GREMLIN Database
DGOR - Galactonate operon transcriptional repressor
UniProt: P31460 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11718
Length: 229 (199)
Sequences: 23400 (17284)
Seq/√Len: 1225.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
126_E203_R3.6871.00
111_R211_E3.2941.00
206_D209_A2.9361.00
133_I196_K2.7421.00
16_Q21_K2.7131.00
23_V26_S2.6411.00
16_Q37_E2.3791.00
104_L108_A2.3491.00
124_Q152_A2.2261.00
97_A160_P2.1471.00
103_N219_A2.0911.00
10_V51_S2.0561.00
59_E69_A2.0261.00
100_E112_W1.9631.00
115_E207_G1.9471.00
14_G55_K1.9451.00
9_I40_T1.9431.00
155_Q163_Q1.8351.00
121_D158_H1.8141.00
122_L203_R1.8101.00
9_I38_F1.8061.00
201_A209_A1.7761.00
152_A155_Q1.7521.00
118_T121_D1.7511.00
60_M66_A1.7451.00
12_T16_Q1.7211.00
107_P215_L1.7041.00
111_R207_G1.6551.00
129_L199_F1.6461.00
138_D141_A1.6401.00
101_V165_L1.6101.00
194_E220_S1.5921.00
30_A42_R1.5911.00
107_P211_E1.5711.00
211_E215_L1.5631.00
15_K19_H1.5621.00
209_A213_A1.5521.00
108_A111_R1.5461.00
150_H195_H1.5201.00
197_A213_A1.4841.00
131_E145_A1.4341.00
121_D156_S1.4311.00
154_L166_S1.4211.00
161_V172_L1.4171.00
110_A210_A1.4161.00
164_Q168_A1.4091.00
103_N215_L1.4071.00
151_E167_I1.4011.00
126_E199_F1.3881.00
200_D204_H1.3861.00
133_I192_L1.3821.00
128_A145_A1.3661.00
10_V55_K1.3621.00
61_K64_R1.3591.00
32_A36_E1.3561.00
204_H209_A1.3501.00
97_A161_V1.3241.00
126_E130_N1.2821.00
103_N222_T1.2811.00
117_A122_L1.2781.00
196_K200_D1.2771.00
207_G211_E1.2701.00
127_S131_E1.2261.00
33_E37_E1.2251.00
131_E148_R1.2031.00
29_P33_E1.2021.00
129_L196_K1.1921.00
27_P67_F1.1911.00
8_R12_T1.1881.00
128_A152_A1.1881.00
103_N107_P1.1821.00
34_L45_I1.1791.00
194_E217_M1.1661.00
61_K67_F1.1591.00
212_Q216_T1.1541.00
148_R152_A1.1471.00
151_E155_Q1.1451.00
12_T38_F1.1451.00
102_R106_E1.1441.00
16_Q38_F1.1431.00
117_A205_Q1.1381.00
215_L219_A1.1361.00
12_T15_K1.1351.00
128_A148_R1.1301.00
153_V202_I1.1291.00
146_D150_H1.1151.00
141_A144_E1.1151.00
209_A212_Q1.1141.00
53_M60_M1.1121.00
110_A214_A1.1071.00
107_P111_R1.1071.00
111_R208_D1.1001.00
129_L132_M1.0971.00
110_A114_A1.0961.00
117_A121_D1.0951.00
117_A156_S1.0811.00
129_L133_I1.0801.00
152_A156_S1.0791.00
97_A159_N1.0781.00
199_F203_R1.0601.00
22_Y68_V1.0601.00
109_I154_L1.0571.00
200_D203_R1.0531.00
122_L199_F1.0451.00
100_E159_N1.0431.00
59_E67_F1.0391.00
126_E196_K1.0371.00
96_S222_T1.0321.00
145_A148_R1.0301.00
124_Q155_Q1.0211.00
122_L205_Q1.0181.00
47_E50_R1.0051.00
165_L168_A1.0031.00
124_Q127_S0.9941.00
201_A206_D0.9881.00
130_N133_I0.9831.00
53_M58_I0.9821.00
112_W116_R0.9681.00
49_F66_A0.9631.00
114_A207_G0.9591.00
124_Q128_A0.9541.00
16_Q22_Y0.9491.00
17_I68_V0.9451.00
108_A211_E0.9441.00
150_H217_M0.9381.00
149_Y199_F0.9361.00
197_A216_T0.9341.00
195_H217_M0.9311.00
193_Q197_A0.9291.00
197_A209_A0.9211.00
144_E148_R0.9141.00
51_S54_A0.9051.00
61_K65_G0.9041.00
163_Q167_I0.9011.00
106_E150_H0.8991.00
197_A200_D0.8981.00
114_A202_I0.8961.00
27_P65_G0.8961.00
116_R158_H0.8941.00
123_A127_S0.8921.00
94_L161_V0.8901.00
198_L214_A0.8891.00
157_V163_Q0.8871.00
208_D212_Q0.8861.00
6_T51_S0.8711.00
10_V14_G0.8681.00
208_D211_E0.8661.00
101_V161_V0.8651.00
108_A112_W0.8641.00
58_I66_A0.8621.00
128_A131_E0.8601.00
41_S44_I0.8501.00
64_R67_F0.8501.00
131_E134_A0.8491.00
192_L196_K0.8471.00
29_P32_A0.8461.00
122_L126_E0.8401.00
35_C45_I0.8371.00
126_E200_D0.8341.00
50_R53_M0.8291.00
14_G57_L0.8271.00
146_D195_H0.8261.00
119_S123_A0.8241.00
197_A201_A0.8231.00
114_A205_Q0.8191.00
117_A202_I0.8181.00
113_A156_S0.8171.00
114_A210_A0.8151.00
121_D124_Q0.8141.00
7_D51_S0.8131.00
102_R218_I0.8111.00
14_G18_V0.8101.00
49_F58_I0.8061.00
33_E36_E0.8061.00
161_V165_L0.8041.00
198_L213_A0.7891.00
119_S205_Q0.7841.00
113_A117_A0.7761.00
130_N196_K0.7741.00
161_V164_Q0.7741.00
40_T45_I0.7721.00
201_A213_A0.7711.00
135_N141_A0.7711.00
125_I152_A0.7701.00
100_E222_T0.7691.00
130_N134_A0.7661.00
34_L49_F0.7651.00
112_W115_E0.7571.00
112_W159_N0.7531.00
151_E170_S0.7521.00
132_M142_F0.7501.00
189_P193_Q0.7411.00
213_A216_T0.7391.00
111_R115_E0.7381.00
101_V162_L0.7281.00
198_L210_A0.7271.00
5_K44_I0.7231.00
123_A203_R0.7231.00
50_R60_M0.7221.00
99_S221_S0.7201.00
100_E116_R0.7111.00
212_Q215_L0.7091.00
123_A126_E0.7091.00
147_I174_R0.7071.00
101_V109_I0.7041.00
124_Q148_R0.7001.00
141_A145_A0.6991.00
219_A223_R0.6961.00
5_K8_R0.6911.00
125_I199_F0.6901.00
131_E141_A0.6871.00
6_T10_V0.6861.00
129_L192_L0.6841.00
51_S55_K0.6771.00
21_K37_E0.6761.00
100_E108_A0.6721.00
74_W158_H0.6721.00
151_E163_Q0.6691.00
216_T220_S0.6681.00
127_S130_N0.6651.00
147_I170_S0.6601.00
121_D155_Q0.6581.00
194_E197_A0.6561.00
94_L160_P0.6551.00
22_Y26_S0.6541.00
44_I48_V0.6501.00
72_N94_L0.6491.00
198_L217_M0.6471.00
148_R151_E0.6461.00
104_L162_L0.6451.00
113_A157_V0.6441.00
121_D152_A0.6421.00
131_E135_N0.6381.00
219_A222_T0.6351.00
135_N138_D0.6341.00
220_S224_R0.6251.00
122_L202_I0.6191.00
110_A207_G0.6181.00
135_N145_A0.6171.00
101_V105_V0.6141.00
109_I157_V0.6141.00
103_N218_I0.6131.00
16_Q20_G0.6081.00
24_P70_P0.6061.00
6_T47_E0.6031.00
74_W97_A0.5921.00
106_E195_H0.5921.00
109_I162_L0.5911.00
25_G70_P0.5901.00
107_P207_G0.5871.00
107_P214_A0.5851.00
63_Y66_A0.5811.00
38_F45_I0.5781.00
142_F191_T0.5781.00
125_I156_S0.5781.00
28_L58_I0.5771.00
32_A35_C0.5761.00
104_L107_P0.5711.00
164_Q172_L0.5711.00
120_S124_Q0.5701.00
111_R215_L0.5631.00
113_A153_V0.5611.00
119_S203_R0.5611.00
13_L34_L0.5581.00
132_M192_L0.5511.00
125_I128_A0.5501.00
112_W157_V0.5461.00
101_V104_L0.5441.00
16_Q19_H0.5431.00
50_R54_A0.5431.00
96_S100_E0.5401.00
136_N139_R0.5391.00
110_A153_V0.5381.00
198_L201_A0.5361.00
175_A179_R0.5361.00
36_E39_A0.5361.00
160_P163_Q0.5341.00
62_R65_G0.5331.00
100_E103_N0.5301.00
147_I151_E0.5291.00
125_I129_L0.5261.00
187_N190_Q0.5251.00
22_Y28_L0.5241.00
140_E178_E0.5221.00
193_Q196_K0.5211.00
164_Q167_I0.5211.00
67_F70_P0.5201.00
177_F180_T0.5191.00
106_E218_I0.5181.00
108_A162_L0.5131.00
22_Y37_E0.5111.00
214_A218_I0.5091.00
12_T37_E0.5051.00
187_N224_R0.5031.00
144_E174_R0.5011.00
69_A175_A0.5011.00
194_E216_T0.5001.00
56_R164_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c7jA 4 0.9039 100 0.153 Contact Map
2di3A 2 0.9694 100 0.155 Contact Map
4p96A 2 0.9956 100 0.155 Contact Map
3sxyA 2 0.8646 100 0.166 Contact Map
2hs5A 1 0.8908 100 0.175 Contact Map
3ihuA 1 0.8821 100 0.18 Contact Map
4p9fA 1 0.9039 100 0.18 Contact Map
1hw1A 2 0.9738 100 0.192 Contact Map
3by6A 2 0.5109 99.9 0.535 Contact Map
3ic7A 2 0.4847 99.9 0.536 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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