YICL - ECOLI - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

YICL - Uncharacterized inner membrane transporter YicL

UniProt:	P31437	Sequences: MGSTRKGMLNVLIAAVLWGSSGVCAQYIMEQSQMSSQFLTMTRLIFAGLILLTLSFVHGDKIFSIINNHKDAISLLIFSVVGALTVQLTFLLTIEKSNAATATVLQFLSPTIIVAWFSLVRKSRPGILVFCAILTSLVGTFLLVTHGNPTSLSISPAALFWGIASAFAAAFYTTYPSTLIARYGTLPVVGWSMLIGGLILLPFYARQGTNFVVNGSLILAFFYLVVIGTSLTFSLYLKGAQLIGGPKASILSCAEPLSSALLSLLLLGITFTLPDWLGTLLILSSVILISMDSRRRARKINRPARHK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11688
Length:	307 (277)
Sequences:	38927 (28490)
Seq/√Len:	1711.8

ECOLI - YICL YHBE YTFF YEDA YIJE EAMA RHTA YDDG RARD YIGM
BACSU - YVBV YWFM YCXC YDED YDFC YETK YCBK YRDR YXXF YBFH YDEK YYAM YOAV YOJE
HALSA - Q9HHP6 Q9HQ34 Q9HPI0
SULSO - Q97UX3 Q97X73 Q97UE8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
93_T	162_G	3.346	1.00
10_N	238_K	2.831	1.00
101_T	159_L	2.751	1.00
238_K	242_L	2.609	1.00
48_G	194_L	2.573	1.00
263_S	269_I	2.567	1.00
92_L	161_W	2.463	1.00
89_T	164_A	2.444	1.00
132_A	285_S	2.433	1.00
41_M	201_L	2.407	1.00
24_C	223_Y	2.326	1.00
238_K	241_Q	2.191	1.00
123_S	177_S	2.166	1.00
112_I	166_A	2.155	1.00
68_N	71_D	2.128	1.00
215_G	219_L	2.092	1.00
26_Q	269_I	2.057	1.00
89_T	161_W	2.043	1.00
116_W	174_T	2.026	1.00
19_G	258_S	1.948	1.00
103_T	259_S	1.944	1.00
46_F	225_V	1.922	1.00
11_V	239_G	1.921	1.00
118_S	125_P	1.911	1.00
45_I	197_G	1.903	1.00
85_T	168_A	1.903	1.00
25_A	91_L	1.872	1.00
160_F	164_A	1.838	1.00
97_S	159_L	1.811	1.00
114_V	133_I	1.811	1.00
117_F	123_S	1.773	1.00
113_I	249_S	1.761	1.00
52_L	190_G	1.752	1.00
108_L	112_I	1.752	1.00
225_V	230_S	1.707	1.00
126_G	129_V	1.692	1.00
71_D	182_R	1.684	1.00
198_L	202_P	1.682	1.00
53_T	56_F	1.681	1.00
97_S	158_A	1.675	1.00
89_T	168_A	1.651	1.00
19_G	262_L	1.642	1.00
20_S	223_Y	1.635	1.00
184_G	187_P	1.634	1.00
48_G	197_G	1.629	1.00
96_K	157_A	1.593	1.00
244_G	247_K	1.590	1.00
287_I	291_M	1.586	1.00
16_V	258_S	1.559	1.00
214_N	217_L	1.557	1.00
112_I	170_A	1.539	1.00
136_S	253_C	1.519	1.00
202_P	205_A	1.518	1.00
272_T	275_D	1.458	1.00
273_L	277_L	1.448	1.00
132_A	289_I	1.431	1.00
41_M	197_G	1.429	1.00
34_M	217_L	1.426	1.00
102_A	162_G	1.410	1.00
116_W	120_V	1.401	1.00
54_L	58_H	1.395	1.00
14_A	239_G	1.386	1.00
92_L	96_K	1.380	1.00
112_I	167_F	1.362	1.00
276_W	280_L	1.358	1.00
74_S	175_Y	1.356	1.00
73_I	77_I	1.355	1.00
76_L	195_I	1.340	1.00
52_L	56_F	1.338	1.00
77_I	175_Y	1.333	1.00
176_P	237_L	1.333	1.00
99_A	263_S	1.325	1.00
139_G	278_G	1.318	1.00
69_H	73_I	1.316	1.00
142_L	281_L	1.315	1.00
97_S	101_T	1.308	1.00
53_T	57_V	1.307	1.00
18_W	232_T	1.302	1.00
262_L	266_L	1.299	1.00
127_I	131_C	1.299	1.00
100_A	260_A	1.291	1.00
70_K	74_S	1.291	1.00
117_F	121_R	1.287	1.00
47_A	193_M	1.278	1.00
70_K	73_I	1.267	1.00
49_L	53_T	1.261	1.00
98_N	101_T	1.259	1.00
132_A	288_L	1.258	1.00
28_I	39_L	1.256	1.00
136_S	285_S	1.255	1.00
215_G	218_I	1.251	1.00
280_L	284_S	1.251	1.00
258_S	262_L	1.249	1.00
96_K	161_W	1.247	1.00
50_I	230_S	1.247	1.00
130_F	134_L	1.246	1.00
10_N	235_L	1.246	1.00
142_L	274_P	1.244	1.00
216_S	219_L	1.238	1.00
170_A	174_T	1.234	1.00
39_L	224_L	1.223	1.00
134_L	138_V	1.213	1.00
178_T	182_R	1.211	1.00
254_A	258_S	1.206	1.00
156_P	160_F	1.199	1.00
31_Q	217_L	1.193	1.00
84_L	199_I	1.192	1.00
80_V	199_I	1.189	1.00
27_Y	220_A	1.188	1.00
271_F	276_W	1.188	1.00
23_V	262_L	1.187	1.00
92_L	95_E	1.186	1.00
56_F	60_D	1.183	1.00
128_L	288_L	1.182	1.00
156_P	159_L	1.180	1.00
219_L	223_Y	1.174	1.00
116_W	171_F	1.174	1.00
199_I	202_P	1.166	1.00
69_H	72_A	1.163	1.00
177_S	244_G	1.161	1.00
79_S	195_I	1.153	1.00
17_L	227_I	1.143	1.00
9_L	13_I	1.141	1.00
41_M	204_Y	1.137	1.00
31_Q	214_N	1.136	1.00
48_G	190_G	1.125	1.00
178_T	181_A	1.119	1.00
35_S	38_F	1.114	1.00
96_K	155_S	1.106	1.00
104_V	279_T	1.102	1.00
8_M	251_L	1.099	1.00
143_L	278_G	1.098	1.00
216_S	220_A	1.091	1.00
26_Q	30_E	1.090	1.00
113_I	245_G	1.089	1.00
41_M	45_I	1.082	1.00
84_L	200_L	1.077	1.00
157_A	161_W	1.071	1.00
37_Q	203_F	1.071	1.00
81_V	171_F	1.058	1.00
208_G	211_F	1.056	1.00
177_S	181_A	1.055	1.00
7_G	239_G	1.053	1.00
99_A	267_L	1.050	1.00
74_S	179_L	1.047	1.00
125_P	130_F	1.044	1.00
240_A	248_A	1.042	1.00
105_L	166_A	1.041	1.00
121_R	174_T	1.040	1.00
96_K	158_A	1.039	1.00
116_W	170_A	1.035	1.00
127_I	130_F	1.035	1.00
94_I	102_A	1.032	1.00
24_C	220_A	1.026	1.00
18_W	236_Y	1.023	1.00
14_A	18_W	1.022	1.00
97_S	162_G	1.021	1.00
71_D	183_Y	1.020	1.00
118_S	124_R	1.019	1.00
81_V	168_A	1.016	1.00
123_S	129_V	1.015	1.00
13_I	235_L	1.015	1.00
128_L	292_D	1.011	1.00
116_W	167_F	1.003	1.00
114_V	125_P	1.002	1.00
128_L	291_M	1.001	1.00
20_S	262_L	1.000	1.00
14_A	235_L	0.998	1.00
113_I	173_T	0.988	1.00
177_S	245_G	0.988	1.00
203_F	207_Q	0.986	1.00
219_L	222_F	0.984	1.00
17_L	235_L	0.977	1.00
40_T	91_L	0.975	1.00
240_A	244_G	0.974	1.00
139_G	282_I	0.964	1.00
25_A	94_I	0.962	1.00
157_A	160_F	0.961	1.00
73_I	76_L	0.955	1.00
28_I	217_L	0.954	1.00
222_F	225_V	0.952	1.00
56_F	59_G	0.949	1.00
108_L	140_T	0.946	1.00
119_L	122_K	0.946	1.00
105_L	159_L	0.945	1.00
116_W	119_L	0.942	1.00
218_I	222_F	0.938	1.00
43_R	229_T	0.937	1.00
105_L	162_G	0.934	1.00
90_F	94_I	0.933	1.00
72_A	195_I	0.930	1.00
60_D	184_G	0.929	1.00
166_A	170_A	0.926	1.00
37_Q	88_L	0.925	1.00
36_S	40_T	0.922	1.00
244_G	248_A	0.918	1.00
273_L	276_W	0.918	1.00
145_T	272_T	0.910	1.00
158_A	162_G	0.909	1.00
138_V	142_L	0.905	1.00
38_F	204_Y	0.904	1.00
45_I	201_L	0.902	1.00
209_T	212_V	0.898	1.00
203_F	206_R	0.891	1.00
50_I	226_V	0.888	1.00
126_G	130_F	0.887	1.00
99_A	269_I	0.877	1.00
74_S	178_T	0.877	1.00
202_P	206_R	0.877	1.00
23_V	266_L	0.877	1.00
25_A	29_M	0.875	1.00
124_R	128_L	0.874	1.00
28_I	220_A	0.873	1.00
104_V	141_F	0.870	1.00
83_A	172_Y	0.869	1.00
50_I	53_T	0.869	1.00
141_F	145_T	0.867	1.00
113_I	170_A	0.867	1.00
44_L	196_G	0.845	1.00
40_T	200_L	0.844	1.00
135_T	285_S	0.839	1.00
243_I	248_A	0.839	1.00
15_A	258_S	0.837	1.00
264_L	271_F	0.832	1.00
15_A	19_G	0.832	1.00
131_C	135_T	0.829	1.00
257_L	279_T	0.826	1.00
7_G	242_L	0.821	1.00
81_V	175_Y	0.821	1.00
23_V	263_S	0.818	1.00
243_I	247_K	0.818	1.00
194_L	198_L	0.809	1.00
75_L	183_Y	0.805	1.00
213_V	218_I	0.802	1.00
79_S	84_L	0.800	1.00
68_N	72_A	0.798	1.00
254_A	257_L	0.796	1.00
277_L	281_L	0.795	1.00
274_P	277_L	0.794	1.00
214_N	218_I	0.791	1.00
52_L	194_L	0.791	1.00
124_R	127_I	0.790	1.00
155_S	159_L	0.789	1.00
152_L	155_S	0.784	1.00
239_G	248_A	0.783	1.00
138_V	281_L	0.782	1.00
279_T	283_L	0.778	1.00
12_L	258_S	0.776	1.00
57_V	60_D	0.771	1.00
88_L	92_L	0.771	1.00
56_F	61_K	0.770	1.00
21_S	228_G	0.765	1.00
84_L	88_L	0.760	1.00
11_V	251_L	0.757	1.00
260_A	271_F	0.753	1.00
190_G	194_L	0.752	1.00
142_L	277_L	0.748	1.00
55_S	59_G	0.747	1.00
162_G	166_A	0.745	1.00
48_G	52_L	0.743	1.00
111_T	136_S	0.743	1.00
171_F	175_Y	0.739	1.00
71_D	74_S	0.730	1.00
59_G	62_I	0.728	1.00
169_A	173_T	0.727	1.00
42_T	46_F	0.724	1.00
75_L	188_V	0.724	1.00
115_A	119_L	0.723	1.00
77_I	80_V	0.723	1.00
85_T	89_T	0.723	1.00
105_L	163_I	0.722	1.00
112_I	163_I	0.722	1.00
118_S	122_K	0.721	1.00
58_H	61_K	0.714	1.00
45_I	49_L	0.714	1.00
183_Y	188_V	0.712	1.00
195_I	198_L	0.712	1.00
140_T	144_V	0.711	1.00
231_L	235_L	0.709	1.00
83_A	233_F	0.709	1.00
284_S	288_L	0.709	1.00
222_F	226_V	0.708	1.00
271_F	275_D	0.706	1.00
114_V	129_V	0.704	1.00
93_T	102_A	0.703	1.00
51_L	230_S	0.703	1.00
227_I	231_L	0.700	1.00
108_L	111_T	0.699	1.00
86_V	168_A	0.698	1.00
223_Y	227_I	0.697	1.00
15_A	254_A	0.696	1.00
135_T	288_L	0.695	1.00
221_F	225_V	0.691	1.00
125_P	129_V	0.688	1.00
260_A	279_T	0.687	1.00
72_A	76_L	0.687	1.00
57_V	61_K	0.686	1.00
54_L	186_L	0.682	1.00
74_S	78_F	0.675	1.00
11_V	243_I	0.675	1.00
113_I	174_T	0.675	1.00
54_L	57_V	0.671	1.00
139_G	285_S	0.670	1.00
123_S	246_P	0.670	1.00
264_L	270_T	0.667	1.00
107_F	166_A	0.665	1.00
195_I	199_I	0.656	1.00
169_A	236_Y	0.656	1.00
217_L	220_A	0.655	1.00
60_D	63_F	0.653	1.00
151_S	154_I	0.652	1.00
285_S	289_I	0.650	1.00
50_I	225_V	0.649	1.00
23_V	99_A	0.648	1.00
220_A	223_Y	0.645	1.00
55_S	190_G	0.645	1.00
86_V	172_Y	0.643	1.00
38_F	42_T	0.641	1.00
263_S	267_L	0.640	1.00
189_V	237_L	0.639	1.00
72_A	191_W	0.639	1.00
22_G	90_F	0.639	1.00
152_L	156_P	0.635	1.00
83_A	192_S	0.633	1.00
97_S	102_A	0.625	1.00
108_L	166_A	0.622	1.00
234_S	238_K	0.622	1.00
58_H	184_G	0.620	1.00
191_W	195_I	0.619	1.00
185_T	189_V	0.619	1.00
187_P	191_W	0.618	1.00
68_N	73_I	0.618	1.00
46_F	50_I	0.618	1.00
110_P	253_C	0.617	1.00
27_Y	267_L	0.615	1.00
17_L	232_T	0.615	1.00
145_T	148_N	0.614	1.00
74_S	77_I	0.613	1.00
250_I	289_I	0.612	1.00
34_M	39_L	0.608	1.00
58_H	62_I	0.607	1.00
261_L	265_L	0.602	1.00
84_L	203_F	0.602	1.00
7_G	243_I	0.601	1.00
37_Q	207_Q	0.600	1.00
189_V	192_S	0.600	1.00
270_T	274_P	0.600	1.00
154_I	157_A	0.599	1.00
22_G	103_T	0.597	1.00
72_A	75_L	0.595	1.00
93_T	158_A	0.595	1.00
120_V	171_F	0.595	1.00
161_W	164_A	0.593	1.00
89_T	165_S	0.591	1.00
194_L	197_G	0.589	1.00
197_G	201_L	0.588	1.00
272_T	276_W	0.588	1.00
90_F	165_S	0.585	1.00
8_M	247_K	0.585	1.00
90_F	102_A	0.584	1.00
115_A	133_I	0.581	1.00
260_A	264_L	0.581	1.00
261_L	264_L	0.579	1.00
275_D	279_T	0.575	1.00
129_V	244_G	0.574	1.00
76_L	80_V	0.574	1.00
121_R	177_S	0.573	1.00
83_A	196_G	0.570	1.00
198_L	201_L	0.568	1.00
47_A	230_S	0.567	1.00
262_L	265_L	0.566	1.00
58_H	186_L	0.565	1.00
121_R	178_T	0.563	1.00
144_V	159_L	0.557	1.00
107_F	110_P	0.553	1.00
29_M	94_I	0.550	1.00
265_L	268_G	0.545	1.00
13_I	17_L	0.545	1.00
22_G	26_Q	0.544	1.00
153_S	156_P	0.542	1.00
167_F	171_F	0.541	1.00
71_D	75_L	0.541	1.00
283_L	287_I	0.541	1.00
173_T	249_S	0.540	1.00
173_T	236_Y	0.540	1.00
191_W	194_L	0.540	1.00
253_C	286_V	0.537	1.00
104_V	144_V	0.534	1.00
213_V	217_L	0.533	1.00
8_M	12_L	0.533	1.00
37_Q	200_L	0.532	1.00
34_M	38_F	0.532	1.00
114_V	118_S	0.529	1.00
172_Y	237_L	0.529	1.00
76_L	199_I	0.528	1.00
12_L	15_A	0.528	1.00
40_T	88_L	0.528	1.00
55_S	187_P	0.525	1.00
15_A	255_E	0.525	1.00
286_V	289_I	0.524	1.00
70_K	182_R	0.524	1.00
23_V	259_S	0.522	1.00
264_L	268_G	0.518	1.00
35_S	207_Q	0.514	1.00
239_G	243_I	0.514	1.00
264_L	276_W	0.513	1.00
83_A	87_Q	0.513	1.00
93_T	97_S	0.510	1.00
108_L	136_S	0.510	1.00
142_L	275_D	0.506	1.00
193_M	197_G	0.505	1.00
47_A	225_V	0.505	1.00
252_S	255_E	0.502	1.00
270_T	275_D	0.502	1.00
43_R	228_G	0.502	1.00
21_S	91_L	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2i68A	2	0.2508	98.9	0.75	Contact Map
3b5dA	2	0.329	98.1	0.805	Contact Map
4pypA	1	0.9349	69.6	0.912	Contact Map
1pw4A	1	0.9642	61	0.917	Contact Map
4j05A	3	0.9349	59.7	0.917	Contact Map
1u7gA	3	0.772	55.2	0.919	Contact Map
4he8J	1	0.4951	49	0.922	Contact Map
4tphA	2	0.8827	45.5	0.924	Contact Map
2cfqA	1	0.5993	39.4	0.927	Contact Map
4zw9A	1	0.9642	38.7	0.927	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0101 seconds.