GREMLIN Database
ADEQ - Adenine permease AdeQ
UniProt: P31440 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11691
Length: 444 (381)
Sequences: 10610 (5846)
Seq/√Len: 299.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
119_F307_A3.6851.00
165_T189_G3.6241.00
33_L336_V3.4261.00
394_M407_L3.1521.00
80_G335_V3.1171.00
390_I411_S3.1171.00
129_T297_Y3.1021.00
29_V332_L2.8501.00
77_I338_G2.8201.00
328_G333_T2.6171.00
78_A305_A2.5421.00
135_Y293_N2.5401.00
82_F301_V2.4991.00
120_W258_I2.4401.00
171_N177_M2.4291.00
77_I335_V2.3751.00
36_G336_V2.3401.00
71_I314_V2.3221.00
127_L131_F2.2631.00
196_I211_S2.2601.00
56_A101_F2.2381.00
181_L186_V2.2151.00
123_V127_L2.1831.00
245_D248_G2.1791.00
193_F365_F2.1751.00
276_V324_V2.1551.00
391_T408_G2.1541.00
421_R424_D2.1401.00
73_G342_L2.1281.00
323_G333_T2.1121.00
217_C221_F2.0971.00
339_V343_L2.0791.00
187_L191_L2.0731.00
306_G311_T2.0611.00
276_V320_S2.0541.00
75_G302_S2.0231.00
123_V304_V1.9991.00
215_T358_A1.9631.00
218_C222_F1.9571.00
400_S403_E1.9361.00
230_V234_P1.9351.00
394_M398_T1.9231.00
126_F304_V1.9121.00
119_F304_V1.9121.00
192_G215_T1.8891.00
175_L178_I1.8811.00
193_F361_G1.8591.00
35_A328_G1.8561.00
130_L297_Y1.8151.00
174_T177_M1.8151.00
189_G361_G1.7981.00
231_Y234_P1.7941.00
188_L215_T1.7931.00
78_A82_F1.7891.00
336_V340_M1.7791.00
73_G338_G1.7791.00
87_V316_A1.7621.00
192_G361_G1.7591.00
88_A337_V1.7581.00
28_T329_R1.7311.00
29_V33_L1.7281.00
236_D239_G1.6941.00
76_S338_G1.6671.00
191_L195_I1.6591.00
35_A333_T1.6531.00
124_G262_M1.6411.00
78_A298_V1.6241.00
382_F386_V1.6061.00
31_T329_R1.6041.00
200_S369_L1.5911.00
97_A312_S1.5841.00
375_A379_W1.5781.00
37_M340_M1.5661.00
393_V397_F1.5511.00
25_H28_T1.5461.00
126_F297_Y1.5381.00
29_V336_V1.5191.00
42_T322_S1.5091.00
33_L37_M1.4851.00
194_F198_V1.4821.00
305_A309_I1.4741.00
213_V217_C1.4721.00
416_K424_D1.4661.00
120_W254_L1.4661.00
291_N294_K1.4591.00
122_A304_V1.4491.00
103_V257_I1.4201.00
219_G224_D1.4081.00
154_G367_G1.4001.00
216_S219_G1.3941.00
197_T365_F1.3811.00
389_F393_V1.3791.00
215_T219_G1.3781.00
128_L133_I1.3631.00
301_V305_A1.3621.00
332_L336_V1.3621.00
93_M96_N1.3531.00
192_G211_S1.3461.00
40_F340_M1.3361.00
165_T360_A1.3311.00
241_I244_V1.3311.00
210_V214_V1.3281.00
75_G314_V1.3171.00
124_G255_A1.3091.00
32_E329_R1.2991.00
208_V362_A1.2971.00
110_S113_T1.2921.00
80_G334_A1.2891.00
190_I194_F1.2861.00
127_L130_L1.2821.00
185_G357_Y1.2821.00
246_L249_A1.2791.00
174_T178_I1.2721.00
73_G77_I1.2681.00
103_V261_F1.2661.00
81_I335_V1.2611.00
196_I365_F1.2581.00
163_K175_L1.2491.00
373_S376_R1.2481.00
206_A210_V1.2481.00
165_T364_I1.2461.00
200_S365_F1.2451.00
112_Q245_D1.2441.00
91_P319_E1.2401.00
195_I211_S1.2361.00
30_R34_I1.2351.00
155_L396_P1.2331.00
55_G61_P1.2261.00
286_N324_V1.2261.00
198_V202_R1.2151.00
158_A364_I1.2091.00
248_G251_T1.2031.00
151_S392_T1.2021.00
132_R136_W1.1901.00
390_I394_M1.1901.00
116_G246_L1.1871.00
253_E256_G1.1861.00
297_Y301_V1.1821.00
128_L262_M1.1771.00
78_A301_V1.1751.00
388_A392_T1.1691.00
240_V244_V1.1651.00
220_L353_I1.1631.00
96_N261_F1.1621.00
126_F300_S1.1601.00
82_F298_V1.1591.00
381_D384_E1.1581.00
323_G328_G1.1581.00
338_G342_L1.1571.00
124_G258_I1.1561.00
414_I418_C1.1541.00
183_S186_V1.1531.00
186_V189_G1.1501.00
247_S250_L1.1501.00
161_G364_I1.1461.00
217_C220_L1.1431.00
383_T419_T1.1421.00
294_K297_Y1.1371.00
135_Y139_S1.1361.00
265_N313_S1.1331.00
117_A254_L1.1321.00
245_D250_L1.1301.00
121_G262_M1.1281.00
182_S185_G1.1251.00
333_T337_V1.1241.00
144_S384_E1.1241.00
184_H187_L1.1191.00
417_V422_W1.1141.00
147_I376_R1.1121.00
374_L392_T1.1031.00
183_S187_L1.0981.00
191_L218_C1.0971.00
126_F130_L1.0971.00
196_I208_V1.0931.00
53_I93_M1.0921.00
199_L207_A1.0901.00
335_V339_V1.0891.00
180_D183_S1.0881.00
211_S215_T1.0821.00
101_F105_G1.0791.00
268_D272_T1.0761.00
193_F197_T1.0701.00
231_Y235_P1.0681.00
189_G364_I1.0681.00
344_V347_F1.0671.00
132_R293_N1.0661.00
25_H330_T1.0631.00
218_C221_F1.0621.00
235_P238_S1.0591.00
63_V312_S1.0551.00
35_A39_T1.0521.00
415_M419_T1.0451.00
336_V339_V1.0421.00
186_V190_I1.0391.00
247_S251_T1.0381.00
234_P238_S1.0351.00
273_L295_A1.0341.00
244_V308_F1.0281.00
28_T31_T1.0271.00
159_L397_F1.0261.00
121_G261_F1.0251.00
395_M404_G1.0241.00
196_I200_S1.0131.00
148_G391_T1.0081.00
301_V304_V1.0071.00
191_L215_T1.0071.00
187_L190_I1.0051.00
343_L346_F1.0021.00
192_G358_A1.0021.00
79_M90_A0.9981.00
277_T290_P0.9971.00
200_S207_A0.9961.00
244_V247_S0.9951.00
411_S415_M0.9941.00
151_S154_G0.9901.00
118_I307_A0.9871.00
124_G259_F0.9861.00
376_R380_D0.9841.00
210_V213_V0.9781.00
304_V307_A0.9771.00
199_L210_V0.9761.00
63_V104_V0.9671.00
87_V276_V0.9651.00
31_T35_A0.9581.00
106_A257_I0.9571.00
197_T386_V0.9511.00
302_S314_V0.9511.00
117_A257_I0.9481.00
237_I240_V0.9421.00
228_S231_Y0.9421.00
116_G120_W0.9341.00
258_I262_M0.9331.00
229_G232_S0.9321.00
87_V324_V0.9231.00
234_P237_I0.9191.00
332_L335_V0.9181.00
321_T325_A0.9161.00
371_T374_L0.9151.00
102_V106_A0.9151.00
74_I305_A0.9141.00
143_L147_I0.9121.00
302_S305_A0.9111.00
163_K170_A0.9111.00
121_G265_N0.9081.00
100_A313_S0.9001.00
398_T403_E0.8981.00
221_F225_V0.8951.00
229_G233_I0.8941.00
216_S353_I0.8941.00
228_S232_S0.8911.00
384_E387_P0.8911.00
228_S233_I0.8891.00
355_P358_A0.8891.00
85_L295_A0.8881.00
235_P242_G0.8861.00
114_G118_I0.8851.00
33_L332_L0.8831.00
50_N96_N0.8771.00
159_L163_K0.8731.00
74_I309_I0.8721.00
63_V67_T0.8691.00
50_N341_F0.8681.00
304_V308_F0.8671.00
245_D251_T0.8671.00
221_F224_D0.8651.00
106_A109_I0.8601.00
225_V228_S0.8591.00
197_T368_V0.8581.00
92_A315_T0.8571.00
265_N303_S0.8561.00
90_A299_D0.8551.00
155_L392_T0.8551.00
189_G357_Y0.8551.00
209_L213_V0.8541.00
375_A378_N0.8451.00
207_A211_S0.8441.00
164_N360_A0.8431.00
375_A380_D0.8431.00
36_G40_F0.8401.00
390_I407_L0.8371.00
252_L256_G0.8361.00
116_G249_A0.8361.00
66_V345_M0.8351.00
72_A76_S0.8311.00
158_A367_G0.8311.00
378_N385_S0.8301.00
121_G313_S0.8301.00
194_F197_T0.8271.00
117_A261_F0.8271.00
205_H326_V0.8261.00
117_A121_G0.8241.00
169_V172_K0.8241.00
69_C73_G0.8221.00
154_G371_T0.8221.00
32_E330_T0.8221.00
150_T275_G0.8201.00
394_M403_E0.8191.00
385_S389_F0.8171.00
36_G340_M0.8161.00
350_L353_I0.8131.00
25_H291_N0.8111.00
212_I215_T0.8111.00
56_A100_A0.8091.00
383_T416_K0.8051.00
322_S326_V0.8041.00
82_F294_K0.7991.00
406_A410_M0.7991.00
82_F297_Y0.7981.00
237_I242_G0.7890.99
26_G30_R0.7880.99
99_F261_F0.7880.99
119_F308_F0.7860.99
235_P239_G0.7850.99
272_T317_Y0.7850.99
159_L176_V0.7840.99
85_L289_F0.7840.99
403_E406_A0.7840.99
346_F349_P0.7830.99
416_K421_R0.7820.99
128_L296_L0.7810.99
198_V418_C0.7760.99
170_A173_D0.7750.99
115_M307_A0.7740.99
231_Y347_F0.7740.99
67_T111_W0.7700.99
246_L308_F0.7690.99
188_L219_G0.7680.99
214_V218_C0.7680.99
118_I313_S0.7630.99
344_V351_V0.7630.99
71_I75_G0.7600.99
283_I289_F0.7570.99
112_Q243_E0.7560.99
57_A64_V0.7550.99
216_S220_L0.7540.99
139_S288_K0.7540.99
129_T135_Y0.7530.99
185_G189_G0.7500.99
242_G308_F0.7490.99
52_Q61_P0.7490.99
195_I214_V0.7470.99
136_W139_S0.7430.99
240_V243_E0.7420.99
115_M118_I0.7400.99
129_T300_S0.7400.99
104_V110_S0.7380.99
262_M266_L0.7330.99
172_K175_L0.7280.99
77_I80_G0.7240.99
283_I286_N0.7240.99
52_Q56_A0.7210.99
152_G396_P0.7210.99
170_A175_L0.7180.99
79_M89_L0.7170.99
238_S241_I0.7170.99
242_G245_D0.7160.99
211_S362_A0.7140.99
383_T387_P0.7130.99
104_V114_G0.7120.99
196_I361_G0.7100.99
277_T289_F0.7100.99
120_W124_G0.7100.99
173_D177_M0.7090.99
60_D64_V0.7080.99
102_V105_G0.7050.99
245_D249_A0.7040.99
77_I81_I0.7020.99
230_V233_I0.7010.99
59_M64_V0.7000.99
85_L291_N0.6990.99
49_V337_V0.6990.99
53_I72_A0.6990.99
266_L296_L0.6960.99
112_Q115_M0.6960.99
219_G225_V0.6950.99
216_S354_V0.6940.99
158_A389_F0.6920.99
89_L314_V0.6900.99
385_S388_A0.6880.99
383_T415_M0.6880.99
256_G260_S0.6850.99
159_L162_L0.6830.99
238_S243_E0.6810.98
67_T310_G0.6800.98
257_I260_S0.6790.98
416_K420_G0.6770.98
407_L411_S0.6770.98
300_S304_V0.6710.98
93_M316_A0.6700.98
219_G222_F0.6700.98
125_L265_N0.6680.98
144_S148_G0.6670.98
199_L204_F0.6670.98
50_N68_T0.6670.98
109_I253_E0.6650.98
197_T201_S0.6640.98
305_A308_F0.6640.98
169_V173_D0.6640.98
122_A303_S0.6620.98
252_L255_A0.6600.98
371_T392_T0.6570.98
278_D376_R0.6570.98
166_G186_V0.6560.98
92_A319_E0.6530.98
148_G388_A0.6530.98
96_N121_G0.6510.98
365_F369_L0.6500.98
236_D240_V0.6500.98
209_L216_S0.6500.98
278_D283_I0.6490.98
412_Y416_K0.6480.98
300_S303_S0.6480.98
337_V344_V0.6420.98
33_L340_M0.6410.98
30_R33_L0.6410.98
195_I215_T0.6400.98
303_S313_S0.6380.98
179_G183_S0.6370.98
159_L175_L0.6370.98
188_L222_F0.6350.98
37_M336_V0.6340.98
193_F364_I0.6340.98
146_R274_I0.6330.98
325_A369_L0.6320.98
191_L222_F0.6320.98
242_G249_A0.6310.98
403_E407_L0.6290.97
152_G395_M0.6280.97
392_T395_M0.6270.97
35_A326_V0.6270.97
413_C417_V0.6270.97
215_T218_C0.6260.97
89_L334_A0.6260.97
50_N93_M0.6260.97
209_L355_P0.6240.97
72_A89_L0.6220.97
229_G234_P0.6220.97
381_D386_V0.6220.97
49_V52_Q0.6210.97
297_Y304_V0.6200.97
220_L225_V0.6200.97
138_I141_I0.6200.97
132_R135_Y0.6200.97
52_Q55_G0.6200.97
142_P412_Y0.6190.97
382_F385_S0.6190.97
75_G306_G0.6180.97
236_D249_A0.6180.97
206_A212_I0.6160.97
79_M298_V0.6150.97
343_L347_F0.6100.97
50_N53_I0.6090.97
72_A341_F0.6090.97
218_C224_D0.6090.97
93_M317_Y0.6080.97
235_P240_V0.6070.97
152_G392_T0.6060.97
254_L257_I0.6050.97
265_N269_S0.6040.97
232_S236_D0.6030.97
124_G128_L0.6030.97
418_C422_W0.6030.97
277_T288_K0.6020.97
269_S316_A0.6020.97
220_L224_D0.6010.97
242_G246_L0.6000.97
116_G247_S0.5990.97
246_L250_L0.5990.97
95_L264_I0.5970.97
96_N100_A0.5960.96
79_M83_A0.5960.96
211_S216_S0.5950.96
151_S371_T0.5950.96
191_L198_V0.5940.96
69_C341_F0.5930.96
53_I57_A0.5920.96
170_A178_I0.5890.96
151_S374_L0.5880.96
234_P240_V0.5870.96
103_V117_A0.5830.96
125_L262_M0.5830.96
191_L194_F0.5820.96
34_I38_T0.5820.96
118_I261_F0.5810.96
272_T316_A0.5810.96
147_I373_S0.5800.96
201_S382_F0.5790.96
79_M314_V0.5770.96
255_A258_I0.5750.96
420_G423_R0.5730.96
386_V390_I0.5730.96
239_G242_G0.5690.95
62_K66_V0.5690.95
214_V217_C0.5670.95
388_A391_T0.5670.95
84_N298_V0.5650.95
374_L385_S0.5650.95
391_T395_M0.5650.95
220_L223_G0.5640.95
208_V212_I0.5620.95
188_L192_G0.5620.95
79_M299_D0.5610.95
269_S315_T0.5590.95
245_D310_G0.5590.95
98_F102_V0.5580.95
181_L184_H0.5580.95
254_L258_I0.5550.95
374_L388_A0.5530.95
31_T34_I0.5530.95
377_V385_S0.5500.95
40_F341_F0.5450.94
238_S242_G0.5440.94
147_I372_S0.5440.94
388_A395_M0.5420.94
384_E416_K0.5360.94
188_L218_C0.5350.94
129_T293_N0.5350.94
116_G254_L0.5340.94
182_S186_V0.5320.94
98_F101_F0.5320.94
391_T396_P0.5310.93
27_T30_R0.5310.93
87_V328_G0.5310.93
100_A114_G0.5300.93
25_H29_V0.5300.93
239_G243_E0.5300.93
302_S306_G0.5290.93
90_A302_S0.5290.93
76_S337_V0.5290.93
271_G317_Y0.5260.93
188_L357_Y0.5260.93
208_V219_G0.5250.93
83_A298_V0.5250.93
169_V180_D0.5240.93
387_P415_M0.5240.93
387_P411_S0.5230.93
244_V248_G0.5230.93
213_V216_S0.5230.93
232_S235_P0.5220.93
140_N421_R0.5220.93
89_L95_L0.5200.93
148_G392_T0.5190.93
381_D416_K0.5190.93
379_W385_S0.5190.93
74_I306_G0.5190.93
26_G29_V0.5170.93
189_G193_F0.5160.92
374_L377_V0.5160.92
214_V221_F0.5140.92
116_G248_G0.5130.92
136_W293_N0.5120.92
310_G408_G0.5120.92
345_M348_S0.5110.92
360_A364_I0.5110.92
208_V211_S0.5110.92
130_L133_I0.5100.92
122_A300_S0.5090.92
320_S328_G0.5090.92
212_I362_A0.5090.92
94_G315_T0.5070.92
63_V111_W0.5060.92
87_V288_K0.5050.92
232_S248_G0.5050.92
100_A104_V0.5050.92
415_M418_C0.5030.92
203_H210_V0.5020.91
357_Y361_G0.5020.91
298_V301_V0.5020.91
66_V70_L0.5020.91
339_V342_L0.5010.91
147_I151_S0.5000.91
113_T254_L0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qe7A 2 0.8468 100 0.544 Contact Map
3o7qA 1 0.4212 25 0.966 Contact Map
2zy9A 2 0.2568 11.8 0.971 Contact Map
2nr9A 2 0.4279 10.6 0.971 Contact Map
2gfpA 2 0.4279 5.5 0.975 Contact Map
1pw4A 1 0.4527 5.3 0.975 Contact Map
1auuA 2 0.0631 4.4 0.976 Contact Map
4us3A 1 0.8581 4.4 0.976 Contact Map
4mhcA 1 0.1284 4 0.976 Contact Map
4b19A 1 0.0676 3.6 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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