GREMLIN Database
YIEP - Uncharacterized HTH-type transcriptional regulator YieP
UniProt: P31475 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11733
Length: 230 (196)
Sequences: 23496 (17191)
Seq/√Len: 1227.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
135_N210_I3.7441.00
120_L218_F3.2561.00
213_D216_A2.9111.00
142_A203_Q2.7641.00
32_E35_T2.7061.00
25_R30_E2.6641.00
25_R46_Q2.3551.00
113_C117_Q2.3011.00
40_E51_R2.2421.00
106_H171_P2.2061.00
133_H163_H2.1811.00
19_A60_T2.0591.00
68_L78_M2.0211.00
23_A64_K1.9741.00
124_T214_G1.9441.00
109_V121_L1.9261.00
18_L49_V1.9241.00
112_I226_R1.8811.00
208_A216_A1.7861.00
131_K210_I1.7761.00
166_E174_T1.7681.00
18_L47_F1.7641.00
130_Q169_A1.7421.00
69_P75_T1.7371.00
127_T130_Q1.7191.00
163_H166_E1.6821.00
138_M206_V1.6691.00
21_K25_R1.6631.00
149_R152_R1.6531.00
116_P222_Q1.6521.00
120_L214_G1.6101.00
110_M176_F1.5881.00
12_K20_E1.5851.00
24_Q28_K1.5771.00
216_A220_A1.5561.00
116_P218_F1.5481.00
218_F222_Q1.5411.00
161_H202_H1.5311.00
117_Q120_L1.4901.00
204_A220_A1.4341.00
175_S179_L1.4201.00
162_E178_S1.4141.00
172_F183_V1.4091.00
207_D211_Q1.4061.00
19_A64_K1.4001.00
112_I222_Q1.3991.00
201_L227_S1.3951.00
140_E156_V1.3871.00
130_Q167_M1.3801.00
137_L156_V1.3781.00
211_Q216_A1.3761.00
70_R73_I1.3681.00
119_C217_A1.3561.00
165_Y177_A1.3521.00
135_N206_V1.3411.00
142_A199_L1.3401.00
41_I45_E1.3111.00
106_H172_F1.3081.00
126_G131_K1.2921.00
203_Q207_D1.2911.00
214_G218_F1.2551.00
136_T140_E1.2551.00
135_N139_A1.2521.00
140_E159_A1.2451.00
112_I116_P1.2141.00
36_I76_R1.2051.00
137_L163_H1.2031.00
42_E46_Q1.1981.00
43_L54_V1.1861.00
17_V21_K1.1851.00
219_K223_A1.1741.00
138_M203_Q1.1711.00
21_K24_Q1.1701.00
38_P42_E1.1651.00
111_R115_E1.1491.00
21_K47_F1.1461.00
216_A219_K1.1451.00
70_R76_R1.1451.00
126_G212_S1.1411.00
162_E166_E1.1321.00
159_A163_H1.1231.00
116_P120_L1.1171.00
25_R47_F1.1151.00
201_L224_L1.1151.00
157_D161_H1.1141.00
106_H170_N1.1051.00
120_L215_D1.0951.00
131_K206_V1.0871.00
126_G167_M1.0861.00
164_I209_I1.0841.00
119_C221_C1.0831.00
119_C123_A1.0811.00
126_G130_Q1.0751.00
163_H167_M1.0731.00
152_R155_E1.0571.00
62_T69_P1.0561.00
137_L159_A1.0561.00
206_V210_I1.0541.00
109_V170_N1.0501.00
207_D210_I1.0491.00
135_N203_Q1.0421.00
138_M142_A1.0411.00
138_M141_M1.0401.00
31_Y77_V1.0401.00
118_A165_Y1.0331.00
133_H166_E1.0241.00
222_Q226_R1.0231.00
133_H136_T1.0101.00
131_K212_S1.0101.00
56_E59_K1.0051.00
202_H224_L0.9961.00
139_A142_A0.9961.00
176_F179_L0.9831.00
68_L76_R0.9821.00
62_T67_V0.9681.00
168_S174_T0.9671.00
12_K17_V0.9661.00
160_W206_V0.9581.00
123_A214_G0.9561.00
156_V159_A0.9531.00
208_A213_D0.9421.00
204_A223_A0.9421.00
200_D204_A0.9351.00
121_L125_V0.9351.00
204_A216_A0.9241.00
161_H224_L0.9231.00
123_A209_I0.9211.00
25_R31_Y0.9191.00
117_Q218_F0.9181.00
58_V75_T0.9161.00
155_E159_A0.9161.00
215_D219_K0.9081.00
15_S60_T0.9051.00
132_A136_T0.9021.00
131_K135_N0.9001.00
133_H137_L0.8981.00
204_A207_D0.8921.00
205_I221_C0.8871.00
19_A23_A0.8771.00
174_T178_S0.8751.00
115_E161_H0.8721.00
36_I74_G0.8721.00
67_V75_T0.8701.00
103_V172_F0.8701.00
60_T63_A0.8701.00
110_M172_F0.8671.00
125_V169_A0.8641.00
70_R74_G0.8631.00
26_I77_V0.8621.00
73_I76_R0.8611.00
117_Q121_L0.8601.00
137_L140_E0.8591.00
215_D218_F0.8581.00
102_Q106_H0.8571.00
40_E55_R0.8481.00
102_Q169_A0.8471.00
140_E143_A0.8411.00
59_K62_T0.8391.00
14_L17_V0.8371.00
44_G54_V0.8361.00
144_L152_R0.8301.00
126_G209_I0.8301.00
23_A66_M0.8241.00
135_N207_D0.8231.00
199_L203_Q0.8231.00
49_V54_V0.8121.00
130_Q133_H0.8101.00
128_A132_A0.8081.00
139_A143_A0.8061.00
123_A217_A0.8061.00
13_N16_Y0.8051.00
42_E45_E0.8041.00
157_D202_H0.8011.00
205_I220_A0.7981.00
23_A27_L0.7981.00
123_A212_S0.7941.00
58_V67_V0.7851.00
50_S53_A0.7831.00
38_P41_I0.7801.00
134_L163_H0.7771.00
139_A203_Q0.7731.00
204_A208_A0.7711.00
172_F176_F0.7711.00
141_M153_W0.7711.00
122_A167_M0.7701.00
43_L58_V0.7671.00
196_V200_D0.7621.00
15_S19_A0.7601.00
14_L53_A0.7591.00
134_L206_V0.7591.00
208_A220_A0.7591.00
16_Y60_T0.7541.00
162_E181_H0.7531.00
128_A212_S0.7521.00
121_L170_N0.7331.00
121_L124_T0.7291.00
172_F175_S0.7251.00
120_L124_T0.7161.00
110_M173_L0.7141.00
152_R156_V0.7081.00
59_K69_P0.7051.00
140_E152_R0.7041.00
205_I217_A0.7001.00
109_V125_V0.6951.00
132_A210_I0.6941.00
219_K222_Q0.6931.00
81_S103_V0.6921.00
220_A223_A0.6921.00
30_E46_Q0.6901.00
132_A135_N0.6871.00
142_A146_E0.6841.00
110_M118_A0.6841.00
158_M185_H0.6811.00
133_H159_A0.6771.00
138_M199_L0.6761.00
103_V171_P0.6661.00
140_E144_L0.6651.00
136_T139_A0.6581.00
162_E174_T0.6531.00
60_T64_K0.6511.00
122_A126_G0.6491.00
131_K209_I0.6461.00
119_C214_G0.6421.00
144_L156_V0.6421.00
12_K16_Y0.6361.00
159_A162_E0.6301.00
201_L204_A0.6291.00
113_C173_L0.6281.00
158_M181_H0.6281.00
109_V117_Q0.6261.00
130_Q166_E0.6231.00
112_I225_L0.6201.00
122_A168_S0.6201.00
53_A57_A0.6201.00
15_S56_E0.6191.00
153_W198_K0.6161.00
130_Q163_H0.6141.00
110_M114_L0.6111.00
31_Y35_T0.6081.00
223_A227_S0.6031.00
118_A168_S0.6021.00
72_R75_T0.6001.00
129_E133_H0.5951.00
116_P214_G0.5951.00
25_R29_G0.5931.00
205_I224_L0.5911.00
111_R225_L0.5891.00
175_S183_V0.5881.00
144_L149_R0.5861.00
78_M186_T0.5791.00
141_M199_L0.5791.00
33_P79_P0.5781.00
118_A173_L0.5771.00
47_F54_V0.5761.00
41_I44_G0.5751.00
134_L167_M0.5741.00
115_E202_H0.5681.00
102_Q171_P0.5661.00
120_L222_Q0.5621.00
122_A164_I0.5601.00
113_C116_P0.5591.00
37_L67_V0.5591.00
193_S196_V0.5591.00
34_G79_P0.5581.00
11_Q17_V0.5561.00
116_P221_C0.5541.00
22_L43_L0.5471.00
114_L177_A0.5401.00
45_E48_G0.5401.00
128_A210_I0.5381.00
59_K63_A0.5361.00
71_P74_G0.5311.00
217_A221_C0.5291.00
194_D197_I0.5251.00
76_R79_P0.5251.00
200_D203_Q0.5221.00
117_Q173_L0.5221.00
165_Y181_H0.5201.00
25_R28_K0.5191.00
102_Q105_D0.5181.00
134_L138_M0.5181.00
142_A200_D0.5171.00
134_L137_L0.5161.00
157_D198_K0.5141.00
27_L66_M0.5131.00
110_M113_C0.5101.00
205_I208_A0.5091.00
144_L148_F0.5041.00
16_Y20_E0.5031.00
116_P119_C0.5021.00
31_Y46_Q0.5001.00
121_L168_S0.5001.00
175_S178_S0.5001.00
119_C164_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ihuA 1 0.8609 100 0.15 Contact Map
4p96A 2 0.9696 100 0.162 Contact Map
3sxyA 2 0.8348 100 0.163 Contact Map
3c7jA 4 0.9 100 0.172 Contact Map
2hs5A 1 0.8565 100 0.172 Contact Map
2di3A 2 0.9217 100 0.173 Contact Map
4p9fA 1 0.8652 100 0.185 Contact Map
1hw1A 2 0.9304 100 0.208 Contact Map
3by6A 2 0.5391 99.9 0.533 Contact Map
3ic7A 2 0.4826 99.9 0.536 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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