GREMLIN Database
CBRA - Protein CbrA
UniProt: P31456 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11714
Length: 354 (314)
Sequences: 28790 (22201)
Seq/√Len: 1252.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_I118_Y3.8931.00
33_K122_L3.3251.00
14_A289_A3.3041.00
7_A148_A3.1681.00
5_D27_Q3.1221.00
5_D149_R2.9851.00
312_W316_R2.7881.00
125_K164_H2.5171.00
110_L113_A2.4671.00
18_L152_V2.4531.00
31_L146_I2.4431.00
25_K301_L2.3291.00
134_H147_T2.2841.00
125_K136_I2.2751.00
122_L138_R2.2741.00
21_K297_R2.2621.00
134_H145_H2.2421.00
127_W134_H2.2421.00
136_I145_H2.2411.00
7_A31_L2.2391.00
105_L109_S2.1871.00
121_S142_W2.1801.00
68_D109_S2.1431.00
7_A135_V2.1431.00
132_K147_T2.0381.00
14_A271_I1.9791.00
227_F231_K1.9721.00
17_A290_L1.9521.00
153_G161_V1.9211.00
59_I66_P1.9171.00
118_Y121_S1.8821.00
68_D110_L1.8691.00
20_R110_L1.8601.00
127_W136_I1.8381.00
121_S137_F1.8161.00
299_V314_A1.8151.00
137_F146_I1.7941.00
27_Q116_E1.7911.00
121_S144_Q1.7831.00
6_V22_L1.7391.00
153_G270_L1.7241.00
129_E134_H1.7231.00
6_V26_M1.7201.00
35_H120_D1.6921.00
293_T297_R1.6861.00
5_D29_I1.6831.00
57_S294_D1.6821.00
123_C135_V1.6821.00
31_L137_F1.6791.00
54_A287_S1.6571.00
154_A271_I1.6561.00
316_R320_L1.6321.00
299_V310_A1.6191.00
228_T232_E1.5801.00
155_D159_S1.5781.00
124_R138_R1.5751.00
262_V265_K1.5601.00
60_R294_D1.5521.00
26_M301_L1.5501.00
67_V71_A1.5411.00
118_Y144_Q1.5391.00
128_R265_K1.5301.00
232_E235_S1.5101.00
111_I115_V1.4981.00
23_A115_V1.4901.00
29_I146_I1.4861.00
295_I299_V1.4851.00
264_G309_T1.4841.00
129_E147_T1.4821.00
7_A146_I1.4811.00
68_D71_A1.4801.00
137_F144_Q1.4761.00
108_K119_H1.4691.00
239_F245_V1.4411.00
264_G269_F1.4371.00
129_E132_K1.4361.00
18_L293_T1.4361.00
229_T232_E1.4321.00
20_R24_G1.4211.00
68_D113_A1.4191.00
19_A30_A1.4031.00
160_M164_H1.3981.00
126_I151_L1.3771.00
66_P70_I1.3741.00
192_C195_D1.3641.00
150_Y308_N1.3591.00
108_K112_P1.3591.00
239_F244_T1.3551.00
295_I314_A1.3551.00
152_V271_I1.3441.00
231_K235_S1.3361.00
269_F296_L1.3341.00
13_P286_I1.3331.00
72_N102_A1.3261.00
291_D318_L1.3181.00
233_K237_F1.3151.00
292_S315_T1.3091.00
136_I143_E1.3091.00
165_L268_A1.2841.00
229_T233_K1.2841.00
298_S314_A1.2831.00
21_K61_D1.2631.00
20_R111_I1.2521.00
9_I123_C1.2491.00
152_V269_F1.2351.00
9_I155_D1.2311.00
262_V312_W1.2171.00
299_V307_L1.2151.00
89_R92_Q1.2081.00
232_E236_A1.2071.00
118_Y146_I1.2041.00
127_W145_H1.1961.00
8_I18_L1.1951.00
109_S112_P1.1951.00
234_M237_F1.1931.00
263_C319_R1.1891.00
240_Q245_V1.1801.00
54_A290_L1.1761.00
239_F242_G1.1701.00
160_M163_R1.1641.00
133_W267_N1.1621.00
176_A179_Q1.1591.00
135_V148_A1.1551.00
82_D86_S1.1541.00
67_V70_I1.1501.00
276_G292_S1.1491.00
7_A29_I1.1481.00
138_R142_W1.1451.00
123_C126_I1.1371.00
124_R143_E1.1261.00
228_T231_K1.1171.00
23_A114_S1.1111.00
227_F230_L1.1101.00
18_L22_L1.1091.00
238_Q242_G1.1061.00
242_G245_V1.1031.00
102_A105_L1.1031.00
123_C161_V1.0961.00
29_I116_E1.0841.00
299_V302_K1.0731.00
17_A61_D1.0711.00
241_F245_V1.0701.00
85_A88_T1.0691.00
5_D26_M1.0651.00
249_K252_V1.0601.00
263_C312_W1.0541.00
28_V115_V1.0531.00
148_A151_L1.0511.00
238_Q241_F1.0461.00
124_R136_I1.0421.00
182_A243_K1.0421.00
128_R267_N1.0371.00
45_P48_G1.0331.00
68_D106_W1.0301.00
11_L16_S1.0301.00
68_D72_N1.0281.00
9_I161_V1.0281.00
137_F142_W1.0271.00
157_A277_F1.0261.00
137_F143_E1.0261.00
138_R143_E1.0261.00
182_A211_Y1.0251.00
48_G286_I1.0231.00
82_D85_A1.0221.00
265_K268_A1.0141.00
278_I288_Y1.0091.00
270_L274_A1.0041.00
17_A21_K1.0021.00
24_G110_L1.0001.00
204_W215_G0.9971.00
195_D198_I0.9921.00
18_L271_I0.9891.00
175_V179_Q0.9881.00
126_I164_H0.9881.00
241_F244_T0.9861.00
30_A117_V0.9851.00
31_L118_Y0.9811.00
36_Q41_G0.9791.00
255_P258_W0.9761.00
174_Y178_Q0.9751.00
126_I165_L0.9741.00
8_I19_A0.9701.00
55_Q66_P0.9681.00
72_N105_L0.9621.00
123_C160_M0.9621.00
128_R133_W0.9601.00
231_K237_F0.9551.00
176_A180_W0.9511.00
320_L324_G0.9491.00
99_N102_A0.9481.00
230_L234_M0.9461.00
41_G119_H0.9441.00
242_G246_K0.9351.00
177_I180_W0.9291.00
182_A210_G0.9271.00
60_R298_S0.9271.00
227_F233_K0.9251.00
31_L121_S0.9241.00
278_I323_F0.9241.00
309_T313_R0.9231.00
8_I28_V0.9211.00
247_S250_C0.9201.00
133_W151_L0.9181.00
233_K236_A0.9181.00
231_K234_M0.9141.00
108_K117_V0.9131.00
295_I298_S0.9121.00
19_A28_V0.9111.00
247_S252_V0.9101.00
16_S111_I0.9061.00
109_S113_A0.9031.00
264_G312_W0.9021.00
72_N106_W0.8991.00
260_D263_C0.8961.00
244_T247_S0.8951.00
173_K176_A0.8931.00
53_D291_D0.8921.00
310_A313_R0.8921.00
240_Q244_T0.8871.00
106_W110_L0.8851.00
20_R61_D0.8841.00
271_I311_Y0.8831.00
188_P191_S0.8821.00
173_K177_I0.8811.00
41_G108_K0.8801.00
239_F243_K0.8771.00
185_H188_P0.8741.00
153_G268_A0.8731.00
222_D225_T0.8731.00
178_Q182_A0.8731.00
48_G100_R0.8671.00
21_K25_K0.8641.00
65_L110_L0.8641.00
230_L237_F0.8641.00
49_L95_Y0.8601.00
69_V106_W0.8591.00
55_Q96_I0.8581.00
56_R59_I0.8581.00
36_Q119_H0.8551.00
243_K246_K0.8531.00
16_S104_D0.8471.00
106_W109_S0.8421.00
302_K310_A0.8401.00
179_Q182_A0.8351.00
16_S108_K0.8351.00
168_D261_F0.8321.00
187_V190_Y0.8261.00
223_G226_R0.8231.00
29_I148_A0.8231.00
248_E251_T0.8201.00
327_V331_C0.8181.00
9_I151_L0.8161.00
182_A245_V0.8121.00
32_D119_H0.8091.00
254_F258_W0.8071.00
23_A111_I0.8071.00
123_C164_H0.8051.00
5_D148_A0.8011.00
53_D284_E0.7991.00
65_L106_W0.7961.00
13_P290_L0.7901.00
22_L26_M0.7901.00
152_V296_L0.7831.00
135_V151_L0.7801.00
270_L275_A0.7801.00
175_V178_Q0.7791.00
250_C254_F0.7781.00
111_I114_S0.7771.00
21_K24_G0.7771.00
269_F311_Y0.7721.00
150_Y269_F0.7721.00
159_S162_R0.7711.00
310_A314_A0.7711.00
23_A28_V0.7691.00
100_R104_D0.7671.00
53_D56_R0.7671.00
19_A115_V0.7661.00
133_W137_F0.7661.00
46_C100_R0.7631.00
49_L97_N0.7551.00
69_V103_F0.7551.00
169_H173_K0.7521.00
22_L297_R0.7511.00
177_I182_A0.7481.00
247_S251_T0.7461.00
161_V268_A0.7441.00
294_D298_S0.7431.00
11_L32_D0.7411.00
112_P116_E0.7381.00
104_D108_K0.7361.00
187_V191_S0.7361.00
31_L148_A0.7361.00
23_A112_P0.7351.00
256_S327_V0.7341.00
227_F235_S0.7341.00
126_I268_A0.7331.00
297_R301_L0.7321.00
22_L300_L0.7301.00
186_P189_F0.7281.00
264_G308_N0.7251.00
246_K250_C0.7251.00
314_A317_K0.7231.00
277_F292_S0.7231.00
278_I282_S0.7221.00
23_A116_E0.7221.00
282_S326_I0.7211.00
19_A111_I0.7191.00
26_M304_P0.7191.00
128_R266_D0.7191.00
303_Q310_A0.7111.00
54_A57_S0.7101.00
98_I103_F0.7091.00
167_P260_D0.7061.00
62_G65_L0.7041.00
5_D146_I0.7031.00
153_G159_S0.7021.00
59_I70_I0.7021.00
34_K42_F0.7001.00
176_A182_A0.6971.00
58_F290_L0.6961.00
79_K87_L0.6921.00
126_I161_V0.6921.00
192_C196_N0.6901.00
185_H189_F0.6901.00
179_Q214_F0.6881.00
170_Q173_K0.6861.00
317_K321_K0.6821.00
260_D270_L0.6811.00
263_C275_A0.6801.00
248_E252_V0.6801.00
167_P265_K0.6801.00
172_R177_I0.6731.00
17_A107_M0.6731.00
25_K297_R0.6701.00
172_R327_V0.6651.00
238_Q244_T0.6631.00
286_I289_A0.6591.00
186_P190_Y0.6531.00
11_L30_A0.6501.00
51_A287_S0.6491.00
306_K310_A0.6491.00
21_K57_S0.6491.00
150_Y300_L0.6481.00
153_G165_L0.6441.00
21_K294_D0.6421.00
230_L233_K0.6411.00
284_E288_Y0.6381.00
58_F65_L0.6371.00
286_I290_L0.6351.00
61_D65_L0.6341.00
36_Q42_F0.6331.00
288_Y322_L0.6301.00
28_V111_I0.6301.00
81_V87_L0.6291.00
281_S330_R0.6261.00
173_K178_Q0.6251.00
238_Q245_V0.6251.00
165_L265_K0.6251.00
193_I196_N0.6201.00
57_S61_D0.6191.00
162_R270_L0.6181.00
219_P222_D0.6151.00
134_H137_F0.6151.00
20_R23_A0.6141.00
227_F234_M0.6141.00
213_I217_A0.6131.00
16_S117_V0.6121.00
161_V164_H0.6121.00
132_K149_R0.6101.00
230_L235_S0.6061.00
66_P69_V0.6031.00
301_L305_E0.6031.00
16_S30_A0.6021.00
172_R176_A0.6011.00
240_Q243_K0.6001.00
53_D318_L0.5991.00
6_V18_L0.5991.00
55_Q59_I0.5961.00
111_I117_V0.5941.00
6_V150_Y0.5931.00
178_Q181_F0.5931.00
254_F257_R0.5911.00
319_R323_F0.5911.00
81_V86_S0.5881.00
227_F237_F0.5871.00
169_H172_R0.5851.00
291_D315_T0.5841.00
18_L297_R0.5821.00
324_G328_K0.5801.00
89_R93_R0.5781.00
208_K211_Y0.5751.00
79_K88_T0.5741.00
173_K182_A0.5741.00
122_L160_M0.5731.00
151_L268_A0.5721.00
259_Q263_C0.5711.00
284_E287_S0.5711.00
202_Y206_I0.5691.00
303_Q306_K0.5691.00
206_I215_G0.5681.00
239_F246_K0.5641.00
57_S60_R0.5631.00
169_H175_V0.5621.00
271_I293_T0.5581.00
229_T236_A0.5571.00
175_V180_W0.5571.00
218_Y222_D0.5571.00
183_E212_F0.5561.00
72_N98_I0.5551.00
171_I175_V0.5551.00
35_H119_H0.5541.00
291_D295_I0.5531.00
321_K324_G0.5521.00
155_D270_L0.5511.00
246_K252_V0.5491.00
83_V86_S0.5491.00
278_I326_I0.5491.00
99_N208_K0.5481.00
172_R175_V0.5451.00
269_F308_N0.5441.00
231_K236_A0.5431.00
74_Q94_S0.5421.00
152_V300_L0.5421.00
84_A87_L0.5421.00
69_V96_I0.5411.00
75_I78_V0.5411.00
44_K48_G0.5391.00
28_V114_S0.5391.00
282_S329_S0.5381.00
14_A152_V0.5381.00
198_I201_C0.5381.00
252_V255_P0.5381.00
21_K293_T0.5361.00
41_G104_D0.5341.00
121_S138_R0.5341.00
279_S282_S0.5321.00
132_K135_V0.5321.00
149_R304_P0.5321.00
243_K247_S0.5311.00
59_I93_R0.5301.00
229_T237_F0.5301.00
276_G315_T0.5301.00
149_R267_N0.5291.00
295_I311_Y0.5281.00
306_K309_T0.5281.00
174_Y177_I0.5261.00
153_G160_M0.5251.00
59_I67_V0.5241.00
79_K82_D0.5231.00
123_C137_F0.5221.00
151_L267_N0.5211.00
65_L69_V0.5191.00
31_L135_V0.5181.00
172_R178_Q0.5171.00
150_Y304_P0.5151.00
263_C316_R0.5151.00
202_Y207_S0.5151.00
18_L300_L0.5141.00
166_Y260_D0.5141.00
20_R115_V0.5131.00
288_Y319_R0.5111.00
289_A293_T0.5101.00
99_N211_Y0.5081.00
298_S302_K0.5081.00
201_C233_K0.5061.00
238_Q243_K0.5051.00
227_F236_A0.5051.00
173_K180_W0.5041.00
174_Y181_F0.5021.00
256_S259_Q0.5011.00
325_K329_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pn0A 3 0.9689 100 0.339 Contact Map
2qa1A 2 0.9576 100 0.348 Contact Map
2qa2A 2 0.9605 100 0.35 Contact Map
2dkhA 2 0.9124 100 0.355 Contact Map
4k5sA 2 0.9633 100 0.366 Contact Map
4n9xA 5 0.9266 100 0.369 Contact Map
4k22A 4 0.9124 100 0.371 Contact Map
4k2xA 2 0.9492 100 0.377 Contact Map
2x3nA 1 0.9266 100 0.378 Contact Map
4bjzA 2 0.9746 100 0.385 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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