GREMLIN Database
ADEP - Adenine permease AdeP
UniProt: P31466 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11724
Length: 445 (381)
Sequences: 10699 (5952)
Seq/√Len: 304.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
118_F306_S3.6391.00
164_A188_G3.4531.00
32_V335_V3.3821.00
389_I410_S3.2131.00
393_M406_L3.1951.00
79_G334_V3.1491.00
128_T296_Y3.0631.00
76_I337_G2.8211.00
28_A331_L2.8211.00
327_G332_T2.6181.00
81_F300_I2.5931.00
134_Y292_K2.5681.00
77_M304_T2.5351.00
119_W257_I2.5041.00
170_N176_S2.3351.00
76_I334_V2.3241.00
70_I313_V2.3101.00
35_G335_V2.2991.00
126_L130_F2.2531.00
55_V100_F2.2191.00
192_F364_Y2.1801.00
205_A209_V2.1751.00
122_I126_L2.1471.00
180_L185_V2.1211.00
122_I303_V2.1181.00
275_V319_S2.1151.00
390_T407_G2.1111.00
322_G332_T2.1101.00
72_A341_L2.1021.00
186_L190_L2.0831.00
420_R423_D2.0731.00
275_V323_V2.0451.00
338_L342_L2.0391.00
305_G310_T1.9971.00
74_G301_S1.9941.00
216_L220_M1.9811.00
118_F303_V1.9541.00
399_S402_E1.9491.00
244_D247_G1.9391.00
209_V215_T1.9371.00
125_L303_V1.9271.00
211_I215_T1.9101.00
174_L177_I1.8921.00
215_T218_G1.8821.00
191_G214_T1.8781.00
393_M397_S1.8671.00
209_V212_V1.8551.00
34_A327_G1.8491.00
129_I296_Y1.8051.00
195_I210_S1.8011.00
86_V315_A1.7871.00
72_A337_G1.7821.00
77_M81_F1.7781.00
191_G360_G1.7621.00
87_A336_V1.7291.00
190_L194_I1.7231.00
188_G360_G1.7231.00
335_V339_L1.7191.00
210_S214_T1.7101.00
192_F360_G1.6761.00
75_S337_G1.6721.00
34_A332_T1.6701.00
27_T328_R1.6651.00
235_S238_T1.6551.00
28_A32_V1.6481.00
30_T328_R1.6381.00
206_A209_V1.6091.00
217_L221_L1.6031.00
374_A378_W1.6001.00
211_I214_T1.5981.00
173_T176_S1.5891.00
392_V396_F1.5741.00
77_M297_V1.5651.00
36_F339_L1.5591.00
193_F197_I1.5461.00
304_T308_I1.5441.00
123_G261_M1.5431.00
202_N205_A1.5371.00
222_G225_H1.5281.00
187_L214_T1.5261.00
24_H27_T1.5261.00
125_L296_Y1.5221.00
96_A311_S1.5211.00
381_L385_V1.5191.00
171_P174_L1.5121.00
28_A335_V1.4871.00
214_T218_G1.4831.00
199_A368_L1.4811.00
121_A303_V1.4791.00
231_S234_P1.4761.00
415_K423_D1.4521.00
215_T219_W1.4431.00
119_W253_L1.4171.00
208_L211_I1.3851.00
32_V36_F1.3851.00
207_V211_I1.3821.00
208_L215_T1.3701.00
173_T177_I1.3631.00
214_T357_A1.3621.00
102_V256_V1.3611.00
196_A364_Y1.3601.00
300_I304_T1.3341.00
123_G254_A1.3301.00
92_M95_N1.3291.00
39_F339_L1.3281.00
209_V213_V1.3161.00
331_L335_V1.3131.00
80_L334_V1.3061.00
31_E328_R1.3031.00
74_G313_V1.2961.00
214_T219_W1.2961.00
164_A359_A1.2941.00
209_V222_G1.2911.00
290_R293_Q1.2911.00
230_V233_P1.2861.00
388_F392_V1.2831.00
153_G366_G1.2821.00
54_G60_T1.2701.00
109_P112_V1.2701.00
189_I193_F1.2701.00
111_Q244_D1.2701.00
102_V260_F1.2691.00
184_S356_Y1.2671.00
126_L129_I1.2651.00
245_L248_S1.2631.00
211_I219_W1.2401.00
79_G333_A1.2381.00
115_G245_L1.2351.00
72_A76_I1.2281.00
243_V246_A1.2271.00
127_L132_V1.2211.00
199_A364_Y1.2161.00
207_V361_A1.2121.00
29_R33_I1.2121.00
216_L219_W1.2051.00
182_S185_V1.1951.00
47_F51_Q1.1921.00
77_M300_I1.1911.00
229_I232_A1.1861.00
131_R135_W1.1861.00
164_A363_I1.1841.00
125_L299_S1.1811.00
389_I393_M1.1791.00
150_S391_A1.1711.00
413_V417_G1.1691.00
116_A253_L1.1671.00
334_V338_L1.1671.00
95_N260_F1.1631.00
134_Y138_A1.1581.00
81_F297_V1.1581.00
197_I201_R1.1541.00
192_F196_A1.1541.00
24_H329_T1.1461.00
195_I364_Y1.1451.00
127_L261_M1.1381.00
252_G255_G1.1371.00
296_Y300_I1.1361.00
207_V210_S1.1361.00
212_V215_T1.1351.00
157_G363_I1.1301.00
240_V243_V1.1271.00
154_L395_P1.1251.00
90_P318_E1.1231.00
322_G327_G1.1221.00
209_V219_W1.1211.00
293_Q296_Y1.1201.00
190_L217_L1.1171.00
182_S186_L1.1151.00
181_T184_S1.1141.00
247_G250_N1.1141.00
264_N312_S1.1091.00
123_G257_I1.1051.00
34_A38_T1.1031.00
146_V375_R1.0981.00
212_V216_L1.0951.00
143_S383_E1.0951.00
332_T336_V1.0931.00
372_S375_R1.0921.00
120_G261_M1.0891.00
337_G341_L1.0851.00
183_H186_L1.0821.00
160_G363_I1.0721.00
100_F104_Q1.0701.00
394_M403_G1.0681.00
206_A210_S1.0661.00
195_I199_A1.0651.00
185_V188_G1.0641.00
414_M418_T1.0631.00
382_T418_T1.0531.00
125_L129_I1.0481.00
416_I421_L1.0431.00
267_D271_T1.0391.00
52_I92_M1.0391.00
179_N182_S1.0341.00
343_V346_L1.0341.00
205_A211_I1.0311.00
123_G258_F1.0311.00
217_L220_M1.0281.00
185_V189_I1.0221.00
162_K174_L1.0211.00
131_R292_K1.0181.00
120_G260_F1.0151.00
246_A250_N1.0141.00
380_D383_E1.0131.00
373_L391_A1.0061.00
27_T30_T1.0021.00
387_A391_A0.9961.00
188_G363_I0.9961.00
272_L294_A0.9931.00
335_V338_L0.9901.00
300_I303_V0.9881.00
243_V307_F0.9881.00
158_M396_F0.9841.00
78_M89_A0.9821.00
375_R379_Q0.9801.00
62_A311_S0.9801.00
191_G210_S0.9781.00
147_G390_T0.9741.00
171_P176_S0.9721.00
257_I261_M0.9721.00
172_E177_I0.9711.00
56_A63_V0.9711.00
211_I218_G0.9671.00
172_E176_S0.9641.00
276_T289_P0.9631.00
47_F321_S0.9611.00
244_D249_F0.9601.00
117_I306_S0.9571.00
246_A249_F0.9551.00
105_A256_V0.9531.00
342_L345_F0.9521.00
86_V323_V0.9461.00
191_G357_A0.9451.00
234_P241_G0.9441.00
209_V218_G0.9391.00
303_V306_S0.9341.00
320_S324_S0.9321.00
150_S153_G0.9311.00
301_S313_V0.9281.00
331_L334_V0.9261.00
206_A211_I0.9231.00
198_L209_V0.9231.00
241_G307_F0.9201.00
301_S304_T0.9201.00
354_P357_A0.9141.00
233_P237_M0.9141.00
219_W222_G0.9111.00
116_A256_V0.9001.00
171_P177_I0.8991.00
101_V105_A0.8961.00
154_L391_A0.8941.00
115_G119_W0.8871.00
410_S414_M0.8871.00
30_T34_A0.8871.00
105_A108_L0.8861.00
86_V275_V0.8841.00
186_L189_I0.8831.00
62_A103_V0.8791.00
239_V243_V0.8791.00
73_F304_T0.8781.00
199_A206_A0.8721.00
142_V146_V0.8661.00
303_V307_F0.8641.00
221_L224_V0.8621.00
208_L212_V0.8611.00
89_A298_D0.8591.00
264_N302_S0.8571.00
84_L294_A0.8571.00
162_K169_A0.8541.00
49_N95_N0.8541.00
397_S402_E0.8531.00
99_A312_S0.8511.00
158_M162_K0.8501.00
196_A385_V0.8471.00
120_G264_N0.8461.00
24_H290_R0.8461.00
374_A379_Q0.8451.00
226_Y229_I0.8391.00
229_I233_P0.8381.00
214_T217_L0.8381.00
200_S204_H0.8371.00
62_A66_T0.8341.00
236_V239_V0.8331.00
51_Q60_T0.8291.00
245_L307_F0.8261.00
196_A367_V0.8251.00
180_L183_H0.8251.00
188_G356_Y0.8251.00
91_A314_T0.8231.00
349_L352_M0.8211.00
384_S388_F0.8211.00
113_G117_I0.8211.00
49_N340_F0.8201.00
116_A260_F0.8201.00
73_F308_I0.8161.00
389_I406_L0.8141.00
233_P236_V0.8131.00
157_G366_G0.8111.00
71_A75_S0.8091.00
251_L255_G0.8091.00
32_V331_L0.8081.00
210_S215_T0.8021.00
31_E329_T0.8021.00
151_G395_P0.8001.00
244_D248_S0.8001.00
35_G39_F0.8001.00
184_S188_G0.7971.00
382_T415_K0.7971.00
370_T373_L0.7951.00
153_G370_T0.7951.00
229_I234_P0.7941.00
58_M63_V0.7931.00
81_F296_Y0.7921.00
377_N384_S0.7911.00
163_N359_A0.7901.00
321_S325_V0.7891.00
120_G312_S0.7881.00
76_I80_L0.7860.99
239_V242_H0.7860.99
194_I210_S0.7850.99
66_T110_W0.7800.99
415_K420_R0.7800.99
116_A120_G0.7750.99
149_T274_G0.7720.99
68_C72_A0.7710.99
158_M175_V0.7690.99
70_I74_G0.7680.99
211_I222_G0.7680.99
138_A287_K0.7670.99
213_V217_L0.7650.99
51_Q55_V0.7630.99
35_G339_L0.7620.99
343_V350_A0.7570.99
261_M265_L0.7570.99
118_F307_F0.7530.99
117_I312_S0.7520.99
111_Q242_H0.7510.99
232_A236_V0.7500.99
169_A174_L0.7470.99
81_F293_Q0.7410.99
405_A409_I0.7410.99
237_M242_H0.7410.99
114_M117_I0.7400.99
383_E386_P0.7390.99
197_I417_G0.7390.99
111_Q114_M0.7360.99
205_A208_L0.7340.99
374_A377_N0.7340.99
227_N230_V0.7340.99
65_V344_I0.7330.99
342_L346_L0.7330.99
127_L295_L0.7310.99
210_S219_W0.7300.99
25_G29_R0.7290.99
114_M306_S0.7290.99
219_W352_M0.7280.99
271_T316_Y0.7280.99
128_T299_S0.7270.99
251_L254_A0.7270.99
128_T134_Y0.7250.99
207_V215_T0.7240.99
115_G248_S0.7230.99
208_L214_T0.7190.99
382_T414_M0.7180.99
151_G394_M0.7120.99
204_H325_V0.7100.99
393_M402_E0.7090.99
212_V222_G0.7080.99
304_T307_F0.7070.99
84_L288_F0.7070.99
193_F196_A0.7070.99
55_V99_A0.7060.99
218_G222_G0.7050.99
402_E405_A0.6980.99
256_V259_S0.6970.99
119_W123_G0.6950.99
135_W138_A0.6940.99
208_L218_G0.6930.99
195_I360_G0.6910.99
228_G231_S0.6900.99
143_S147_G0.6900.99
52_I71_A0.6900.99
234_P237_M0.6860.99
207_V218_G0.6860.99
225_H228_G0.6860.99
84_L290_R0.6850.99
151_G391_A0.6820.99
92_M315_A0.6810.99
190_L214_T0.6800.99
282_A288_F0.6800.99
198_L206_A0.6790.99
255_G259_S0.6780.99
195_I207_V0.6760.98
276_T288_F0.6750.98
218_G224_V0.6710.98
205_A210_S0.6710.98
238_T242_H0.6660.98
48_V336_V0.6640.98
76_I79_G0.6630.98
237_M240_V0.6630.98
172_E175_V0.6530.98
88_L333_A0.6500.98
94_L263_V0.6490.98
170_N175_V0.6480.98
196_A200_S0.6470.98
268_S315_A0.6430.98
276_T287_K0.6430.98
66_T309_G0.6410.98
49_N67_T0.6400.98
97_F101_V0.6400.98
157_G388_F0.6400.98
124_L264_N0.6390.98
78_M297_V0.6380.98
415_K419_G0.6350.98
101_V104_Q0.6340.98
231_S236_V0.6340.98
169_A177_I0.6330.98
95_N120_G0.6320.98
88_L313_V0.6310.98
244_D250_N0.6270.98
78_M88_L0.6260.98
237_M241_G0.6260.98
212_V219_W0.6240.97
200_S381_L0.6230.97
302_S312_S0.6230.97
68_C340_F0.6220.97
29_R32_V0.6210.97
145_R273_I0.6200.97
170_N173_T0.6200.97
215_T222_G0.6170.97
48_V51_Q0.6160.97
98_F260_F0.6160.97
220_M224_V0.6160.97
74_G305_G0.6160.97
103_V113_G0.6140.97
59_D63_V0.6120.97
227_N231_S0.6110.97
299_S302_S0.6100.97
190_L213_V0.6090.97
254_A257_I0.6080.97
34_A325_V0.6070.97
412_C416_I0.6070.97
209_V221_L0.6070.97
411_Y415_K0.6060.97
277_D375_R0.6050.97
103_V109_P0.6040.97
382_T386_P0.6030.97
131_R134_Y0.6010.97
71_A340_F0.6010.97
137_I140_I0.6000.97
228_G234_P0.5990.97
209_V214_T0.5990.97
147_G387_A0.5980.97
265_L295_L0.5970.97
299_S303_V0.5970.97
95_N99_A0.5950.97
158_M161_L0.5930.97
417_G421_L0.5930.97
187_L218_G0.5910.97
178_G182_S0.5900.96
324_S368_L0.5880.96
364_Y368_L0.5870.96
36_F335_V0.5870.96
121_A302_S0.5860.96
373_L384_S0.5860.96
92_M316_Y0.5820.96
108_L252_G0.5800.96
71_A88_L0.5770.96
210_S218_G0.5760.96
406_L410_S0.5760.96
181_T185_V0.5740.96
384_S387_A0.5740.96
208_L221_L0.5710.96
232_A235_S0.5710.96
296_Y303_V0.5710.96
119_W122_I0.5700.96
61_S65_V0.5700.96
49_N92_M0.5700.96
336_V343_V0.5690.96
91_A318_E0.5690.96
215_T352_M0.5690.96
192_F363_I0.5680.96
33_I37_T0.5670.96
253_L256_V0.5670.96
215_T353_V0.5670.96
150_S370_T0.5660.96
271_T315_A0.5650.95
190_L197_I0.5640.95
123_G127_L0.5640.95
51_Q54_G0.5640.95
214_T221_L0.5630.95
32_V339_L0.5620.95
301_S305_G0.5610.95
78_M298_D0.5610.95
244_D309_G0.5590.95
90_P94_L0.5580.95
205_A215_T0.5560.95
169_A173_T0.5560.95
241_G246_A0.5550.95
201_R204_H0.5540.95
65_V69_L0.5540.95
63_V239_V0.5530.95
49_N52_I0.5520.95
232_A241_G0.5510.95
190_L221_L0.5510.95
168_V172_E0.5510.95
39_F340_F0.5500.95
386_P410_S0.5500.95
277_D282_A0.5500.95
238_T241_G0.5490.95
373_L376_V0.5470.95
194_I214_T0.5470.95
78_M313_V0.5470.95
129_I132_V0.5450.95
99_A113_G0.5440.94
235_S351_G0.5440.94
135_W292_K0.5430.94
230_V235_S0.5430.94
117_I260_F0.5430.94
228_G232_A0.5430.94
168_V171_P0.5420.94
124_L261_M0.5410.94
187_L230_V0.5400.94
373_L378_W0.5400.94
93_G97_F0.5390.94
268_S314_T0.5380.94
387_A390_T0.5370.94
359_A363_I0.5360.94
194_I198_L0.5360.94
86_V287_K0.5350.94
377_N381_L0.5340.94
143_S380_D0.5340.94
232_A237_M0.5340.94
210_S361_A0.5330.94
88_L94_L0.5320.94
309_G407_G0.5320.94
115_G253_L0.5300.94
208_L354_P0.5300.94
99_A103_V0.5300.94
115_G246_A0.5290.94
264_N268_S0.5290.94
146_V372_S0.5280.94
381_L384_S0.5280.94
234_P238_T0.5280.94
97_F100_F0.5280.94
26_T29_R0.5270.94
200_S203_I0.5260.93
370_T391_A0.5240.93
190_L193_F0.5230.93
82_A297_V0.5230.93
385_V389_I0.5230.93
170_N177_I0.5210.93
141_P411_Y0.5210.93
259_S401_T0.5200.93
146_V371_S0.5190.93
150_S373_L0.5170.93
91_A95_N0.5160.93
218_G221_L0.5150.93
68_C344_I0.5140.93
78_M82_A0.5130.93
93_G98_F0.5130.93
419_G422_R0.5110.92
86_V327_G0.5110.92
102_V116_A0.5110.92
253_L257_I0.5100.92
222_G226_Y0.5090.92
208_L222_G0.5080.92
73_F305_G0.5060.92
187_L190_L0.5050.92
113_G116_A0.5020.92
165_G185_V0.5020.92
372_S376_V0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qe7A 2 0.8472 100 0.547 Contact Map
3o7qA 1 0.418 25.5 0.966 Contact Map
2nr9A 2 0.4067 14.8 0.969 Contact Map
4z7fA 2 0.3281 14.1 0.97 Contact Map
4us3A 1 0.8315 5.8 0.975 Contact Map
3nd0A 2 0.5685 5.2 0.975 Contact Map
2zy9A 2 0.2629 5.2 0.975 Contact Map
1pw4A 1 0.4494 5.2 0.975 Contact Map
4dc2Z 1 0.0045 3.4 0.977 Contact Map
4qtnA 3 0.1708 3.4 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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