GREMLIN Database
YIDZ - HTH-type transcriptional regulator YidZ
UniProt: P31463 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11721
Length: 319 (286)
Sequences: 78974 (56806)
Seq/√Len: 3359.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_E81_M3.5961.00
22_E31_R3.3951.00
173_E312_K2.6781.00
102_A146_V2.5771.00
74_N88_K2.4311.00
18_L31_R2.2911.00
188_H203_Y2.2371.00
245_A254_A2.2111.00
98_K129_K2.1971.00
177_S289_P2.1951.00
174_V177_S2.1841.00
179_V258_R2.1661.00
174_V289_P2.1251.00
98_K127_T2.0921.00
27_K30_K2.0861.00
52_D67_L2.0491.00
196_N199_T2.0461.00
15_C42_S2.0441.00
21_Q76_A2.0401.00
246_A270_P2.0251.00
118_Q310_T1.9911.00
74_N81_M1.9901.00
242_L265_Q1.9861.00
177_S287_E1.9851.00
17_Q72_E1.9781.00
17_Q76_A1.9731.00
100_E129_K1.9551.00
206_I252_L1.9241.00
18_L21_Q1.9221.00
17_Q21_Q1.9201.00
18_L22_E1.8971.00
181_C258_R1.8921.00
20_M64_P1.8811.00
15_C39_V1.8791.00
78_W82_S1.8541.00
72_E76_A1.8161.00
184_L274_L1.8121.00
25_V43_L1.8011.00
246_A265_Q1.7721.00
56_V63_S1.7401.00
204_P232_A1.7151.00
71_M85_L1.7081.00
181_C273_A1.7071.00
172_Y291_T1.6871.00
70_S88_K1.6701.00
140_A145_E1.6491.00
20_M72_E1.6161.00
139_D143_R1.6131.00
119_I307_L1.6051.00
22_E27_K1.5961.00
21_Q31_R1.5871.00
17_Q75_L1.5641.00
171_D296_K1.5601.00
16_L72_E1.5411.00
15_C34_V1.5131.00
12_L42_S1.4921.00
119_I126_A1.4901.00
215_T219_D1.4871.00
12_L49_W1.4831.00
173_E294_W1.4801.00
26_T36_P1.4631.00
66_P69_V1.4601.00
74_N77_E1.4501.00
24_S27_K1.4461.00
35_T38_A1.4371.00
53_P56_V1.4321.00
18_L32_I1.4251.00
9_D12_L1.4191.00
12_L45_K1.4131.00
17_Q79_M1.4081.00
151_S293_L1.3991.00
308_R312_K1.3911.00
153_R291_T1.3841.00
171_D294_W1.3811.00
74_N84_L1.3771.00
78_W85_L1.3651.00
300_H304_I1.3631.00
109_M239_E1.3591.00
294_W308_R1.3531.00
186_K270_P1.3461.00
100_E131_R1.3231.00
140_A146_V1.3131.00
58_S63_S1.3121.00
96_G125_Q1.3111.00
306_W309_E1.3001.00
292_L308_R1.2981.00
10_L82_S1.2981.00
148_I304_I1.2951.00
118_Q122_R1.2941.00
133_W137_S1.2901.00
141_I149_G1.2881.00
142_T169_A1.2881.00
184_L253_L1.2771.00
71_M86_L1.2721.00
178_D259_Y1.2681.00
120_Y232_A1.2671.00
81_M84_L1.2631.00
148_I292_L1.2611.00
122_R310_T1.2591.00
203_Y253_L1.2461.00
248_P252_L1.2451.00
265_Q270_P1.2441.00
73_Q77_E1.2321.00
74_N85_L1.2171.00
258_R273_A1.2171.00
186_K272_V1.2071.00
243_F246_A1.2061.00
241_S254_A1.2041.00
174_V291_T1.1991.00
120_Y204_P1.1971.00
70_S73_Q1.1871.00
69_V73_Q1.1861.00
258_R262_Y1.1831.00
44_A48_A1.1831.00
117_K121_Q1.1741.00
193_Q272_V1.1701.00
16_L55_F1.1691.00
34_V38_A1.1611.00
189_P203_Y1.1561.00
117_K247_Q1.1561.00
172_Y293_L1.1431.00
222_L227_R1.1361.00
49_W86_L1.1311.00
16_L20_M1.1291.00
41_K45_K1.1291.00
118_Q121_Q1.1171.00
41_K44_A1.1171.00
129_K234_S1.1161.00
206_I241_S1.1141.00
16_L54_L1.1141.00
204_P230_T1.1081.00
99_F307_L1.1071.00
25_V62_L1.0901.00
123_Y306_W1.0891.00
133_W140_A1.0871.00
40_S44_A1.0821.00
194_T277_P1.0821.00
183_W273_A1.0811.00
185_R248_P1.0791.00
119_I310_T1.0791.00
11_N14_L1.0781.00
77_E84_L1.0781.00
262_Y267_H1.0761.00
295_H298_N1.0761.00
309_E312_K1.0721.00
273_A276_L1.0651.00
13_L75_L1.0641.00
70_S74_N1.0621.00
19_L28_A1.0611.00
195_W199_T1.0591.00
18_L28_A1.0581.00
235_L241_S1.0551.00
14_L83_N1.0541.00
142_T167_P1.0531.00
305_V309_E1.0521.00
108_M132_N1.0491.00
42_S45_K1.0481.00
114_A247_Q1.0471.00
78_W81_M1.0411.00
243_F247_Q1.0371.00
173_E308_R1.0331.00
115_L311_I1.0201.00
86_L90_H1.0081.00
64_P68_M1.0061.00
242_L246_A0.9971.00
216_W219_D0.9911.00
179_V287_E0.9861.00
20_M55_F0.9841.00
119_I123_Y0.9831.00
34_V39_V0.9811.00
182_V253_L0.9741.00
183_W261_Q0.9731.00
8_L49_W0.9711.00
83_N86_L0.9701.00
197_L278_F0.9701.00
80_Q84_L0.9661.00
184_L188_H0.9641.00
188_H191_L0.9571.00
15_C32_I0.9571.00
131_R140_A0.9561.00
83_N87_D0.9521.00
235_L244_M0.9521.00
19_L25_V0.9501.00
71_M75_L0.9431.00
140_A143_R0.9401.00
122_R313_N0.9401.00
16_L64_P0.9391.00
207_S231_I0.9331.00
310_T313_N0.9291.00
28_A39_V0.9261.00
45_K48_A0.9261.00
115_L310_T0.9151.00
70_S92_Q0.9121.00
55_F62_L0.9111.00
52_D89_P0.9101.00
205_H229_R0.9071.00
16_L46_L0.9051.00
301_N304_I0.9011.00
102_A149_G0.8991.00
27_K31_R0.8901.00
146_V149_G0.8871.00
20_M68_M0.8851.00
216_W220_N0.8841.00
188_H204_P0.8831.00
127_T230_T0.8801.00
105_S237_E0.8801.00
155_S167_P0.8771.00
169_A296_K0.8721.00
77_E80_Q0.8721.00
23_R63_S0.8691.00
126_A303_K0.8661.00
73_Q76_A0.8621.00
204_P231_I0.8581.00
153_R289_P0.8521.00
261_Q265_Q0.8501.00
26_T30_K0.8481.00
58_S61_G0.8441.00
101_L148_I0.8441.00
170_I293_L0.8411.00
67_L92_Q0.8381.00
190_A203_Y0.8381.00
11_N42_S0.8361.00
266_L269_L0.8331.00
184_L189_P0.8321.00
102_A151_S0.8301.00
189_P193_Q0.8261.00
171_D174_V0.8231.00
32_I39_V0.8231.00
309_E313_N0.8191.00
192_H204_P0.8181.00
188_H192_H0.8171.00
20_M23_R0.8131.00
221_V225_L0.8111.00
67_L89_P0.8111.00
131_R146_V0.8101.00
97_L126_A0.8101.00
183_W254_A0.8091.00
97_L303_K0.8081.00
300_H305_V0.8051.00
23_R69_V0.8041.00
44_A53_P0.8001.00
196_N277_P0.7991.00
10_L79_M0.7971.00
16_L71_M0.7961.00
198_D201_L0.7951.00
199_T202_R0.7911.00
19_L43_L0.7881.00
82_S85_L0.7871.00
82_S86_L0.7831.00
179_V275_P0.7801.00
84_L88_K0.7801.00
19_L55_F0.7771.00
21_Q72_E0.7761.00
36_P40_S0.7751.00
81_M85_L0.7711.00
187_D191_L0.7661.00
22_E28_A0.7661.00
67_L70_S0.7641.00
23_R61_G0.7591.00
95_R123_Y0.7591.00
265_Q268_Q0.7591.00
148_I307_L0.7561.00
302_P306_W0.7531.00
183_W256_A0.7491.00
246_A268_Q0.7451.00
14_L18_L0.7391.00
85_L89_P0.7351.00
266_L273_A0.7341.00
184_L190_A0.7341.00
122_R306_W0.7331.00
12_L15_C0.7321.00
185_R188_H0.7301.00
191_L272_V0.7301.00
25_V39_V0.7251.00
75_L78_W0.7201.00
221_V224_E0.7181.00
56_V65_T0.7161.00
142_T170_I0.7151.00
119_I306_W0.7131.00
90_H93_T0.7131.00
218_L222_L0.7121.00
184_L272_V0.7101.00
64_P69_V0.7091.00
19_L39_V0.7091.00
56_V61_G0.7071.00
63_S69_V0.7031.00
298_N301_N0.7021.00
183_W266_L0.7021.00
8_L86_L0.7021.00
237_E240_Q0.7021.00
100_E146_V0.6991.00
261_Q266_L0.6971.00
76_A80_Q0.6971.00
103_A108_M0.6961.00
137_S140_A0.6941.00
215_T234_S0.6911.00
69_V72_E0.6911.00
38_A42_S0.6901.00
147_D304_I0.6861.00
179_V279_D0.6841.00
220_N223_Q0.6821.00
196_N278_F0.6771.00
67_L71_M0.6761.00
306_W310_T0.6751.00
198_D225_L0.6721.00
220_N224_E0.6711.00
201_L227_R0.6681.00
66_P70_S0.6671.00
209_C234_S0.6661.00
100_E147_D0.6651.00
144_G295_H0.6641.00
118_Q313_N0.6631.00
187_D248_P0.6611.00
257_P260_C0.6611.00
84_L87_D0.6611.00
47_R52_D0.6591.00
233_M244_M0.6581.00
80_Q83_N0.6571.00
202_R230_T0.6561.00
150_F311_I0.6541.00
71_M89_P0.6521.00
25_V61_G0.6451.00
99_F303_K0.6421.00
14_L17_Q0.6411.00
74_N78_W0.6391.00
208_I241_S0.6371.00
187_D190_A0.6371.00
75_L79_M0.6361.00
109_M243_F0.6351.00
30_K33_N0.6331.00
187_D272_V0.6301.00
47_R57_N0.6281.00
103_A112_L0.6271.00
127_T234_S0.6261.00
11_N45_K0.6261.00
182_V200_F0.6261.00
217_A221_V0.6241.00
19_L24_S0.6241.00
205_H253_L0.6191.00
28_A32_I0.6161.00
43_L47_R0.6151.00
302_P305_V0.6121.00
141_I293_L0.6121.00
216_W221_V0.6091.00
244_M252_L0.6091.00
219_D223_Q0.6051.00
96_G127_T0.6041.00
132_N236_P0.6041.00
186_K269_L0.6031.00
241_S245_A0.6011.00
209_C236_P0.6001.00
105_S134_D0.6001.00
307_L311_I0.6001.00
182_V255_T0.5991.00
218_L221_V0.5971.00
112_L115_L0.5941.00
87_D91_H0.5921.00
148_I308_R0.5911.00
99_F148_I0.5871.00
194_T275_P0.5861.00
152_G288_V0.5821.00
178_D288_V0.5811.00
176_F290_F0.5811.00
114_A117_K0.5801.00
190_A195_W0.5801.00
50_F71_M0.5801.00
222_L229_R0.5761.00
14_L79_M0.5751.00
182_V205_H0.5751.00
64_P72_E0.5751.00
171_D297_R0.5741.00
70_S89_P0.5731.00
217_A220_N0.5701.00
294_W305_V0.5691.00
11_N15_C0.5681.00
52_D56_V0.5681.00
37_S41_K0.5671.00
38_A41_K0.5661.00
180_P255_T0.5641.00
50_F89_P0.5631.00
215_T221_V0.5631.00
141_I170_I0.5631.00
235_L240_Q0.5611.00
116_S128_I0.5601.00
276_L279_D0.5601.00
55_F64_P0.5591.00
132_N237_E0.5591.00
102_A131_R0.5581.00
102_A133_W0.5581.00
194_T199_T0.5561.00
123_Y126_A0.5551.00
114_A118_Q0.5541.00
97_L125_Q0.5541.00
79_M83_N0.5501.00
188_H253_L0.5461.00
35_T41_K0.5451.00
16_L68_M0.5441.00
50_F53_P0.5441.00
219_D222_L0.5431.00
107_L111_M0.5421.00
184_L191_L0.5391.00
215_T218_L0.5371.00
25_V36_P0.5351.00
175_L292_L0.5341.00
210_W234_S0.5331.00
139_D145_E0.5321.00
121_Q191_L0.5261.00
15_C43_L0.5251.00
266_L270_P0.5241.00
91_H95_R0.5231.00
109_M237_E0.5231.00
189_P192_H0.5201.00
73_Q88_K0.5191.00
20_M69_V0.5181.00
304_I308_R0.5171.00
256_A261_Q0.5151.00
15_C28_A0.5141.00
183_W271_L0.5131.00
97_L123_Y0.5131.00
87_D90_H0.5131.00
111_M115_L0.5121.00
79_M82_S0.5111.00
150_F292_L0.5091.00
23_R62_L0.5081.00
238_F257_P0.5081.00
153_R172_Y0.5071.00
53_P67_L0.5071.00
25_V57_N0.5061.00
43_L55_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2esnA 3 0.931 100 0.094 Contact Map
1uthA 2 0.6991 100 0.118 Contact Map
3fzvA 4 0.8966 100 0.128 Contact Map
2h98A 2 0.6364 100 0.139 Contact Map
3fxqA 3 0.9185 100 0.14 Contact Map
2h9bA 2 0.6364 100 0.14 Contact Map
1ixcA 4 0.906 100 0.142 Contact Map
1al3A 1 0.6552 100 0.144 Contact Map
3szpA 3 0.9028 100 0.146 Contact Map
4x6gA 4 0.9342 100 0.147 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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