YIEL - ECOLI - GREMLIN Contacts

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YIEL - Uncharacterized protein YieL

UniProt:	P31471	Sequences: MNIKIAALTLAIASGISAQWAIAADMPASPAPTIPVKQYVTQVNADNSVTFRYFAPGAKNVSVVVGVPVPDNIHPMTKDEAGVWSWRTPILKGNLYEYFFNVDGVRSIDTGTAMTNPQRQVNSSMILVPGSYLDTRSVAHGDLIAITYHSNALQSERQMYVWTPPGYTGMGEPLPVLYFYHGFGDTGRSAIDQGRIPQIMDNLLAEGKIKPMLVVIPDTETDAKGIIPEDFVPQERRKVFYPLNAKAADRELMNDIIPLISKRFNVRKDADGRALAGLSQGGYQALVSGMNHLESFGWLATFSGVTTTTVPDEGVAARLNDPAAINQQLRNFTVVVGDKDVVTGKDIAGLKTELEQKKINFDYQEYPGLNHEMDVWRPAYAAFVQKLFK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11729
Length:	389 (314)
Sequences:	2606 (2229)
Seq/√Len:	125.8

ECOLI - YIEL FES
BACSU - YUXL
HALSA - Q9HN07 Q9HS46

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
289_G	299_L	5.616	1.00
259_L	263_R	4.236	1.00
285_A	299_L	3.612	1.00
168_T	171_G	3.175	1.00
267_R	272_G	3.110	1.00
149_H	156_E	2.786	1.00
315_V	318_R	2.763	1.00
314_G	318_R	2.691	1.00
174_L	213_L	2.595	1.00
264_F	267_R	2.582	1.00
167_Y	174_L	2.560	1.00
316_A	320_N	2.490	1.00
176_V	215_V	2.482	1.00
355_E	361_F	2.391	1.00
161_V	215_V	2.354	1.00
318_R	322_P	2.346	1.00
275_L	288_S	2.215	1.00
261_S	266_V	2.190	1.00
317_A	320_N	2.146	1.00
324_A	327_Q	2.108	1.00
315_V	319_L	2.033	1.00
144_I	163_T	2.028	1.00
320_N	323_A	1.967	1.00
51_F	54_F	1.962	1.00
313_E	322_P	1.941	1.00
318_R	321_D	1.940	1.00
348_A	365_E	1.909	1.00
147_T	156_E	1.891	1.00
244_N	247_A	1.882	1.00
197_P	200_M	1.864	1.00
244_N	251_E	1.852	1.00
316_A	321_D	1.790	1.00
54_F	57_G	1.781	1.00
312_D	315_V	1.771	1.00
353_E	357_K	1.760	1.00
244_N	250_R	1.757	1.00
146_I	159_M	1.744	1.00
313_E	323_A	1.736	1.00
242_P	245_A	1.720	1.00
66_G	70_P	1.701	1.00
312_D	318_R	1.697	1.00
162_W	201_D	1.689	1.00
274_A	298_W	1.670	1.00
351_K	361_F	1.648	1.00
344_G	348_A	1.646	1.00
178_Y	215_V	1.646	1.00
278_L	302_F	1.631	1.00
259_L	262_K	1.624	1.00
312_D	319_L	1.610	1.00
351_K	355_E	1.593	1.00
303_S	373_M	1.565	1.00
314_G	317_A	1.562	1.00
318_R	323_A	1.559	1.00
352_T	356_Q	1.554	1.00
179_F	276_A	1.529	1.00
286_L	332_F	1.513	1.00
312_D	323_A	1.507	1.00
294_E	329_L	1.501	1.00
344_G	365_E	1.499	1.00
135_T	140_H	1.491	1.00
79_D	82_G	1.487	1.00
82_G	85_S	1.483	1.00
161_V	213_L	1.478	1.00
306_T	350_L	1.474	1.00
312_D	316_A	1.468	1.00
243_L	251_E	1.465	1.00
61_V	65_V	1.465	1.00
316_A	323_A	1.462	1.00
114_M	117_P	1.461	1.00
110_T	115_T	1.453	1.00
109_D	112_T	1.446	1.00
307_T	310_V	1.434	1.00
312_D	322_P	1.429	1.00
168_T	172_E	1.427	1.00
316_A	319_L	1.415	1.00
315_V	322_P	1.411	1.00
258_P	261_S	1.407	1.00
312_D	320_N	1.404	1.00
315_V	320_N	1.401	1.00
246_K	249_D	1.399	1.00
249_D	252_L	1.399	1.00
189_S	193_Q	1.398	1.00
243_L	247_A	1.384	1.00
313_E	317_A	1.382	1.00
278_L	303_S	1.378	1.00
317_A	321_D	1.375	1.00
123_S	126_I	1.375	1.00
313_E	320_N	1.369	1.00
280_Q	284_Q	1.368	1.00
85_S	98_Y	1.366	1.00
313_E	318_R	1.359	1.00
312_D	317_A	1.358	1.00
43_V	47_N	1.354	1.00
248_A	251_E	1.347	1.00
151_N	154_Q	1.344	1.00
104_G	107_S	1.341	1.00
289_G	330_R	1.334	1.00
298_W	331_N	1.333	1.00
338_D	365_E	1.332	1.00
140_H	143_L	1.325	1.00
245_A	249_D	1.323	1.00
248_A	252_L	1.321	1.00
301_T	304_G	1.316	1.00
314_G	319_L	1.307	1.00
213_L	266_V	1.296	1.00
199_I	202_N	1.293	1.00
148_Y	159_M	1.292	1.00
301_T	334_V	1.269	1.00
316_A	322_P	1.259	1.00
319_L	323_A	1.239	1.00
65_V	70_P	1.225	0.99
73_I	77_T	1.212	0.99
317_A	322_P	1.211	0.99
255_D	258_P	1.210	0.99
85_S	89_P	1.199	0.99
275_L	285_A	1.197	0.99
148_Y	217_P	1.192	0.99
77_T	80_E	1.191	0.99
256_I	259_L	1.189	0.99
255_D	259_L	1.182	0.99
180_Y	275_L	1.182	0.99
257_I	261_S	1.179	0.99
198_Q	201_D	1.179	0.99
250_R	253_M	1.169	0.99
351_K	363_Y	1.165	0.99
179_F	216_I	1.163	0.99
317_A	323_A	1.160	0.99
67_V	70_P	1.158	0.99
279_S	371_H	1.155	0.99
126_I	129_P	1.154	0.99
94_N	98_Y	1.148	0.99
110_T	113_A	1.148	0.99
120_Q	124_S	1.148	0.99
256_I	260_I	1.146	0.99
167_Y	213_L	1.144	0.99
44_N	48_S	1.140	0.99
314_G	320_N	1.140	0.99
354_L	359_I	1.135	0.99
333_T	364_Q	1.134	0.99
275_L	299_L	1.130	0.99
55_A	59_K	1.123	0.99
56_P	63_V	1.121	0.99
280_Q	283_Y	1.113	0.99
82_G	87_R	1.109	0.99
247_A	251_E	1.106	0.99
338_D	367_P	1.106	0.99
286_L	301_T	1.102	0.99
54_F	58_A	1.101	0.99
183_F	305_V	1.097	0.99
243_L	250_R	1.090	0.99
249_D	255_D	1.082	0.99
190_A	193_Q	1.080	0.99
120_Q	128_V	1.075	0.99
43_V	46_D	1.073	0.99
314_G	322_P	1.065	0.99
163_T	213_L	1.052	0.98
241_Y	244_N	1.051	0.98
163_T	167_Y	1.046	0.98
77_T	86_W	1.042	0.98
298_W	330_R	1.040	0.98
168_T	174_L	1.039	0.98
62_S	65_V	1.028	0.98
315_V	323_A	1.028	0.98
287_V	290_M	1.024	0.98
252_L	258_P	1.020	0.98
95_L	98_Y	1.018	0.98
326_N	329_L	1.015	0.98
251_E	255_D	1.013	0.98
119_R	122_N	1.011	0.98
334_V	350_L	1.008	0.98
124_S	129_P	0.992	0.98
260_I	266_V	0.982	0.97
247_A	250_R	0.971	0.97
314_G	323_A	0.969	0.97
115_T	120_Q	0.962	0.97
91_L	94_N	0.954	0.97
51_F	55_A	0.952	0.97
242_P	250_R	0.950	0.97
83_V	87_R	0.950	0.97
98_Y	102_V	0.949	0.97
44_N	47_N	0.948	0.97
80_E	83_V	0.941	0.97
77_T	81_A	0.939	0.97
83_V	89_P	0.938	0.97
181_H	278_L	0.936	0.97
73_I	78_K	0.933	0.97
66_G	69_V	0.927	0.96
303_S	370_N	0.927	0.96
261_S	273_R	0.917	0.96
326_N	330_R	0.916	0.96
152_A	255_D	0.914	0.96
50_T	54_F	0.914	0.96
42_Q	52_R	0.908	0.96
167_Y	171_G	0.908	0.96
276_A	302_F	0.905	0.96
244_N	252_L	0.904	0.96
283_Y	287_V	0.903	0.96
85_S	97_E	0.899	0.96
138_V	141_G	0.896	0.96
119_R	123_S	0.891	0.96
136_R	141_G	0.889	0.95
178_Y	256_I	0.887	0.95
304_G	347_I	0.884	0.95
54_F	63_V	0.884	0.95
73_I	80_E	0.883	0.95
299_L	332_F	0.881	0.95
241_Y	248_A	0.879	0.95
287_V	291_N	0.879	0.95
65_V	68_P	0.879	0.95
283_Y	305_V	0.875	0.95
164_P	174_L	0.875	0.95
83_V	86_W	0.874	0.95
145_A	158_Q	0.873	0.95
257_I	273_R	0.873	0.95
167_Y	265_N	0.865	0.95
85_S	95_L	0.864	0.95
55_A	63_V	0.863	0.95
202_N	210_K	0.862	0.95
64_V	70_P	0.860	0.95
252_L	255_D	0.860	0.95
97_E	102_V	0.859	0.95
42_Q	45_A	0.858	0.94
101_N	106_R	0.857	0.94
42_Q	46_D	0.854	0.94
120_Q	123_S	0.852	0.94
313_E	321_D	0.852	0.94
241_Y	246_K	0.852	0.94
74_H	80_E	0.850	0.94
259_L	266_V	0.848	0.94
245_A	251_E	0.846	0.94
313_E	316_A	0.844	0.94
146_I	259_L	0.843	0.94
310_V	346_D	0.838	0.94
325_I	328_Q	0.835	0.94
114_M	118_Q	0.834	0.94
283_Y	336_V	0.832	0.94
116_N	125_M	0.830	0.93
88_T	92_K	0.829	0.93
74_H	78_K	0.829	0.93
94_N	97_E	0.825	0.93
77_T	82_G	0.822	0.93
79_D	83_V	0.820	0.93
178_Y	257_I	0.820	0.93
351_K	365_E	0.817	0.93
251_E	256_I	0.810	0.93
137_S	141_G	0.806	0.92
319_L	322_P	0.803	0.92
288_S	292_H	0.803	0.92
285_A	289_G	0.801	0.92
271_D	297_G	0.800	0.92
336_V	343_T	0.800	0.92
64_V	67_V	0.798	0.92
303_S	376_W	0.791	0.92
184_G	221_T	0.791	0.92
84_W	97_E	0.790	0.92
168_T	213_L	0.790	0.92
63_V	70_P	0.790	0.92
187_G	190_A	0.787	0.92
73_I	83_V	0.785	0.91
256_I	261_S	0.781	0.91
118_Q	121_V	0.776	0.91
123_S	129_P	0.776	0.91
178_Y	261_S	0.763	0.90
181_H	219_T	0.762	0.90
158_Q	218_D	0.761	0.90
325_I	330_R	0.758	0.90
122_N	126_I	0.758	0.90
57_G	60_N	0.754	0.90
77_T	84_W	0.753	0.90
42_Q	47_N	0.752	0.90
353_E	356_Q	0.752	0.90
76_M	84_W	0.751	0.90
53_Y	60_N	0.751	0.90
49_V	53_Y	0.751	0.90
135_T	138_V	0.744	0.89
122_N	129_P	0.744	0.89
83_V	88_T	0.744	0.89
334_V	354_L	0.744	0.89
110_T	129_P	0.742	0.89
257_I	295_S	0.741	0.89
90_I	96_Y	0.733	0.88
166_G	174_L	0.731	0.88
62_S	66_G	0.728	0.88
246_K	250_R	0.725	0.88
64_V	68_P	0.723	0.88
180_Y	284_Q	0.723	0.88
119_R	126_I	0.722	0.88
56_P	59_K	0.721	0.88
105_V	108_I	0.716	0.87
261_S	264_F	0.714	0.87
75_P	79_D	0.714	0.87
198_Q	202_N	0.712	0.87
310_V	349_G	0.711	0.87
217_P	256_I	0.708	0.87
116_N	122_N	0.707	0.87
131_S	134_D	0.706	0.86
249_D	256_I	0.704	0.86
125_M	128_V	0.703	0.86
325_I	329_L	0.702	0.86
327_Q	330_R	0.701	0.86
56_P	60_N	0.698	0.86
58_A	61_V	0.697	0.86
253_M	258_P	0.695	0.86
112_T	122_N	0.694	0.86
118_Q	128_V	0.694	0.86
179_F	196_I	0.692	0.85
45_A	51_F	0.690	0.85
88_T	94_N	0.690	0.85
55_A	58_A	0.689	0.85
278_L	373_M	0.689	0.85
56_P	62_S	0.688	0.85
341_V	370_N	0.685	0.85
117_P	121_V	0.685	0.85
121_V	127_L	0.681	0.84
78_K	84_W	0.680	0.84
326_N	357_K	0.679	0.84
74_H	84_W	0.679	0.84
283_Y	340_D	0.678	0.84
252_L	256_I	0.676	0.84
89_P	98_Y	0.676	0.84
81_A	84_W	0.676	0.84
339_K	342_V	0.676	0.84
76_M	100_F	0.674	0.84
109_D	124_S	0.673	0.84
91_L	97_E	0.673	0.84
96_Y	101_N	0.672	0.84
114_M	127_L	0.672	0.84
124_S	127_L	0.669	0.83
312_D	321_D	0.669	0.83
75_P	85_S	0.668	0.83
181_H	218_D	0.667	0.83
137_S	140_H	0.666	0.83
54_F	61_V	0.664	0.83
82_G	99_F	0.663	0.83
51_F	60_N	0.663	0.83
196_I	200_M	0.660	0.83
305_V	343_T	0.659	0.82
84_W	87_R	0.659	0.82
78_K	83_V	0.657	0.82
303_S	372_E	0.652	0.82
252_L	257_I	0.649	0.81
348_A	352_T	0.646	0.81
218_D	341_V	0.645	0.81
92_K	95_L	0.645	0.81
123_S	128_V	0.643	0.81
243_L	248_A	0.642	0.81
305_V	308_T	0.640	0.81
97_E	100_F	0.639	0.80
90_I	93_G	0.635	0.80
73_I	102_V	0.634	0.80
88_T	100_F	0.632	0.80
54_F	62_S	0.632	0.80
176_V	266_V	0.631	0.80
120_Q	127_L	0.630	0.80
349_G	352_T	0.630	0.80
57_G	61_V	0.629	0.79
43_V	49_V	0.629	0.79
352_T	355_E	0.628	0.79
244_N	248_A	0.626	0.79
86_W	91_L	0.626	0.79
313_E	319_L	0.625	0.79
286_L	304_G	0.624	0.79
241_Y	250_R	0.621	0.79
130_G	134_D	0.621	0.79
149_H	153_L	0.619	0.78
213_L	265_N	0.619	0.78
260_I	263_R	0.619	0.78
139_A	142_D	0.618	0.78
188_R	192_D	0.617	0.78
79_D	84_W	0.617	0.78
71_D	74_H	0.617	0.78
240_F	244_N	0.615	0.78
94_N	102_V	0.613	0.78
96_Y	100_F	0.612	0.78
119_R	129_P	0.611	0.77
86_W	89_P	0.606	0.77
55_A	61_V	0.606	0.77
302_F	373_M	0.604	0.77
350_L	354_L	0.603	0.77
50_T	55_A	0.602	0.76
60_N	65_V	0.600	0.76
302_F	366_Y	0.597	0.76
314_G	321_D	0.596	0.76
255_D	263_R	0.596	0.76
43_V	48_S	0.596	0.76
51_F	65_V	0.596	0.76
90_I	101_N	0.596	0.76
83_V	102_V	0.595	0.76
329_L	359_I	0.593	0.75
299_L	330_R	0.593	0.75
177_L	276_A	0.593	0.75
278_L	376_W	0.592	0.75
49_V	128_V	0.591	0.75
46_D	53_Y	0.590	0.75
181_H	342_V	0.590	0.75
200_M	214_V	0.589	0.75
84_W	89_P	0.589	0.75
369_L	375_V	0.584	0.74
116_N	123_S	0.583	0.74
77_T	83_V	0.583	0.74
278_L	372_E	0.579	0.74
46_D	51_F	0.579	0.74
136_R	139_A	0.578	0.74
349_G	353_E	0.576	0.73
221_T	224_K	0.574	0.73
73_I	82_G	0.573	0.73
82_G	86_W	0.572	0.73
257_I	266_V	0.570	0.72
328_Q	350_L	0.569	0.72
95_L	102_V	0.567	0.72
53_Y	56_P	0.567	0.72
63_V	71_D	0.566	0.72
63_V	66_G	0.563	0.72
246_K	252_L	0.563	0.72
261_S	267_R	0.562	0.71
344_G	363_Y	0.561	0.71
140_H	201_D	0.561	0.71
109_D	117_P	0.559	0.71
303_S	336_V	0.559	0.71
109_D	128_V	0.556	0.71
116_N	120_Q	0.556	0.71
242_P	246_K	0.556	0.71
306_T	310_V	0.555	0.70
98_Y	101_N	0.551	0.70
114_M	122_N	0.548	0.70
55_A	60_N	0.547	0.69
163_T	174_L	0.546	0.69
262_K	266_V	0.544	0.69
375_V	378_P	0.542	0.69
117_P	126_I	0.542	0.69
336_V	344_G	0.541	0.69
346_D	349_G	0.539	0.68
245_A	250_R	0.539	0.68
218_D	222_D	0.538	0.68
218_D	221_T	0.538	0.68
72_N	75_P	0.536	0.68
307_T	349_G	0.535	0.68
180_Y	217_P	0.534	0.68
74_H	79_D	0.532	0.67
42_Q	48_S	0.532	0.67
133_L	139_A	0.530	0.67
93_G	96_Y	0.529	0.67
167_Y	172_E	0.529	0.67
241_Y	245_A	0.528	0.67
117_P	128_V	0.527	0.67
164_P	213_L	0.527	0.67
118_Q	122_N	0.526	0.66
117_P	120_Q	0.525	0.66
180_Y	219_T	0.525	0.66
62_S	75_P	0.522	0.66
302_F	369_L	0.517	0.65
182_G	279_S	0.517	0.65
62_S	70_P	0.517	0.65
243_L	252_L	0.515	0.65
48_S	51_F	0.515	0.65
192_D	197_P	0.514	0.65
347_I	351_K	0.514	0.65
366_Y	375_V	0.514	0.65
75_P	78_K	0.512	0.64
47_N	50_T	0.512	0.64
132_Y	136_R	0.509	0.64
240_F	243_L	0.509	0.64
215_V	256_I	0.508	0.64
276_A	285_A	0.508	0.64
115_T	118_Q	0.506	0.63
183_F	280_Q	0.506	0.63
59_K	68_P	0.505	0.63
93_G	102_V	0.504	0.63
182_G	219_T	0.503	0.63
56_P	61_V	0.503	0.63
245_A	248_A	0.500	0.63

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3c8dA	2	0.8689	100	0.427	Contact Map
1jjfA	1	0.6221	100	0.546	Contact Map
4w9rA	2	0.5758	100	0.567	Contact Map
1gklA	1	0.6427	100	0.579	Contact Map
1xfdA	2	0.9357	100	0.583	Contact Map
2gzsA	1	0.6118	100	0.586	Contact Map
3gffA	2	0.5913	100	0.589	Contact Map
2uz0A	4	0.5707	100	0.59	Contact Map
2z3zA	2	0.8946	100	0.592	Contact Map
4rotA	4	0.5887	100	0.593	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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