1.0770.85
69_Q182_C1.0760.85
28_G34_H1.0730.84
352_Y363_D1.0650.84
392_E395_V1.0620.84
63_G69_Q1.0580.84
173_C403_F1.0540.83
326_L331_R1.0530.83
70_A216_D1.0480.83
280_E360_G1.0370.82
35_A43_G1.0340.82
327_D390_A1.0280.82
41_A47_P1.0240.82
165_N387_N1.0230.81
345_M378_G1.0220.81
19_K25_A1.0190.81
93_L199_H1.0180.81
79_V177_V1.0160.81
90_L94_L1.0150.81
178_L371_Y1.0150.81
354_L363_D1.0120.81
122_I125_G1.0100.81
407_P414_D1.0080.80
242_S248_M1.0070.80
16_R20_V1.0000.80
146_R149_L1.0000.80
144_D150_A0.9940.80
66_T180_Q0.9930.79
58_G408_G0.9920.79
91_F406_L0.9850.79
66_T69_Q0.9810.79
28_G32_V0.9800.79
300_T308_H0.9750.78
375_L397_P0.9730.78
57_Y409_V0.9730.78
18_L27_A0.9730.78
332_L386_L0.9730.78
205_S307_Q0.9720.78
172_L398_I0.9710.78
227_P234_K0.9700.78
20_V31_P0.9690.78
143_F153_M0.9670.78
27_A33_A0.9670.78
12_P16_R0.9670.78
413_N418_S0.9590.77
22_G27_A0.9560.77
16_R21_I0.9560.77
238_A336_R0.9550.77
233_F294_F0.9540.77
248_M346_L0.9540.77
94_L200_T0.9480.76
343_S382_V0.9430.76
231_L328_S0.9430.76
84_K87_L0.9430.76
44_T47_P0.9420.76
24_L34_H0.9380.75
13_S18_L0.9200.74
140_H153_M0.9180.74
76_A403_F0.9160.74
240_P318_D0.9160.74
23_A27_A0.9160.74
240_P247_L0.9110.73
263_W404_F0.9060.73
244_N248_M0.9050.73
63_G133_T0.9030.73
82_S86_D0.9030.73
325_A328_S0.9030.73
56_F98_F0.9010.72
30_C35_A0.9000.72
42_P47_P0.8930.72
61_Q64_I0.8890.71
88_E415_Y0.8880.71
142_L147_F0.8860.71
26_L48_D0.8850.71
48_D52_E0.8830.71
42_P50_R0.8810.71
13_S16_R0.8800.71
16_R22_G0.8780.70
158_Q374_D0.8780.70
32_V35_A0.8770.70
75_V193_L0.8760.70
51_N419_A0.8760.70
133_T180_Q0.8740.70
376_E384_K0.8720.70
410_K414_D0.8720.70
45_L48_D0.8700.70
19_K29_S0.8670.70
43_G53_K0.8670.70
233_F291_Q0.8650.69
89_R328_S0.8640.69
74_L178_L0.8640.69
73_M209_K0.8600.69
156_K269_Y0.8590.69
231_L278_R0.8580.69
173_C399_G0.8570.69
400_G404_F0.8540.68
222_K310_H0.8540.68
73_M189_V0.8520.68
378_G382_V0.8500.68
41_A46_S0.8500.68
43_G46_S0.8490.68
222_K225_E0.8490.68
340_S382_V0.8470.68
24_L31_P0.8470.68
231_L330_I0.8460.68
20_V24_L0.8410.67
21_I30_C0.8410.67
306_M311_D0.8400.67
285_T392_E0.8380.67
28_G35_A0.8370.67
164_P387_N0.8350.67
415_Y418_S0.8350.67
328_S333_A0.8320.66
30_C46_S0.8320.66
158_Q161_T0.8290.66
25_A111_P0.8260.66
165_N388_G0.8230.65
268_S405_A0.8220.65
12_P33_A0.8220.65
57_Y411_D0.8210.65
59_E410_K0.8180.65
306_M313_P0.8170.65
168_L399_G0.8160.65
49_A52_E0.8150.65
35_A41_A0.8140.65
29_S41_A0.8130.65
150_A153_M0.8110.64
19_K33_A0.8080.64
279_V364_M0.8080.64
35_A410_K0.8060.64
69_Q184_N0.8050.64
24_L46_S0.8020.63
65_L380_L0.8010.63
254_V404_F0.7980.63
199_H203_L0.7970.63
42_P59_E0.7920.62
165_N395_V0.7900.62
153_M157_L0.7900.62
32_V45_L0.7900.62
248_M252_V0.7880.62
20_V27_A0.7870.62
166_D169_D0.7850.62
137_S405_A0.7830.62
68_Q214_I0.7830.62
206_V356_V0.7820.61
84_K421_L0.7800.61
317_S323_V0.7800.61
12_P41_A0.7790.61
18_L28_G0.7770.61
29_S45_L0.7760.61
87_L91_F0.7760.61
63_G180_Q0.7750.61
63_G208_W0.7750.61
27_A419_A0.7710.60
88_E418_S0.7700.60
24_L30_C0.7690.60
27_A411_D0.7690.60
168_L173_C0.7670.60
85_A88_E0.7660.60
26_L29_S0.7650.60
294_F395_V0.7650.60
327_D332_L0.7630.60
349_G366_L0.7610.59
64_I133_T0.7580.59
47_P50_R0.7560.59
76_A174_H0.7530.59
159_K174_H0.7520.58
30_C49_A0.7500.58
343_S378_G0.7480.58
315_Y339_E0.7470.58
133_T137_S0.7470.58
229_N368_F0.7450.58
21_I55_P0.7410.57
23_A28_G0.7400.57
172_L363_D0.7370.57
12_P20_V0.7320.56
119_D191_H0.7280.56
245_D248_M0.7240.56
28_G33_A0.7230.55
389_E392_E0.7220.55
221_S243_Q0.7210.55
77_F177_V0.7180.55
31_P34_H0.7170.55
41_A51_N0.7160.55
47_P52_E0.7160.55
60_H253_W0.7140.55
213_F230_L0.7140.55
226_T237_T0.7130.54
141_S144_D0.7110.54
290_Q298_K0.7080.54
59_E299_Q0.7060.54
135_T142_L0.7060.54
23_A59_E0.7040.54
17_L21_I0.7000.53
34_H421_L0.6990.53
152_Q261_P0.6930.52
244_N247_L0.6920.52
112_N115_L0.6890.52
18_L22_G0.6890.52
95_T102_T0.6880.52
13_S19_K0.6880.52
156_K376_E0.6880.52
34_H42_P0.6880.52
35_A42_P0.6870.52
22_G30_C0.6850.52
180_Q350_Y0.6850.52
14_R17_L0.6850.52
140_H160_M0.6810.51
172_L399_G0.6810.51
277_F349_G0.6810.51
100_F105_G0.6800.51
231_L276_Q0.6790.51
74_L367_L0.6790.51
113_P288_K0.6790.51
233_F298_K0.6780.51
247_L344_L0.6770.51
194_R309_E0.6760.51
265_I300_T0.6760.51
71_A211_E0.6760.51
392_E398_I0.6750.50
34_H53_K0.6730.50
395_V399_G0.6720.50
153_M156_K0.6690.50
240_P251_V0.6680.50
64_I252_V0.6670.50
234_K280_E0.6660.50
306_M309_E0.6640.49
298_K378_G0.6640.49
241_D248_M0.6620.49
143_F263_W0.6610.49
13_S30_C0.6600.49
238_A330_I0.6600.49
372_Q395_V0.6600.49
280_E362_L0.6590.49
80_L205_S0.6590.49
46_S50_R0.6590.49
291_Q298_K0.6590.49
66_T350_Y0.6580.49
244_N312_V0.6570.49
132_L142_L0.6560.48
41_A45_L0.6560.48
226_T234_K0.6560.48
165_N332_L0.6540.48
140_H143_F0.6540.48
141_S374_D0.6530.48
16_R380_L0.6520.48
59_E249_Q0.6510.48
231_L391_L0.6490.48
345_M386_L0.6470.48
255_T265_I0.6430.47
23_A336_R0.6430.47
41_A48_D0.6410.47
272_V399_G0.6400.47
156_K159_K0.6390.47
276_Q398_I0.6390.47
133_T182_C0.6380.47
13_S47_P0.6370.47
56_F409_V0.6370.47
23_A50_R0.6370.47
46_S53_K0.6360.46
352_Y398_I0.6360.46
22_G34_H0.6350.46
32_V44_T0.6340.46
283_D309_E0.6330.46
211_E354_L0.6330.46
41_A44_T0.6320.46
19_K23_A0.6300.46
231_L395_V0.6300.46
13_S21_I0.6290.46
130_D400_G0.6290.46
73_M181_I0.6290.46
331_R335_P0.6250.45
324_I328_S0.6250.45
134_I196_I0.6240.45
172_L272_V0.6240.45
390_A393_E0.6230.45
140_H401_G0.6230.45
56_F408_G0.6220.45
26_L35_A0.6200.45
154_P163_F0.6190.45
294_F368_F0.6180.45
13_S34_H0.6160.44
147_F152_Q0.6160.44
35_A47_P0.6150.44
17_L33_A0.6140.44
195_D199_H0.6130.44
65_L248_M0.6130.44
267_G404_F0.6120.44
16_R31_P0.6110.44
60_H267_G0.6100.44
274_L401_G0.6100.44
146_R157_L0.6100.44
22_G28_G0.6090.44
302_A309_E0.6090.44
43_G325_A0.6080.43
391_L397_P0.6070.43
89_R93_L0.6060.43
19_K43_G0.6050.43
149_L407_P0.6050.43
156_K375_L0.6040.43
98_F179_L0.6040.43
77_F206_V0.6030.43
221_S241_D0.6020.43
294_F391_L0.5990.43
25_A146_R0.5970.42
44_T52_E0.5960.42
13_S26_L0.5960.42
251_V345_M0.5950.42
136_L179_L0.5950.42
134_I193_L0.5920.42
97_R195_D0.5920.42
16_R33_A0.5910.42
26_L34_H0.5910.42
154_P158_Q0.5900.42
201_P231_L0.5880.41
236_G368_F0.5880.41
23_A51_N0.5870.41
349_G370_C0.5870.41
16_R35_A0.5870.41
99_A105_G0.5850.41
372_Q392_E0.5850.41
25_A32_V0.5850.41
62_A331_R0.5840.41
155_K260_E0.5820.41
284_R393_E0.5820.41
142_L407_P0.5800.41
99_A103_Q0.5800.41
23_A54_Q0.5790.41
410_K419_A0.5780.40
47_P151_P0.5780.40
132_L137_S0.5780.40
21_I28_G0.5770.40
221_S335_P0.5760.40
216_D349_G0.5760.40
279_V404_F0.5760.40
27_A43_G0.5740.40
229_N275_I0.5740.40
26_L49_A0.5740.40
331_R403_F0.5740.40
153_M158_Q0.5740.40
63_G182_C0.5690.40
17_L167_S0.5660.39
16_R34_H0.5660.39
26_L43_G0.5660.39
157_L375_L0.5640.39
69_Q72_M0.5640.39
14_R18_L0.5640.39
101_L104_G0.5630.39
271_A368_F0.5620.39
19_K297_D0.5610.39
42_P46_S0.5600.39
27_A46_S0.5600.39
285_T293_I0.5590.39
98_F134_I0.5570.38
32_V46_S0.5570.38
12_P43_G0.5570.38
12_P42_P0.5560.38
94_L195_D0.5560.38
35_A49_A0.5550.38
141_S176_D0.5540.38
19_K41_A0.5530.38
410_K421_L0.5520.38
136_L204_L0.5520.38
291_Q297_D0.5520.38
28_G54_Q0.5510.38
149_L152_Q0.5510.38
395_V398_I0.5500.38
43_G48_D0.5490.38
44_T268_S0.5480.37
263_W282_W0.5450.37
165_N276_Q0.5440.37
215_S298_K0.5440.37
46_S52_E0.5440.37
322_K351_S0.5430.37
159_K247_L0.5420.37
44_T50_R0.5410.37
376_E381_T0.5410.37
181_I269_Y0.5410.37
333_A383_Q0.5400.37
27_A32_V0.5390.37
42_P55_P0.5390.37
104_G191_H0.5380.36
324_I330_I0.5370.36
100_F107_A0.5370.36
44_T48_D0.5370.36
25_A45_L0.5350.36
32_V299_Q0.5350.36
158_Q380_L0.5340.36
22_G378_G0.5330.36
104_G107_A0.5330.36
12_P44_T0.5320.36
194_R198_K0.5320.36
344_L378_G0.5310.36
286_P289_E0.5300.36
127_I137_S0.5300.36
241_D245_D0.5290.36
194_R283_D0.5280.35
23_A31_P0.5270.35
328_S390_A0.5270.35
16_R44_T0.5260.35
226_T309_E0.5260.35
26_L46_S0.5250.35
35_A45_L0.5240.35
46_S134_I0.5230.35
42_P48_D0.5230.35
159_K397_P0.5220.35
335_P344_L0.5210.35
63_G228_I0.5210.35
27_A31_P0.5210.35
195_D198_K0.5200.35
325_A336_R0.5200.35
66_T135_T0.5200.35
325_A332_L0.5190.35
35_A51_N0.5190.35
30_C48_D0.5180.35
28_G47_P0.5180.35
47_P51_N0.5180.35
225_E240_P0.5170.34
34_H47_P0.5140.34
20_V42_P0.5140.34
89_R92_R0.5140.34
333_A401_G0.5130.34
250_K300_T0.5120.34
29_S410_K0.5090.34
122_I230_L0.5080.34
33_A150_A0.5080.34
57_Y410_K0.5070.34
45_L410_K0.5060.33
261_P264_T0.5060.33
43_G88_E0.5060.33
238_A335_P0.5060.33
343_S381_T0.5050.33
139_G154_P0.5040.33
216_D300_T0.5020.33
105_G171_A0.5010.33
125_G225_E0.5000.33
137_S185_T0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4grcA 2 0.8345 100 0.201 Contact Map
4gt2B 2 0.8605 100 0.22 Contact Map
3o72A 2 0.8842 100 0.241 Contact Map
4gs1A 2 0.8534 100 0.287 Contact Map
3vxjA 1 0.7849 100 0.334 Contact Map
4w7kA 1 0.7825 100 0.342 Contact Map
4g2cA 2 0.844 100 0.349 Contact Map
2gvkA 5 0.7092 100 0.378 Contact Map
2iizA 2 0.7069 100 0.386 Contact Map
4gu7A 2 0.7139 100 0.402 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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