ADEC - ECOLI - GREMLIN Contacts

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ADEC - Adenine deaminase

UniProt:	P31441	Sequences: MNNSINHKFHHISRAEYQELLAVSRGDAVADYIIDNVSILDLINGGEISGPIVIKGRYIAGVGAEYTDAPALQRIDARGATAVPGFIDAHLHIESSMMTPVTFETATLPRGLTTVICDPHEIVNVMGEAGFAWFARCAEQARQNQYLQVSSCVPALEGCDVNGASFTLEQMLAWRDHPQVTGLAEMMDYPGVISGQNALLDKLDAFRHLTLDGHCPGLGGKELNAYITAGIENCHESYQLEEGRRKLQLGMSLMIREGSAARNLNALAPLINEFNSPQCMLCTDDRNPWEIAHEGHIDALIRRLIEQHNVPLHVAYRVASWSTARHFGLNHLGLLAPGKQADIVLLSDARKVTVQQVLVKGEPIDAQTLQAEESARLAQSAPPYGNTIARQPVSASDFALQFTPGKRYRVIDVIHNELITHSHSSVYSENGFDRDDVSFIAVLERYGQRLAPACGLLGGFGLNEGALAATVSHDSHNIVVIGRSAEEMALAVNQVIQDGGGLCVVRNGQVQSHLPLPIAGLMSTDTAQSLAEQIDALKAAARECGPLPDEPFIQMAFLSLPVIPALKLTSQGLFDGEKFAFTTLEVTE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11692
Length:	588 (558)
Sequences:	1535 (1133)
Seq/√Len:	48.0

ECOLI - ADEC
BACSU - ADEC YERA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
34_I	77_A	4.939	1.00
494_Q	513_H	4.282	1.00
494_Q	497_Q	4.135	1.00
52_I	82_A	4.026	1.00
480_V	488_M	3.722	1.00
409_R	582_T	3.562	1.00
167_T	170_Q	3.465	1.00
525_D	529_S	3.421	1.00
484_S	487_E	3.372	1.00
86_F	352_V	3.291	1.00
39_I	50_G	3.290	1.00
439_F	485_A	3.273	1.00
110_R	298_D	3.261	1.00
409_R	422_S	3.244	1.00
77_A	345_L	3.164	1.00
298_D	302_R	3.142	1.00
46_G	248_Q	3.109	1.00
358_L	363_P	3.100	1.00
347_S	353_T	3.075	1.00
22_A	27_D	3.072	1.00
464_E	506_R	3.065	1.00
102_T	105_T	2.994	1.00
37_V	82_A	2.913	1.00
186_M	199_L	2.888	1.00
440_I	568_L	2.850	1.00
395_A	486_E	2.749	1.00
565_A	577_E	2.739	1.00
478_I	492_V	2.690	1.00
23_V	60_A	2.642	1.00
412_D	458_G	2.627	1.00
277_P	325_R	2.623	1.00
441_A	488_M	2.605	1.00
525_D	533_Q	2.598	1.00
468_A	491_A	2.524	1.00
38_S	49_S	2.506	1.00
441_A	480_V	2.486	1.00
83_V	346_L	2.463	1.00
498_D	513_H	2.461	1.00
82_A	343_I	2.445	1.00
161_V	570_S	2.432	1.00
82_A	345_L	2.400	1.00
37_V	77_A	2.359	1.00
33_I	71_A	2.340	1.00
412_D	423_H	2.315	1.00
487_E	508_G	2.303	1.00
457_L	558_L	2.291	1.00
347_S	355_Q	2.265	1.00
132_A	177_H	2.260	1.00
188_D	191_G	2.257	1.00
421_H	565_A	2.224	1.00
41_D	44_N	2.209	1.00
139_E	179_Q	2.199	1.00
34_I	345_L	2.180	1.00
281_L	304_L	2.171	1.00
398_F	492_V	2.145	1.00
293_H	535_D	2.087	1.00
305_I	352_V	2.070	1.00
412_D	421_H	2.058	1.00
40_L	83_V	2.039	1.00
504_V	540_A	2.024	1.00
348_D	351_K	1.998	0.99
136_R	139_E	1.994	0.99
80_A	355_Q	1.972	0.99
43_I	334_L	1.960	0.99
575_D	578_K	1.960	0.99
493_N	496_I	1.911	0.99
490_L	494_Q	1.899	0.99
480_V	492_V	1.889	0.99
38_S	47_E	1.883	0.99
301_I	344_V	1.883	0.99
22_A	28_A	1.876	0.99
460_F	481_I	1.872	0.99
395_A	489_A	1.863	0.99
40_L	47_E	1.855	0.99
356_Q	363_P	1.838	0.99
470_T	478_I	1.816	0.99
335_L	343_I	1.813	0.99
39_I	52_I	1.779	0.99
316_Y	352_V	1.771	0.99
512_S	540_A	1.768	0.99
489_A	493_N	1.767	0.99
365_D	368_T	1.747	0.99
123_V	131_F	1.740	0.98
80_A	345_L	1.736	0.98
224_N	249_L	1.735	0.98
400_L	456_L	1.707	0.98
265_N	307_Q	1.707	0.98
75_I	358_L	1.703	0.98
161_V	571_Q	1.678	0.98
149_V	171_M	1.673	0.98
265_N	303_R	1.672	0.98
132_A	136_R	1.659	0.98
495_V	503_C	1.644	0.98
247_L	279_C	1.637	0.98
444_E	450_L	1.620	0.98
144_N	332_L	1.620	0.98
93_I	145_Q	1.616	0.98
490_L	508_G	1.610	0.97
59_I	343_I	1.610	0.97
41_D	46_G	1.604	0.97
112_L	296_H	1.601	0.97
98_M	530_L	1.594	0.97
23_V	55_K	1.588	0.97
41_D	48_I	1.587	0.97
345_L	358_L	1.584	0.97
25_R	222_E	1.581	0.97
45_G	314_V	1.580	0.97
36_N	76_D	1.579	0.97
31_D	55_K	1.578	0.97
498_D	503_C	1.567	0.97
316_Y	320_S	1.564	0.97
126_M	519_A	1.563	0.97
281_L	297_I	1.561	0.97
390_R	496_I	1.545	0.97
356_Q	366_A	1.542	0.97
443_L	492_V	1.539	0.97
494_Q	498_D	1.534	0.97
159_C	574_F	1.524	0.96
19_E	55_K	1.523	0.96
422_S	582_T	1.510	0.96
393_V	489_A	1.508	0.96
340_Q	360_K	1.477	0.96
32_Y	54_I	1.461	0.95
408_Y	456_L	1.452	0.95
252_S	280_M	1.447	0.95
505_V	510_V	1.444	0.95
45_G	317_R	1.442	0.95
303_R	307_Q	1.442	0.95
388_I	470_T	1.440	0.95
60_A	228_T	1.440	0.95
517_P	524_T	1.437	0.95
109_P	365_D	1.436	0.95
407_R	425_S	1.436	0.95
203_L	211_L	1.433	0.95
29_V	72_L	1.425	0.95
80_A	347_S	1.418	0.95
89_A	282_C	1.415	0.95
437_V	456_L	1.414	0.95
408_Y	426_V	1.411	0.95
144_N	360_K	1.407	0.94
400_L	454_C	1.406	0.94
106_A	527_A	1.400	0.94
29_V	70_P	1.390	0.94
441_A	454_C	1.385	0.94
129_A	132_A	1.372	0.94
40_L	316_Y	1.366	0.94
233_N	326_H	1.364	0.93
398_F	489_A	1.362	0.93
144_N	359_V	1.351	0.93
19_E	56_G	1.348	0.93
244_R	248_Q	1.341	0.93
561_P	569_T	1.338	0.93
495_V	498_D	1.335	0.93
317_R	321_W	1.329	0.93
426_V	456_L	1.325	0.92
309_N	318_V	1.321	0.92
438_S	483_R	1.320	0.92
132_A	173_A	1.318	0.92
257_E	265_N	1.314	0.92
261_A	418_L	1.307	0.92
30_A	53_V	1.303	0.92
464_E	483_R	1.297	0.92
40_L	312_L	1.295	0.92
34_I	54_I	1.291	0.91
148_Q	182_G	1.290	0.91
52_I	335_L	1.288	0.91
129_A	383_P	1.279	0.91
172_L	207_R	1.273	0.91
252_S	278_Q	1.267	0.91
470_T	492_V	1.264	0.91
539_A	543_E	1.260	0.90
271_I	318_V	1.258	0.90
301_I	319_A	1.248	0.90
574_F	581_F	1.247	0.90
254_M	282_C	1.242	0.90
515_P	533_Q	1.239	0.90
263_N	266_A	1.239	0.90
566_L	582_T	1.235	0.89
303_R	306_E	1.234	0.89
301_I	305_I	1.231	0.89
518_I	524_T	1.225	0.89
43_I	339_K	1.225	0.89
132_A	174_W	1.221	0.89
443_L	470_T	1.218	0.89
529_S	532_E	1.215	0.89
45_G	312_L	1.215	0.89
263_N	417_E	1.212	0.89
236_E	256_R	1.206	0.88
54_I	343_I	1.205	0.88
161_V	451_A	1.201	0.88
138_A	179_Q	1.194	0.88
504_V	544_C	1.194	0.88
282_C	327_F	1.194	0.88
188_D	196_Q	1.191	0.88
393_V	398_F	1.183	0.87
523_S	530_L	1.181	0.87
468_A	480_V	1.179	0.87
186_M	191_G	1.178	0.87
346_L	352_V	1.174	0.87
346_L	354_V	1.174	0.87
135_A	179_Q	1.169	0.87
227_I	251_M	1.168	0.87
139_E	177_H	1.167	0.87
388_I	499_G	1.160	0.86
503_C	513_H	1.160	0.86
487_E	490_L	1.158	0.86
102_T	527_A	1.156	0.86
433_D	438_S	1.155	0.86
128_E	174_W	1.152	0.86
40_L	81_T	1.151	0.86
443_L	452_P	1.150	0.86
19_E	28_A	1.144	0.86
53_V	63_G	1.137	0.85
277_P	317_R	1.136	0.85
472_S	479_V	1.135	0.85
23_V	30_A	1.130	0.85
278_Q	325_R	1.125	0.85
223_L	245_R	1.124	0.85
240_L	270_L	1.123	0.84
451_A	570_S	1.121	0.84
195_G	200_L	1.118	0.84
473_H	476_H	1.117	0.84
297_I	319_A	1.113	0.84
482_G	488_M	1.111	0.84
22_A	195_G	1.109	0.84
494_Q	503_C	1.107	0.84
252_S	326_H	1.106	0.84
138_A	141_A	1.104	0.83
301_I	320_S	1.104	0.83
148_Q	181_T	1.102	0.83
252_S	325_R	1.100	0.83
526_T	529_S	1.097	0.83
479_V	559_S	1.095	0.83
37_V	345_L	1.094	0.83
107_T	115_V	1.088	0.83
86_F	344_V	1.086	0.82
495_V	499_G	1.084	0.82
22_A	25_R	1.084	0.82
201_D	205_A	1.083	0.82
117_C	147_L	1.083	0.82
387_T	390_R	1.082	0.82
83_V	344_V	1.076	0.82
305_I	311_P	1.072	0.82
409_R	424_S	1.070	0.81
444_E	449_R	1.069	0.81
39_I	62_V	1.068	0.81
99_T	518_I	1.066	0.81
115_V	143_Q	1.063	0.81
159_C	581_F	1.060	0.81
334_L	339_K	1.058	0.81
233_N	327_F	1.053	0.80
71_A	74_R	1.050	0.80
512_S	536_A	1.050	0.80
48_I	248_Q	1.047	0.80
332_L	340_Q	1.046	0.80
343_I	358_L	1.041	0.80
190_P	579_F	1.040	0.80
491_A	505_V	1.039	0.79
47_E	349_A	1.038	0.79
398_F	488_M	1.038	0.79
54_I	358_L	1.037	0.79
317_R	322_S	1.037	0.79
175_R	209_L	1.036	0.79
280_M	326_H	1.033	0.79
36_N	78_R	1.033	0.79
407_R	424_S	1.031	0.79
82_A	335_L	1.028	0.79
282_C	319_A	1.025	0.79
26_G	221_K	1.025	0.79
37_V	343_I	1.020	0.78
481_I	555_M	1.019	0.78
396_S	399_A	1.017	0.78
149_V	174_W	1.012	0.78
33_I	53_V	1.009	0.77
109_P	143_Q	1.008	0.77
440_I	481_I	1.007	0.77
160_D	570_S	1.007	0.77
32_Y	75_I	1.007	0.77
91_L	103_F	1.004	0.77
311_P	315_A	1.002	0.77
386_N	499_G	1.001	0.77
44_N	248_Q	0.993	0.76
479_V	568_L	0.993	0.76
34_I	358_L	0.993	0.76
35_D	74_R	0.990	0.76
114_T	146_Y	0.990	0.76
144_N	340_Q	0.988	0.76
155_A	475_S	0.987	0.76
402_F	428_S	0.985	0.76
47_E	81_T	0.984	0.76
254_M	327_F	0.983	0.76
309_N	315_A	0.969	0.75
331_H	340_Q	0.969	0.75
440_I	558_L	0.968	0.74
363_P	366_A	0.968	0.74
42_L	334_L	0.965	0.74
89_A	323_T	0.964	0.74
469_A	556_A	0.961	0.74
128_E	173_A	0.959	0.74
440_I	455_G	0.958	0.74
104_E	142_R	0.957	0.74
50_G	62_V	0.954	0.73
122_I	130_G	0.945	0.73
146_Y	181_T	0.941	0.72
268_A	309_N	0.939	0.72
532_E	536_A	0.938	0.72
73_Q	362_E	0.938	0.72
220_G	245_R	0.936	0.72
490_L	510_V	0.932	0.72
191_G	199_L	0.932	0.72
398_F	441_A	0.931	0.72
59_I	62_V	0.931	0.72
91_L	283_T	0.927	0.71
240_L	244_R	0.921	0.71
253_L	270_L	0.920	0.71
23_V	28_A	0.919	0.71
85_G	113_T	0.918	0.70
108_L	143_Q	0.917	0.70
574_F	579_F	0.917	0.70
255_I	281_L	0.916	0.70
32_Y	358_L	0.915	0.70
188_D	199_L	0.912	0.70
233_N	282_C	0.911	0.70
414_I	421_H	0.911	0.70
457_L	460_F	0.910	0.70
276_S	314_V	0.910	0.70
391_Q	448_Q	0.905	0.69
533_Q	536_A	0.905	0.69
24_S	225_A	0.903	0.69
405_G	425_S	0.901	0.69
81_T	349_A	0.901	0.69
198_A	202_K	0.900	0.69
355_Q	367_Q	0.899	0.69
141_A	145_Q	0.899	0.69
35_D	51_P	0.899	0.69
187_M	562_V	0.896	0.69
192_V	203_L	0.896	0.69
254_M	280_M	0.894	0.68
96_S	103_F	0.894	0.68
441_A	492_V	0.893	0.68
122_I	134_F	0.890	0.68
464_E	507_N	0.888	0.68
210_T	326_H	0.888	0.68
120_H	473_H	0.884	0.68
242_E	245_R	0.884	0.68
301_I	316_Y	0.884	0.68
219_G	245_R	0.884	0.68
121_E	473_H	0.883	0.67
468_A	492_V	0.882	0.67
175_R	205_A	0.882	0.67
152_C	187_M	0.879	0.67
138_A	145_Q	0.873	0.67
490_L	505_V	0.872	0.66
243_G	270_L	0.870	0.66
120_H	187_M	0.870	0.66
297_I	300_L	0.870	0.66
305_I	316_Y	0.869	0.66
115_V	145_Q	0.867	0.66
95_S	473_H	0.867	0.66
103_F	115_V	0.866	0.66
131_F	174_W	0.865	0.66
120_H	476_H	0.865	0.66
101_V	137_C	0.863	0.66
392_P	496_I	0.861	0.65
202_K	206_F	0.858	0.65
249_L	337_P	0.857	0.65
21_L	195_G	0.856	0.65
199_L	202_K	0.850	0.64
443_L	478_I	0.850	0.64
112_L	553_I	0.849	0.64
265_N	306_E	0.849	0.64
506_R	511_Q	0.846	0.64
95_S	476_H	0.842	0.64
321_W	325_R	0.841	0.64
467_L	541_A	0.840	0.64
52_I	62_V	0.840	0.64
457_L	481_I	0.839	0.63
438_S	481_I	0.839	0.63
381_A	387_T	0.838	0.63
133_W	137_C	0.838	0.63
152_C	191_G	0.837	0.63
216_P	246_K	0.837	0.63
89_A	327_F	0.837	0.63
171_M	175_R	0.836	0.63
126_M	130_G	0.834	0.63
366_A	369_L	0.832	0.63
95_S	285_D	0.830	0.63
568_L	573_L	0.828	0.62
175_R	259_S	0.827	0.62
41_D	334_L	0.826	0.62
436_D	461_G	0.825	0.62
172_L	205_A	0.825	0.62
175_R	206_F	0.825	0.62
40_L	349_A	0.824	0.62
391_Q	496_I	0.823	0.62
53_V	61_G	0.822	0.62
126_M	384_Y	0.822	0.62
121_E	476_H	0.821	0.62
166_F	171_M	0.821	0.62
305_I	348_D	0.819	0.62
517_P	523_S	0.818	0.61
75_I	363_P	0.817	0.61
348_D	353_T	0.817	0.61
33_I	74_R	0.816	0.61
131_F	149_V	0.816	0.61
540_A	543_E	0.813	0.61
200_L	203_L	0.811	0.61
95_S	120_H	0.809	0.61
73_Q	363_P	0.808	0.61
77_A	82_A	0.807	0.60
541_A	544_C	0.803	0.60
494_Q	510_V	0.802	0.60
243_G	253_L	0.799	0.60
473_H	560_L	0.791	0.59
281_L	300_L	0.791	0.59
91_L	96_S	0.790	0.59
545_G	551_P	0.789	0.59
146_Y	332_L	0.781	0.58
134_F	522_M	0.781	0.58
255_I	268_A	0.780	0.58
38_S	81_T	0.778	0.58
116_I	327_F	0.778	0.58
468_A	495_V	0.778	0.58
149_V	180_V	0.777	0.57
471_V	521_L	0.776	0.57
362_E	369_L	0.773	0.57
296_H	553_I	0.771	0.57
514_L	530_L	0.770	0.57
87_I	116_I	0.770	0.57
219_G	255_I	0.769	0.57
465_G	487_E	0.766	0.56
27_D	245_R	0.765	0.56
220_G	223_L	0.760	0.56
107_T	143_Q	0.755	0.55
47_E	312_L	0.755	0.55
135_A	147_L	0.754	0.55
39_I	343_I	0.753	0.55
269_P	307_Q	0.753	0.55
277_P	322_S	0.753	0.55
103_F	107_T	0.751	0.55
31_D	72_L	0.751	0.55
541_A	550_E	0.750	0.55
246_K	253_L	0.750	0.55
423_H	458_G	0.749	0.55
103_F	296_H	0.745	0.54
418_L	567_K	0.744	0.54
410_V	423_H	0.743	0.54
354_V	357_V	0.743	0.54
110_R	354_V	0.743	0.54
329_L	332_L	0.743	0.54
33_I	51_P	0.739	0.54
104_E	141_A	0.739	0.54
170_Q	173_A	0.739	0.54
294_E	299_A	0.738	0.54
161_V	449_R	0.737	0.54
215_C	246_K	0.737	0.54
89_A	254_M	0.737	0.54
261_A	557_F	0.736	0.53
87_I	324_A	0.735	0.53
257_E	303_R	0.732	0.53
87_I	323_T	0.730	0.53
124_N	163_G	0.730	0.53
151_S	473_H	0.729	0.53
529_S	533_Q	0.728	0.53
162_N	475_S	0.728	0.53
20_L	60_A	0.725	0.52
475_S	561_P	0.724	0.52
433_D	483_R	0.723	0.52
66_Y	69_A	0.722	0.52
169_E	201_D	0.719	0.52
484_S	488_M	0.718	0.52
93_I	100_P	0.718	0.52
514_L	533_Q	0.717	0.52
98_M	527_A	0.716	0.51
207_R	509_Q	0.712	0.51
454_C	485_A	0.708	0.51
121_E	560_L	0.708	0.51
33_I	69_A	0.707	0.51
472_S	559_S	0.705	0.50
85_G	320_S	0.704	0.50
286_R	300_L	0.704	0.50
123_V	234_C	0.700	0.50
310_V	314_V	0.699	0.50
280_M	323_T	0.696	0.49
187_M	473_H	0.696	0.49
95_S	121_E	0.696	0.49
281_L	319_A	0.695	0.49
187_M	476_H	0.693	0.49
171_M	205_A	0.693	0.49
467_L	504_V	0.692	0.49
223_L	227_I	0.691	0.49
476_H	560_L	0.691	0.49
28_A	55_K	0.688	0.49
436_D	459_G	0.688	0.49
95_S	560_L	0.686	0.48
238_Y	419_I	0.686	0.48
151_S	183_L	0.686	0.48
40_L	346_L	0.686	0.48
393_V	492_V	0.685	0.48
95_S	187_M	0.684	0.48
59_I	335_L	0.682	0.48
227_I	249_L	0.681	0.48
305_I	347_S	0.680	0.48
42_L	317_R	0.680	0.48
243_G	320_S	0.679	0.48
173_A	176_D	0.679	0.48
160_D	561_P	0.678	0.48
176_D	207_R	0.676	0.47
114_T	144_N	0.675	0.47
392_P	497_Q	0.674	0.47
314_V	317_R	0.673	0.47
336_A	339_K	0.672	0.47
511_Q	544_C	0.672	0.47
285_D	473_H	0.672	0.47
121_E	125_V	0.670	0.47
330_N	339_K	0.669	0.47
241_E	245_R	0.666	0.46
460_F	469_A	0.665	0.46
42_L	312_L	0.665	0.46
507_N	510_V	0.665	0.46
283_T	504_V	0.665	0.46
240_L	243_G	0.663	0.46
470_T	498_D	0.663	0.46
285_D	476_H	0.662	0.46
151_S	187_M	0.661	0.46
124_N	476_H	0.660	0.46
426_V	437_V	0.659	0.46
471_V	502_L	0.659	0.46
288_P	553_I	0.658	0.46
487_E	507_N	0.658	0.46
316_Y	346_L	0.657	0.46
120_H	154_P	0.655	0.45
120_H	560_L	0.654	0.45
259_S	327_F	0.654	0.45
241_E	425_S	0.653	0.45
253_L	279_C	0.653	0.45
488_M	492_V	0.651	0.45
86_F	320_S	0.651	0.45
455_G	568_L	0.649	0.45
193_I	225_A	0.649	0.45
153_V	560_L	0.648	0.45
91_L	296_H	0.648	0.45
438_S	457_L	0.645	0.44
151_S	476_H	0.644	0.44
523_S	533_Q	0.642	0.44
247_L	253_L	0.641	0.44
345_L	355_Q	0.639	0.44
75_I	356_Q	0.637	0.44
237_S	242_E	0.637	0.44
316_Y	349_A	0.637	0.44
96_S	107_T	0.637	0.44
85_G	342_D	0.636	0.43
121_E	474_D	0.635	0.43
73_Q	396_S	0.634	0.43
200_L	206_F	0.634	0.43
552_F	556_A	0.633	0.43
156_L	475_S	0.631	0.43
211_L	231_I	0.629	0.43
117_C	184_A	0.628	0.43
571_Q	581_F	0.627	0.43
74_R	78_R	0.626	0.42
20_L	23_V	0.625	0.42
128_E	170_Q	0.625	0.42
197_N	201_D	0.625	0.42
536_A	540_A	0.625	0.42
436_D	483_R	0.624	0.42
123_V	166_F	0.624	0.42
124_N	473_H	0.623	0.42
97_M	471_V	0.623	0.42
54_I	301_I	0.621	0.42
541_A	546_P	0.621	0.42
73_Q	366_A	0.621	0.42
236_E	258_G	0.620	0.42
123_V	174_W	0.620	0.42
286_R	297_I	0.620	0.42
398_F	480_V	0.618	0.42
97_M	287_N	0.617	0.42
418_L	563_I	0.617	0.42
386_N	389_A	0.616	0.41
428_S	431_G	0.616	0.41
112_L	470_T	0.615	0.41
317_R	320_S	0.615	0.41
125_V	163_G	0.615	0.41
289_W	550_E	0.614	0.41
25_R	225_A	0.614	0.41
89_A	472_S	0.613	0.41
94_E	285_D	0.613	0.41
311_P	316_Y	0.612	0.41
117_C	203_L	0.612	0.41
320_S	324_A	0.612	0.41
282_C	297_I	0.612	0.41
344_V	354_V	0.611	0.41
135_A	177_H	0.610	0.41
153_V	187_M	0.609	0.41
55_K	60_A	0.608	0.41
125_V	446_Y	0.608	0.41
414_I	417_E	0.608	0.41
217_G	419_I	0.608	0.41
384_Y	387_T	0.607	0.41
365_D	370_Q	0.607	0.41
408_Y	455_G	0.607	0.41
239_Q	242_E	0.607	0.41
422_S	566_L	0.606	0.40
86_F	346_L	0.606	0.40
453_A	568_L	0.605	0.40
385_G	524_T	0.605	0.40
390_R	443_L	0.605	0.40
188_D	456_L	0.605	0.40
34_I	343_I	0.604	0.40
181_T	192_V	0.604	0.40
420_T	562_V	0.603	0.40
23_V	228_T	0.603	0.40
97_M	516_L	0.602	0.40
95_S	151_S	0.602	0.40
418_L	557_F	0.599	0.40
348_D	358_L	0.599	0.40
223_L	249_L	0.598	0.40
394_S	397_D	0.597	0.40
153_V	476_H	0.597	0.40
242_E	442_V	0.597	0.40
283_T	300_L	0.597	0.40
273_E	523_S	0.597	0.40
486_E	490_L	0.596	0.40
381_A	388_I	0.596	0.40
113_T	283_T	0.596	0.40
504_V	552_F	0.595	0.39
305_I	321_W	0.594	0.39
104_E	523_S	0.594	0.39
34_I	82_A	0.594	0.39
155_A	187_M	0.593	0.39
517_P	525_D	0.593	0.39
124_N	154_P	0.592	0.39
254_M	326_H	0.592	0.39
88_D	296_H	0.592	0.39
245_R	249_L	0.592	0.39
233_N	254_M	0.592	0.39
86_F	354_V	0.591	0.39
446_Y	450_L	0.591	0.39
247_L	309_N	0.591	0.39
215_C	218_L	0.590	0.39
497_Q	513_H	0.590	0.39
389_A	447_G	0.590	0.39
442_V	570_S	0.589	0.39
272_N	275_N	0.588	0.39
104_E	138_A	0.587	0.39
306_E	434_R	0.585	0.38
215_C	242_E	0.585	0.38
299_A	302_R	0.584	0.38
41_D	339_K	0.583	0.38
121_E	285_D	0.582	0.38
120_H	152_C	0.581	0.38
124_N	560_L	0.581	0.38
98_M	288_P	0.579	0.38
73_Q	356_Q	0.578	0.38
459_G	569_T	0.577	0.38
120_H	153_V	0.577	0.38
409_R	566_L	0.577	0.38
20_L	56_G	0.577	0.38
247_L	270_L	0.576	0.38
108_L	365_D	0.576	0.38
122_I	519_A	0.576	0.38
291_I	296_H	0.575	0.38
276_S	318_V	0.575	0.38
183_L	206_F	0.572	0.37
41_D	249_L	0.570	0.37
255_I	303_R	0.569	0.37
538_K	550_E	0.569	0.37
436_D	458_G	0.568	0.37
162_N	171_M	0.568	0.37
120_H	562_V	0.567	0.37
381_A	384_Y	0.567	0.37
305_I	354_V	0.567	0.37
320_S	323_T	0.566	0.37
285_D	477_N	0.565	0.37
87_I	114_T	0.565	0.37
486_E	508_G	0.564	0.37
171_M	203_L	0.563	0.36
306_E	351_K	0.563	0.36
265_N	301_I	0.563	0.36
302_R	354_V	0.562	0.36
152_C	475_S	0.561	0.36
369_L	396_S	0.561	0.36
212_D	233_N	0.561	0.36
523_S	526_T	0.560	0.36
285_D	474_D	0.559	0.36
54_I	345_L	0.559	0.36
27_D	195_G	0.558	0.36
410_V	536_A	0.558	0.36
120_H	151_S	0.556	0.36
96_S	477_N	0.556	0.36
337_P	566_L	0.556	0.36
149_V	175_R	0.556	0.36
393_V	443_L	0.556	0.36
432_F	483_R	0.556	0.36
432_F	535_D	0.556	0.36
103_F	567_K	0.556	0.36
130_G	134_F	0.556	0.36
504_V	537_L	0.556	0.36
542_R	580_A	0.555	0.36
405_G	434_R	0.555	0.36
470_T	491_A	0.554	0.36
120_H	124_N	0.554	0.36
237_S	263_N	0.552	0.35
202_K	242_E	0.552	0.35
39_I	47_E	0.552	0.35
258_G	439_F	0.552	0.35
269_P	272_N	0.552	0.35
279_C	318_V	0.551	0.35
130_G	519_A	0.551	0.35
58_Y	330_N	0.551	0.35
83_V	316_Y	0.551	0.35
390_R	493_N	0.550	0.35
152_C	155_A	0.550	0.35
233_N	574_F	0.549	0.35
438_S	546_P	0.548	0.35
260_A	280_M	0.548	0.35
165_S	495_V	0.546	0.35
174_W	177_H	0.546	0.35
97_M	418_L	0.544	0.35
241_E	507_N	0.544	0.35
94_E	120_H	0.543	0.35
240_L	269_P	0.542	0.34
462_L	544_C	0.542	0.34
224_N	337_P	0.542	0.34
301_I	352_V	0.541	0.34
144_N	342_D	0.540	0.34
107_T	152_C	0.540	0.34
108_L	359_V	0.539	0.34
305_I	350_R	0.538	0.34
289_W	343_I	0.538	0.34
402_F	409_R	0.538	0.34
248_Q	507_N	0.537	0.34
416_N	549_D	0.536	0.34
124_N	187_M	0.535	0.34
69_A	72_L	0.535	0.34
511_Q	540_A	0.535	0.34
410_V	437_V	0.535	0.34
137_C	140_Q	0.534	0.34
76_D	79_G	0.534	0.34
83_V	335_L	0.533	0.34
124_N	285_D	0.533	0.34
53_V	71_A	0.533	0.34
116_I	580_A	0.532	0.34
96_S	233_N	0.532	0.34
38_S	78_R	0.532	0.34
120_H	474_D	0.532	0.34
257_E	262_R	0.531	0.33
129_A	197_N	0.531	0.33
52_I	360_K	0.531	0.33
346_L	355_Q	0.530	0.33
489_A	496_I	0.530	0.33
133_W	136_R	0.530	0.33
86_F	309_N	0.530	0.33
142_R	568_L	0.530	0.33
551_P	557_F	0.530	0.33
484_S	507_N	0.529	0.33
115_V	504_V	0.529	0.33
169_E	539_A	0.529	0.33
61_G	224_N	0.528	0.33
266_A	269_P	0.528	0.33
120_H	125_V	0.528	0.33
154_P	473_H	0.527	0.33
121_E	187_M	0.527	0.33
209_L	518_I	0.527	0.33
272_N	309_N	0.526	0.33
565_A	575_D	0.526	0.33
180_V	209_L	0.526	0.33
187_M	191_G	0.525	0.33
96_S	285_D	0.525	0.33
49_S	78_R	0.525	0.33
558_L	567_K	0.525	0.33
124_N	153_V	0.524	0.33
187_M	560_L	0.524	0.33
204_D	539_A	0.524	0.33
255_I	265_N	0.524	0.33
244_R	270_L	0.524	0.33
148_Q	212_D	0.524	0.33
120_H	285_D	0.523	0.33
509_Q	532_E	0.523	0.33
430_N	578_K	0.523	0.33
363_P	403_T	0.523	0.33
137_C	225_A	0.523	0.33
186_M	231_I	0.522	0.33
70_P	74_R	0.522	0.33
437_V	455_G	0.522	0.33
114_T	325_R	0.522	0.33
217_G	247_L	0.521	0.33
121_E	151_S	0.520	0.33
27_D	193_I	0.520	0.33
54_I	239_Q	0.520	0.33
525_D	530_L	0.520	0.33
125_V	153_V	0.519	0.32
83_V	86_F	0.519	0.32
156_L	561_P	0.518	0.32
51_P	65_E	0.518	0.32
32_Y	57_R	0.518	0.32
205_A	455_G	0.518	0.32
402_F	426_V	0.517	0.32
210_T	323_T	0.517	0.32
345_L	362_E	0.516	0.32
89_A	280_M	0.515	0.32
80_A	346_L	0.514	0.32
70_P	73_Q	0.513	0.32
112_L	216_P	0.513	0.32
446_Y	560_L	0.513	0.32
95_S	562_V	0.513	0.32
286_R	299_A	0.512	0.32
534_I	538_K	0.511	0.32
459_G	472_S	0.510	0.32
233_N	253_L	0.510	0.32
155_A	568_L	0.510	0.32
105_T	141_A	0.509	0.32
455_G	514_L	0.508	0.31
356_Q	367_Q	0.508	0.31
370_Q	374_S	0.508	0.31
298_D	354_V	0.508	0.31
428_S	432_F	0.507	0.31
366_A	373_E	0.506	0.31
51_P	71_A	0.506	0.31
281_L	318_V	0.505	0.31
400_L	426_V	0.505	0.31
261_A	287_N	0.505	0.31
217_G	239_Q	0.505	0.31
311_P	349_A	0.503	0.31
128_E	132_A	0.503	0.31
289_W	535_D	0.503	0.31
216_P	553_I	0.502	0.31
191_G	456_L	0.502	0.31
312_L	316_Y	0.502	0.31
153_V	473_H	0.502	0.31
387_T	576_G	0.501	0.31
121_E	124_N	0.501	0.31
224_N	298_D	0.500	0.31
446_Y	449_R	0.500	0.31
83_V	352_V	0.500	0.31
392_P	543_E	0.500	0.31
152_C	562_V	0.500	0.31

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3nqbA	2	0.9779	100	0.322	Contact Map
2icsA	1	0.551	100	0.801	Contact Map
2vunA	3	0.5714	100	0.802	Contact Map
2ogjA	4	0.568	100	0.806	Contact Map
3mtwA	5	0.5561	100	0.811	Contact Map
3be7A	5	0.5561	100	0.811	Contact Map
4whbE	3	0.5816	100	0.813	Contact Map
1onwA	5	0.5748	100	0.815	Contact Map
3lnpA	2	0.5901	100	0.816	Contact Map
4c65A	6	0.5765	100	0.819	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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