GREMLIN Database
YIEL - Uncharacterized protein YieL
UniProt: P31471 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11729
Length: 389 (314)
Sequences: 2606 (2229)
Seq/√Len: 125.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
289_G299_L5.6161.00
259_L263_R4.2361.00
285_A299_L3.6121.00
168_T171_G3.1751.00
267_R272_G3.1101.00
149_H156_E2.7861.00
315_V318_R2.7631.00
314_G318_R2.6911.00
174_L213_L2.5951.00
264_F267_R2.5821.00
167_Y174_L2.5601.00
316_A320_N2.4901.00
176_V215_V2.4821.00
355_E361_F2.3911.00
161_V215_V2.3541.00
318_R322_P2.3461.00
275_L288_S2.2151.00
261_S266_V2.1901.00
317_A320_N2.1461.00
324_A327_Q2.1081.00
315_V319_L2.0331.00
144_I163_T2.0281.00
320_N323_A1.9671.00
51_F54_F1.9621.00
313_E322_P1.9411.00
318_R321_D1.9401.00
348_A365_E1.9091.00
147_T156_E1.8911.00
244_N247_A1.8821.00
197_P200_M1.8641.00
244_N251_E1.8521.00
316_A321_D1.7901.00
54_F57_G1.7811.00
312_D315_V1.7711.00
353_E357_K1.7601.00
244_N250_R1.7571.00
146_I159_M1.7441.00
313_E323_A1.7361.00
242_P245_A1.7201.00
66_G70_P1.7011.00
312_D318_R1.6971.00
162_W201_D1.6891.00
274_A298_W1.6701.00
351_K361_F1.6481.00
344_G348_A1.6461.00
178_Y215_V1.6461.00
278_L302_F1.6311.00
259_L262_K1.6241.00
312_D319_L1.6101.00
351_K355_E1.5931.00
303_S373_M1.5651.00
314_G317_A1.5621.00
318_R323_A1.5591.00
352_T356_Q1.5541.00
179_F276_A1.5291.00
286_L332_F1.5131.00
312_D323_A1.5071.00
294_E329_L1.5011.00
344_G365_E1.4991.00
135_T140_H1.4911.00
79_D82_G1.4871.00
82_G85_S1.4831.00
161_V213_L1.4781.00
306_T350_L1.4741.00
312_D316_A1.4681.00
243_L251_E1.4651.00
61_V65_V1.4651.00
316_A323_A1.4621.00
114_M117_P1.4611.00
110_T115_T1.4531.00
109_D112_T1.4461.00
307_T310_V1.4341.00
312_D322_P1.4291.00
168_T172_E1.4271.00
316_A319_L1.4151.00
315_V322_P1.4111.00
258_P261_S1.4071.00
312_D320_N1.4041.00
315_V320_N1.4011.00
246_K249_D1.3991.00
249_D252_L1.3991.00
189_S193_Q1.3981.00
243_L247_A1.3841.00
313_E317_A1.3821.00
278_L303_S1.3781.00
317_A321_D1.3751.00
123_S126_I1.3751.00
313_E320_N1.3691.00
280_Q284_Q1.3681.00
85_S98_Y1.3661.00
313_E318_R1.3591.00
312_D317_A1.3581.00
43_V47_N1.3541.00
248_A251_E1.3471.00
151_N154_Q1.3441.00
104_G107_S1.3411.00
289_G330_R1.3341.00
298_W331_N1.3331.00
338_D365_E1.3321.00
140_H143_L1.3251.00
245_A249_D1.3231.00
248_A252_L1.3211.00
301_T304_G1.3161.00
314_G319_L1.3071.00
213_L266_V1.2961.00
199_I202_N1.2931.00
148_Y159_M1.2921.00
301_T334_V1.2691.00
316_A322_P1.2591.00
319_L323_A1.2391.00
65_V70_P1.2250.99
73_I77_T1.2120.99
317_A322_P1.2110.99
255_D258_P1.2100.99
85_S89_P1.1990.99
275_L285_A1.1970.99
148_Y217_P1.1920.99
77_T80_E1.1910.99
256_I259_L1.1890.99
255_D259_L1.1820.99
180_Y275_L1.1820.99
257_I261_S1.1790.99
198_Q201_D1.1790.99
250_R253_M1.1690.99
351_K363_Y1.1650.99
179_F216_I1.1630.99
317_A323_A1.1600.99
67_V70_P1.1580.99
279_S371_H1.1550.99
126_I129_P1.1540.99
94_N98_Y1.1480.99
110_T113_A1.1480.99
120_Q124_S1.1480.99
256_I260_I1.1460.99
167_Y213_L1.1440.99
44_N48_S1.1400.99
314_G320_N1.1400.99
354_L359_I1.1350.99
333_T364_Q1.1340.99
275_L299_L1.1300.99
55_A59_K1.1230.99
56_P63_V1.1210.99
280_Q283_Y1.1130.99
82_G87_R1.1090.99
247_A251_E1.1060.99
338_D367_P1.1060.99
286_L301_T1.1020.99
54_F58_A1.1010.99
183_F305_V1.0970.99
243_L250_R1.0900.99
249_D255_D1.0820.99
190_A193_Q1.0800.99
120_Q128_V1.0750.99
43_V46_D1.0730.99
314_G322_P1.0650.99
163_T213_L1.0520.98
241_Y244_N1.0510.98
163_T167_Y1.0460.98
77_T86_W1.0420.98
298_W330_R1.0400.98
168_T174_L1.0390.98
62_S65_V1.0280.98
315_V323_A1.0280.98
287_V290_M1.0240.98
252_L258_P1.0200.98
95_L98_Y1.0180.98
326_N329_L1.0150.98
251_E255_D1.0130.98
119_R122_N1.0110.98
334_V350_L1.0080.98
124_S129_P0.9920.98
260_I266_V0.9820.97
247_A250_R0.9710.97
314_G323_A0.9690.97
115_T120_Q0.9620.97
91_L94_N0.9540.97
51_F55_A0.9520.97
242_P250_R0.9500.97
83_V87_R0.9500.97
98_Y102_V0.9490.97
44_N47_N0.9480.97
80_E83_V0.9410.97
77_T81_A0.9390.97
83_V89_P0.9380.97
181_H278_L0.9360.97
73_I78_K0.9330.97
66_G69_V0.9270.96
303_S370_N0.9270.96
261_S273_R0.9170.96
326_N330_R0.9160.96
152_A255_D0.9140.96
50_T54_F0.9140.96
42_Q52_R0.9080.96
167_Y171_G0.9080.96
276_A302_F0.9050.96
244_N252_L0.9040.96
283_Y287_V0.9030.96
85_S97_E0.8990.96
138_V141_G0.8960.96
119_R123_S0.8910.96
136_R141_G0.8890.95
178_Y256_I0.8870.95
304_G347_I0.8840.95
54_F63_V0.8840.95
73_I80_E0.8830.95
299_L332_F0.8810.95
241_Y248_A0.8790.95
287_V291_N0.8790.95
65_V68_P0.8790.95
283_Y305_V0.8750.95
164_P174_L0.8750.95
83_V86_W0.8740.95
145_A158_Q0.8730.95
257_I273_R0.8730.95
167_Y265_N0.8650.95
85_S95_L0.8640.95
55_A63_V0.8630.95
202_N210_K0.8620.95
64_V70_P0.8600.95
252_L255_D0.8600.95
97_E102_V0.8590.95
42_Q45_A0.8580.94
101_N106_R0.8570.94
42_Q46_D0.8540.94
120_Q123_S0.8520.94
313_E321_D0.8520.94
241_Y246_K0.8520.94
74_H80_E0.8500.94
259_L266_V0.8480.94
245_A251_E0.8460.94
313_E316_A0.8440.94
146_I259_L0.8430.94
310_V346_D0.8380.94
325_I328_Q0.8350.94
114_M118_Q0.8340.94
283_Y336_V0.8320.94
116_N125_M0.8300.93
88_T92_K0.8290.93
74_H78_K0.8290.93
94_N97_E0.8250.93
77_T82_G0.8220.93
79_D83_V0.8200.93
178_Y257_I0.8200.93
351_K365_E0.8170.93
251_E256_I0.8100.93
137_S141_G0.8060.92
319_L322_P0.8030.92
288_S292_H0.8030.92
285_A289_G0.8010.92
271_D297_G0.8000.92
336_V343_T0.8000.92
64_V67_V0.7980.92
303_S376_W0.7910.92
184_G221_T0.7910.92
84_W97_E0.7900.92
168_T213_L0.7900.92
63_V70_P0.7900.92
187_G190_A0.7870.92
73_I83_V0.7850.91
256_I261_S0.7810.91
118_Q121_V0.7760.91
123_S129_P0.7760.91
178_Y261_S0.7630.90
181_H219_T0.7620.90
158_Q218_D0.7610.90
325_I330_R0.7580.90
122_N126_I0.7580.90
57_G60_N0.7540.90
77_T84_W0.7530.90
42_Q47_N0.7520.90
353_E356_Q0.7520.90
76_M84_W0.7510.90
53_Y60_N0.7510.90
49_V53_Y0.7510.90
135_T138_V0.7440.89
122_N129_P0.7440.89
83_V88_T0.7440.89
334_V354_L0.7440.89
110_T129_P0.7420.89
257_I295_S0.7410.89
90_I96_Y0.7330.88
166_G174_L0.7310.88
62_S66_G0.7280.88
246_K250_R0.7250.88
64_V68_P0.7230.88
180_Y284_Q0.7230.88
119_R126_I0.7220.88
56_P59_K0.7210.88
105_V108_I0.7160.87
261_S264_F0.7140.87
75_P79_D0.7140.87
198_Q202_N0.7120.87
310_V349_G0.7110.87
217_P256_I0.7080.87
116_N122_N0.7070.87
131_S134_D0.7060.86
249_D256_I0.7040.86
125_M128_V0.7030.86
325_I329_L0.7020.86
327_Q330_R0.7010.86
56_P60_N0.6980.86
58_A61_V0.6970.86
253_M258_P0.6950.86
112_T122_N0.6940.86
118_Q128_V0.6940.86
179_F196_I0.6920.85
45_A51_F0.6900.85
88_T94_N0.6900.85
55_A58_A0.6890.85
278_L373_M0.6890.85
56_P62_S0.6880.85
341_V370_N0.6850.85
117_P121_V0.6850.85
121_V127_L0.6810.84
78_K84_W0.6800.84
326_N357_K0.6790.84
74_H84_W0.6790.84
283_Y340_D0.6780.84
252_L256_I0.6760.84
89_P98_Y0.6760.84
81_A84_W0.6760.84
339_K342_V0.6760.84
76_M100_F0.6740.84
109_D124_S0.6730.84
91_L97_E0.6730.84
96_Y101_N0.6720.84
114_M127_L0.6720.84
124_S127_L0.6690.83
312_D321_D0.6690.83
75_P85_S0.6680.83
181_H218_D0.6670.83
137_S140_H0.6660.83
54_F61_V0.6640.83
82_G99_F0.6630.83
51_F60_N0.6630.83
196_I200_M0.6600.83
305_V343_T0.6590.82
84_W87_R0.6590.82
78_K83_V0.6570.82
303_S372_E0.6520.82
252_L257_I0.6490.81
348_A352_T0.6460.81
218_D341_V0.6450.81
92_K95_L0.6450.81
123_S128_V0.6430.81
243_L248_A0.6420.81
305_V308_T0.6400.81
97_E100_F0.6390.80
90_I93_G0.6350.80
73_I102_V0.6340.80
88_T100_F0.6320.80
54_F62_S0.6320.80
176_V266_V0.6310.80
120_Q127_L0.6300.80
349_G352_T0.6300.80
57_G61_V0.6290.79
43_V49_V0.6290.79
352_T355_E0.6280.79
244_N248_A0.6260.79
86_W91_L0.6260.79
313_E319_L0.6250.79
286_L304_G0.6240.79
241_Y250_R0.6210.79
130_G134_D0.6210.79
149_H153_L0.6190.78
213_L265_N0.6190.78
260_I263_R0.6190.78
139_A142_D0.6180.78
188_R192_D0.6170.78
79_D84_W0.6170.78
71_D74_H0.6170.78
240_F244_N0.6150.78
94_N102_V0.6130.78
96_Y100_F0.6120.78
119_R129_P0.6110.77
86_W89_P0.6060.77
55_A61_V0.6060.77
302_F373_M0.6040.77
350_L354_L0.6030.77
50_T55_A0.6020.76
60_N65_V0.6000.76
302_F366_Y0.5970.76
314_G321_D0.5960.76
255_D263_R0.5960.76
43_V48_S0.5960.76
51_F65_V0.5960.76
90_I101_N0.5960.76
83_V102_V0.5950.76
329_L359_I0.5930.75
299_L330_R0.5930.75
177_L276_A0.5930.75
278_L376_W0.5920.75
49_V128_V0.5910.75
46_D53_Y0.5900.75
181_H342_V0.5900.75
200_M214_V0.5890.75
84_W89_P0.5890.75
369_L375_V0.5840.74
116_N123_S0.5830.74
77_T83_V0.5830.74
278_L372_E0.5790.74
46_D51_F0.5790.74
136_R139_A0.5780.74
349_G353_E0.5760.73
221_T224_K0.5740.73
73_I82_G0.5730.73
82_G86_W0.5720.73
257_I266_V0.5700.72
328_Q350_L0.5690.72
95_L102_V0.5670.72
53_Y56_P0.5670.72
63_V71_D0.5660.72
63_V66_G0.5630.72
246_K252_L0.5630.72
261_S267_R0.5620.71
344_G363_Y0.5610.71
140_H201_D0.5610.71
109_D117_P0.5590.71
303_S336_V0.5590.71
109_D128_V0.5560.71
116_N120_Q0.5560.71
242_P246_K0.5560.71
306_T310_V0.5550.70
98_Y101_N0.5510.70
114_M122_N0.5480.70
55_A60_N0.5470.69
163_T174_L0.5460.69
262_K266_V0.5440.69
375_V378_P0.5420.69
117_P126_I0.5420.69
336_V344_G0.5410.69
346_D349_G0.5390.68
245_A250_R0.5390.68
218_D222_D0.5380.68
218_D221_T0.5380.68
72_N75_P0.5360.68
307_T349_G0.5350.68
180_Y217_P0.5340.68
74_H79_D0.5320.67
42_Q48_S0.5320.67
133_L139_A0.5300.67
93_G96_Y0.5290.67
167_Y172_E0.5290.67
241_Y245_A0.5280.67
117_P128_V0.5270.67
164_P213_L0.5270.67
118_Q122_N0.5260.66
117_P120_Q0.5250.66
180_Y219_T0.5250.66
62_S75_P0.5220.66
302_F369_L0.5170.65
182_G279_S0.5170.65
62_S70_P0.5170.65
243_L252_L0.5150.65
48_S51_F0.5150.65
192_D197_P0.5140.65
347_I351_K0.5140.65
366_Y375_V0.5140.65
75_P78_K0.5120.64
47_N50_T0.5120.64
132_Y136_R0.5090.64
240_F243_L0.5090.64
215_V256_I0.5080.64
276_A285_A0.5080.64
115_T118_Q0.5060.63
183_F280_Q0.5060.63
59_K68_P0.5050.63
93_G102_V0.5040.63
182_G219_T0.5030.63
56_P61_V0.5030.63
245_A248_A0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c8dA 2 0.8689 100 0.427 Contact Map
1jjfA 1 0.6221 100 0.546 Contact Map
4w9rA 2 0.5758 100 0.567 Contact Map
1gklA 1 0.6427 100 0.579 Contact Map
1xfdA 2 0.9357 100 0.583 Contact Map
2gzsA 1 0.6118 100 0.586 Contact Map
3gffA 2 0.5913 100 0.589 Contact Map
2uz0A 4 0.5707 100 0.59 Contact Map
2z3zA 2 0.8946 100 0.592 Contact Map
4rotA 4 0.5887 100 0.593 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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