YIEH - ECOLI - GREMLIN Contacts

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YIEH - 6-phosphogluconate phosphatase

UniProt:	P31467	Sequences: MSRIEAVFFDCDGTLVDSEVICSRAYVTMFQEFGITLDPEEVFKRFKGVKLYEIIDIVSLEHGVTLAKTEAEHVYRAEVARLFDSELEAIEGAGALLSAITAPMCVVSNGPNNKMQHSMGKLNMLHYFPDKLFSGYDIQRWKPDPALMFHAAKAMNVNVENCILVDDSVAGAQSGIDAGMEVFYFCADPHNKPIVHPKVTTFTHLSQLPELWKARGWDITA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11725
Length:	221 (203)
Sequences:	28856 (22645)
Seq/√Len:	1589.4

ECOLI - YIEH GPH YNIC YIGB YRFG YJJG YQAB YFBT PGMB YIHX
BACSU - YFNB YSAA YHCW PPAX PGMB
HALSA - Q9HQE2 Q9HP74 Q9HSS2 Q9HMC4
SULSO - Q7LXL6 Q97ZU6 Q7LX46 Q97YZ1 Q97WT6 Q97X58

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
5_E	161_N	4.196	1.00
120_G	125_L	2.933	1.00
150_H	154_A	2.877	1.00
140_R	144_D	2.872	1.00
175_G	182_V	2.601	1.00
112_N	116_Q	2.562	1.00
166_D	171_G	2.513	1.00
98_S	127_Y	2.437	1.00
6_A	157_V	2.419	1.00
94_G	98_S	2.402	1.00
4_I	181_E	2.360	1.00
150_H	153_K	2.278	1.00
105_C	131_K	2.195	1.00
112_N	137_D	2.167	1.00
32_E	74_V	2.136	1.00
9_F	104_M	2.134	1.00
108_S	115_M	2.115	1.00
176_I	199_V	2.090	1.00
140_R	146_A	2.082	1.00
152_A	162_C	2.077	1.00
107_V	147_L	2.076	1.00
203_T	207_Q	2.066	1.00
172_A	182_V	1.984	1.00
131_K	154_A	1.932	1.00
158_N	161_N	1.910	1.00
173_Q	177_D	1.896	1.00
28_T	78_E	1.880	1.00
7_V	102_A	1.828	1.00
101_T	127_Y	1.787	1.00
181_E	199_V	1.758	1.00
99_A	209_P	1.757	1.00
164_L	175_G	1.691	1.00
152_A	180_M	1.674	1.00
163_I	183_F	1.651	1.00
93_A	205_L	1.612	1.00
8_F	164_L	1.570	1.00
116_Q	125_L	1.561	1.00
8_F	151_A	1.558	1.00
186_C	203_T	1.555	1.00
104_M	128_F	1.550	1.00
152_A	159_V	1.543	1.00
157_V	162_C	1.526	1.00
6_A	155_M	1.507	1.00
8_F	107_V	1.496	1.00
33_F	74_V	1.468	1.00
7_V	100_I	1.439	1.00
53_E	56_D	1.433	1.00
4_I	163_I	1.374	1.00
7_V	165_V	1.373	1.00
90_I	187_A	1.369	1.00
105_C	155_M	1.366	1.00
183_F	202_F	1.347	1.00
32_E	78_E	1.314	1.00
204_H	207_Q	1.311	1.00
96_L	205_L	1.299	1.00
186_C	201_T	1.297	1.00
11_C	115_M	1.280	1.00
78_E	81_R	1.279	1.00
183_F	200_T	1.278	1.00
14_T	165_V	1.276	1.00
96_L	209_P	1.265	1.00
74_V	78_E	1.265	1.00
169_V	173_Q	1.262	1.00
67_A	70_E	1.260	1.00
28_T	82_L	1.260	1.00
15_L	93_A	1.258	1.00
116_Q	120_G	1.257	1.00
28_T	32_E	1.235	1.00
11_C	16_V	1.220	1.00
101_T	104_M	1.203	1.00
148_M	164_L	1.194	1.00
11_C	106_V	1.193	1.00
133_F	154_A	1.187	1.00
145_P	149_F	1.183	1.00
12_D	18_S	1.183	1.00
8_F	162_C	1.176	1.00
92_G	95_A	1.176	1.00
74_V	77_A	1.164	1.00
89_A	124_M	1.159	1.00
95_A	206_S	1.137	1.00
148_M	174_S	1.135	1.00
115_M	134_S	1.133	1.00
6_A	103_P	1.122	1.00
24_R	28_T	1.105	1.00
29_M	33_F	1.104	1.00
162_C	180_M	1.103	1.00
148_M	180_M	1.094	1.00
6_A	162_C	1.072	1.00
52_Y	56_D	1.069	1.00
24_R	82_L	1.066	1.00
78_E	82_L	1.063	1.00
107_V	151_A	1.056	1.00
146_A	150_H	1.053	1.00
70_E	74_V	1.050	1.00
149_F	153_K	1.037	1.00
49_V	53_E	1.030	1.00
84_D	117_H	1.029	1.00
27_V	31_Q	1.007	1.00
151_A	155_M	1.004	1.00
94_G	127_Y	1.001	1.00
192_K	196_H	0.998	1.00
77_A	81_R	0.997	1.00
106_V	128_F	0.993	1.00
97_L	128_F	0.993	1.00
123_N	126_H	0.992	1.00
133_F	151_A	0.986	1.00
31_Q	37_L	0.984	1.00
11_C	110_G	0.976	1.00
176_I	182_V	0.974	1.00
149_F	178_A	0.972	1.00
172_A	198_K	0.970	1.00
112_N	134_S	0.970	1.00
73_H	77_A	0.964	1.00
6_A	105_C	0.944	1.00
56_D	68_K	0.938	1.00
95_A	98_S	0.935	1.00
164_L	180_M	0.935	1.00
28_T	31_Q	0.930	1.00
24_R	27_V	0.930	1.00
148_M	166_D	0.927	1.00
117_H	121_K	0.926	1.00
117_H	120_G	0.923	1.00
89_A	94_G	0.920	1.00
12_D	110_G	0.919	1.00
131_K	155_M	0.914	1.00
8_F	155_M	0.909	1.00
115_M	118_S	0.906	1.00
149_F	159_V	0.904	1.00
92_G	204_H	0.898	1.00
170_A	173_Q	0.890	1.00
108_S	134_S	0.889	1.00
112_N	136_Y	0.888	1.00
39_P	42_V	0.887	1.00
49_V	57_I	0.886	1.00
75_Y	79_V	0.884	1.00
57_I	60_L	0.883	1.00
165_V	183_F	0.878	1.00
181_E	200_T	0.876	1.00
146_A	149_F	0.875	1.00
98_S	126_H	0.874	1.00
53_E	57_I	0.873	1.00
56_D	60_L	0.872	1.00
104_M	127_Y	0.865	1.00
24_R	86_E	0.865	1.00
51_L	55_I	0.861	1.00
163_I	181_E	0.858	1.00
174_S	178_A	0.857	1.00
159_V	180_M	0.856	1.00
90_I	93_A	0.855	1.00
182_V	199_V	0.853	1.00
8_F	180_M	0.842	1.00
51_L	54_I	0.835	1.00
100_I	104_M	0.829	1.00
38_D	42_V	0.829	1.00
69_T	73_H	0.828	1.00
90_I	185_F	0.823	1.00
97_L	127_Y	0.822	1.00
92_G	206_S	0.814	1.00
11_C	118_S	0.809	1.00
202_F	208_L	0.809	1.00
82_L	85_S	0.808	1.00
4_I	102_A	0.808	1.00
110_G	115_M	0.806	1.00
7_V	163_I	0.801	1.00
41_E	45_R	0.799	1.00
50_K	54_I	0.792	1.00
23_S	27_V	0.782	1.00
105_C	151_A	0.781	1.00
184_Y	201_T	0.780	1.00
50_K	53_E	0.779	1.00
139_Q	146_A	0.777	1.00
30_F	35_I	0.777	1.00
133_F	150_H	0.775	1.00
138_I	150_H	0.765	1.00
12_D	167_D	0.761	1.00
12_D	108_S	0.757	1.00
5_E	102_A	0.755	1.00
172_A	184_Y	0.753	1.00
25_A	29_M	0.749	1.00
5_E	103_P	0.747	1.00
147_L	151_A	0.746	1.00
183_F	208_L	0.745	1.00
193_P	196_H	0.744	1.00
4_I	161_N	0.741	1.00
134_S	137_D	0.739	1.00
16_V	118_S	0.736	1.00
38_D	41_E	0.731	1.00
16_V	122_L	0.726	1.00
137_D	154_A	0.724	1.00
157_V	161_N	0.720	1.00
94_G	123_N	0.719	1.00
72_E	76_R	0.716	1.00
184_Y	195_V	0.711	1.00
27_V	39_P	0.710	1.00
148_M	171_G	0.710	1.00
187_A	205_L	0.709	1.00
94_G	126_H	0.707	1.00
20_V	88_E	0.700	1.00
103_P	157_V	0.698	1.00
173_Q	176_I	0.694	1.00
17_D	88_E	0.693	1.00
31_Q	36_T	0.693	1.00
41_E	44_K	0.692	1.00
64_V	67_A	0.691	1.00
165_V	208_L	0.688	1.00
119_M	125_L	0.686	1.00
13_G	19_E	0.686	1.00
89_A	122_L	0.682	1.00
8_F	105_C	0.682	1.00
109_N	141_W	0.681	1.00
109_N	143_P	0.674	1.00
115_M	132_L	0.671	1.00
55_I	59_S	0.671	1.00
202_F	205_L	0.670	1.00
185_F	205_L	0.668	1.00
25_A	78_E	0.666	1.00
22_C	110_G	0.665	1.00
164_L	171_G	0.660	1.00
27_V	38_D	0.658	1.00
205_L	209_P	0.658	1.00
202_F	209_P	0.657	1.00
14_T	171_G	0.657	1.00
159_V	162_C	0.657	1.00
145_P	177_D	0.656	1.00
192_K	203_T	0.653	1.00
92_G	96_L	0.651	1.00
107_V	164_L	0.651	1.00
147_L	174_S	0.651	1.00
12_D	118_S	0.650	1.00
70_E	73_H	0.644	1.00
116_Q	132_L	0.642	1.00
16_V	87_L	0.640	1.00
33_F	70_E	0.639	1.00
57_I	61_E	0.639	1.00
27_V	37_L	0.638	1.00
79_V	83_F	0.635	1.00
184_Y	198_K	0.630	1.00
95_A	99_A	0.625	1.00
45_R	57_I	0.624	1.00
42_V	45_R	0.620	1.00
80_A	113_N	0.614	1.00
133_F	147_L	0.610	1.00
131_K	151_A	0.606	1.00
96_L	165_V	0.604	1.00
22_C	75_Y	0.600	1.00
206_S	209_P	0.600	1.00
60_L	63_G	0.598	1.00
22_C	26_Y	0.592	1.00
52_Y	69_T	0.591	1.00
81_R	85_S	0.590	1.00
115_M	119_M	0.588	1.00
82_L	86_E	0.586	1.00
98_S	101_T	0.583	1.00
5_E	157_V	0.581	1.00
29_M	74_V	0.581	1.00
164_L	174_S	0.581	1.00
152_A	157_V	0.580	1.00
193_P	197_P	0.579	1.00
148_M	175_G	0.578	1.00
21_I	87_L	0.576	1.00
8_F	148_M	0.576	1.00
120_G	126_H	0.575	1.00
17_D	20_V	0.574	1.00
84_D	121_K	0.573	1.00
22_C	79_V	0.571	1.00
9_F	96_L	0.567	1.00
93_A	96_L	0.566	1.00
44_K	47_K	0.565	1.00
14_T	185_F	0.565	1.00
43_F	46_F	0.562	1.00
76_R	80_A	0.562	1.00
77_A	80_A	0.558	1.00
18_S	110_G	0.557	1.00
91_E	204_H	0.556	1.00
113_N	117_H	0.555	1.00
101_T	126_H	0.552	1.00
91_E	206_S	0.551	1.00
110_G	166_D	0.548	1.00
89_A	93_A	0.548	1.00
52_Y	68_K	0.547	1.00
92_G	187_A	0.547	1.00
110_G	114_K	0.543	1.00
93_A	97_L	0.541	1.00
138_I	147_L	0.536	1.00
170_A	174_S	0.534	1.00
135_G	147_L	0.532	1.00
149_F	152_A	0.532	1.00
23_S	43_F	0.530	1.00
73_H	76_R	0.530	1.00
26_Y	30_F	0.529	1.00
52_Y	72_E	0.529	1.00
80_A	117_H	0.527	1.00
128_F	132_L	0.527	1.00
69_T	72_E	0.525	1.00
96_L	100_I	0.525	1.00
20_V	24_R	0.525	1.00
152_A	178_A	0.523	1.00
190_H	193_P	0.516	1.00
131_K	134_S	0.515	1.00
109_N	170_A	0.513	1.00
119_M	124_M	0.511	1.00
96_L	99_A	0.510	1.00
7_V	104_M	0.506	1.00
31_Q	34_G	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2fdrA	1	0.9638	100	0.283	Contact Map
3iruA	4	0.991	100	0.294	Contact Map
4eekA	2	0.9774	100	0.297	Contact Map
4uw9A	1	0.9186	100	0.297	Contact Map
1te2A	2	0.9593	100	0.3	Contact Map
3l5kA	1	0.9774	100	0.305	Contact Map
1swvA	2	0.9638	100	0.307	Contact Map
3s6jA	2	0.9593	100	0.309	Contact Map
2om6A	2	0.9548	100	0.309	Contact Map
3kbbA	1	0.9548	100	0.31	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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