GREMLIN Database
CBRC - UPF0167 protein CbrC
UniProt: P31469 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11727
Length: 195 (170)
Sequences: 146 (115)
Seq/√Len: 8.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_F71_G4.7170.99
137_G140_D3.8930.98
75_D119_Q3.3530.94
45_P116_G3.0040.90
58_W62_D2.7900.86
106_E110_R2.7700.86
116_G119_Q2.6890.84
17_P20_T2.6090.82
114_Y130_C2.5460.81
14_H20_T2.5300.80
107_L129_F2.4160.77
42_Y60_I2.3830.76
12_K106_E2.2700.72
116_G120_E2.1770.69
105_K109_E2.1000.66
42_Y57_P2.0790.65
123_L151_L2.0050.62
131_V183_L1.9940.62
177_G190_L1.9740.61
52_V153_E1.9480.60
169_L177_G1.9470.60
58_W64_S1.9170.58
135_Y176_Q1.8550.56
7_P149_A1.8510.56
136_V140_D1.8390.55
130_C190_L1.7630.52
174_H194_F1.7270.50
46_F60_I1.6450.47
169_L179_L1.6180.46
39_S191_W1.6020.45
133_I179_L1.4830.40
72_S76_D1.4810.40
103_M107_L1.4670.39
141_I147_E1.4400.38
75_D120_E1.4370.38
20_T33_C1.4320.38
114_Y190_L1.4120.37
103_M129_F1.4030.37
74_Q116_G1.3950.36
120_E184_H1.3950.36
8_L21_G1.3940.36
13_Y128_D1.3720.35
18_L21_G1.3590.35
26_D41_Y1.3310.34
179_L188_L1.3300.34
78_S116_G1.3290.34
105_K163_S1.3160.33
137_G173_G1.3150.33
103_M127_G1.3050.33
8_L27_K1.3040.33
66_A173_G1.2780.32
125_H189_R1.2680.31
70_A181_R1.2600.31
17_P57_P1.2580.31
137_G179_L1.2330.30
27_K30_E1.2280.30
116_G176_Q1.2250.30
123_L189_R1.2200.30
42_Y46_F1.1940.29
52_V186_G1.1830.28
75_D78_S1.1740.28
7_P10_Q1.1520.27
45_P74_Q1.1490.27
78_S119_Q1.1440.27
23_F38_T1.1440.27
45_P125_H1.1420.27
14_H61_A1.1410.27
100_P103_M1.1370.27
67_E100_P1.1370.27
12_K183_L1.1240.26
120_E178_Y1.1220.26
33_C55_L1.1210.26
131_V137_G1.1210.26
7_P184_H1.1150.26
12_K138_W1.1110.26
42_Y45_P1.1110.26
131_V179_L1.0990.26
136_V168_C1.0920.25
171_K176_Q1.0910.25
99_Y107_L1.0830.25
108_V119_Q1.0830.25
23_F40_V1.0710.25
23_F57_P1.0590.24
23_F60_I1.0580.24
137_G169_L1.0480.24
66_A124_A1.0260.23
17_P191_W1.0260.23
108_V116_G1.0230.23
31_C34_C1.0140.23
43_S124_A1.0040.23
17_P42_Y0.9970.22
64_S75_D0.9900.22
55_L171_K0.9840.22
100_P121_F0.9800.22
169_L172_G0.9790.22
36_Q142_K0.9780.22
14_H17_P0.9760.22
114_Y177_G0.9720.22
19_E167_K0.9710.22
183_L186_G0.9590.21
60_I131_V0.9560.21
52_V69_F0.9450.21
173_G178_Y0.9400.21
146_D194_F0.9330.20
57_P60_I0.9220.20
22_A68_K0.9150.20
65_A185_C0.9150.20
130_C177_G0.9040.20
21_G28_T0.9020.20
26_D39_S0.8980.20
77_A169_L0.8930.19
14_H113_G0.8890.19
16_K21_G0.8800.19
53_E101_D0.8790.19
17_P22_A0.8710.19
135_Y171_K0.8690.19
69_F105_K0.8680.19
145_L189_R0.8660.19
137_G177_G0.8470.18
136_V177_G0.8390.18
42_Y55_L0.8370.18
136_V179_L0.8360.18
74_Q113_G0.8270.18
10_Q161_R0.8150.17
74_Q78_S0.8130.17
75_D116_G0.8100.17
17_P21_G0.8100.17
20_T173_G0.8030.17
78_S108_V0.7980.17
131_V135_Y0.7960.17
66_A165_L0.7940.17
9_P21_G0.7920.17
36_Q109_E0.7910.17
64_S170_Q0.7830.17
36_Q100_P0.7740.16
51_E153_E0.7730.16
166_A194_F0.7710.16
23_F46_F0.7670.16
18_L28_T0.7660.16
33_C149_A0.7660.16
129_F133_I0.7590.16
23_F55_L0.7490.16
8_L170_Q0.7430.16
78_S107_L0.7420.16
16_K35_E0.7270.15
151_L166_A0.7220.15
50_D109_E0.7210.15
140_D143_D0.7190.15
77_A125_H0.7090.15
43_S48_C0.7080.15
32_D54_H0.7080.15
41_Y191_W0.6980.15
119_Q178_Y0.6960.15
179_L190_L0.6950.15
136_V173_G0.6940.15
37_Q67_E0.6930.15
150_N175_C0.6920.15
142_K166_A0.6890.14
30_E186_G0.6850.14
72_S140_D0.6750.14
73_F110_R0.6750.14
45_P78_S0.6740.14
132_F135_Y0.6700.14
156_E192_G0.6700.14
11_F31_C0.6640.14
11_F34_C0.6640.14
125_H150_N0.6620.14
80_E123_L0.6610.14
35_E141_I0.6610.14
46_F125_H0.6540.14
18_L167_K0.6540.14
138_W141_I0.6540.14
16_K19_E0.6500.14
71_G135_Y0.6350.13
143_D148_F0.6340.13
100_P141_I0.6340.13
12_K133_I0.6320.13
62_D139_N0.6310.13
66_A128_D0.6300.13
12_K171_K0.6250.13
136_V169_L0.6200.13
41_Y154_D0.6150.13
136_V162_N0.6120.13
145_L148_F0.6100.13
147_E190_L0.6090.13
27_K141_I0.6070.13
138_W147_E0.6020.13
148_F188_L0.6020.13
125_H138_W0.6010.13
38_T136_V0.5980.13
38_T42_Y0.5970.13
162_N169_L0.5940.13
43_S131_V0.5900.12
32_D124_A0.5900.12
14_H67_E0.5880.12
169_L190_L0.5880.12
130_C189_R0.5870.12
78_S133_I0.5870.12
133_I169_L0.5830.12
18_L25_Q0.5790.12
108_V125_H0.5780.12
8_L164_D0.5700.12
51_E142_K0.5700.12
39_S159_G0.5690.12
52_V71_G0.5690.12
60_I125_H0.5680.12
79_I172_G0.5680.12
16_K20_T0.5660.12
116_G130_C0.5650.12
81_G151_L0.5640.12
12_K67_E0.5630.12
57_P132_F0.5630.12
23_F150_N0.5630.12
74_Q125_H0.5600.12
53_E186_G0.5580.12
11_F15_P0.5560.12
8_L101_D0.5560.12
69_F116_G0.5560.12
110_R134_G0.5550.12
119_Q125_H0.5530.12
70_A170_Q0.5490.12
36_Q158_F0.5470.12
62_D70_A0.5450.12
133_I190_L0.5440.12
69_F167_K0.5410.12
161_R164_D0.5380.12
72_S144_R0.5350.11
78_S194_F0.5260.11
45_P55_L0.5190.11
79_I119_Q0.5180.11
107_L176_Q0.5130.11
100_P181_R0.5110.11
38_T58_W0.5060.11
58_W121_F0.5060.11
78_S113_G0.5010.11
63_G182_C0.5000.11
63_G111_T0.5000.11
63_G193_D0.5000.11
59_C63_G0.5000.11
56_C193_D0.5000.11
111_T180_F0.5000.11
111_T182_C0.5000.11
111_T193_D0.5000.11
56_C182_C0.5000.11
56_C180_F0.5000.11
56_C111_T0.5000.11
56_C63_G0.5000.11
180_F193_D0.5000.11
59_C111_T0.5000.11
59_C180_F0.5000.11
59_C193_D0.5000.11
63_G180_F0.5000.11
59_C182_C0.5000.11
56_C59_C0.5000.11
182_C193_D0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1s24A 1 0.2256 46.7 0.958 Contact Map
1lkoA 3 0.3282 36.6 0.96 Contact Map
3pwfA 4 0.3077 28.7 0.962 Contact Map
4aybP 1 0.0769 20.1 0.965 Contact Map
4qiwP 1 0.0667 16.8 0.966 Contact Map
4tpuA 3 0.3179 13.9 0.967 Contact Map
4qf3A 2 0.2103 13.4 0.968 Contact Map
1dx8A 1 0.2974 12.4 0.968 Contact Map
2l43A 1 0.3231 10.6 0.969 Contact Map
2md7B 1 0.2256 10.1 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0073 seconds.