GREMLIN Database
YIEH - 6-phosphogluconate phosphatase
UniProt: P31467 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11725
Length: 221 (203)
Sequences: 28856 (22645)
Seq/√Len: 1589.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_E161_N4.1961.00
120_G125_L2.9331.00
150_H154_A2.8771.00
140_R144_D2.8721.00
175_G182_V2.6011.00
112_N116_Q2.5621.00
166_D171_G2.5131.00
98_S127_Y2.4371.00
6_A157_V2.4191.00
94_G98_S2.4021.00
4_I181_E2.3601.00
150_H153_K2.2781.00
105_C131_K2.1951.00
112_N137_D2.1671.00
32_E74_V2.1361.00
9_F104_M2.1341.00
108_S115_M2.1151.00
176_I199_V2.0901.00
140_R146_A2.0821.00
152_A162_C2.0771.00
107_V147_L2.0761.00
203_T207_Q2.0661.00
172_A182_V1.9841.00
131_K154_A1.9321.00
158_N161_N1.9101.00
173_Q177_D1.8961.00
28_T78_E1.8801.00
7_V102_A1.8281.00
101_T127_Y1.7871.00
181_E199_V1.7581.00
99_A209_P1.7571.00
164_L175_G1.6911.00
152_A180_M1.6741.00
163_I183_F1.6511.00
93_A205_L1.6121.00
8_F164_L1.5701.00
116_Q125_L1.5611.00
8_F151_A1.5581.00
186_C203_T1.5551.00
104_M128_F1.5501.00
152_A159_V1.5431.00
157_V162_C1.5261.00
6_A155_M1.5071.00
8_F107_V1.4961.00
33_F74_V1.4681.00
7_V100_I1.4391.00
53_E56_D1.4331.00
4_I163_I1.3741.00
7_V165_V1.3731.00
90_I187_A1.3691.00
105_C155_M1.3661.00
183_F202_F1.3471.00
32_E78_E1.3141.00
204_H207_Q1.3111.00
96_L205_L1.2991.00
186_C201_T1.2971.00
11_C115_M1.2801.00
78_E81_R1.2791.00
183_F200_T1.2781.00
14_T165_V1.2761.00
96_L209_P1.2651.00
74_V78_E1.2651.00
169_V173_Q1.2621.00
67_A70_E1.2601.00
28_T82_L1.2601.00
15_L93_A1.2581.00
116_Q120_G1.2571.00
28_T32_E1.2351.00
11_C16_V1.2201.00
101_T104_M1.2031.00
148_M164_L1.1941.00
11_C106_V1.1931.00
133_F154_A1.1871.00
145_P149_F1.1831.00
12_D18_S1.1831.00
8_F162_C1.1761.00
92_G95_A1.1761.00
74_V77_A1.1641.00
89_A124_M1.1591.00
95_A206_S1.1371.00
148_M174_S1.1351.00
115_M134_S1.1331.00
6_A103_P1.1221.00
24_R28_T1.1051.00
29_M33_F1.1041.00
162_C180_M1.1031.00
148_M180_M1.0941.00
6_A162_C1.0721.00
52_Y56_D1.0691.00
24_R82_L1.0661.00
78_E82_L1.0631.00
107_V151_A1.0561.00
146_A150_H1.0531.00
70_E74_V1.0501.00
149_F153_K1.0371.00
49_V53_E1.0301.00
84_D117_H1.0291.00
27_V31_Q1.0071.00
151_A155_M1.0041.00
94_G127_Y1.0011.00
192_K196_H0.9981.00
77_A81_R0.9971.00
106_V128_F0.9931.00
97_L128_F0.9931.00
123_N126_H0.9921.00
133_F151_A0.9861.00
31_Q37_L0.9841.00
11_C110_G0.9761.00
176_I182_V0.9741.00
149_F178_A0.9721.00
172_A198_K0.9701.00
112_N134_S0.9701.00
73_H77_A0.9641.00
6_A105_C0.9441.00
56_D68_K0.9381.00
95_A98_S0.9351.00
164_L180_M0.9351.00
28_T31_Q0.9301.00
24_R27_V0.9301.00
148_M166_D0.9271.00
117_H121_K0.9261.00
117_H120_G0.9231.00
89_A94_G0.9201.00
12_D110_G0.9191.00
131_K155_M0.9141.00
8_F155_M0.9091.00
115_M118_S0.9061.00
149_F159_V0.9041.00
92_G204_H0.8981.00
170_A173_Q0.8901.00
108_S134_S0.8891.00
112_N136_Y0.8881.00
39_P42_V0.8871.00
49_V57_I0.8861.00
75_Y79_V0.8841.00
57_I60_L0.8831.00
165_V183_F0.8781.00
181_E200_T0.8761.00
146_A149_F0.8751.00
98_S126_H0.8741.00
53_E57_I0.8731.00
56_D60_L0.8721.00
104_M127_Y0.8651.00
24_R86_E0.8651.00
51_L55_I0.8611.00
163_I181_E0.8581.00
174_S178_A0.8571.00
159_V180_M0.8561.00
90_I93_A0.8551.00
182_V199_V0.8531.00
8_F180_M0.8421.00
51_L54_I0.8351.00
100_I104_M0.8291.00
38_D42_V0.8291.00
69_T73_H0.8281.00
90_I185_F0.8231.00
97_L127_Y0.8221.00
92_G206_S0.8141.00
11_C118_S0.8091.00
202_F208_L0.8091.00
82_L85_S0.8081.00
4_I102_A0.8081.00
110_G115_M0.8061.00
7_V163_I0.8011.00
41_E45_R0.7991.00
50_K54_I0.7921.00
23_S27_V0.7821.00
105_C151_A0.7811.00
184_Y201_T0.7801.00
50_K53_E0.7791.00
139_Q146_A0.7771.00
30_F35_I0.7771.00
133_F150_H0.7751.00
138_I150_H0.7651.00
12_D167_D0.7611.00
12_D108_S0.7571.00
5_E102_A0.7551.00
172_A184_Y0.7531.00
25_A29_M0.7491.00
5_E103_P0.7471.00
147_L151_A0.7461.00
183_F208_L0.7451.00
193_P196_H0.7441.00
4_I161_N0.7411.00
134_S137_D0.7391.00
16_V118_S0.7361.00
38_D41_E0.7311.00
16_V122_L0.7261.00
137_D154_A0.7241.00
157_V161_N0.7201.00
94_G123_N0.7191.00
72_E76_R0.7161.00
184_Y195_V0.7111.00
27_V39_P0.7101.00
148_M171_G0.7101.00
187_A205_L0.7091.00
94_G126_H0.7071.00
20_V88_E0.7001.00
103_P157_V0.6981.00
173_Q176_I0.6941.00
17_D88_E0.6931.00
31_Q36_T0.6931.00
41_E44_K0.6921.00
64_V67_A0.6911.00
165_V208_L0.6881.00
119_M125_L0.6861.00
13_G19_E0.6861.00
89_A122_L0.6821.00
8_F105_C0.6821.00
109_N141_W0.6811.00
109_N143_P0.6741.00
115_M132_L0.6711.00
55_I59_S0.6711.00
202_F205_L0.6701.00
185_F205_L0.6681.00
25_A78_E0.6661.00
22_C110_G0.6651.00
164_L171_G0.6601.00
27_V38_D0.6581.00
205_L209_P0.6581.00
202_F209_P0.6571.00
14_T171_G0.6571.00
159_V162_C0.6571.00
145_P177_D0.6561.00
192_K203_T0.6531.00
92_G96_L0.6511.00
107_V164_L0.6511.00
147_L174_S0.6511.00
12_D118_S0.6501.00
70_E73_H0.6441.00
116_Q132_L0.6421.00
16_V87_L0.6401.00
33_F70_E0.6391.00
57_I61_E0.6391.00
27_V37_L0.6381.00
79_V83_F0.6351.00
184_Y198_K0.6301.00
95_A99_A0.6251.00
45_R57_I0.6241.00
42_V45_R0.6201.00
80_A113_N0.6141.00
133_F147_L0.6101.00
131_K151_A0.6061.00
96_L165_V0.6041.00
22_C75_Y0.6001.00
206_S209_P0.6001.00
60_L63_G0.5981.00
22_C26_Y0.5921.00
52_Y69_T0.5911.00
81_R85_S0.5901.00
115_M119_M0.5881.00
82_L86_E0.5861.00
98_S101_T0.5831.00
5_E157_V0.5811.00
29_M74_V0.5811.00
164_L174_S0.5811.00
152_A157_V0.5801.00
193_P197_P0.5791.00
148_M175_G0.5781.00
21_I87_L0.5761.00
8_F148_M0.5761.00
120_G126_H0.5751.00
17_D20_V0.5741.00
84_D121_K0.5731.00
22_C79_V0.5711.00
9_F96_L0.5671.00
93_A96_L0.5661.00
44_K47_K0.5651.00
14_T185_F0.5651.00
43_F46_F0.5621.00
76_R80_A0.5621.00
77_A80_A0.5581.00
18_S110_G0.5571.00
91_E204_H0.5561.00
113_N117_H0.5551.00
101_T126_H0.5521.00
91_E206_S0.5511.00
110_G166_D0.5481.00
89_A93_A0.5481.00
52_Y68_K0.5471.00
92_G187_A0.5471.00
110_G114_K0.5431.00
93_A97_L0.5411.00
138_I147_L0.5361.00
170_A174_S0.5341.00
135_G147_L0.5321.00
149_F152_A0.5321.00
23_S43_F0.5301.00
73_H76_R0.5301.00
26_Y30_F0.5291.00
52_Y72_E0.5291.00
80_A117_H0.5271.00
128_F132_L0.5271.00
69_T72_E0.5251.00
96_L100_I0.5251.00
20_V24_R0.5251.00
152_A178_A0.5231.00
190_H193_P0.5161.00
131_K134_S0.5151.00
109_N170_A0.5131.00
119_M124_M0.5111.00
96_L99_A0.5101.00
7_V104_M0.5061.00
31_Q34_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fdrA 1 0.9638 100 0.283 Contact Map
3iruA 4 0.991 100 0.294 Contact Map
4eekA 2 0.9774 100 0.297 Contact Map
4uw9A 1 0.9186 100 0.297 Contact Map
1te2A 2 0.9593 100 0.3 Contact Map
3l5kA 1 0.9774 100 0.305 Contact Map
1swvA 2 0.9638 100 0.307 Contact Map
3s6jA 2 0.9593 100 0.309 Contact Map
2om6A 2 0.9548 100 0.309 Contact Map
3kbbA 1 0.9548 100 0.31 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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