GREMLIN Database
YIEK - Uncharacterized protein YieK
UniProt: P31470 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11728
Length: 240 (216)
Sequences: 5198 (3739)
Seq/√Len: 254.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
81_T85_N3.5951.00
196_A232_A2.8091.00
7_E231_K2.7201.00
105_N108_E2.7151.00
128_A197_G2.6501.00
188_N224_S2.6101.00
46_Y49_T2.4891.00
8_D11_E2.4521.00
202_L229_A2.4271.00
84_R89_T2.2741.00
200_Q204_N2.1771.00
101_L176_V2.1751.00
111_Q115_R2.1741.00
23_Y30_V2.1111.00
56_W92_G2.0511.00
229_A234_A2.0481.00
6_T15_V2.0251.00
13_S42_G1.9941.00
73_K80_I1.9881.00
23_Y188_N1.9771.00
167_D170_L1.9461.00
85_N89_T1.9221.00
120_D187_K1.8901.00
20_L43_M1.8871.00
145_Q185_A1.8751.00
12_M194_S1.8681.00
14_R46_Y1.8631.00
122_V186_A1.8561.00
62_F88_F1.8291.00
18_H50_L1.7961.00
80_I84_R1.7761.00
150_P174_S1.7671.00
203_K207_Q1.7581.00
21_L50_L1.7401.00
41_K86_L1.7361.00
204_N214_V1.7111.00
61_Y99_Q1.7001.00
29_R61_Y1.6971.00
99_Q112_K1.6511.00
184_M218_V1.6051.00
126_L193_V1.5571.00
9_Y13_S1.5541.00
39_T192_I1.5511.00
196_A235_A1.5461.00
107_R111_Q1.5301.00
21_L55_P1.5211.00
104_D108_E1.5131.00
5_I234_A1.5101.00
48_T90_P1.4681.00
43_M123_V1.4621.00
84_R95_E1.4611.00
45_E86_L1.4421.00
20_L32_L1.4341.00
61_Y97_N1.4051.00
35_T65_F1.4021.00
24_M60_C1.3941.00
19_H228_I1.3911.00
80_I100_K1.3761.00
94_K97_N1.3381.00
7_E11_E1.3361.00
193_V202_L1.3361.00
33_A122_V1.3241.00
121_L190_L1.3231.00
108_E112_K1.3181.00
74_E81_T1.3131.00
201_A214_V1.3111.00
58_D92_G1.3091.00
130_G214_V1.2841.00
126_L205_V1.2611.00
168_F171_V1.2541.00
178_M182_S1.2471.00
126_L216_A1.2471.00
15_V18_H1.2431.00
46_Y50_L1.2321.00
31_N63_Y1.2171.00
205_V216_A1.2131.00
33_A65_F1.2091.00
76_E81_T1.2091.00
188_N226_M1.2081.00
205_V227_V1.2061.00
64_N83_L1.2021.00
16_A43_M1.1851.00
24_M30_V1.1831.00
42_G45_E1.1771.00
43_M192_I1.1731.00
108_E111_Q1.1711.00
133_C183_I1.1671.00
20_L121_L1.1661.00
111_Q114_A1.1621.00
78_V81_T1.1581.00
114_A185_A1.1541.00
19_H188_N1.1541.00
6_T228_I1.1521.00
10_Q42_G1.1511.00
31_N61_Y1.1331.00
221_L225_L1.1271.00
9_Y42_G1.1221.00
199_A235_A1.1161.00
112_K115_R1.1151.00
16_A190_L1.1111.00
93_I97_N1.1011.00
6_T11_E1.0961.00
110_D182_S1.0851.00
16_A228_I1.0811.00
28_R59_N1.0811.00
6_T12_M1.0711.00
19_H190_L1.0691.00
18_H22_G1.0661.00
57_Y60_C1.0541.00
27_T120_D1.0521.00
199_A203_K1.0441.00
41_K45_E1.0401.00
5_I231_K1.0141.00
13_S43_M1.0121.00
201_A204_N1.0111.00
106_Y110_D1.0051.00
166_G170_L1.0041.00
27_T187_K1.0001.00
82_N86_L0.9981.00
61_Y94_K0.9931.00
41_K82_N0.9911.00
33_A119_L0.9891.00
4_I226_M0.9871.00
30_V60_C0.9871.00
103_I107_R0.9811.00
4_I15_V0.9791.00
110_D145_Q0.9711.00
102_T105_N0.9691.00
63_Y116_E0.9641.00
168_F173_D0.9631.00
181_K185_A0.9611.00
9_Y194_S0.9581.00
45_E90_P0.9361.00
56_W59_N0.9341.00
55_P60_C0.9331.00
34_I62_F0.9201.00
180_P218_V0.9191.00
58_D94_K0.9121.00
50_L54_K0.9021.00
30_V121_L0.8821.00
57_Y91_A0.8821.00
12_M228_I0.8791.00
35_T122_V0.8791.00
186_A189_L0.8781.00
102_T108_E0.8731.00
19_H23_Y0.8721.00
4_I228_I0.8701.00
142_F218_V0.8651.00
34_I44_Y0.8550.99
11_E14_R0.8550.99
126_L202_L0.8550.99
148_E174_S0.8540.99
191_I216_A0.8520.99
202_L205_V0.8520.99
184_M222_H0.8420.99
113_L119_L0.8410.99
39_T194_S0.8400.99
27_T30_V0.8390.99
84_R100_K0.8300.99
84_R98_I0.8240.99
66_D131_H0.8230.99
205_V214_V0.8230.99
104_D107_R0.8210.99
72_G75_G0.8200.99
10_Q46_Y0.8200.99
42_G46_Y0.8150.99
119_L122_V0.8120.99
88_F98_I0.8120.99
142_F212_E0.8070.99
214_V217_S0.8050.99
68_I79_T0.8020.99
118_G187_K0.8000.99
20_L123_V0.7990.99
204_N213_D0.7980.99
73_K84_R0.7960.99
202_L227_V0.7960.99
145_Q181_K0.7940.99
189_L225_L0.7940.99
63_Y112_K0.7920.99
68_I175_Y0.7870.99
169_S173_D0.7830.99
10_Q14_R0.7800.99
77_G173_D0.7690.99
40_P44_Y0.7660.99
105_N176_V0.7640.99
35_T132_F0.7590.99
65_F178_M0.7540.99
14_R18_H0.7540.99
184_M219_L0.7530.99
209_P217_S0.7500.99
16_A192_I0.7480.99
65_F183_I0.7470.99
148_E176_V0.7450.99
123_V192_I0.7430.99
63_Y99_Q0.7420.98
83_L88_F0.7410.98
199_A234_A0.7410.98
110_D147_V0.7390.98
229_A233_A0.7390.98
139_T147_V0.7360.98
113_L118_G0.7330.98
45_E49_T0.7310.98
61_Y116_E0.7300.98
183_I189_L0.7290.98
79_T175_Y0.7280.98
69_P148_E0.7250.98
210_V221_L0.7240.98
18_H54_K0.7240.98
38_S82_N0.7220.98
204_N208_G0.7190.98
15_V19_H0.7120.98
32_L62_F0.7120.98
144_E147_V0.7110.98
110_D114_A0.7070.98
128_A201_A0.7040.98
36_A79_T0.7020.98
132_F191_I0.7010.98
10_Q45_E0.7000.98
9_Y12_M0.7000.98
168_F172_P0.7000.98
11_E15_V0.6970.98
73_K100_K0.6970.98
124_L183_I0.6960.98
138_N212_E0.6950.98
68_I134_G0.6950.98
130_G201_A0.6950.98
184_M221_L0.6920.98
200_Q203_K0.6920.98
16_A20_L0.6810.97
133_C177_T0.6770.97
126_L201_A0.6710.97
29_R59_N0.6620.97
21_L47_L0.6520.97
50_L55_P0.6520.97
48_T86_L0.6470.96
38_S128_A0.6450.96
17_A47_L0.6440.96
47_L57_Y0.6430.96
15_V228_I0.6400.96
94_K98_I0.6400.96
62_F83_L0.6390.96
230_D233_A0.6390.96
20_L24_M0.6380.96
5_I229_A0.6330.96
140_T143_H0.6290.96
95_E98_I0.6270.96
38_S41_K0.6220.96
21_L54_K0.6220.96
53_G57_Y0.6180.95
68_I136_L0.6120.95
17_A46_Y0.6060.95
63_Y113_L0.6040.95
180_P215_P0.6040.95
34_I83_L0.6040.95
77_G170_L0.6030.95
14_R50_L0.6000.95
64_N100_K0.6000.95
27_T59_N0.6000.95
139_T213_D0.5970.94
122_V183_I0.5930.94
206_L227_V0.5920.94
190_L228_I0.5880.94
70_F78_V0.5880.94
24_M32_L0.5870.94
13_S46_Y0.5860.94
201_A205_V0.5830.94
134_G175_Y0.5820.94
63_Y119_L0.5810.94
64_N80_I0.5770.93
136_L175_Y0.5770.93
96_E101_L0.5760.93
50_L53_G0.5750.93
65_F133_C0.5730.93
218_V221_L0.5700.93
19_H226_M0.5690.93
22_G25_S0.5680.93
65_F122_V0.5650.93
208_G211_T0.5640.93
232_A235_A0.5620.93
189_L219_L0.5590.92
205_V220_Q0.5580.92
106_Y109_H0.5560.92
148_E152_Q0.5550.92
191_I227_V0.5540.92
202_L206_L0.5530.92
144_E181_K0.5520.92
93_I96_E0.5520.92
35_T44_Y0.5510.92
167_D173_D0.5510.92
80_I98_I0.5480.92
97_N101_L0.5470.92
17_A21_L0.5450.91
139_T144_E0.5450.91
187_K223_P0.5440.91
211_T217_S0.5430.91
169_S172_P0.5410.91
209_P220_Q0.5380.91
66_D198_K0.5360.91
208_G220_Q0.5360.91
125_G198_K0.5360.91
3_L206_L0.5330.90
122_V133_C0.5300.90
101_L109_H0.5300.90
54_K91_A0.5290.90
84_R88_F0.5290.90
79_T136_L0.5260.90
170_L173_D0.5260.90
119_L186_A0.5260.90
177_T181_K0.5250.90
31_N117_G0.5250.90
167_D172_P0.5230.90
87_F91_A0.5220.90
79_T134_G0.5210.89
19_H22_G0.5210.89
149_F175_Y0.5160.89
36_A136_L0.5150.89
135_N183_I0.5090.88
208_G214_V0.5090.88
21_L25_S0.5080.88
113_L117_G0.5070.88
12_M16_A0.5040.88
132_F219_L0.5010.88
49_T90_P0.5000.87
16_A24_M0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tx2A 1 0.9292 100 0.097 Contact Map
3icoA 1 0.9333 100 0.1 Contact Map
4tm7A 1 0.925 100 0.101 Contact Map
3eb9A 1 0.925 100 0.11 Contact Map
3cssA 1 0.9292 100 0.164 Contact Map
3e15A 2 0.9792 100 0.164 Contact Map
1vl1A 1 0.8625 100 0.171 Contact Map
3lwdA 2 0.8833 100 0.195 Contact Map
1y89A 2 0.925 100 0.209 Contact Map
3lhiA 1 0.8958 100 0.211 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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