GREMLIN Database
YIDJ - Uncharacterized sulfatase YidJ
UniProt: P31447 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11705
Length: 497 (403)
Sequences: 9558 (7488)
Seq/√Len: 373.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
337_A351_N4.9771.00
270_T274_R4.9481.00
175_Q268_A4.0341.00
38_E313_R3.9281.00
388_D405_R3.8611.00
167_S190_Y3.3821.00
267_N271_P3.2491.00
31_N263_G3.1991.00
388_D403_D3.1731.00
67_Q348_P3.0221.00
11_T14_Q2.9611.00
41_R321_Q2.9401.00
403_D406_N2.8331.00
423_V426_K2.7761.00
390_K410_E2.7071.00
203_Y260_D2.6971.00
201_V205_E2.6391.00
314_S317_G2.6331.00
45_A326_V2.5741.00
268_A271_P2.5741.00
20_G33_D2.5691.00
171_V268_A2.4511.00
168_N264_R2.3991.00
169_R172_D2.3291.00
170_A186_M2.3261.00
386_T426_K2.3081.00
386_T430_A2.2481.00
91_A341_I2.2421.00
43_N323_D2.2401.00
338_L353_L2.1891.00
6_F339_A2.1391.00
207_Y256_D2.1121.00
266_I279_V2.1051.00
326_V352_I2.0871.00
266_I274_R2.0821.00
7_L279_V2.0731.00
43_N321_Q2.0721.00
40_I322_V2.0621.00
336_M341_I2.0491.00
415_I424_R2.0311.00
9_V262_I2.0281.00
367_R430_A2.0191.00
6_F88_F1.9711.00
337_A353_L1.9681.00
21_C41_R1.9641.00
14_Q281_Y1.9401.00
274_R313_R1.9131.00
89_K121_D1.8931.00
84_M185_L1.8801.00
98_I186_M1.8791.00
206_K256_D1.8781.00
40_I320_R1.8741.00
10_M282_T1.8411.00
11_T281_Y1.8181.00
63_I81_I1.8131.00
22_Y41_R1.7911.00
278_W312_I1.7901.00
172_D176_Q1.7871.00
188_V265_V1.7721.00
278_W338_L1.7621.00
94_H182_E1.7561.00
280_I335_M1.7501.00
35_L311_I1.7111.00
414_L420_F1.7071.00
353_L357_E1.6991.00
32_I281_Y1.6891.00
34_S270_T1.6881.00
333_P349_G1.6821.00
280_I312_I1.6741.00
44_S385_V1.6591.00
96_C173_F1.6561.00
261_Q264_R1.6481.00
302_Y400_E1.6441.00
171_V264_R1.6441.00
39_G311_I1.6391.00
34_S38_E1.6351.00
55_A328_H1.6351.00
190_Y261_Q1.6351.00
11_T258_V1.6251.00
170_A188_V1.5981.00
31_N34_S1.5981.00
391_L428_H1.5961.00
82_S90_D1.5911.00
97_Y187_V1.5901.00
35_L262_I1.5721.00
184_F273_Q1.5641.00
420_F423_V1.5561.00
424_R428_H1.5221.00
400_E413_N1.5211.00
331_L335_M1.5131.00
175_Q271_P1.5121.00
167_S265_V1.5101.00
167_S171_V1.4941.00
28_N256_D1.4931.00
46_Y306_T1.4921.00
7_L184_F1.4771.00
167_S261_Q1.4631.00
8_F280_I1.4471.00
7_L269_L1.4461.00
94_H177_P1.4451.00
332_L347_L1.4321.00
389_F423_V1.4221.00
164_H261_Q1.3891.00
29_T33_D1.3881.00
5_N184_F1.3741.00
87_Y332_L1.3661.00
21_C33_D1.3501.00
303_D385_V1.3481.00
42_F310_L1.3471.00
193_P255_N1.3441.00
273_Q276_N1.3401.00
14_Q255_N1.3311.00
290_G293_K1.3241.00
416_D424_R1.3181.00
367_R386_T1.3121.00
202_E260_D1.3061.00
317_G357_E1.3011.00
274_R279_V1.2981.00
47_T308_I1.2911.00
389_F420_F1.2891.00
96_C186_M1.2871.00
45_A310_L1.2811.00
161_T257_F1.2791.00
8_F282_T1.2751.00
278_W314_S1.2711.00
384_W430_A1.2701.00
204_L253_A1.2621.00
205_E208_A1.2581.00
64_Y329_I1.2471.00
63_I346_I1.2451.00
14_Q193_P1.2401.00
141_W144_G1.2321.00
20_G29_T1.2311.00
28_N207_Y1.2191.00
430_A433_D1.2161.00
386_T427_M1.2101.00
390_K404_R1.2091.00
426_K430_A1.2081.00
47_T55_A1.1951.00
35_L313_R1.1821.00
164_H257_F1.1811.00
203_Y256_D1.1731.00
35_L39_G1.1691.00
209_D249_P1.1681.00
429_D433_D1.1661.00
9_V265_V1.1551.00
391_L427_M1.1481.00
3_R91_A1.1461.00
163_A192_E1.1451.00
421_A425_S1.1411.00
8_F185_L1.1361.00
391_L424_R1.1291.00
10_M59_L1.1271.00
38_E274_R1.1211.00
314_S338_L1.1141.00
122_Y176_Q1.1091.00
87_Y336_M1.1061.00
31_N267_N1.1041.00
256_D260_D1.0981.00
166_I188_V1.0971.00
28_N206_K1.0961.00
16_T307_R1.0951.00
190_Y258_V1.0891.00
434_Y437_K1.0861.00
88_F335_M1.0861.00
262_I266_I1.0851.00
384_W391_L1.0841.00
142_R169_R1.0821.00
46_Y303_D1.0811.00
162_W166_I1.0721.00
53_T70_P1.0721.00
173_F177_P1.0691.00
303_D307_R1.0671.00
269_L279_V1.0651.00
48_C327_S1.0601.00
269_L274_R1.0491.00
34_S267_N1.0481.00
36_A41_R1.0461.00
34_S266_I1.0441.00
303_D390_K1.0391.00
425_S429_D1.0381.00
86_R118_W1.0371.00
200_P203_Y1.0351.00
42_F355_V1.0351.00
7_L186_M1.0331.00
388_D423_V1.0311.00
66_N371_E1.0311.00
7_L277_T1.0291.00
401_L423_V1.0241.00
389_F401_L1.0211.00
174_L265_V1.0191.00
38_E318_E1.0171.00
4_P276_N1.0171.00
88_F341_I1.0161.00
171_V175_Q1.0071.00
425_S428_H1.0041.00
6_F335_M1.0041.00
87_Y90_D1.0001.00
401_L424_R0.9981.00
27_L252_F0.9941.00
82_S86_R0.9931.00
97_Y189_S0.9891.00
208_A249_P0.9851.00
257_F261_Q0.9851.00
200_P257_F0.9831.00
370_I383_C0.9831.00
5_N277_T0.9791.00
16_T22_Y0.9791.00
322_V355_V0.9741.00
28_N210_F0.9611.00
399_D428_H0.9601.00
58_G329_I0.9571.00
24_G252_F0.9531.00
38_E270_T0.9501.00
8_F59_L0.9491.00
389_F414_L0.9431.00
310_L331_L0.9431.00
266_I313_R0.9421.00
32_I262_I0.9401.00
204_L250_L0.9361.00
82_S87_Y0.9351.00
14_Q19_V0.9341.00
10_M189_S0.9341.00
389_F403_D0.9311.00
46_Y385_V0.9291.00
272_E275_E0.9251.00
201_V204_L0.9241.00
4_P314_S0.9221.00
32_I311_I0.9161.00
40_I318_E0.9081.00
428_H432_L0.9061.00
174_L268_A0.9051.00
98_I122_Y0.8971.00
58_G68_S0.8941.00
310_L326_V0.8941.00
34_S37_A0.8931.00
136_K139_S0.8931.00
421_A424_R0.8901.00
5_N273_Q0.8901.00
21_C36_A0.8851.00
301_M383_C0.8851.00
58_G65_A0.8841.00
430_A434_Y0.8841.00
423_V427_M0.8811.00
63_I68_S0.8811.00
63_I67_Q0.8811.00
355_V363_V0.8801.00
33_D37_A0.8801.00
52_C56_R0.8771.00
88_F185_L0.8741.00
13_T287_E0.8741.00
167_S264_R0.8721.00
88_F339_A0.8721.00
84_M332_L0.8701.00
382_R393_L0.8631.00
87_Y91_A0.8561.00
386_T423_V0.8521.00
393_L428_H0.8511.00
268_A273_Q0.8481.00
96_C122_Y0.8451.00
350_E364_E0.8431.00
6_F278_W0.8411.00
322_V325_P0.8411.00
184_F277_T0.8411.00
199_C253_A0.8401.00
94_H180_A0.8401.00
202_E205_E0.8401.00
9_V279_V0.8381.00
384_W434_Y0.8371.00
172_D175_Q0.8361.00
199_C204_L0.8311.00
401_L427_M0.8311.00
327_S368_Y0.8301.00
267_N270_T0.8281.00
123_W126_G0.8261.00
35_L266_I0.8241.00
260_D264_R0.8231.00
93_Y339_A0.8231.00
44_S307_R0.8211.00
6_F338_L0.8171.00
19_V29_T0.8161.00
384_W431_L0.8161.00
73_N76_A0.8131.00
57_A70_P0.8131.00
205_E253_A0.8121.00
36_A311_I0.8081.00
216_E409_N0.8081.00
270_T313_R0.8061.00
283_S308_I0.8051.00
163_A261_Q0.8031.00
19_V22_Y0.8021.00
94_H173_F0.7991.00
177_P180_A0.7981.00
42_F356_K0.7951.00
124_F169_R0.7941.00
279_V313_R0.7931.00
77_P83_T0.7911.00
160_F165_R0.7911.00
265_V268_A0.7881.00
264_R267_N0.7881.00
60_F187_V0.7871.00
171_V265_V0.7861.00
24_G27_L0.7861.00
27_L256_D0.7831.00
13_T285_H0.7791.00
8_F335_M0.7761.00
382_R431_L0.7761.00
383_C392_V0.7751.00
238_S241_G0.7741.00
19_V32_I0.7731.00
64_Y327_S0.7721.00
48_C58_G0.7721.00
4_P93_Y0.7711.00
168_N171_V0.7711.00
47_T328_H0.7711.00
192_E258_V0.7691.00
164_H200_P0.7691.00
249_P253_A0.7681.00
60_F103_L0.7681.00
325_P368_Y0.7651.00
160_F168_N0.7641.00
295_I298_G0.7631.00
165_R169_R0.7631.00
45_A328_H0.7621.00
306_T370_I0.7611.00
363_V366_N0.7601.00
301_M392_V0.7581.00
266_I270_T0.7511.00
404_R410_E0.7491.00
98_I173_F0.7481.00
8_F331_L0.7471.00
344_P347_L0.7451.00
122_Y142_R0.7411.00
385_V388_D0.7411.00
429_D432_L0.7401.00
391_L399_D0.7381.00
312_I356_K0.7361.00
87_Y341_I0.7361.00
414_L423_V0.7331.00
4_P278_W0.7331.00
85_G88_F0.7331.00
199_C250_L0.7321.00
332_L336_M0.7321.00
57_A68_S0.7311.00
29_T255_N0.7311.00
333_P347_L0.7311.00
401_L414_L0.7301.00
168_N172_D0.7251.00
336_M343_K0.7241.00
18_M251_Y0.7241.00
237_P241_G0.7221.00
163_A190_Y0.7221.00
358_P361_V0.7201.00
208_A211_Y0.7191.00
48_C328_H0.7191.00
322_V326_V0.7171.00
203_Y257_F0.7171.00
50_P301_M0.7151.00
278_W335_M0.7151.00
161_T164_H0.7131.00
140_L143_N0.7121.00
202_E206_K0.7101.00
39_G313_R0.7101.00
351_N354_A0.7080.99
174_L186_M0.7080.99
420_F424_R0.7070.99
84_M88_F0.7070.99
413_N416_D0.7060.99
29_T32_I0.7050.99
324_T355_V0.7050.99
383_C390_K0.7040.99
13_T298_G0.7040.99
98_I170_A0.7020.99
157_D160_F0.6980.99
245_L249_P0.6980.99
321_Q324_T0.6970.99
87_Y344_P0.6950.99
433_D437_K0.6950.99
301_M381_V0.6950.99
350_E363_V0.6950.99
101_W104_D0.6930.99
240_V243_D0.6910.99
89_K95_T0.6910.99
393_L432_L0.6900.99
295_I302_Y0.6870.99
32_I35_L0.6870.99
406_N412_H0.6840.99
241_G245_L0.6830.99
236_M239_P0.6810.99
94_H179_R0.6790.99
83_T86_R0.6770.99
21_C311_I0.6760.99
206_K260_D0.6740.99
236_M241_G0.6730.99
171_V261_Q0.6720.99
85_G89_K0.6710.99
258_V262_I0.6710.99
114_C117_E0.6710.99
60_F85_G0.6700.99
23_S33_D0.6690.99
367_R371_E0.6670.99
137_E141_W0.6640.99
164_H202_E0.6640.99
116_P123_W0.6620.99
48_C64_Y0.6620.99
312_I352_I0.6600.99
98_I166_I0.6580.99
7_L265_V0.6580.99
24_G28_N0.6570.99
115_P118_W0.6550.99
7_L273_Q0.6540.99
352_I356_K0.6530.99
10_M187_V0.6500.99
258_V281_Y0.6490.99
140_L144_G0.6480.99
393_L435_M0.6470.99
263_G267_N0.6470.99
26_P252_F0.6470.99
23_S26_P0.6450.99
337_A354_A0.6450.99
369_E384_W0.6420.99
214_L218_A0.6420.99
414_L419_R0.6420.99
306_T383_C0.6360.99
20_G28_N0.6350.99
384_W427_M0.6340.99
42_F326_V0.6340.99
251_Y255_N0.6340.99
126_G129_Y0.6330.99
20_G27_L0.6320.99
161_T254_C0.6310.99
18_M252_F0.6310.99
21_C32_I0.6310.99
135_E138_I0.6300.99
287_E291_A0.6280.99
179_R182_E0.6280.99
192_E254_C0.6270.99
163_A257_F0.6260.99
210_F249_P0.6240.99
289_M297_K0.6220.99
367_R370_I0.6210.99
361_V364_E0.6190.99
45_A308_I0.6180.99
117_E121_D0.6160.99
97_Y101_W0.6160.99
42_F312_I0.6140.99
14_Q18_M0.6130.99
282_T328_H0.6130.99
61_T81_I0.6130.99
298_G305_I0.6120.99
123_W129_Y0.6090.98
42_F322_V0.6080.98
203_Y206_K0.6070.98
407_D412_H0.6060.98
212_Y249_P0.6060.98
398_S413_N0.6050.98
193_P251_Y0.6030.98
53_T73_N0.6010.98
164_H168_N0.6000.98
139_S143_N0.6000.98
9_V188_V0.5970.98
184_F269_L0.5970.98
203_Y253_A0.5970.98
324_T363_V0.5940.98
202_E257_F0.5940.98
60_F120_A0.5940.98
85_G97_Y0.5920.98
424_R427_M0.5920.98
287_E290_G0.5920.98
156_I159_T0.5920.98
40_I356_K0.5910.98
125_D129_Y0.5910.98
190_Y262_I0.5880.98
368_Y371_E0.5860.98
214_L217_K0.5850.98
367_R434_Y0.5850.98
37_A319_R0.5840.98
164_H264_R0.5840.98
335_M339_A0.5830.98
11_T193_P0.5830.98
44_S323_D0.5820.98
168_N261_Q0.5820.98
291_A304_D0.5800.98
132_E198_T0.5790.98
262_I281_Y0.5780.98
167_S188_V0.5770.98
86_R90_D0.5770.98
163_A167_S0.5770.98
35_L281_Y0.5760.98
86_R89_K0.5760.98
53_T102_H0.5760.98
40_I319_R0.5760.98
303_D404_R0.5740.98
334_T352_I0.5740.98
199_C254_C0.5740.98
10_M328_H0.5730.98
237_P246_Y0.5720.98
369_E434_Y0.5710.98
308_I328_H0.5710.98
280_I331_L0.5700.98
244_G247_H0.5670.98
59_L331_L0.5650.98
84_M335_M0.5650.98
338_L357_E0.5640.98
167_S170_A0.5640.98
97_Y123_W0.5640.98
385_V404_R0.5630.97
174_L177_P0.5630.97
35_L279_V0.5620.97
68_S81_I0.5610.97
432_L436_D0.5610.97
350_E355_V0.5610.97
388_D406_N0.5610.97
307_R408_P0.5600.97
48_C329_I0.5590.97
123_W130_L0.5590.97
355_V364_E0.5580.97
48_C65_A0.5580.97
214_L241_G0.5580.97
416_D421_A0.5570.97
7_L174_L0.5560.97
282_T310_L0.5550.97
10_M55_A0.5550.97
137_E143_N0.5550.97
27_L207_Y0.5540.97
166_I191_D0.5540.97
237_P240_V0.5540.97
139_S142_R0.5530.97
287_E293_K0.5510.97
419_R422_D0.5500.97
366_N430_A0.5500.97
180_A273_Q0.5500.97
41_R311_I0.5490.97
367_R384_W0.5490.97
236_M240_V0.5490.97
123_W127_A0.5490.97
336_M347_L0.5490.97
90_D95_T0.5490.97
38_E266_I0.5490.97
115_P121_D0.5480.97
432_L435_M0.5480.97
115_P119_D0.5470.97
292_H304_D0.5460.97
354_A359_R0.5460.97
27_L193_P0.5460.97
64_Y348_P0.5450.97
350_E365_F0.5410.97
6_F185_L0.5410.97
325_P385_V0.5410.97
34_S274_R0.5410.97
285_H308_I0.5380.97
7_L188_V0.5380.97
116_P144_G0.5380.97
27_L255_N0.5380.97
124_F165_R0.5360.97
250_L254_C0.5360.97
294_L408_P0.5350.97
296_S300_A0.5340.97
274_R315_P0.5330.97
16_T285_H0.5320.96
416_D419_R0.5310.96
389_F405_R0.5300.96
85_G120_A0.5290.96
324_T387_D0.5290.96
120_A126_G0.5290.96
370_I373_D0.5290.96
136_K140_L0.5280.96
11_T32_I0.5280.96
94_H121_D0.5280.96
156_I160_F0.5270.96
138_I141_W0.5240.96
174_L273_Q0.5230.96
52_C100_K0.5220.96
354_A358_P0.5220.96
242_D246_Y0.5220.96
51_V54_P0.5220.96
197_F287_E0.5210.96
46_Y387_D0.5190.96
401_L413_N0.5190.96
177_P182_E0.5190.96
287_E292_H0.5180.96
19_V311_I0.5170.96
313_R317_G0.5160.96
139_S144_G0.5150.96
357_E360_G0.5140.96
209_D212_Y0.5120.96
424_R431_L0.5120.96
22_Y311_I0.5110.96
136_K142_R0.5100.96
8_F187_V0.5090.95
31_N266_I0.5090.95
120_A187_V0.5080.95
20_G36_A0.5080.95
126_G191_D0.5080.95
276_N316_Q0.5070.95
82_S85_G0.5070.95
246_Y249_P0.5050.95
136_K141_W0.5050.95
275_E313_R0.5040.95
91_A339_A0.5030.95
433_D436_D0.5030.95
152_Q155_H0.5020.95
19_V33_D0.5010.95
79_K118_W0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vqrA 3 0.9034 100 0.245 Contact Map
4upiA 2 0.9618 100 0.25 Contact Map
4uplA 2 0.9799 100 0.254 Contact Map
4uphA 2 0.9014 100 0.256 Contact Map
4upkA 3 0.9095 100 0.266 Contact Map
1hdhA 1 0.841 100 0.278 Contact Map
3b5qA 1 0.8833 100 0.288 Contact Map
2qzuA 2 0.8531 100 0.292 Contact Map
1p49A 3 0.8431 100 0.301 Contact Map
1aukA 3 0.831 100 0.301 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0134 seconds.