GREMLIN Database
YICL - Uncharacterized inner membrane transporter YicL
UniProt: P31437 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11688
Length: 307 (277)
Sequences: 38927 (28490)
Seq/√Len: 1711.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
93_T162_G3.3461.00
10_N238_K2.8311.00
101_T159_L2.7511.00
238_K242_L2.6091.00
48_G194_L2.5731.00
263_S269_I2.5671.00
92_L161_W2.4631.00
89_T164_A2.4441.00
132_A285_S2.4331.00
41_M201_L2.4071.00
24_C223_Y2.3261.00
238_K241_Q2.1911.00
123_S177_S2.1661.00
112_I166_A2.1551.00
68_N71_D2.1281.00
215_G219_L2.0921.00
26_Q269_I2.0571.00
89_T161_W2.0431.00
116_W174_T2.0261.00
19_G258_S1.9481.00
103_T259_S1.9441.00
46_F225_V1.9221.00
11_V239_G1.9211.00
118_S125_P1.9111.00
45_I197_G1.9031.00
85_T168_A1.9031.00
25_A91_L1.8721.00
160_F164_A1.8381.00
97_S159_L1.8111.00
114_V133_I1.8111.00
117_F123_S1.7731.00
113_I249_S1.7611.00
52_L190_G1.7521.00
108_L112_I1.7521.00
225_V230_S1.7071.00
126_G129_V1.6921.00
71_D182_R1.6841.00
198_L202_P1.6821.00
53_T56_F1.6811.00
97_S158_A1.6751.00
89_T168_A1.6511.00
19_G262_L1.6421.00
20_S223_Y1.6351.00
184_G187_P1.6341.00
48_G197_G1.6291.00
96_K157_A1.5931.00
244_G247_K1.5901.00
287_I291_M1.5861.00
16_V258_S1.5591.00
214_N217_L1.5571.00
112_I170_A1.5391.00
136_S253_C1.5191.00
202_P205_A1.5181.00
272_T275_D1.4581.00
273_L277_L1.4481.00
132_A289_I1.4311.00
41_M197_G1.4291.00
34_M217_L1.4261.00
102_A162_G1.4101.00
116_W120_V1.4011.00
54_L58_H1.3951.00
14_A239_G1.3861.00
92_L96_K1.3801.00
112_I167_F1.3621.00
276_W280_L1.3581.00
74_S175_Y1.3561.00
73_I77_I1.3551.00
76_L195_I1.3401.00
52_L56_F1.3381.00
77_I175_Y1.3331.00
176_P237_L1.3331.00
99_A263_S1.3251.00
139_G278_G1.3181.00
69_H73_I1.3161.00
142_L281_L1.3151.00
97_S101_T1.3081.00
53_T57_V1.3071.00
18_W232_T1.3021.00
262_L266_L1.2991.00
127_I131_C1.2991.00
100_A260_A1.2911.00
70_K74_S1.2911.00
117_F121_R1.2871.00
47_A193_M1.2781.00
70_K73_I1.2671.00
49_L53_T1.2611.00
98_N101_T1.2591.00
132_A288_L1.2581.00
28_I39_L1.2561.00
136_S285_S1.2551.00
215_G218_I1.2511.00
280_L284_S1.2511.00
258_S262_L1.2491.00
96_K161_W1.2471.00
50_I230_S1.2471.00
130_F134_L1.2461.00
10_N235_L1.2461.00
142_L274_P1.2441.00
216_S219_L1.2381.00
170_A174_T1.2341.00
39_L224_L1.2231.00
134_L138_V1.2131.00
178_T182_R1.2111.00
254_A258_S1.2061.00
156_P160_F1.1991.00
31_Q217_L1.1931.00
84_L199_I1.1921.00
80_V199_I1.1891.00
27_Y220_A1.1881.00
271_F276_W1.1881.00
23_V262_L1.1871.00
92_L95_E1.1861.00
56_F60_D1.1831.00
128_L288_L1.1821.00
156_P159_L1.1801.00
219_L223_Y1.1741.00
116_W171_F1.1741.00
199_I202_P1.1661.00
69_H72_A1.1631.00
177_S244_G1.1611.00
79_S195_I1.1531.00
17_L227_I1.1431.00
9_L13_I1.1411.00
41_M204_Y1.1371.00
31_Q214_N1.1361.00
48_G190_G1.1251.00
178_T181_A1.1191.00
35_S38_F1.1141.00
96_K155_S1.1061.00
104_V279_T1.1021.00
8_M251_L1.0991.00
143_L278_G1.0981.00
216_S220_A1.0911.00
26_Q30_E1.0901.00
113_I245_G1.0891.00
41_M45_I1.0821.00
84_L200_L1.0771.00
157_A161_W1.0711.00
37_Q203_F1.0711.00
81_V171_F1.0581.00
208_G211_F1.0561.00
177_S181_A1.0551.00
7_G239_G1.0531.00
99_A267_L1.0501.00
74_S179_L1.0471.00
125_P130_F1.0441.00
240_A248_A1.0421.00
105_L166_A1.0411.00
121_R174_T1.0401.00
96_K158_A1.0391.00
116_W170_A1.0351.00
127_I130_F1.0351.00
94_I102_A1.0321.00
24_C220_A1.0261.00
18_W236_Y1.0231.00
14_A18_W1.0221.00
97_S162_G1.0211.00
71_D183_Y1.0201.00
118_S124_R1.0191.00
81_V168_A1.0161.00
123_S129_V1.0151.00
13_I235_L1.0151.00
128_L292_D1.0111.00
116_W167_F1.0031.00
114_V125_P1.0021.00
128_L291_M1.0011.00
20_S262_L1.0001.00
14_A235_L0.9981.00
113_I173_T0.9881.00
177_S245_G0.9881.00
203_F207_Q0.9861.00
219_L222_F0.9841.00
17_L235_L0.9771.00
40_T91_L0.9751.00
240_A244_G0.9741.00
139_G282_I0.9641.00
25_A94_I0.9621.00
157_A160_F0.9611.00
73_I76_L0.9551.00
28_I217_L0.9541.00
222_F225_V0.9521.00
56_F59_G0.9491.00
108_L140_T0.9461.00
119_L122_K0.9461.00
105_L159_L0.9451.00
116_W119_L0.9421.00
218_I222_F0.9381.00
43_R229_T0.9371.00
105_L162_G0.9341.00
90_F94_I0.9331.00
72_A195_I0.9301.00
60_D184_G0.9291.00
166_A170_A0.9261.00
37_Q88_L0.9251.00
36_S40_T0.9221.00
244_G248_A0.9181.00
273_L276_W0.9181.00
145_T272_T0.9101.00
158_A162_G0.9091.00
138_V142_L0.9051.00
38_F204_Y0.9041.00
45_I201_L0.9021.00
209_T212_V0.8981.00
203_F206_R0.8911.00
50_I226_V0.8881.00
126_G130_F0.8871.00
99_A269_I0.8771.00
74_S178_T0.8771.00
202_P206_R0.8771.00
23_V266_L0.8771.00
25_A29_M0.8751.00
124_R128_L0.8741.00
28_I220_A0.8731.00
104_V141_F0.8701.00
83_A172_Y0.8691.00
50_I53_T0.8691.00
141_F145_T0.8671.00
113_I170_A0.8671.00
44_L196_G0.8451.00
40_T200_L0.8441.00
135_T285_S0.8391.00
243_I248_A0.8391.00
15_A258_S0.8371.00
264_L271_F0.8321.00
15_A19_G0.8321.00
131_C135_T0.8291.00
257_L279_T0.8261.00
7_G242_L0.8211.00
81_V175_Y0.8211.00
23_V263_S0.8181.00
243_I247_K0.8181.00
194_L198_L0.8091.00
75_L183_Y0.8051.00
213_V218_I0.8021.00
79_S84_L0.8001.00
68_N72_A0.7981.00
254_A257_L0.7961.00
277_L281_L0.7951.00
274_P277_L0.7941.00
214_N218_I0.7911.00
52_L194_L0.7911.00
124_R127_I0.7901.00
155_S159_L0.7891.00
152_L155_S0.7841.00
239_G248_A0.7831.00
138_V281_L0.7821.00
279_T283_L0.7781.00
12_L258_S0.7761.00
57_V60_D0.7711.00
88_L92_L0.7711.00
56_F61_K0.7701.00
21_S228_G0.7651.00
84_L88_L0.7601.00
11_V251_L0.7571.00
260_A271_F0.7531.00
190_G194_L0.7521.00
142_L277_L0.7481.00
55_S59_G0.7471.00
162_G166_A0.7451.00
48_G52_L0.7431.00
111_T136_S0.7431.00
171_F175_Y0.7391.00
71_D74_S0.7301.00
59_G62_I0.7281.00
169_A173_T0.7271.00
42_T46_F0.7241.00
75_L188_V0.7241.00
115_A119_L0.7231.00
77_I80_V0.7231.00
85_T89_T0.7231.00
105_L163_I0.7221.00
112_I163_I0.7221.00
118_S122_K0.7211.00
58_H61_K0.7141.00
45_I49_L0.7141.00
183_Y188_V0.7121.00
195_I198_L0.7121.00
140_T144_V0.7111.00
231_L235_L0.7091.00
83_A233_F0.7091.00
284_S288_L0.7091.00
222_F226_V0.7081.00
271_F275_D0.7061.00
114_V129_V0.7041.00
93_T102_A0.7031.00
51_L230_S0.7031.00
227_I231_L0.7001.00
108_L111_T0.6991.00
86_V168_A0.6981.00
223_Y227_I0.6971.00
15_A254_A0.6961.00
135_T288_L0.6951.00
221_F225_V0.6911.00
125_P129_V0.6881.00
260_A279_T0.6871.00
72_A76_L0.6871.00
57_V61_K0.6861.00
54_L186_L0.6821.00
74_S78_F0.6751.00
11_V243_I0.6751.00
113_I174_T0.6751.00
54_L57_V0.6711.00
139_G285_S0.6701.00
123_S246_P0.6701.00
264_L270_T0.6671.00
107_F166_A0.6651.00
195_I199_I0.6561.00
169_A236_Y0.6561.00
217_L220_A0.6551.00
60_D63_F0.6531.00
151_S154_I0.6521.00
285_S289_I0.6501.00
50_I225_V0.6491.00
23_V99_A0.6481.00
220_A223_Y0.6451.00
55_S190_G0.6451.00
86_V172_Y0.6431.00
38_F42_T0.6411.00
263_S267_L0.6401.00
189_V237_L0.6391.00
72_A191_W0.6391.00
22_G90_F0.6391.00
152_L156_P0.6351.00
83_A192_S0.6331.00
97_S102_A0.6251.00
108_L166_A0.6221.00
234_S238_K0.6221.00
58_H184_G0.6201.00
191_W195_I0.6191.00
185_T189_V0.6191.00
187_P191_W0.6181.00
68_N73_I0.6181.00
46_F50_I0.6181.00
110_P253_C0.6171.00
27_Y267_L0.6151.00
17_L232_T0.6151.00
145_T148_N0.6141.00
74_S77_I0.6131.00
250_I289_I0.6121.00
34_M39_L0.6081.00
58_H62_I0.6071.00
261_L265_L0.6021.00
84_L203_F0.6021.00
7_G243_I0.6011.00
37_Q207_Q0.6001.00
189_V192_S0.6001.00
270_T274_P0.6001.00
154_I157_A0.5991.00
22_G103_T0.5971.00
72_A75_L0.5951.00
93_T158_A0.5951.00
120_V171_F0.5951.00
161_W164_A0.5931.00
89_T165_S0.5911.00
194_L197_G0.5891.00
197_G201_L0.5881.00
272_T276_W0.5881.00
90_F165_S0.5851.00
8_M247_K0.5851.00
90_F102_A0.5841.00
115_A133_I0.5811.00
260_A264_L0.5811.00
261_L264_L0.5791.00
275_D279_T0.5751.00
129_V244_G0.5741.00
76_L80_V0.5741.00
121_R177_S0.5731.00
83_A196_G0.5701.00
198_L201_L0.5681.00
47_A230_S0.5671.00
262_L265_L0.5661.00
58_H186_L0.5651.00
121_R178_T0.5631.00
144_V159_L0.5571.00
107_F110_P0.5531.00
29_M94_I0.5501.00
265_L268_G0.5451.00
13_I17_L0.5451.00
22_G26_Q0.5441.00
153_S156_P0.5421.00
167_F171_F0.5411.00
71_D75_L0.5411.00
283_L287_I0.5411.00
173_T249_S0.5401.00
173_T236_Y0.5401.00
191_W194_L0.5401.00
253_C286_V0.5371.00
104_V144_V0.5341.00
213_V217_L0.5331.00
8_M12_L0.5331.00
37_Q200_L0.5321.00
34_M38_F0.5321.00
114_V118_S0.5291.00
172_Y237_L0.5291.00
76_L199_I0.5281.00
12_L15_A0.5281.00
40_T88_L0.5281.00
55_S187_P0.5251.00
15_A255_E0.5251.00
286_V289_I0.5241.00
70_K182_R0.5241.00
23_V259_S0.5221.00
264_L268_G0.5181.00
35_S207_Q0.5141.00
239_G243_I0.5141.00
264_L276_W0.5131.00
83_A87_Q0.5131.00
93_T97_S0.5101.00
108_L136_S0.5101.00
142_L275_D0.5061.00
193_M197_G0.5051.00
47_A225_V0.5051.00
252_S255_E0.5021.00
270_T275_D0.5021.00
43_R228_G0.5021.00
21_S91_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i68A 2 0.2508 98.9 0.75 Contact Map
3b5dA 2 0.329 98.1 0.805 Contact Map
4pypA 1 0.9349 69.6 0.912 Contact Map
1pw4A 1 0.9642 61 0.917 Contact Map
4j05A 3 0.9349 59.7 0.917 Contact Map
1u7gA 3 0.772 55.2 0.919 Contact Map
4he8J 1 0.4951 49 0.922 Contact Map
4tphA 2 0.8827 45.5 0.924 Contact Map
2cfqA 1 0.5993 39.4 0.927 Contact Map
4zw9A 1 0.9642 38.7 0.927 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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