GREMLIN Database
YIDK - Uncharacterized symporter YidK
UniProt: P31448 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11706
Length: 571 (469)
Sequences: 11238 (7114)
Seq/√Len: 328.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
442_I474_V6.1171.00
370_E373_Q4.3951.00
431_I475_M4.0301.00
274_S277_E3.9571.00
366_N373_Q3.9301.00
18_V22_W3.6231.00
442_I470_I3.4191.00
219_Q222_E3.3531.00
175_I386_A3.3351.00
438_V478_I3.2491.00
476_L480_F3.2001.00
208_G302_I3.1921.00
439_A475_M3.1721.00
361_Y369_A3.1561.00
446_S470_I3.1511.00
478_I482_K3.1091.00
206_V210_I3.1021.00
474_V478_I3.0921.00
432_P482_K3.0301.00
372_Q376_T2.9571.00
435_A479_G2.8491.00
434_L482_K2.7811.00
424_M475_M2.6731.00
110_E118_R2.6731.00
162_A165_L2.6631.00
376_T380_K2.6481.00
171_G390_V2.5921.00
303_A316_A2.5091.00
11_G15_L2.4981.00
183_L271_A2.4271.00
33_Q40_R2.4131.00
42_L187_A2.4001.00
380_K384_F2.3441.00
438_V474_V2.2831.00
273_K277_E2.2211.00
108_F425_G2.1901.00
432_P435_A2.1891.00
66_G314_D2.1341.00
34_G39_G2.1021.00
369_A373_Q2.0981.00
219_Q223_Q2.0711.00
222_E226_T2.0561.00
421_I436_A2.0471.00
434_L438_V2.0421.00
113_Y431_I2.0381.00
168_I172_L2.0311.00
428_F431_I2.0251.00
14_L18_V1.9981.00
58_T140_S1.9831.00
445_I449_T1.9661.00
387_I391_L1.9651.00
435_A478_I1.9451.00
432_P479_G1.9431.00
200_G336_V1.9251.00
202_L206_V1.8921.00
358_M362_R1.8861.00
473_V477_V1.8561.00
356_F381_F1.8471.00
222_E225_T1.8411.00
12_F16_V1.8331.00
361_Y377_V1.8311.00
424_M472_V1.8191.00
428_F480_F1.8161.00
430_R480_F1.7921.00
181_G185_A1.7851.00
307_Y323_N1.7811.00
233_N236_G1.7811.00
366_N369_A1.7701.00
46_V191_S1.7691.00
428_F476_L1.7581.00
37_L40_R1.7581.00
376_T379_R1.7521.00
102_I111_E1.7431.00
276_A280_K1.7391.00
362_R374_L1.7261.00
276_A279_Q1.7251.00
277_E280_K1.7211.00
19_I192_I1.7211.00
435_A439_A1.6951.00
361_Y366_N1.6911.00
110_E115_K1.6851.00
174_G345_F1.6851.00
228_H231_K1.6661.00
356_F360_I1.6451.00
230_E233_N1.6351.00
430_R483_P1.6271.00
319_T323_N1.6191.00
231_K235_I1.6151.00
438_V442_I1.6061.00
331_G335_A1.5961.00
6_I10_V1.5781.00
190_D268_R1.5441.00
107_D359_G1.5391.00
217_F221_I1.5231.00
44_A277_E1.5191.00
49_A191_S1.5161.00
164_W394_P1.5081.00
373_Q376_T1.4821.00
218_M222_E1.4711.00
15_L19_I1.4711.00
120_I437_K1.4661.00
349_L386_A1.4631.00
47_I272_S1.4631.00
172_L176_L1.4581.00
432_P483_P1.4481.00
142_A167_V1.4451.00
223_Q226_T1.4381.00
93_F423_I1.4331.00
442_I446_S1.4291.00
221_I224_L1.4271.00
116_T437_K1.4211.00
231_K234_S1.4181.00
112_R425_G1.4141.00
361_Y373_Q1.4121.00
469_C473_V1.4111.00
114_D433_A1.4021.00
352_A385_I1.3921.00
218_M221_I1.3851.00
123_F360_I1.3851.00
143_L312_K1.3841.00
16_V192_I1.3751.00
365_I369_A1.3701.00
167_V390_V1.3441.00
10_V14_L1.3331.00
369_A374_L1.3311.00
31_S34_G1.3131.00
124_C444_I1.3121.00
171_G386_A1.3081.00
107_D358_M1.2921.00
446_S474_V1.2891.00
110_E363_R1.2881.00
165_L169_L1.2831.00
141_G170_L1.2811.00
36_F378_G1.2741.00
118_R359_G1.2551.00
174_G342_I1.2401.00
5_Q328_P1.2381.00
375_V379_R1.2381.00
470_I474_V1.2351.00
356_F361_Y1.2301.00
189_A346_N1.2291.00
54_T347_G1.2251.00
108_F112_R1.2231.00
220_G224_L1.2211.00
50_S347_G1.2191.00
165_L168_I1.2171.00
434_L478_I1.2151.00
38_A183_L1.2141.00
104_T354_T1.2111.00
15_L192_I1.2091.00
190_D346_N1.2071.00
123_F127_I1.2041.00
22_W26_K1.2021.00
373_Q377_V1.2011.00
168_I390_V1.1951.00
99_K275_L1.1891.00
430_R484_R1.1891.00
138_L171_G1.1871.00
115_K119_I1.1871.00
449_T453_L1.1861.00
117_T437_K1.1811.00
432_P478_I1.1681.00
164_W168_I1.1661.00
27_T34_G1.1581.00
168_I394_P1.1571.00
68_A75_V1.1551.00
48_A284_L1.1501.00
76_M80_V1.1471.00
221_I225_T1.1431.00
177_Y342_I1.1421.00
469_C472_V1.1401.00
232_L236_G1.1391.00
310_L313_A1.1371.00
234_S237_G1.1331.00
472_V476_L1.1251.00
7_L11_G1.1241.00
199_I203_M1.1231.00
38_A42_L1.1181.00
433_A437_K1.1171.00
378_G382_G1.1131.00
195_I199_I1.1111.00
229_A232_L1.1081.00
146_N163_I1.1031.00
117_T436_A1.1021.00
174_G346_N1.1001.00
211_A306_L1.0991.00
193_N346_N1.0981.00
431_I479_G1.0931.00
161_A166_L1.0881.00
357_S378_G1.0801.00
119_I364_I1.0801.00
439_A443_G1.0781.00
431_I435_A1.0781.00
220_G223_Q1.0741.00
470_I473_V1.0721.00
33_Q101_G1.0701.00
7_L10_V1.0681.00
134_L389_S1.0631.00
474_V477_V1.0621.00
121_I440_M1.0571.00
116_T433_A1.0561.00
430_R485_A1.0541.00
357_S377_V1.0471.00
179_V383_F1.0441.00
424_M431_I1.0441.00
120_I440_M1.0411.00
12_F342_I1.0401.00
138_L167_V1.0391.00
235_I238_P1.0391.00
425_G436_A1.0371.00
381_F384_F1.0371.00
17_A20_T1.0321.00
149_F160_G1.0311.00
361_Y365_I1.0301.00
417_P471_N1.0271.00
120_I441_G1.0231.00
244_I247_A1.0231.00
439_A471_N1.0181.00
321_V333_F1.0171.00
434_L481_I1.0141.00
203_M207_F1.0131.00
371_P374_L1.0121.00
377_V381_F1.0111.00
44_A48_A1.0101.00
190_D347_G1.0091.00
225_T229_A1.0091.00
421_I440_M1.0081.00
464_L468_F1.0011.00
52_M288_L1.0011.00
109_L117_T0.9951.00
212_M220_G0.9921.00
54_T190_D0.9901.00
15_L18_V0.9881.00
124_C440_M0.9821.00
88_F92_I0.9821.00
115_K363_R0.9811.00
126_L356_F0.9781.00
486_T489_T0.9721.00
428_F479_G0.9631.00
214_K219_Q0.9601.00
228_H235_I0.9601.00
177_Y346_N0.9591.00
36_F354_T0.9571.00
205_P295_V0.9541.00
318_P321_V0.9511.00
424_M476_L0.9471.00
203_M329_M0.9461.00
98_L275_L0.9381.00
223_Q305_H0.9371.00
113_Y475_M0.9351.00
146_N160_G0.9311.00
484_R490_F0.9311.00
220_G302_I0.9291.00
443_G447_Y0.9281.00
207_F211_A0.9271.00
21_W25_R0.9261.00
100_R111_E0.9241.00
356_F385_I0.9241.00
350_N353_S0.9221.00
17_A21_W0.9191.00
112_R428_F0.9181.00
57_S133_F0.9181.00
50_S53_L0.9171.00
201_G296_L0.9151.00
302_I306_L0.9141.00
193_N339_G0.9141.00
487_P490_F0.9131.00
443_G471_N0.9071.00
126_L352_A0.9051.00
81_T85_T0.9041.00
83_A290_M0.9041.00
214_K217_F0.9041.00
312_K315_M0.9031.00
369_A377_V0.9031.00
53_L268_R0.8981.00
403_L406_W0.8951.00
449_T452_Y0.8941.00
70_K313_A0.8931.00
343_S346_N0.8911.00
113_Y425_G0.8901.00
135_P392_V0.8881.00
232_L235_I0.8791.00
94_L98_L0.8771.00
44_A280_K0.8761.00
450_I466_C0.8761.00
319_T322_N0.8741.00
109_L121_I0.8721.00
46_V187_A0.8701.00
466_C469_C0.8701.00
50_S268_R0.8701.00
12_F339_G0.8681.00
353_S357_S0.8671.00
303_A320_L0.8651.00
189_A193_N0.8621.00
228_H234_S0.8611.00
58_T341_V0.8601.00
421_I471_N0.8601.00
4_L7_L0.8551.00
43_K277_E0.8541.00
50_S187_A0.8521.00
83_A286_A0.8511.00
409_Q451_N0.8491.00
435_A438_V0.8491.00
471_N475_M0.8481.00
257_F262_N0.8471.00
476_L479_G0.8461.00
228_H232_L0.8461.00
9_F13_T0.8431.00
133_F262_N0.8431.00
5_Q330_V0.8391.00
68_A301_L0.8391.00
23_K27_T0.8361.00
361_Y364_I0.8361.00
458_F466_C0.8361.00
167_V393_A0.8341.00
420_T472_V0.8341.00
232_L238_P0.8321.00
387_I390_V0.8311.00
67_Q71_S0.8301.00
94_L97_Y0.8281.00
249_T252_I0.8211.00
384_F388_V0.8201.00
149_F161_A0.8171.00
321_V330_V0.8161.00
220_G225_T0.8151.00
177_Y193_N0.8131.00
21_W180_I0.8131.00
18_V21_W0.8121.00
477_V481_I0.8121.00
27_T30_G0.8111.00
254_V258_Y0.8101.00
186_M189_A0.8081.00
299_P320_L0.8081.00
204_V208_G0.8071.00
406_W410_L0.8061.00
429_P490_F0.8051.00
49_A194_G0.8051.00
177_Y343_S0.8041.00
362_R367_Q0.8041.00
442_I478_I0.8041.00
119_I360_I0.8031.00
13_T16_V0.8011.00
437_K441_G0.8001.00
229_A233_N0.8001.00
69_Y310_L0.7951.00
211_A324_V0.7951.00
253_L257_F0.7941.00
91_L283_L0.7931.00
485_A489_T0.7921.00
208_G211_A0.7911.00
50_S54_T0.7891.00
477_V480_F0.7871.00
233_N237_G0.7861.00
12_F20_T0.7851.00
61_L201_G0.7841.00
4_L8_S0.7831.00
38_A271_A0.7831.00
87_I91_L0.7821.00
432_P484_R0.7811.00
283_L287_V0.7801.00
204_V317_Y0.7781.00
434_L483_P0.7781.00
231_K237_G0.7771.00
44_A284_L0.7771.00
428_F435_A0.7751.00
287_V291_L0.7731.00
272_S278_G0.7721.00
73_M301_L0.7721.00
30_G34_G0.7711.00
441_G445_I0.7711.00
472_V475_M0.7701.00
193_N343_S0.7701.00
391_L395_W0.7681.00
207_F210_I0.7651.00
315_M319_T0.7641.00
9_F338_F0.7641.00
231_K238_P0.7611.00
223_Q227_V0.7601.00
254_V257_F0.7581.00
85_T89_L0.7571.00
428_F432_P0.7550.99
310_L319_T0.7540.99
255_N262_N0.7520.99
94_L278_G0.7510.99
186_M347_G0.7500.99
446_S450_I0.7500.99
380_K383_F0.7500.99
193_N344_T0.7480.99
177_Y185_A0.7480.99
95_P279_Q0.7480.99
24_V180_I0.7480.99
484_R487_P0.7470.99
252_I257_F0.7470.99
22_W25_R0.7450.99
60_Q293_P0.7450.99
483_P486_T0.7440.99
69_Y309_D0.7430.99
161_A169_L0.7410.99
404_Y408_K0.7410.99
403_L407_M0.7410.99
485_A488_F0.7400.99
391_L394_P0.7400.99
402_G405_S0.7390.99
20_T24_V0.7380.99
193_N342_I0.7360.99
382_G386_A0.7350.99
198_V202_L0.7270.99
61_L333_F0.7260.99
486_T490_F0.7240.99
119_I123_F0.7230.99
8_S331_G0.7230.99
22_W188_V0.7220.99
163_I167_V0.7190.99
69_Y316_A0.7180.99
125_F128_A0.7170.99
353_S382_G0.7160.99
50_S190_D0.7160.99
481_I484_R0.7160.99
485_A490_F0.7150.99
272_S277_E0.7120.99
7_L14_L0.7120.99
468_F471_N0.7080.99
424_M428_F0.7030.99
356_F377_V0.7020.99
446_S449_T0.7010.99
26_K184_R0.7010.99
398_N401_Q0.7000.99
143_L146_N0.6960.99
328_P332_F0.6960.99
20_T23_K0.6950.99
27_T184_R0.6920.99
299_P317_Y0.6910.99
53_L193_N0.6910.99
408_K412_G0.6890.99
143_L314_D0.6870.99
57_S61_L0.6860.99
444_I448_I0.6840.99
183_L187_A0.6830.99
54_T263_Q0.6830.99
86_L89_L0.6830.99
35_Y382_G0.6810.99
107_D111_E0.6800.99
390_V394_P0.6790.99
188_V191_S0.6790.99
212_M305_H0.6780.99
234_S238_P0.6770.99
137_V345_F0.6760.99
109_L421_I0.6760.99
114_D117_T0.6760.99
220_G305_H0.6760.99
16_V20_T0.6730.99
361_Y367_Q0.6710.99
27_T375_V0.6710.99
357_S374_L0.6690.99
34_G184_R0.6690.99
166_L170_L0.6690.99
227_V304_F0.6690.99
353_S381_F0.6680.99
217_F220_G0.6680.99
8_S328_P0.6670.99
210_I217_F0.6670.99
304_F316_A0.6660.99
242_L246_A0.6660.99
232_L237_G0.6660.99
121_I418_L0.6660.99
344_T348_F0.6650.99
348_F351_S0.6640.99
118_R122_D0.6630.99
231_K236_G0.6630.99
103_A107_D0.6620.99
244_I248_F0.6600.99
190_D343_S0.6590.99
117_T433_A0.6590.99
23_K188_V0.6590.99
246_A250_G0.6590.99
141_G341_V0.6580.99
315_M318_P0.6580.99
263_Q351_S0.6570.99
448_I452_Y0.6560.99
5_Q331_G0.6560.99
42_L47_I0.6530.99
462_Y466_C0.6490.98
121_I128_A0.6490.98
54_T268_R0.6460.98
21_W24_V0.6460.98
79_E86_L0.6420.98
45_P49_A0.6400.98
114_D486_T0.6390.98
175_I179_V0.6390.98
8_S335_A0.6380.98
45_P191_S0.6380.98
17_A176_L0.6370.98
239_T242_L0.6370.98
19_I23_K0.6340.98
463_V467_T0.6330.98
133_F348_F0.6320.98
407_M411_N0.6310.98
121_I125_F0.6300.98
63_G133_F0.6300.98
32_Q371_P0.6290.98
388_V391_L0.6280.98
95_P275_L0.6280.98
42_L271_A0.6270.98
467_T471_N0.6260.98
167_V171_G0.6260.98
204_V333_F0.6260.98
33_Q371_P0.6250.98
263_Q354_T0.6230.98
12_F193_N0.6230.98
142_A163_I0.6220.98
431_I439_A0.6210.98
146_N162_A0.6210.98
478_I481_I0.6200.98
366_N371_P0.6200.98
96_R99_K0.6180.98
430_R434_L0.6180.98
349_L382_G0.6170.98
186_M268_R0.6140.98
137_V344_T0.6140.98
175_I383_F0.6130.98
320_L324_V0.6120.98
138_L185_A0.6100.98
53_L194_G0.6090.98
178_A346_N0.6080.98
401_Q406_W0.6080.98
201_G295_V0.6080.98
145_L166_L0.6070.98
390_V393_A0.6060.98
53_L190_D0.6060.98
87_I282_A0.6050.98
202_L205_P0.6050.98
94_L275_L0.6040.98
11_G18_V0.6030.98
17_A24_V0.6010.97
297_V301_L0.6000.97
365_I368_N0.6000.97
5_Q8_S0.5990.97
434_L437_K0.5960.97
224_L227_V0.5960.97
419_V423_I0.5950.97
93_F97_Y0.5950.97
247_A250_G0.5940.97
258_Y262_N0.5930.97
139_Y143_L0.5920.97
249_T257_F0.5920.97
78_W82_S0.5910.97
16_V24_V0.5900.97
268_R347_G0.5880.97
325_L329_M0.5880.97
55_N289_K0.5880.97
113_Y424_M0.5880.97
461_L465_A0.5870.97
228_H237_G0.5860.97
443_G446_S0.5860.97
117_T121_I0.5850.97
208_G213_G0.5840.97
147_S315_M0.5830.97
204_V321_V0.5830.97
348_F418_L0.5830.97
16_V23_K0.5830.97
482_K485_A0.5810.97
26_K30_G0.5800.97
193_N340_A0.5800.97
79_E82_S0.5790.97
307_Y319_T0.5790.97
171_G393_A0.5780.97
13_T17_A0.5770.97
209_L213_G0.5770.97
104_T359_G0.5770.97
119_I363_R0.5770.97
342_I346_N0.5760.97
209_L298_L0.5740.97
119_I122_D0.5740.97
286_A290_M0.5740.97
227_V231_K0.5740.97
443_G474_V0.5730.97
184_R188_V0.5720.97
102_I107_D0.5710.97
113_Y436_A0.5700.97
114_D488_F0.5700.97
49_A288_L0.5700.97
32_Q374_L0.5700.97
229_A235_I0.5700.97
143_L147_S0.5690.97
439_A442_I0.5680.96
459_H466_C0.5680.96
305_H308_Q0.5660.96
67_Q70_K0.5660.96
438_V441_G0.5660.96
57_S137_V0.5660.96
250_G253_L0.5650.96
447_Y467_T0.5650.96
408_K411_N0.5630.96
243_P246_A0.5630.96
54_T178_A0.5610.96
43_K46_V0.5600.96
251_L254_V0.5580.96
465_A469_C0.5570.96
326_P329_M0.5550.96
205_P298_L0.5540.96
43_K47_I0.5540.96
161_A165_L0.5540.96
289_K293_P0.5540.96
306_L320_L0.5540.96
186_M350_N0.5540.96
304_F308_Q0.5530.96
229_A234_S0.5530.96
189_A268_R0.5530.96
96_R427_F0.5530.96
52_M292_D0.5510.96
12_F336_V0.5510.96
142_A166_L0.5500.96
134_L345_F0.5500.96
67_Q75_V0.5490.96
374_L378_G0.5490.96
446_S467_T0.5490.96
55_N82_S0.5480.96
436_A443_G0.5480.96
145_L149_F0.5470.96
435_A474_V0.5470.96
125_F418_L0.5470.96
445_I448_I0.5460.96
31_S39_G0.5450.96
473_V476_L0.5450.96
106_P121_I0.5440.96
59_E411_N0.5440.96
438_V477_V0.5440.96
263_Q348_F0.5430.95
353_S378_G0.5420.95
129_T348_F0.5400.95
57_S260_C0.5390.95
115_K118_R0.5380.95
430_R433_A0.5380.95
314_D425_G0.5380.95
301_L305_H0.5380.95
122_D355_L0.5370.95
199_I202_L0.5370.95
52_M194_G0.5360.95
32_Q35_Y0.5360.95
327_V330_V0.5350.95
280_K284_L0.5350.95
106_P125_F0.5350.95
431_I436_A0.5350.95
177_Y181_G0.5340.95
451_N463_V0.5340.95
362_R371_P0.5340.95
228_H236_G0.5340.95
230_E236_G0.5330.95
32_Q36_F0.5330.95
325_L333_F0.5320.95
86_L289_K0.5290.95
64_L68_A0.5290.95
361_Y374_L0.5280.95
35_Y379_R0.5280.95
51_L348_F0.5280.95
210_I213_G0.5270.95
46_V188_V0.5270.95
122_D360_I0.5270.95
217_F225_T0.5270.95
230_E234_S0.5260.95
357_S381_F0.5260.95
55_N411_N0.5260.95
81_T90_A0.5260.95
133_F137_V0.5240.95
131_V388_V0.5230.94
430_R476_L0.5230.94
203_M206_V0.5230.94
168_I387_I0.5230.94
4_L327_V0.5230.94
24_V27_T0.5220.94
40_R98_L0.5210.94
253_L256_T0.5210.94
340_A343_S0.5210.94
105_I422_I0.5210.94
306_L324_V0.5210.94
187_A190_D0.5210.94
219_Q305_H0.5200.94
16_V21_W0.5190.94
420_T475_M0.5180.94
48_A52_M0.5180.94
13_T20_T0.5170.94
254_V259_W0.5170.94
280_K283_L0.5150.94
245_G249_T0.5130.94
442_I445_I0.5130.94
147_S318_P0.5130.94
230_E235_I0.5120.94
128_A413_I0.5120.94
114_D489_T0.5110.94
249_T465_A0.5110.94
59_E133_F0.5100.94
412_G447_Y0.5100.94
458_F461_L0.5080.94
89_L94_L0.5070.94
85_T88_F0.5050.93
136_I410_L0.5050.93
460_F464_L0.5040.93
330_V334_G0.5040.93
128_A414_Y0.5020.93
440_M443_G0.5020.93
4_L328_P0.5020.93
275_L279_Q0.5020.93
137_V140_S0.5010.93
43_K188_V0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xq2A 2 0.9002 100 0.223 Contact Map
3dh4A 3 0.8214 100 0.28 Contact Map
3l1lA 2 0.718 99.3 0.876 Contact Map
3giaA 1 0.7373 99.1 0.882 Contact Map
4wgvA 2 0.6427 99.1 0.887 Contact Map
2jlnA 1 0.7373 98.7 0.901 Contact Map
4djkA 2 0.718 98.6 0.903 Contact Map
4c7rA 3 0.7706 96.5 0.937 Contact Map
2a65A 2 0.7688 94.9 0.944 Contact Map
2wswA 3 0.7023 94.8 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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