GREMLIN Database
PTXC - Putative permease IIC component GlvC
UniProt: P31452 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11710
Length: 368 (344)
Sequences: 1792 (887)
Seq/√Len: 47.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_V92_M5.5751.00
94_S179_A4.8941.00
61_W65_R4.2541.00
295_M311_L4.2321.00
303_N306_K4.2231.00
292_S327_L3.9131.00
23_G361_N3.8411.00
160_K174_Y3.5931.00
341_V345_L3.5681.00
149_I186_C3.4291.00
340_A344_V3.3111.00
220_T350_S3.2321.00
223_E276_G3.1111.00
293_L297_F3.0331.00
285_I319_M3.0311.00
351_T355_L2.7711.00
150_V179_A2.7551.00
146_I183_M2.7151.00
11_A79_L2.5961.00
67_M140_I2.5481.00
221_F343_A2.5081.00
222_L235_I2.4901.00
13_F233_H2.4351.00
160_K170_Q2.4281.00
296_Y308_A2.4181.00
29_A60_G2.3591.00
221_F340_A2.3411.00
288_A291_I2.3091.00
308_A312_I2.2641.00
148_G152_A2.2351.00
332_L339_F2.2311.00
181_L185_P2.2271.00
146_I186_C2.2251.00
174_Y178_I2.2211.00
69_L92_M2.1561.00
242_G245_A2.1461.00
153_L182_V2.0871.00
353_M358_V2.0451.00
307_V311_L2.0271.00
92_M96_L2.0110.99
213_A355_L2.0010.99
82_Q154_H1.9940.99
279_L346_A1.9700.99
178_I182_V1.9660.99
225_I343_A1.9300.99
157_L178_I1.9240.99
296_Y304_R1.9060.99
94_S146_I1.8990.99
305_V308_A1.8930.99
48_L52_I1.8490.99
213_A351_T1.8470.99
161_K164_V1.8200.99
297_F304_R1.7820.99
149_I182_V1.7600.99
320_L367_I1.7520.99
257_H260_E1.7520.99
295_M307_V1.7050.98
296_Y311_L1.6930.98
301_P304_R1.6720.98
258_L263_L1.6170.98
292_S311_L1.6160.97
254_W261_F1.5970.97
23_G317_T1.5830.97
21_F180_F1.5740.97
295_M298_T1.5680.97
30_I57_E1.5680.97
188_W192_L1.5660.97
77_I88_C1.5620.97
79_L148_G1.5610.97
257_H261_F1.5320.97
221_F225_I1.5290.96
94_S183_M1.5120.96
291_I295_M1.5050.96
46_N49_F1.4850.96
153_L178_I1.4780.96
319_M366_L1.4670.96
279_L287_G1.4400.95
240_I363_G1.4380.95
146_I150_V1.4250.95
221_F344_V1.4230.95
278_A349_M1.4180.95
266_E269_K1.4130.95
24_I28_L1.4120.94
26_V64_F1.4100.94
127_L134_K1.3950.94
98_W190_T1.3920.94
297_F301_P1.3790.94
214_L218_V1.3710.94
288_A327_L1.3570.93
223_E346_A1.3550.93
200_G203_S1.3500.93
337_L340_A1.3480.93
153_L174_Y1.3360.93
352_V355_L1.3270.92
314_A318_A1.3140.92
207_F211_A1.2890.91
260_E266_E1.2870.91
272_F275_G1.2830.91
58_E104_A1.2790.91
112_Y134_K1.2700.91
130_M133_I1.2700.91
248_G265_A1.2690.91
5_I8_F1.2690.91
219_Y274_E1.2630.90
204_L207_F1.2630.90
312_I315_T1.2570.90
256_Q260_E1.2560.90
247_E251_Q1.2550.90
94_S150_V1.2520.90
149_I183_M1.2500.90
103_N107_M1.2410.90
212_G215_G1.2350.89
216_V354_Y1.2290.89
4_Q8_F1.2250.89
246_V260_E1.2240.89
328_E331_F1.2210.89
76_P151_T1.2160.89
14_T77_I1.2150.89
76_P91_V1.1950.88
216_V271_L1.1840.87
261_F265_A1.1820.87
298_T304_R1.1820.87
287_G342_H1.1740.87
246_V251_Q1.1540.86
278_A353_M1.1510.86
348_S352_V1.1430.85
128_T137_D1.1350.85
146_I153_L1.1330.85
221_F347_A1.1300.85
217_W221_F1.0920.83
217_W348_S1.0870.82
95_F99_N1.0730.82
205_Q245_A1.0660.81
223_E350_S1.0630.81
160_K178_I1.0610.81
167_G323_I1.0600.81
185_P189_L1.0540.80
240_I362_M1.0490.80
284_K364_G1.0380.79
254_W260_E1.0360.79
260_E267_P1.0310.79
251_Q254_W1.0300.79
248_G251_Q1.0250.78
157_L160_K1.0250.78
82_Q159_D1.0240.78
293_L296_Y1.0140.78
229_T332_L1.0090.77
206_A210_S1.0030.77
278_A284_K0.9980.77
291_I342_H0.9970.76
225_I340_A0.9970.76
98_W142_G0.9900.76
145_I218_V0.9870.76
194_W336_P0.9850.76
254_W257_H0.9840.76
217_W351_T0.9810.75
199_M203_S0.9800.75
28_L32_L0.9770.75
273_P278_A0.9760.75
157_L174_Y0.9760.75
350_S364_G0.9740.75
44_D47_S0.9710.75
248_G252_M0.9670.74
284_K318_A0.9630.74
293_L298_T0.9610.74
299_A304_R0.9600.74
45_P50_A0.9580.74
98_W146_I0.9560.73
21_F181_L0.9550.73
17_L168_I0.9520.73
85_G290_G0.9480.73
260_E265_A0.9400.72
220_T347_A0.9360.72
254_W263_L0.9350.72
227_I284_K0.9350.72
310_L314_A0.9340.72
33_Q46_N0.9320.71
58_E61_W0.9320.71
64_F323_I0.9260.71
296_Y312_I0.9250.71
113_F127_L0.9240.71
154_H270_S0.9230.71
54_H57_E0.9190.70
141_I192_L0.9170.70
288_A314_A0.9160.70
149_I152_A0.9160.70
12_M172_T0.9100.70
174_Y217_W0.9090.70
216_V359_V0.9080.69
47_S50_A0.9080.69
324_T328_E0.9080.69
304_R308_A0.9040.69
285_I292_S0.9020.69
33_Q57_E0.8990.69
138_T142_G0.8870.68
145_I190_T0.8780.67
33_Q53_V0.8750.67
254_W259_Q0.8750.67
130_M134_K0.8720.66
213_A354_Y0.8720.66
73_V88_C0.8680.66
87_A155_N0.8670.66
6_Q9_G0.8600.65
170_Q174_Y0.8590.65
360_G368_D0.8570.65
163_P169_F0.8560.65
112_Y127_L0.8530.65
145_I186_C0.8470.64
189_L192_L0.8440.64
175_V178_I0.8440.64
68_P297_F0.8420.64
182_V186_C0.8350.63
288_A318_A0.8330.63
265_A269_K0.8310.63
309_G327_L0.8290.62
4_Q152_A0.8260.62
240_I284_K0.8250.62
6_Q78_G0.8220.62
246_V266_E0.8210.62
339_F342_H0.8200.62
337_L341_V0.8160.61
252_M258_L0.8110.61
131_A134_K0.8080.60
140_I143_A0.8080.60
26_V367_I0.8060.60
285_I342_H0.8050.60
179_A327_L0.7940.59
287_G291_I0.7940.59
138_T194_W0.7940.59
52_I341_V0.7920.59
301_P305_V0.7910.59
102_I138_T0.7860.58
18_L93_V0.7840.58
219_Y339_F0.7820.58
157_L320_L0.7820.58
182_V189_L0.7760.57
276_G339_F0.7750.57
293_L301_P0.7750.57
173_S176_V0.7750.57
249_G273_P0.7730.57
156_R182_V0.7720.57
252_M261_F0.7720.57
345_L348_S0.7720.57
72_A143_A0.7710.57
95_F142_G0.7670.56
26_V61_W0.7660.56
150_V178_I0.7660.56
315_T319_M0.7640.56
45_P49_F0.7640.56
256_Q261_F0.7630.56
260_E269_K0.7620.56
247_E253_Y0.7610.56
99_N133_I0.7610.56
292_S315_T0.7570.55
76_P87_A0.7570.55
186_C193_G0.7540.55
225_I353_M0.7520.55
101_F187_A0.7490.55
7_R155_N0.7480.54
17_L176_V0.7430.54
2_L8_F0.7420.54
133_I136_L0.7390.54
240_I272_F0.7390.54
227_I332_L0.7350.53
288_A342_H0.7350.53
327_L330_T0.7340.53
257_H265_A0.7340.53
250_I253_Y0.7320.53
140_I145_I0.7290.53
353_M357_G0.7260.52
195_P233_H0.7230.52
264_S267_P0.7180.51
110_G133_I0.7170.51
69_L131_A0.7170.51
20_P224_R0.7150.51
258_L261_F0.7150.51
163_P166_L0.7130.51
151_T155_N0.7130.51
90_A317_T0.7110.51
317_T330_T0.7100.51
253_Y257_H0.7090.51
189_L193_G0.7020.50
127_L131_A0.7010.50
328_E342_H0.7000.50
299_A311_L0.6990.50
105_M191_L0.6990.50
194_W197_V0.6960.49
183_M186_C0.6950.49
311_L330_T0.6950.49
149_I153_L0.6950.49
54_H58_E0.6950.49
150_V153_L0.6950.49
252_M255_A0.6930.49
81_K344_V0.6920.49
27_G31_L0.6900.49
221_F229_T0.6860.48
30_I34_N0.6860.48
68_P140_I0.6850.48
127_L130_M0.6830.48
96_L131_A0.6830.48
218_V237_G0.6830.48
225_I276_G0.6830.48
27_G30_I0.6800.48
279_L349_M0.6780.47
32_L53_V0.6750.47
183_M187_A0.6750.47
59_G101_F0.6720.47
247_E250_I0.6720.47
207_F218_V0.6720.47
334_I337_L0.6680.46
289_V292_S0.6670.46
186_C190_T0.6670.46
58_E65_R0.6640.46
223_E279_L0.6630.46
290_G318_A0.6580.45
156_R213_A0.6580.45
244_A260_E0.6560.45
132_G135_T0.6560.45
74_G277_F0.6530.45
49_F53_V0.6530.45
99_N102_I0.6530.45
88_C91_V0.6520.45
75_L148_G0.6520.45
240_I364_G0.6510.45
97_T180_F0.6510.45
130_M136_L0.6490.45
153_L183_M0.6480.45
50_A54_H0.6480.45
66_N96_L0.6460.44
240_I277_F0.6420.44
223_E235_I0.6400.44
321_V365_G0.6400.44
251_Q256_Q0.6400.44
246_V269_K0.6380.44
273_P277_F0.6380.44
293_L308_A0.6370.43
106_G127_L0.6360.43
44_D49_F0.6340.43
20_P313_P0.6310.43
142_G194_W0.6310.43
84_Q154_H0.6290.43
76_P80_A0.6280.43
106_G110_G0.6270.42
295_M327_L0.6270.42
153_L157_L0.6270.42
208_L234_F0.6260.42
191_L195_P0.6260.42
33_Q47_S0.6250.42
211_A218_V0.6250.42
76_P88_C0.6250.42
154_H172_T0.6240.42
2_L297_F0.6220.42
224_R324_T0.6220.42
23_G224_R0.6220.42
229_T349_M0.6200.42
254_W258_L0.6190.42
165_F316_L0.6190.42
202_E206_A0.6180.42
51_Q108_T0.6180.42
82_Q87_A0.6170.41
161_K170_Q0.6160.41
207_F210_S0.6160.41
235_I238_Q0.6160.41
129_M134_K0.6150.41
310_L334_I0.6150.41
237_G241_F0.6150.41
74_G144_I0.6130.41
284_K349_M0.6130.41
203_S206_A0.6130.41
139_S242_G0.6130.41
219_Y240_I0.6120.41
219_Y235_I0.6120.41
263_L266_E0.6110.41
208_L271_L0.6100.41
295_M302_E0.6100.41
181_L315_T0.6090.41
93_V180_F0.6070.40
21_F311_L0.6070.40
276_G364_G0.6050.40
168_I176_V0.6030.40
31_L59_G0.6030.40
180_F183_M0.6030.40
273_P284_K0.5990.40
172_T290_G0.5990.40
192_L305_V0.5980.40
194_W198_Q0.5980.40
29_A57_E0.5980.40
193_G196_K0.5970.40
80_A215_G0.5960.39
113_F129_M0.5960.39
141_I145_I0.5960.39
74_G89_L0.5950.39
17_L240_I0.5950.39
33_Q50_A0.5950.39
246_V267_P0.5950.39
351_T358_V0.5940.39
181_L184_I0.5940.39
299_A307_V0.5930.39
276_G350_S0.5920.39
29_A53_V0.5920.39
214_L344_V0.5900.39
294_A299_A0.5890.39
217_W347_A0.5880.39
152_A157_L0.5880.39
330_T334_I0.5880.39
311_L334_I0.5870.39
352_V356_F0.5860.38
48_L51_Q0.5860.38
349_M353_M0.5840.38
20_P25_V0.5830.38
249_G254_W0.5830.38
247_E252_M0.5830.38
290_G293_L0.5820.38
203_S207_F0.5820.38
263_L273_P0.5810.38
152_A156_R0.5800.38
80_A301_P0.5790.38
28_L152_A0.5780.38
277_F284_K0.5780.38
135_T142_G0.5760.38
9_G12_M0.5750.37
276_G279_L0.5730.37
143_A147_S0.5730.37
98_W183_M0.5720.37
152_A188_W0.5710.37
9_G78_G0.5710.37
166_L178_I0.5710.37
277_F286_F0.5700.37
244_A269_K0.5690.37
20_P277_F0.5690.37
200_G204_L0.5680.37
99_N136_L0.5670.37
192_L196_K0.5650.37
132_G136_L0.5630.36
240_I278_A0.5630.36
77_I84_Q0.5620.36
24_I237_G0.5620.36
256_Q265_A0.5620.36
201_I216_V0.5620.36
246_V249_G0.5610.36
107_M200_G0.5610.36
246_V265_A0.5610.36
188_W191_L0.5610.36
191_L209_R0.5610.36
78_G239_F0.5590.36
219_Y239_F0.5560.36
23_G309_G0.5540.35
13_F173_S0.5530.35
72_A288_A0.5520.35
258_L273_P0.5520.35
285_I315_T0.5510.35
79_L198_Q0.5490.35
177_I180_F0.5490.35
173_S275_G0.5480.35
16_V30_I0.5470.35
32_L91_V0.5470.35
16_V170_Q0.5450.35
150_V183_M0.5440.35
225_I332_L0.5430.34
166_L362_M0.5430.34
275_G365_G0.5420.34
227_I346_A0.5420.34
272_F279_L0.5410.34
58_E101_F0.5400.34
250_I254_W0.5400.34
182_V304_R0.5370.34
20_P78_G0.5350.34
94_S178_I0.5330.34
10_G80_A0.5330.34
176_V321_V0.5320.33
81_K88_C0.5320.33
98_W187_A0.5320.33
136_L198_Q0.5320.33
306_K314_A0.5310.33
234_F272_F0.5290.33
60_G287_G0.5280.33
212_G234_F0.5280.33
23_G99_N0.5260.33
361_N364_G0.5260.33
166_L181_L0.5250.33
142_G187_A0.5240.33
256_Q259_Q0.5230.33
317_T367_I0.5230.33
284_K287_G0.5230.33
146_I191_L0.5230.33
13_F17_L0.5210.33
182_V185_P0.5210.33
160_K175_V0.5190.32
33_Q60_G0.5190.32
146_I178_I0.5180.32
23_G64_F0.5180.32
77_I81_K0.5180.32
244_A266_E0.5160.32
10_G56_I0.5150.32
198_Q272_F0.5140.32
252_M259_Q0.5130.32
128_T131_A0.5130.32
6_Q10_G0.5110.32
22_A321_V0.5100.32
95_F197_V0.5100.32
102_I191_L0.5100.32
3_S199_M0.5090.31
290_G297_F0.5080.31
87_A316_L0.5070.31
85_G363_G0.5070.31
75_L164_V0.5060.31
246_V250_I0.5060.31
223_E343_A0.5050.31
222_L347_A0.5050.31
270_S273_P0.5040.31
276_G343_A0.5030.31
205_Q244_A0.5030.31
214_L340_A0.5030.31
238_Q243_P0.5030.31
69_L300_A0.5010.31
3_S196_K0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qnqA 2 0.8995 100 0.673 Contact Map
4b19A 1 0.0815 7.3 0.98 Contact Map
2micA 2 0.1114 4.9 0.982 Contact Map
2z34C 1 0.0571 4.2 0.982 Contact Map
3fhtA 1 0.1304 3.5 0.983 Contact Map
3fmpB 1 0 3.3 0.983 Contact Map
2bf1A 1 0.1739 3.3 0.983 Contact Map
4c48C 1 0.1223 3.2 0.983 Contact Map
2mvhA 1 0.0489 2.7 0.984 Contact Map
2kv5A 1 0.0897 2.7 0.984 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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