GREMLIN Database
GLVG - Putative inactive 6-phospho-alpha-glucosidase
UniProt: P31450 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11708
Length: 212 (202)
Sequences: 1615 (832)
Seq/√Len: 58.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_E135_K5.1661.00
71_P132_Y4.3031.00
75_F137_S3.7291.00
133_M142_M3.6191.00
49_A67_Y3.4561.00
72_E132_Y3.1581.00
134_E160_R3.0801.00
49_A53_K3.0701.00
34_A66_S3.0251.00
133_M163_A2.9331.00
34_A64_A2.8071.00
5_S36_K2.7541.00
70_D73_V2.5551.00
36_K66_S2.3761.00
123_I155_A2.2911.00
141_W164_K2.2891.00
130_V156_T2.2581.00
105_V113_P2.2541.00
187_D190_Q2.2521.00
87_V125_G2.2241.00
133_M137_S2.1821.00
73_V76_S2.1411.00
46_E49_A2.1061.00
131_D134_E2.0861.00
66_S73_V2.0501.00
134_E162_N2.0001.00
46_E50_E1.9811.00
72_E136_Y1.9571.00
128_E131_D1.9501.00
127_L155_A1.8851.00
194_R206_S1.8611.00
36_K68_T1.7600.99
123_I151_I1.7340.99
7_V78_V1.7310.99
12_G39_D1.6480.99
5_S34_A1.6440.99
196_Y205_I1.6440.99
56_L65_F1.6220.99
122_S125_G1.6050.99
83_A126_V1.5660.98
42_G46_E1.5580.98
139_N164_K1.5260.98
68_T74_A1.5110.98
91_P94_E1.5050.98
94_E98_K1.5000.98
86_R93_R1.4450.97
50_E53_K1.3920.97
56_L63_I1.3810.97
97_E107_G1.3730.96
7_V75_F1.3660.96
81_V133_M1.3410.96
93_R107_G1.3400.96
156_T165_I1.3380.96
85_I129_L1.3230.96
130_V133_M1.3220.96
53_K57_K1.3200.95
126_V156_T1.3150.95
154_E158_R1.3140.95
20_V35_L1.3140.95
100_P103_H1.2960.95
126_V152_V1.2880.95
119_G123_I1.2720.94
96_D121_R1.2590.94
79_D139_N1.2460.94
195_Y204_A1.2360.94
192_R208_S1.2330.94
92_M95_L1.2060.93
16_T84_H1.2010.93
7_V36_K1.2000.93
6_V30_F1.1820.92
132_Y136_Y1.1670.91
22_M170_D1.1640.91
38_Y74_A1.1620.91
93_R97_E1.1610.91
81_V140_A1.1260.90
176_E193_V1.1260.90
160_R163_A1.1210.90
41_D89_K1.1140.89
111_C201_W1.1100.89
115_G121_R1.0880.88
76_S136_Y1.0850.88
42_G69_T1.0790.88
46_E67_Y1.0710.88
131_D160_R1.0550.87
195_Y202_W1.0490.86
9_A129_L1.0440.86
19_I84_H1.0410.86
100_P117_A1.0030.84
52_C65_F0.9990.84
7_V38_Y0.9960.83
125_G128_E0.9910.83
17_P109_E0.9890.83
75_F136_Y0.9820.83
71_P75_F0.9760.82
150_A201_W0.9640.81
85_I149_A0.9580.81
9_A142_M0.9490.80
45_Q67_Y0.9490.80
169_C200_H0.9460.80
175_I202_W0.9410.80
145_Y150_A0.9380.80
131_D159_L0.9360.79
149_A172_P0.9350.79
177_S188_R0.9320.79
96_D115_G0.9320.79
127_L159_L0.9320.79
176_E204_A0.9310.79
110_T115_G0.9290.79
86_R97_E0.9290.79
184_G187_D0.9240.79
119_G155_A0.9120.78
130_V162_N0.9070.77
152_V155_A0.8980.77
131_D135_K0.8980.77
33_R64_A0.8970.76
24_L56_L0.8930.76
6_V23_L0.8930.76
109_E118_Y0.8900.76
23_L35_L0.8840.75
174_G178_R0.8790.75
100_P114_G0.8730.74
91_P95_L0.8710.74
77_D139_N0.8660.74
95_L99_I0.8620.74
15_F84_H0.8600.73
194_R205_I0.8580.73
111_C151_I0.8550.73
35_L63_I0.8520.73
153_A167_N0.8510.73
43_A46_E0.8500.72
56_L61_P0.8400.72
109_E198_L0.8380.71
86_R118_Y0.8360.71
37_F52_C0.8340.71
97_E108_Q0.8290.71
185_L190_Q0.8240.70
13_S18_G0.8120.69
193_V204_A0.8080.69
179_M207_R0.8080.69
128_E132_Y0.8030.68
9_A75_F0.8020.68
53_K183_V0.8010.68
110_T151_I0.7970.68
171_M202_W0.7920.67
127_L131_D0.7920.67
117_A137_S0.7900.67
113_P157_R0.7890.67
157_R165_I0.7860.66
53_K73_V0.7840.66
142_M163_A0.7830.66
192_R206_S0.7820.66
171_M175_I0.7730.65
180_A203_S0.7710.65
8_V82_M0.7600.64
5_S78_V0.7600.64
48_I52_C0.7520.63
52_C56_L0.7460.62
78_V137_S0.7410.62
71_P128_E0.7400.62
65_F173_I0.7360.61
110_T121_R0.7310.61
57_K191_M0.7270.60
107_G114_G0.7270.60
176_E188_R0.7200.60
55_I59_K0.7150.59
45_Q69_T0.7130.59
66_S135_K0.7120.59
134_E163_A0.7090.58
55_I140_A0.7080.58
97_E109_E0.7060.58
53_K139_N0.7030.58
82_M164_K0.6970.57
106_V109_E0.6910.57
75_F132_Y0.6900.56
86_R107_G0.6870.56
14_T90_Y0.6770.55
12_G40_N0.6740.55
169_C199_N0.6680.54
38_Y75_F0.6670.54
16_T19_I0.6660.54
68_T73_V0.6650.54
183_V207_R0.6640.54
18_G145_Y0.6620.53
119_G151_I0.6610.53
87_V122_S0.6610.53
75_F81_V0.6590.53
150_A172_P0.6580.53
44_R93_R0.6560.53
122_S152_V0.6550.53
42_G135_K0.6530.52
83_A146_S0.6520.52
78_V81_V0.6520.52
24_L90_Y0.6500.52
18_G170_D0.6450.51
147_N199_N0.6440.51
69_T73_V0.6430.51
149_A170_D0.6400.51
180_A185_L0.6400.51
118_Y122_S0.6390.51
149_A171_M0.6380.51
91_P131_D0.6360.50
97_E106_V0.6320.50
109_E149_A0.6290.50
112_G121_R0.6270.49
17_P51_A0.6260.49
180_A191_M0.6260.49
18_G21_L0.6210.49
143_L166_L0.6200.49
76_S131_D0.6190.49
15_F90_Y0.6160.48
181_Q189_K0.6150.48
53_K66_S0.6140.48
53_K64_A0.6090.47
83_A165_I0.6050.47
109_E145_Y0.6040.47
131_D162_N0.6030.47
4_F33_R0.6010.47
137_S163_A0.6010.47
26_N29_R0.5970.46
94_E113_P0.5940.46
53_K67_Y0.5930.46
18_G22_M0.5920.46
9_A40_N0.5920.46
197_G200_H0.5910.45
28_D31_P0.5900.45
95_L102_R0.5900.45
9_A71_P0.5900.45
4_F24_L0.5890.45
52_C84_H0.5880.45
176_E191_M0.5860.45
108_Q153_A0.5760.44
96_D112_G0.5720.43
17_P201_W0.5720.43
8_V20_V0.5710.43
9_A38_Y0.5710.43
99_I103_H0.5680.43
116_I119_G0.5640.43
56_L62_D0.5630.42
51_A58_E0.5630.42
6_V104_G0.5630.42
93_R109_E0.5620.42
111_C117_A0.5620.42
48_I67_Y0.5620.42
39_D108_Q0.5610.42
160_R201_W0.5590.42
141_W195_Y0.5560.42
131_D163_A0.5530.41
103_H113_P0.5530.41
88_G92_M0.5530.41
153_A165_I0.5530.41
113_P166_L0.5500.41
80_F143_L0.5480.41
93_R106_V0.5470.41
147_N200_H0.5460.41
141_W166_L0.5430.40
20_V56_L0.5420.40
93_R108_Q0.5420.40
87_V114_G0.5420.40
96_D114_G0.5420.40
100_P113_P0.5410.40
147_N169_C0.5400.40
109_E172_P0.5380.40
86_R101_L0.5370.40
50_E67_Y0.5330.39
11_G168_I0.5330.39
128_E135_K0.5320.39
110_T118_Y0.5300.39
112_G146_S0.5250.38
14_T18_G0.5240.38
8_V89_K0.5240.38
123_I144_N0.5230.38
89_K146_S0.5230.38
174_G177_S0.5220.38
98_K102_R0.5220.38
93_R110_T0.5200.38
11_G52_C0.5200.38
11_G49_A0.5190.38
97_E172_P0.5180.38
83_A133_M0.5170.38
46_E128_E0.5170.38
117_A205_I0.5160.37
142_M156_T0.5160.37
20_V52_C0.5160.37
85_I125_G0.5140.37
121_R145_Y0.5130.37
23_L52_C0.5130.37
92_M125_G0.5130.37
29_R181_Q0.5130.37
88_G115_G0.5130.37
49_A65_F0.5110.37
114_G121_R0.5110.37
188_R191_M0.5100.37
184_G192_R0.5090.37
7_V81_V0.5090.37
191_M207_R0.5080.37
175_I207_R0.5080.37
51_A116_I0.5080.37
10_G13_S0.5070.37
191_M204_A0.5040.36
17_P97_E0.5040.36
17_P107_G0.5030.36
24_L116_I0.5020.36
178_R182_I0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1u8xX 1 0.9858 100 0.387 Contact Map
1obbA 2 0.967 100 0.398 Contact Map
1up7A 3 0.967 100 0.4 Contact Map
1s6yA 1 0.9811 100 0.401 Contact Map
3u95A 2 0.9623 100 0.44 Contact Map
3fefA 3 0.967 100 0.454 Contact Map
1pzgA 4 0.8962 100 0.631 Contact Map
4plzA 4 0.8208 100 0.648 Contact Map
4rorA 4 0.8585 100 0.656 Contact Map
2hjrA 4 0.8491 100 0.658 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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