GREMLIN Database
RAVA - ATPase RavA
UniProt: P31473 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11731
Length: 498 (434)
Sequences: 2622 (1963)
Seq/√Len: 94.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
409_K412_L3.0691.00
444_G448_Q3.0251.00
472_F476_D2.9641.00
372_L379_H2.9451.00
365_L369_P2.9431.00
406_F409_K2.9291.00
409_K413_E2.8581.00
36_A39_G2.7331.00
28_A31_L2.7001.00
405_G409_K2.6671.00
360_S365_L2.6441.00
270_S273_A2.5511.00
348_R352_Q2.5381.00
458_R462_A2.4841.00
464_F468_Q2.4711.00
422_V425_V2.4271.00
451_E455_S2.4151.00
376_E379_H2.4101.00
359_A363_T2.3801.00
111_V114_D2.3781.00
372_L376_E2.3031.00
263_S267_S2.2861.00
78_T81_E2.2171.00
474_P481_I2.1891.00
351_Y354_P2.1891.00
429_G432_L2.1861.00
465_S469_K2.1331.00
375_M379_H2.1281.00
351_Y355_V2.1101.00
446_I453_L2.0921.00
416_S419_H2.0791.00
348_R355_V2.0731.00
372_L377_V2.0731.00
110_I114_D2.0571.00
423_R427_L2.0541.00
425_V432_L1.9391.00
372_L375_M1.9221.00
267_S270_S1.9171.00
360_S377_V1.9161.00
374_D379_H1.9021.00
422_V426_S1.9011.00
340_R344_I1.8981.00
367_Q379_H1.8881.00
416_S424_D1.8881.00
352_Q356_N1.8631.00
407_A412_L1.8531.00
405_G414_V1.8511.00
365_L377_V1.8491.00
464_F474_P1.8431.00
416_S425_V1.8271.00
358_T363_T1.8181.00
347_R354_P1.8171.00
367_Q372_L1.7841.00
367_Q376_E1.7831.00
464_F471_L1.7821.00
407_A414_V1.7591.00
330_Q337_T1.7551.00
369_P372_L1.7461.00
471_L481_I1.7431.00
360_S363_T1.7411.00
405_G413_E1.7231.00
110_I113_L1.7231.00
416_S422_V1.7221.00
89_Q92_K1.7211.00
429_G436_G1.7201.00
453_L460_Q1.6991.00
373_H379_H1.6801.00
478_L481_I1.6471.00
369_P379_H1.6341.00
333_K337_T1.6311.00
360_S364_L1.5841.00
405_G408_Q1.5691.00
462_A466_E1.5671.00
165_E168_Y1.5671.00
88_I92_K1.5661.00
406_F412_L1.5531.00
450_L453_L1.5371.00
340_R343_G1.5351.00
347_R355_V1.5321.00
471_L474_P1.5151.00
407_A413_E1.5141.00
361_T372_L1.5111.00
110_I115_E1.5091.00
365_L370_L1.5011.00
102_S105_L1.4991.00
399_G403_G1.4991.00
408_Q414_V1.4971.00
279_L283_C1.4961.00
397_I400_K1.4901.00
352_Q355_V1.4861.00
267_S273_A1.4841.00
471_L478_L1.4821.00
225_P241_K1.4751.00
382_F385_S1.4711.00
165_E170_R1.4681.00
370_L373_H1.4641.00
232_I241_K1.4591.00
323_H330_Q1.4561.00
355_V360_S1.4481.00
365_L379_H1.4471.00
400_K403_G1.4371.00
383_E386_A1.4321.00
267_S271_A1.4300.99
234_M238_Q1.4290.99
432_L436_G1.4000.99
365_L372_L1.3920.99
406_F413_E1.3920.99
360_S372_L1.3920.99
347_R351_Y1.3770.99
422_V429_G1.3770.99
361_T365_L1.3750.99
454_E458_R1.3620.99
339_I343_G1.3610.99
360_S369_P1.3560.99
464_F467_Q1.3550.99
87_S91_L1.3490.99
384_R387_L1.3410.99
225_P228_V1.3410.99
398_R402_N1.3360.99
472_F475_G1.3270.99
477_W481_I1.3260.99
330_Q333_K1.3240.99
389_Q392_S1.3180.99
212_Y215_W1.3180.99
382_F387_L1.3170.99
373_H376_E1.3130.99
423_R426_S1.3010.99
360_S367_Q1.2950.99
368_K372_L1.2830.99
453_L456_D1.2820.99
395_G398_R1.2790.99
405_G412_L1.2780.99
216_Q219_I1.2580.99
367_Q375_M1.2580.99
323_H337_T1.2560.99
322_R326_L1.2550.99
294_I297_Q1.2520.99
111_V115_E1.2520.99
460_Q471_L1.2520.99
35_A42_V1.2480.99
453_L457_W1.2410.99
232_I236_R1.2320.98
455_S459_K1.2300.98
345_F349_Q1.2270.98
386_A391_L1.2260.98
209_D215_W1.2240.98
387_L392_S1.2240.98
369_P373_H1.2230.98
404_I407_A1.2220.98
27_H31_L1.2160.98
380_I384_R1.2120.98
467_Q471_L1.2090.98
364_L373_H1.2000.98
460_Q467_Q1.1900.98
383_E388_E1.1890.98
103_G108_A1.1890.98
381_S385_S1.1880.98
404_I414_V1.1840.98
200_P203_D1.1830.98
381_S384_R1.1790.98
53_S70_E1.1790.98
369_P376_E1.1740.98
460_Q463_L1.1650.98
384_R392_S1.1560.98
225_P232_I1.1550.98
215_W219_I1.1480.98
344_I351_Y1.1480.98
396_E400_K1.1460.98
382_F386_A1.1450.98
424_D432_L1.1440.98
310_Q314_T1.1440.98
460_Q478_L1.1430.98
322_R336_L1.1400.97
391_L394_G1.1380.97
228_V232_I1.1280.97
358_T365_L1.1250.97
417_A425_V1.1250.97
467_Q474_P1.1230.97
386_A389_Q1.1210.97
416_S426_S1.1210.97
464_F478_L1.1150.97
236_R242_L1.1150.97
364_L369_P1.1150.97
398_R401_L1.1140.97
320_V330_Q1.1110.97
283_C287_D1.1090.97
236_R241_K1.1090.97
313_L317_G1.1080.97
329_Q336_L1.1080.97
474_P477_W1.1080.97
208_T215_W1.1070.97
236_R240_D1.1020.97
419_H424_D1.1010.97
366_L369_P1.0950.97
475_G479_G1.0950.97
407_A411_N1.0940.97
384_R388_E1.0940.97
367_Q370_L1.0920.97
348_R353_L1.0910.97
208_T211_E1.0890.97
35_A39_G1.0870.97
369_P375_M1.0850.97
211_E215_W1.0830.97
467_Q478_L1.0790.96
360_S376_E1.0750.96
347_R350_Q1.0740.96
360_S373_H1.0730.96
270_S274_P1.0730.96
460_Q481_I1.0710.96
82_V85_P1.0660.96
398_R403_G1.0650.96
396_E402_N1.0610.96
461_H464_F1.0550.96
375_M378_V1.0540.96
326_L329_Q1.0460.96
232_I235_L1.0440.96
365_L378_V1.0430.96
453_L474_P1.0420.96
102_S108_A1.0410.96
380_I383_E1.0410.96
446_I474_P1.0400.96
425_V429_G1.0370.96
88_I91_L1.0340.96
412_L416_S1.0340.96
363_T366_L1.0310.95
235_L239_L1.0310.95
432_L435_P1.0300.95
419_H422_V1.0280.95
260_L263_S1.0270.95
289_Q293_L1.0270.95
471_L475_G1.0250.95
369_P377_V1.0250.95
444_G447_K1.0240.95
294_I298_I1.0210.95
208_T216_Q1.0200.95
464_F481_I1.0190.95
105_L108_A1.0180.95
209_D216_Q1.0160.95
451_E454_E1.0140.95
404_I409_K1.0120.95
263_S273_A1.0050.95
391_L396_E1.0030.95
358_T361_T1.0030.95
422_V432_L1.0010.95
411_N415_D1.0010.95
399_G402_N1.0000.95
397_I401_L1.0000.95
396_E399_G0.9810.94
206_Q209_D0.9800.94
323_H326_L0.9750.94
308_Q311_G0.9740.94
421_V425_V0.9730.94
417_A422_V0.9720.94
457_W464_F0.9720.94
84_G87_S0.9680.94
235_L241_K0.9660.94
296_Q300_V0.9630.93
419_H425_V0.9600.93
384_R393_K0.9600.93
321_Q325_Q0.9590.93
370_L379_H0.9580.93
283_C286_Y0.9560.93
209_D212_Y0.9540.93
211_E219_I0.9530.93
228_V240_D0.9520.93
348_R351_Y0.9510.93
322_R329_Q0.9490.93
397_I403_G0.9460.93
280_L283_C0.9450.93
365_L368_K0.9430.93
370_L376_E0.9410.93
430_S434_L0.9410.93
417_A420_L0.9400.93
425_V439_A0.9400.93
320_V323_H0.9360.92
327_Q331_S0.9320.92
357_V363_T0.9310.92
329_Q335_A0.9310.92
468_Q474_P0.9300.92
461_H465_S0.9290.92
406_F414_V0.9290.92
407_A410_L0.9270.92
440_E481_I0.9260.92
323_H327_Q0.9260.92
429_G433_A0.9260.92
212_Y216_Q0.9260.92
331_S337_T0.9240.92
435_P439_A0.9220.92
236_R239_L0.9200.92
298_I306_A0.9190.92
357_V360_S0.9170.92
386_A392_S0.9120.91
385_S388_E0.9120.91
291_L294_I0.9100.91
460_Q464_F0.9090.91
428_Q432_L0.9090.91
388_E392_S0.9060.91
263_S266_F0.9060.91
367_Q377_V0.9050.91
441_G445_E0.9040.91
364_L372_L0.8990.91
422_V439_A0.8970.91
31_L34_L0.8930.91
468_Q472_F0.8920.91
366_L370_L0.8910.90
364_L379_H0.8870.90
391_L400_K0.8830.90
208_T212_Y0.8830.90
327_Q330_Q0.8830.90
295_Q298_I0.8810.90
322_R330_Q0.8810.90
469_K473_I0.8800.90
113_L118_K0.8800.90
385_S392_S0.8790.90
361_T379_H0.8780.90
341_L345_F0.8770.90
382_F391_L0.8750.90
207_V212_Y0.8710.89
473_I477_W0.8670.89
271_A274_P0.8670.89
381_S387_L0.8670.89
425_V428_Q0.8660.89
367_Q373_H0.8660.89
325_Q329_Q0.8660.89
320_V324_L0.8660.89
211_E216_Q0.8600.89
77_S82_V0.8560.89
290_S294_I0.8510.88
463_L466_E0.8510.88
166_A170_R0.8490.88
209_D219_I0.8480.88
35_A38_S0.8470.88
114_D117_W0.8450.88
373_H378_V0.8450.88
365_L376_E0.8390.88
371_K375_M0.8380.88
140_A144_K0.8360.87
465_S468_Q0.8350.87
433_A436_G0.8330.87
474_P480_R0.8330.87
437_S440_E0.8320.87
395_G399_G0.8280.87
467_Q475_G0.8240.87
347_R353_L0.8240.87
344_I347_R0.8230.87
459_K463_L0.8220.87
410_L414_V0.8220.87
453_L471_L0.8160.86
232_I239_L0.8160.86
369_P374_D0.8150.86
384_R389_Q0.8150.86
470_C474_P0.8130.86
371_K377_V0.8120.86
424_D427_L0.8110.86
308_Q312_M0.8090.86
316_L319_I0.8090.86
433_A437_S0.8080.86
268_G271_A0.8080.86
404_I413_E0.8030.85
322_R332_D0.8020.85
423_R429_G0.8020.85
467_Q477_W0.7990.85
409_K414_V0.7980.85
405_G411_N0.7980.85
446_I478_L0.7960.85
323_H333_K0.7950.85
326_L331_S0.7950.85
474_P478_L0.7950.85
102_S107_E0.7950.85
397_I402_N0.7950.85
427_L431_T0.7900.84
215_W218_E0.7860.84
350_Q355_V0.7860.84
453_L464_F0.7840.84
312_M319_I0.7830.84
77_S85_P0.7830.84
324_L328_Q0.7810.84
303_T307_W0.7810.84
231_L236_R0.7800.84
384_R394_G0.7800.84
207_V219_I0.7770.83
440_E453_L0.7730.83
370_L374_D0.7730.83
347_R356_N0.7730.83
355_V372_L0.7690.83
360_S370_L0.7680.83
297_Q301_L0.7680.83
212_Y219_I0.7660.82
328_Q332_D0.7640.82
308_Q319_I0.7630.82
383_E389_Q0.7630.82
349_Q354_P0.7610.82
326_L330_Q0.7590.82
387_L402_N0.7580.82
330_Q336_L0.7570.82
466_E470_C0.7530.81
363_T375_M0.7520.81
204_A208_T0.7520.81
103_G107_E0.7500.81
322_R333_K0.7500.81
461_H474_P0.7490.81
231_L237_Q0.7490.81
385_S389_Q0.7470.81
391_L402_N0.7460.81
358_T375_M0.7440.81
381_S388_E0.7430.81
323_H332_D0.7420.80
372_L378_V0.7420.80
410_L413_E0.7420.80
332_D335_A0.7400.80
411_N414_V0.7360.80
468_Q471_L0.7340.80
386_A393_K0.7340.80
381_S386_A0.7310.79
450_L454_E0.7300.79
300_V304_G0.7300.79
384_R395_G0.7300.79
470_C473_I0.7300.79
360_S379_H0.7290.79
453_L481_I0.7290.79
421_V426_S0.7260.79
315_R318_A0.7250.79
460_Q468_Q0.7240.79
291_L295_Q0.7230.79
260_L264_A0.7230.79
370_L375_M0.7220.79
309_Q312_M0.7210.79
340_R348_R0.7200.78
368_K371_K0.7200.78
395_G401_L0.7180.78
207_V211_E0.7160.78
426_S429_G0.7150.78
235_L238_Q0.7100.77
383_E390_W0.7090.77
447_K451_E0.7080.77
330_Q335_A0.7080.77
272_V276_D0.7060.77
322_R337_T0.7060.77
299_D303_T0.7050.77
213_E216_Q0.7040.77
263_S270_S0.7030.77
334_T338_V0.7010.77
429_G435_P0.7010.77
383_E387_L0.7000.76
431_T435_P0.6970.76
404_I411_N0.6970.76
205_L211_E0.6930.76
208_T218_E0.6910.76
434_L438_S0.6900.75
408_Q412_L0.6870.75
470_C481_I0.6870.75
426_S433_A0.6870.75
326_L333_K0.6860.75
298_I302_M0.6860.75
265_F268_G0.6860.75
388_E397_I0.6830.75
446_I460_Q0.6820.75
409_K416_S0.6790.74
339_I342_G0.6780.74
205_L208_T0.6780.74
225_P235_L0.6780.74
449_Q474_P0.6770.74
424_D433_A0.6770.74
313_L316_L0.6750.74
228_V231_L0.6750.74
269_R273_A0.6750.74
132_N138_N0.6740.74
428_Q460_Q0.6740.74
360_S374_D0.6730.74
269_R272_V0.6710.73
250_D253_W0.6690.73
347_R352_Q0.6690.73
424_D439_A0.6670.73
290_S293_L0.6670.73
439_A478_L0.6670.73
291_L297_Q0.6660.73
290_S298_I0.6650.73
365_L373_H0.6650.73
404_I408_Q0.6630.72
345_F348_R0.6630.72
388_E391_L0.6600.72
324_L327_Q0.6590.72
329_Q333_K0.6590.72
445_E449_Q0.6570.72
371_K379_H0.6570.72
390_W394_G0.6560.72
315_R319_I0.6530.71
237_Q240_D0.6520.71
454_E457_W0.6500.71
87_S92_K0.6490.71
468_Q478_L0.6460.71
446_I449_Q0.6440.70
408_Q413_E0.6430.70
436_G439_A0.6420.70
404_I412_L0.6410.70
368_K379_H0.6380.70
355_V371_K0.6370.69
382_F389_Q0.6360.69
132_N166_A0.6350.69
373_H377_V0.6330.69
371_K376_E0.6320.69
358_T364_L0.6320.69
424_D429_G0.6300.69
471_L477_W0.6300.69
321_Q326_L0.6270.68
386_A394_G0.6250.68
331_S334_T0.6240.68
420_L425_V0.6200.67
453_L478_L0.6200.67
228_V241_K0.6200.67
425_V435_P0.6200.67
235_L240_D0.6190.67
467_Q481_I0.6190.67
383_E392_S0.6180.67
355_V376_E0.6170.67
207_V216_Q0.6170.67
391_L398_R0.6160.67
380_I385_S0.6160.67
156_E159_E0.6160.67
225_P236_R0.6150.67
126_T132_N0.6130.67
186_F190_L0.6120.66
167_L170_R0.6110.66
425_V433_A0.6110.66
380_I392_S0.6100.66
387_L398_R0.6050.66
264_A267_S0.6040.65
320_V334_T0.6020.65
382_F393_K0.6020.65
384_R391_L0.6000.65
446_I464_F0.5990.65
168_Y171_M0.5990.65
208_T213_E0.5990.65
56_A152_A0.5980.65
476_D480_R0.5970.65
457_W460_Q0.5930.64
446_I471_L0.5930.64
358_T374_D0.5920.64
228_V236_R0.5920.64
279_L287_D0.5910.64
424_D428_Q0.5890.63
425_V430_S0.5890.63
328_Q331_S0.5880.63
274_P278_I0.5880.63
350_Q353_L0.5880.63
387_L390_W0.5880.63
87_S90_A0.5880.63
406_F410_L0.5860.63
212_Y218_E0.5850.63
322_R325_Q0.5830.63
395_G403_G0.5820.63
393_K398_R0.5820.63
26_S30_R0.5820.63
265_F269_R0.5820.63
465_S471_L0.5790.62
180_V185_N0.5790.62
213_E217_K0.5790.62
364_L368_K0.5780.62
361_T376_E0.5780.62
348_R354_P0.5750.62
459_K462_A0.5750.62
447_K460_Q0.5730.61
358_T369_P0.5730.61
181_Q185_N0.5730.61
205_L216_Q0.5720.61
467_Q480_R0.5720.61
262_A267_S0.5720.61
221_E225_P0.5700.61
388_E395_G0.5690.61
382_F392_S0.5660.60
364_L370_L0.5650.60
416_S420_L0.5640.60
394_G398_R0.5620.60
365_L375_M0.5620.60
453_L467_Q0.5610.60
461_H478_L0.5610.60
279_L282_D0.5600.60
404_I417_A0.5600.60
387_L391_L0.5600.60
329_Q332_D0.5580.59
468_Q481_I0.5570.59
208_T219_I0.5570.59
355_V359_A0.5560.59
426_S432_L0.5550.59
309_Q313_L0.5540.59
224_L231_L0.5540.59
370_L377_V0.5530.59
325_Q328_Q0.5520.59
330_Q334_T0.5500.58
341_L348_R0.5500.58
382_F388_E0.5490.58
358_T379_H0.5490.58
135_Q138_N0.5480.58
128_L131_I0.5480.58
380_I387_L0.5470.58
267_S274_P0.5470.58
320_V333_K0.5460.58
423_R432_L0.5460.58
448_Q452_E0.5440.57
262_A265_F0.5440.57
363_T379_H0.5430.57
346_S350_Q0.5420.57
361_T374_D0.5420.57
419_H426_S0.5410.57
238_Q241_K0.5410.57
297_Q303_T0.5400.57
464_F477_W0.5400.57
457_W467_Q0.5390.57
231_L235_L0.5380.57
112_F117_W0.5380.57
129_T133_E0.5370.56
446_I481_I0.5370.56
403_G414_V0.5360.56
315_R322_R0.5360.56
360_S371_K0.5350.56
428_Q435_P0.5350.56
418_Q429_G0.5350.56
206_Q211_E0.5320.56
227_H241_K0.5310.56
387_L393_K0.5310.56
328_Q336_L0.5280.55
371_K374_D0.5280.55
341_L354_P0.5270.55
363_T371_K0.5260.55
274_P277_L0.5240.55
374_D377_V0.5240.55
418_Q425_V0.5230.55
141_H149_L0.5170.54
384_R397_I0.5150.53
464_F473_I0.5140.53
251_R255_K0.5140.53
381_S392_S0.5130.53
424_D435_P0.5130.53
386_A402_N0.5120.53
273_A277_L0.5120.53
329_Q338_V0.5120.53
456_D460_Q0.5100.53
393_K400_K0.5100.53
457_W471_L0.5100.53
232_I240_D0.5090.53
446_I461_H0.5080.52
392_S402_N0.5060.52
381_S390_W0.5040.52
437_S441_G0.5040.52
225_P240_D0.5040.52
360_S366_L0.5040.52
231_L234_M0.5020.52
460_Q474_P0.5020.52
112_F115_E0.5020.52
343_G354_P0.5010.51
396_E403_G0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rh7A 1 0.9056 100 0.288 Contact Map
3vkgA 2 0.8333 100 0.351 Contact Map
4akgA 2 0.5542 100 0.558 Contact Map
3nbxX 1 0.9618 100 0.651 Contact Map
4r7yA 3 0.5643 100 0.732 Contact Map
2r44A 1 0.6064 100 0.742 Contact Map
3ja82 1 0.5924 99.9 0.748 Contact Map
3ja83 1 0.5442 99.9 0.759 Contact Map
3ja84 1 0.5562 99.9 0.759 Contact Map
3f8tA 1 0.494 99.9 0.762 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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