GREMLIN Database
DGOK - 2-dehydro-3-deoxygalactonokinase
UniProt: P31459 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11717
Length: 292 (281)
Sequences: 762 (592)
Seq/√Len: 35.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
166_L171_S9.0121.00
63_M67_V6.1731.00
105_L152_I5.3111.00
188_T261_Q4.6201.00
84_C87_S3.8601.00
191_L262_A3.5271.00
81_V105_L3.3371.00
115_V212_V3.1161.00
29_R53_D3.0781.00
123_L145_V2.9781.00
183_S220_Q2.7911.00
92_L102_I2.7771.00
249_L256_T2.7741.00
192_E265_A2.7651.00
195_L266_M2.5551.00
35_V69_S2.4561.00
17_A54_W2.4281.00
7_A20_Y2.3771.00
166_L170_H2.2930.99
126_A135_Y2.2770.99
163_L201_L2.1580.99
123_L135_Y2.1250.99
8_I17_A2.1120.99
71_V175_A2.0700.99
8_I63_M2.0360.98
102_I286_I2.0080.98
177_L211_H2.0070.98
79_L83_A1.9630.98
142_C233_E1.9370.98
167_L171_S1.9060.98
158_V233_E1.8850.97
68_G101_I1.8820.97
127_R147_A1.8790.97
70_N75_V1.8260.97
148_D153_N1.8030.97
80_S106_C1.7590.96
64_A283_I1.7360.96
11_G16_R1.7300.96
176_G211_H1.7260.96
182_N223_E1.7190.96
273_V278_A1.7060.95
126_A273_V1.7030.95
160_T229_L1.7020.95
137_M145_V1.6820.95
21_Q24_H1.6730.95
47_L61_V1.6730.95
106_C213_L1.6680.95
140_T166_L1.6620.95
146_Q154_D1.6510.94
35_V71_V1.6380.94
200_I232_A1.6300.94
284_R287_A1.6030.94
33_A49_E1.5970.93
207_V224_F1.5930.93
136_V223_E1.5630.93
140_T226_S1.5280.92
232_A236_S1.5150.91
157_T205_F1.5050.91
140_T171_S1.5020.91
164_H168_L1.5010.91
78_Y226_S1.4980.91
9_D16_R1.4930.91
78_Y140_T1.4860.91
27_E54_W1.4790.90
260_Q264_Q1.4420.89
163_L204_L1.4340.89
132_S148_D1.4230.89
263_F268_C1.4000.88
66_M117_R1.3950.88
126_A147_A1.3660.87
154_D239_D1.3460.86
119_E208_R1.3430.86
84_C151_Q1.3410.86
280_Q284_R1.3190.85
223_E258_R1.3150.84
69_S102_I1.3000.84
85_F152_I1.2980.84
38_L41_K1.2630.82
28_S276_D1.2600.82
117_R208_R1.2520.81
164_H222_S1.2430.81
47_L51_T1.2240.80
251_A256_T1.2140.79
164_H226_S1.2110.79
68_G76_A1.2080.79
158_V237_M1.2000.78
66_M208_R1.1860.78
274_A277_T1.1740.77
234_V263_F1.1710.77
143_K208_R1.1700.77
117_R141_H1.1700.77
136_V144_W1.1580.76
74_K101_I1.1560.76
62_V100_W1.1530.76
12_S66_M1.1510.75
119_E143_K1.1500.75
76_A93_T1.1490.75
16_R161_G1.1400.75
122_Q226_S1.1300.74
187_F262_A1.1200.73
12_S35_V1.1090.73
187_F191_L1.1080.73
64_A121_T1.1070.72
216_L221_V1.1030.72
113_H210_S1.1020.72
14_N113_H1.1020.72
231_G262_A1.1000.72
207_V221_V1.0790.71
15_L50_V1.0740.70
187_F230_I1.0660.70
279_F283_I1.0650.69
48_A97_D1.0580.69
11_G34_G1.0450.68
141_H205_F1.0360.67
141_H162_E1.0340.67
18_W209_A1.0190.66
119_E141_H1.0160.66
17_A51_T1.0090.65
168_L174_G1.0030.65
246_A271_T1.0030.65
85_F96_G0.9960.64
7_A76_A0.9950.64
76_A105_L0.9860.63
66_M141_H0.9830.63
239_D269_D0.9760.63
126_A250_V0.9750.63
11_G140_T0.9720.62
11_G117_R0.9710.62
122_Q140_T0.9690.62
190_G194_G0.9640.62
187_F226_S0.9600.61
34_G119_E0.9540.61
207_V225_L0.9520.61
184_A257_A0.9360.59
94_S98_N0.9320.59
162_E205_F0.9310.59
66_M119_E0.9280.59
209_A213_L0.9200.58
10_W78_Y0.9190.58
117_R143_K0.9120.57
153_N242_A0.9110.57
144_W237_M0.9090.57
49_E132_S0.9060.57
143_K205_F0.9010.56
70_N212_V0.9000.56
105_L133_S0.8980.56
190_G228_L0.8980.56
62_V177_L0.8980.56
148_D242_A0.8960.56
190_G224_F0.8900.55
140_T143_K0.8900.55
209_A224_F0.8880.55
67_V101_I0.8860.55
148_D185_D0.8850.55
189_A216_L0.8840.55
149_S242_A0.8810.55
119_E161_G0.8790.55
23_D26_L0.8760.54
34_G104_G0.8740.54
109_H112_N0.8700.54
72_G119_E0.8700.54
20_Y44_A0.8620.53
36_T172_L0.8620.53
135_Y147_A0.8610.53
247_I268_C0.8580.53
74_K93_T0.8520.52
64_A279_F0.8500.52
143_K226_S0.8500.52
68_G283_I0.8500.52
15_L29_R0.8490.52
92_L100_W0.8490.52
36_T174_G0.8490.52
12_S16_R0.8460.52
5_Y20_Y0.8460.52
10_W226_S0.8440.52
11_G78_Y0.8420.51
78_Y205_F0.8410.51
78_Y164_H0.8370.51
249_L273_V0.8370.51
145_V155_F0.8250.50
122_Q186_A0.8240.50
195_L238_R0.8220.50
159_M233_E0.8200.49
148_D151_Q0.8150.49
44_A97_D0.8100.49
205_F226_S0.8100.49
233_E259_Y0.8030.48
231_G259_Y0.8020.48
93_T105_L0.8000.48
34_G117_R0.7990.48
122_Q143_K0.7990.48
51_T54_W0.7980.48
259_Y262_A0.7970.48
142_C255_L0.7950.47
254_S258_R0.7920.47
207_V211_H0.7920.47
34_G143_K0.7860.47
162_E171_S0.7820.46
16_R140_T0.7820.46
78_Y119_E0.7810.46
274_A278_A0.7810.46
114_N157_T0.7810.46
170_H174_G0.7770.46
160_T231_G0.7760.46
136_V249_L0.7740.46
126_A130_A0.7720.45
132_S149_S0.7710.45
43_P73_W0.7710.45
141_H208_R0.7670.45
143_K161_G0.7630.45
78_Y143_K0.7620.45
126_A133_S0.7620.45
123_L147_A0.7620.45
159_M229_L0.7610.44
249_L260_Q0.7610.44
114_N205_F0.7600.44
142_C158_V0.7550.44
173_I225_L0.7500.43
38_L46_V0.7480.43
76_A101_I0.7450.43
136_V258_R0.7420.43
83_A105_L0.7410.43
188_T191_L0.7370.42
51_T55_R0.7340.42
32_E39_N0.7330.42
198_P286_I0.7320.42
72_G117_R0.7280.42
120_E208_R0.7270.42
199_A232_A0.7240.41
140_T208_R0.7230.41
253_T256_T0.7230.41
146_Q153_N0.7220.41
139_G227_G0.7200.41
16_R119_E0.7190.41
114_N232_A0.7160.41
10_W187_F0.7140.40
162_E208_R0.7140.40
94_S100_W0.7140.40
183_S186_A0.7110.40
7_A280_Q0.7090.40
77_P80_S0.7090.40
210_S213_L0.7070.40
85_F123_L0.7070.40
63_M100_W0.7060.40
16_R226_S0.7050.40
88_I103_P0.7050.40
117_R162_E0.7000.39
9_D78_Y0.6960.39
260_Q272_A0.6960.39
95_V278_A0.6960.39
68_G226_S0.6950.39
59_T277_T0.6950.39
48_A96_G0.6940.39
7_A71_V0.6940.39
8_I69_S0.6940.39
126_A144_W0.6920.39
108_S114_N0.6920.39
35_V67_V0.6860.38
92_L286_I0.6810.38
63_M99_I0.6810.38
28_S176_G0.6770.37
64_A67_V0.6770.37
141_H212_V0.6760.37
43_P166_L0.6750.37
56_E85_F0.6720.37
68_G103_P0.6720.37
25_C254_S0.6720.37
42_S46_V0.6710.37
9_D12_S0.6690.37
6_I54_W0.6690.37
68_G73_W0.6690.37
9_D13_T0.6650.36
184_A261_Q0.6640.36
66_M143_K0.6630.36
51_T102_I0.6610.36
161_G226_S0.6600.36
38_L99_I0.6590.36
136_V247_I0.6590.36
93_T147_A0.6580.36
189_A193_R0.6570.36
61_V234_V0.6560.36
185_D196_N0.6560.36
86_S152_I0.6560.36
120_E162_E0.6550.36
30_Q38_L0.6530.36
145_V252_G0.6460.35
121_T283_I0.6460.35
33_A69_S0.6440.35
126_A152_I0.6430.35
105_L234_V0.6430.35
34_G208_R0.6420.35
8_I14_N0.6420.35
10_W140_T0.6390.34
5_Y284_R0.6370.34
13_T83_A0.6330.34
149_S195_L0.6310.34
6_I84_C0.6300.34
265_A277_T0.6300.34
91_Q102_I0.6290.34
32_E62_V0.6270.34
30_Q288_H0.6260.33
249_L270_V0.6260.33
140_T164_H0.6260.33
16_R34_G0.6260.33
78_Y208_R0.6230.33
104_G117_R0.6220.33
163_L258_R0.6220.33
234_V266_M0.6210.33
209_A231_G0.6210.33
280_Q287_A0.6210.33
207_V213_L0.6180.33
9_D140_T0.6180.33
119_E140_T0.6170.33
5_Y287_A0.6140.33
78_Y117_R0.6130.32
113_H209_A0.6120.32
136_V263_F0.6100.32
72_G161_G0.6100.32
172_L224_F0.6090.32
38_L67_V0.6070.32
123_L164_H0.6060.32
188_T265_A0.6060.32
92_L135_Y0.6050.32
121_T174_G0.6030.32
190_G227_G0.6030.32
34_G120_E0.6020.32
168_L222_S0.6020.32
13_T37_R0.6000.31
43_P101_I0.6000.31
209_A267_G0.5970.31
73_W115_V0.5970.31
71_V76_A0.5960.31
11_G119_E0.5950.31
17_A67_V0.5940.31
43_P75_V0.5930.31
188_T264_Q0.5900.31
54_W96_G0.5890.31
69_S72_G0.5890.31
90_E257_A0.5860.30
263_F266_M0.5860.30
16_R122_Q0.5850.30
178_P217_P0.5840.30
42_S45_A0.5810.30
95_V101_I0.5780.30
158_V236_S0.5770.30
12_S34_G0.5760.30
12_S172_L0.5760.30
143_K157_T0.5750.30
66_M205_F0.5750.30
115_V159_M0.5750.30
274_A280_Q0.5740.30
13_T261_Q0.5740.30
10_W122_Q0.5720.29
203_Q207_V0.5720.29
226_S230_I0.5700.29
15_L35_V0.5700.29
122_Q164_H0.5690.29
24_H276_D0.5680.29
163_L253_T0.5680.29
130_A189_A0.5680.29
34_G66_M0.5680.29
145_V152_I0.5660.29
205_F212_V0.5660.29
92_L212_V0.5640.29
104_G119_E0.5620.29
257_A261_Q0.5610.29
279_F282_G0.5600.29
6_I76_A0.5580.28
16_R66_M0.5570.28
61_V95_V0.5560.28
149_S271_T0.5550.28
252_G274_A0.5550.28
36_T121_T0.5540.28
78_Y115_V0.5540.28
8_I221_V0.5530.28
269_D272_A0.5500.28
77_P201_L0.5500.28
176_G221_V0.5500.28
10_W262_A0.5500.28
165_H169_N0.5490.28
15_L258_R0.5450.28
206_E210_S0.5440.27
115_V143_K0.5430.27
91_Q220_Q0.5420.27
91_Q185_D0.5410.27
205_F208_R0.5410.27
18_W286_I0.5390.27
5_Y102_I0.5390.27
5_Y280_Q0.5380.27
98_N235_A0.5380.27
29_R51_T0.5370.27
134_L260_Q0.5370.27
71_V278_A0.5350.27
12_S173_I0.5350.27
103_P283_I0.5340.27
210_S224_F0.5340.27
58_K97_D0.5340.27
282_G286_I0.5340.27
13_T212_V0.5330.27
11_G66_M0.5330.27
61_V216_L0.5330.27
79_L188_T0.5310.27
35_V70_N0.5270.26
19_L54_W0.5240.26
11_G122_Q0.5240.26
160_T228_L0.5180.26
18_W67_V0.5180.26
188_T192_E0.5170.26
75_V117_R0.5100.25
239_D243_H0.5100.25
11_G104_G0.5090.25
190_G220_Q0.5080.25
154_D244_Q0.5060.25
7_A18_W0.5060.25
78_Y141_H0.5050.25
166_L197_T0.5050.25
73_W78_Y0.5030.25
24_H218_R0.5020.25
62_V235_A0.5020.25
213_L280_Q0.5010.25
199_A251_A0.5010.25
238_R243_H0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3r1xA 4 1 100 0.044 Contact Map
3t69A 2 0.9897 100 0.057 Contact Map
1huxA 2 0.8185 96.2 0.932 Contact Map
2qm1A 2 0.9555 95.5 0.935 Contact Map
2e2oA 2 0.8699 95.2 0.936 Contact Map
3bexA 2 0.8048 94.7 0.938 Contact Map
4ehuA 2 0.8082 94.4 0.939 Contact Map
1sazA 3 0.9692 93.6 0.941 Contact Map
3djcA 5 0.8219 92.9 0.943 Contact Map
3enoA 1 0.887 92.1 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0101 seconds.