GREMLIN Database
SETC - Sugar efflux transporter C
UniProt: P31436 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11687
Length: 394 (370)
Sequences: 169803 (122812)
Seq/√Len: 6384.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
102_R106_I3.9961.00
97_L110_T3.9061.00
80_R131_E3.8701.00
90_F117_F3.7201.00
99_A176_L3.3151.00
62_M112_V3.2111.00
94_A110_T3.0501.00
70_L120_T2.9111.00
105_F109_S2.8041.00
92_V182_F2.7981.00
87_C120_T2.7871.00
75_D340_G2.7791.00
133_A143_F2.7641.00
103_N106_I2.7221.00
335_M342_A2.6671.00
141_V278_K2.6451.00
94_A117_F2.5781.00
251_T254_L2.5641.00
292_S319_F2.5561.00
104_Y108_L2.5481.00
282_K333_D2.5011.00
231_A357_A2.4281.00
134_D137_G2.4111.00
227_S353_G2.4071.00
48_R51_M2.4021.00
265_L314_I2.3321.00
299_S312_L2.3301.00
81_K85_L2.3241.00
66_V116_S2.2531.00
94_A113_L2.1691.00
137_G142_M2.1241.00
269_M318_I2.1221.00
375_W379_G2.1181.00
307_A311_E2.1021.00
169_F173_V2.0751.00
74_S124_Q2.0361.00
51_M104_Y2.0271.00
101_N106_I2.0001.00
20_L150_Q1.9991.00
281_G284_L1.9711.00
96_T179_A1.9001.00
101_N110_T1.8511.00
85_L190_W1.7981.00
92_V186_G1.7961.00
78_G82_L1.7931.00
275_Y279_R1.7771.00
94_A114_L1.7491.00
55_F107_L1.7151.00
72_R76_K1.7101.00
301_L375_W1.7051.00
235_L361_D1.6891.00
58_G112_V1.6861.00
98_F110_T1.6861.00
58_G108_L1.6851.00
296_F312_L1.6721.00
71_A75_D1.6651.00
66_V119_S1.6611.00
99_A179_A1.6481.00
296_F319_F1.6471.00
62_M66_V1.6441.00
301_L378_I1.6311.00
187_L191_L1.6301.00
47_A104_Y1.6261.00
294_M385_M1.6241.00
223_F349_T1.6131.00
85_L186_G1.6021.00
211_P215_R1.5941.00
176_L180_I1.5841.00
250_L254_L1.5771.00
47_A51_M1.5671.00
66_V69_F1.5551.00
209_I212_S1.5311.00
294_M382_G1.5041.00
289_A322_I1.4801.00
363_I367_I1.4661.00
92_V179_A1.4651.00
287_L385_M1.4441.00
170_S173_V1.4441.00
106_I110_T1.4311.00
105_F108_L1.4201.00
73_H83_L1.4111.00
82_L86_L1.4081.00
262_A317_A1.4051.00
273_A322_I1.4001.00
173_V176_L1.4001.00
69_F72_R1.4001.00
49_P366_E1.3851.00
89_L186_G1.3821.00
232_A381_L1.3801.00
307_A310_L1.3701.00
212_S338_K1.3651.00
284_L287_L1.3651.00
274_G278_K1.3611.00
372_A375_W1.3511.00
74_S80_R1.3481.00
368_W372_A1.3461.00
82_L85_L1.3421.00
87_C117_F1.3421.00
142_M278_K1.3331.00
130_R140_T1.3311.00
27_G151_I1.3251.00
305_T308_V1.3201.00
92_V183_V1.3071.00
73_H77_Q1.3061.00
77_Q83_L1.2981.00
283_R287_L1.2921.00
234_N354_W1.2901.00
86_L90_F1.2791.00
61_I355_I1.2761.00
212_S215_R1.2691.00
298_A302_M1.2671.00
208_E211_P1.2641.00
98_F107_L1.2631.00
164_E168_G1.2611.00
160_P260_G1.2601.00
245_I255_T1.2601.00
131_E339_I1.2581.00
276_Y280_I1.2511.00
372_A376_L1.2491.00
265_L269_M1.2491.00
371_H375_W1.2471.00
188_I192_F1.2461.00
272_I275_Y1.2421.00
90_F94_A1.2421.00
269_M272_I1.2291.00
75_D341_S1.2281.00
266_E321_G1.2231.00
291_V385_M1.2191.00
245_I252_D1.2081.00
39_I43_D1.1801.00
140_T333_D1.1721.00
135_R140_T1.1701.00
207_V210_L1.1651.00
96_T100_W1.1651.00
288_I292_S1.1651.00
275_Y278_K1.1651.00
244_I250_L1.1631.00
254_L257_E1.1561.00
379_G383_I1.1511.00
298_A378_I1.1491.00
207_V211_P1.1481.00
165_L173_V1.1471.00
296_F316_N1.1461.00
129_A147_L1.1441.00
189_V193_L1.1431.00
271_L275_Y1.1361.00
57_T359_S1.1281.00
219_T223_F1.1211.00
375_W378_I1.1081.00
353_G357_A1.1071.00
97_L100_W1.1001.00
167_M253_K1.0981.00
362_G366_E1.0981.00
64_I355_I1.0971.00
81_K195_S1.0971.00
293_G381_L1.0921.00
88_C186_G1.0891.00
220_R224_V1.0871.00
289_A323_L1.0861.00
294_M298_A1.0851.00
291_V295_C1.0831.00
296_F315_L1.0821.00
287_L389_L1.0731.00
382_G386_I1.0731.00
290_I384_A1.0711.00
50_I366_E1.0681.00
243_F248_L1.0641.00
62_M115_S1.0631.00
257_E261_I1.0571.00
37_L52_V1.0551.00
160_P164_E1.0531.00
77_Q82_L1.0501.00
281_G285_L1.0481.00
338_K341_S1.0461.00
50_I54_F1.0451.00
85_L189_V1.0421.00
82_L195_S1.0421.00
51_M108_L1.0361.00
376_L380_M1.0311.00
214_H220_R1.0301.00
29_A32_L1.0271.00
22_V121_A1.0251.00
57_T355_I1.0221.00
217_R221_L1.0221.00
91_G117_F1.0201.00
216_K220_R1.0181.00
15_T132_H1.0181.00
180_I184_V1.0181.00
93_L97_L1.0171.00
54_F359_S1.0101.00
97_L106_I1.0091.00
311_E314_I1.0071.00
78_G83_L1.0061.00
109_S113_L1.0041.00
284_L288_I1.0001.00
303_A312_L0.9971.00
59_S115_S0.9971.00
225_V388_L0.9941.00
59_S118_A0.9891.00
75_D80_R0.9871.00
289_A319_F0.9751.00
268_P271_L0.9751.00
142_M146_F0.9701.00
331_F346_Y0.9671.00
28_I158_G0.9671.00
44_E172_K0.9621.00
58_G62_M0.9601.00
68_Q72_R0.9591.00
71_A340_G0.9561.00
80_R127_A0.9561.00
100_W176_L0.9541.00
133_A137_G0.9481.00
299_S302_M0.9471.00
128_L193_L0.9411.00
183_V187_L0.9411.00
191_L194_P0.9361.00
83_L86_L0.9341.00
378_I382_G0.9321.00
64_I348_N0.9311.00
364_M368_W0.9271.00
376_L379_G0.9261.00
18_A188_I0.9241.00
243_F247_E0.9241.00
186_G190_W0.9211.00
230_W350_S0.9201.00
99_A172_K0.9141.00
111_G115_S0.9131.00
268_P272_I0.9131.00
53_G57_T0.9131.00
54_F58_G0.9091.00
287_L291_V0.9081.00
39_I44_E0.9051.00
102_R172_K0.8991.00
196_I199_N0.8961.00
206_P209_I0.8951.00
208_E212_S0.8941.00
42_A49_P0.8941.00
106_I109_S0.8931.00
211_P214_H0.8901.00
85_L89_L0.8891.00
206_P211_P0.8891.00
24_F154_A0.8871.00
80_R195_S0.8861.00
43_D46_K0.8861.00
264_G268_P0.8861.00
297_Y301_L0.8821.00
53_G239_N0.8821.00
280_I285_L0.8811.00
265_L268_P0.8771.00
280_I284_L0.8761.00
218_D221_L0.8651.00
130_R339_I0.8651.00
277_M326_I0.8641.00
287_L290_I0.8631.00
296_F299_S0.8631.00
217_R220_R0.8591.00
294_M381_L0.8581.00
161_L164_E0.8561.00
86_L89_L0.8551.00
226_C346_Y0.8491.00
292_S296_F0.8481.00
51_M54_F0.8481.00
152_S266_E0.8471.00
290_I385_M0.8451.00
123_P126_F0.8451.00
253_K257_E0.8451.00
294_M378_I0.8441.00
325_G329_L0.8301.00
165_L169_F0.8281.00
142_M275_Y0.8261.00
179_A183_V0.8251.00
173_V177_T0.8251.00
44_E171_F0.8221.00
163_Y256_G0.8211.00
295_C299_S0.8191.00
67_S347_A0.8191.00
311_E315_L0.8181.00
308_V311_E0.8171.00
78_G195_S0.8161.00
176_L179_A0.8131.00
269_M273_A0.8121.00
91_G182_F0.8091.00
228_M380_M0.8071.00
201_P204_T0.8071.00
22_V84_I0.8071.00
285_L288_I0.8051.00
95_C179_A0.8031.00
89_L93_L0.8011.00
42_A52_V0.8001.00
239_N362_G0.7961.00
373_L376_L0.7961.00
55_F108_L0.7951.00
36_T166_A0.7951.00
16_A133_A0.7931.00
329_L333_D0.7921.00
87_C124_Q0.7911.00
29_A111_G0.7911.00
95_C114_L0.7891.00
84_I128_L0.7861.00
258_M310_L0.7841.00
95_C178_A0.7831.00
66_V70_L0.7831.00
21_L185_C0.7821.00
288_I291_V0.7821.00
291_V294_M0.7781.00
96_T176_L0.7761.00
144_S329_L0.7731.00
363_I366_E0.7721.00
180_I183_V0.7721.00
332_Q343_T0.7711.00
89_L92_V0.7691.00
78_G81_K0.7651.00
111_G114_L0.7641.00
70_L119_S0.7641.00
206_P212_S0.7641.00
244_I309_E0.7601.00
81_K190_W0.7581.00
344_T348_N0.7571.00
303_A308_V0.7551.00
136_T142_M0.7491.00
59_S63_G0.7481.00
386_I389_L0.7471.00
30_G63_G0.7451.00
360_V363_I0.7441.00
72_R341_S0.7391.00
302_M375_W0.7361.00
369_S372_A0.7361.00
157_I160_P0.7341.00
194_P197_Q0.7341.00
29_A178_A0.7291.00
123_P127_A0.7281.00
261_I310_L0.7241.00
216_K334_L0.7231.00
156_V264_G0.7221.00
109_S112_V0.7211.00
272_I276_Y0.7211.00
155_W263_A0.7171.00
98_F101_N0.7151.00
298_A301_L0.7131.00
54_F108_L0.7111.00
229_M323_L0.7101.00
20_L146_F0.7091.00
25_L29_A0.7081.00
18_A185_C0.7031.00
31_A155_W0.7021.00
359_S363_I0.7021.00
32_L174_M0.7011.00
224_V228_M0.7001.00
260_G264_G0.6951.00
226_C230_W0.6911.00
212_S337_E0.6881.00
205_Q208_E0.6861.00
352_V356_I0.6851.00
130_R144_S0.6831.00
24_F157_I0.6831.00
128_L132_H0.6821.00
293_G319_F0.6821.00
178_A181_A0.6821.00
144_S332_Q0.6811.00
276_Y285_L0.6791.00
380_M384_A0.6781.00
152_S267_I0.6751.00
166_A174_M0.6731.00
173_V180_I0.6731.00
244_I248_L0.6721.00
373_L377_A0.6721.00
205_Q209_I0.6721.00
308_V312_L0.6711.00
81_K194_P0.6711.00
28_I178_A0.6701.00
56_F238_I0.6681.00
177_T180_I0.6681.00
130_R332_Q0.6671.00
149_A267_I0.6671.00
310_L314_I0.6641.00
98_F114_L0.6641.00
377_A381_L0.6631.00
200_I204_T0.6621.00
306_P310_L0.6621.00
374_F378_I0.6621.00
154_A158_G0.6611.00
84_I189_V0.6601.00
240_M313_Q0.6581.00
55_F104_Y0.6571.00
299_S303_A0.6571.00
88_C185_C0.6561.00
370_Y373_L0.6551.00
289_A326_I0.6541.00
262_A313_Q0.6531.00
65_L68_Q0.6531.00
119_S123_P0.6531.00
150_Q154_A0.6491.00
23_A147_L0.6491.00
235_L377_A0.6491.00
228_M384_A0.6491.00
50_I359_S0.6471.00
29_A91_G0.6461.00
92_V96_T0.6451.00
159_P260_G0.6441.00
120_T124_Q0.6421.00
381_L385_M0.6401.00
149_A271_L0.6361.00
187_L190_W0.6361.00
47_A52_V0.6341.00
250_L258_M0.6341.00
187_L192_F0.6331.00
172_K176_L0.6331.00
42_A47_A0.6321.00
197_Q200_I0.6311.00
315_L319_F0.6311.00
91_G118_A0.6311.00
65_L69_F0.6291.00
111_G122_N0.6291.00
61_I64_I0.6281.00
332_Q339_I0.6271.00
74_S83_L0.6251.00
223_F346_Y0.6231.00
51_M55_F0.6221.00
93_L96_T0.6221.00
70_L73_H0.6211.00
322_I326_I0.6211.00
50_I53_G0.6191.00
199_N203_V0.6181.00
129_A143_F0.6151.00
98_F175_Y0.6151.00
16_A143_F0.6151.00
254_L258_M0.6141.00
84_I125_M0.6141.00
164_E167_M0.6121.00
365_V373_L0.6111.00
57_T358_G0.6081.00
64_I351_R0.6061.00
63_G351_R0.6061.00
53_G362_G0.6041.00
24_F150_Q0.6031.00
164_E257_E0.6021.00
221_L387_C0.5991.00
261_I265_L0.5981.00
368_W371_H0.5971.00
220_R223_F0.5961.00
126_F147_L0.5951.00
102_R105_F0.5941.00
36_T174_M0.5941.00
163_Y257_E0.5941.00
162_A174_M0.5931.00
110_T113_L0.5931.00
67_S344_T0.5911.00
224_V387_C0.5911.00
100_W106_I0.5901.00
163_Y260_G0.5901.00
238_I241_P0.5881.00
140_T332_Q0.5881.00
59_S111_G0.5841.00
261_I314_I0.5821.00
273_A276_Y0.5811.00
210_L338_K0.5791.00
18_A192_F0.5781.00
244_I258_M0.5781.00
368_W373_L0.5781.00
226_C350_S0.5781.00
70_L123_P0.5761.00
269_M321_G0.5751.00
210_L214_H0.5751.00
149_A152_S0.5741.00
224_V227_S0.5741.00
91_G121_A0.5721.00
181_A184_V0.5711.00
239_N361_D0.5691.00
242_L245_I0.5691.00
141_V329_L0.5681.00
188_I191_L0.5681.00
25_L181_A0.5681.00
15_T18_A0.5671.00
17_A20_L0.5651.00
184_V188_I0.5651.00
97_L101_N0.5651.00
310_L313_Q0.5651.00
231_A380_M0.5651.00
361_D373_L0.5651.00
207_V212_S0.5641.00
293_G296_F0.5621.00
287_L388_L0.5601.00
239_N242_L0.5591.00
51_M105_F0.5571.00
301_L371_H0.5561.00
216_K338_K0.5541.00
223_F227_S0.5521.00
85_L88_C0.5501.00
339_I343_T0.5501.00
317_A321_G0.5491.00
287_L294_M0.5491.00
60_A358_G0.5471.00
355_I359_S0.5471.00
141_V274_G0.5461.00
314_I318_I0.5461.00
170_S174_M0.5451.00
193_L197_Q0.5451.00
57_T61_I0.5441.00
328_M332_Q0.5421.00
160_P163_Y0.5411.00
148_R152_S0.5411.00
330_Y334_L0.5401.00
198_R201_P0.5401.00
258_M261_I0.5391.00
312_L315_L0.5391.00
356_I360_V0.5391.00
184_V187_L0.5391.00
213_T342_A0.5381.00
383_I387_C0.5381.00
215_R220_R0.5371.00
95_C111_G0.5351.00
32_L162_A0.5351.00
353_G356_I0.5351.00
385_M389_L0.5341.00
218_D334_L0.5331.00
159_P259_I0.5321.00
131_E196_I0.5321.00
23_A27_G0.5301.00
314_I317_A0.5301.00
182_F186_G0.5301.00
70_L83_L0.5291.00
48_R366_E0.5291.00
127_A340_G0.5281.00
383_I386_I0.5271.00
331_F334_L0.5271.00
67_S348_N0.5261.00
22_V189_V0.5261.00
200_I203_V0.5251.00
263_A267_I0.5231.00
193_L196_I0.5231.00
227_S349_T0.5221.00
15_T194_P0.5211.00
38_S42_A0.5211.00
68_Q348_N0.5201.00
312_L316_N0.5191.00
87_C121_A0.5171.00
365_V370_Y0.5161.00
158_G162_A0.5141.00
340_G344_T0.5101.00
369_S373_L0.5101.00
244_I255_T0.5101.00
98_F111_G0.5091.00
49_P365_V0.5091.00
272_I318_I0.5071.00
276_Y279_R0.5071.00
43_D245_I0.5061.00
125_M128_L0.5041.00
74_S340_G0.5041.00
379_G386_I0.5031.00
257_E260_G0.5031.00
372_A379_G0.5021.00
156_V260_G0.5011.00
166_A169_F0.5011.00
84_I124_Q0.5011.00
177_T181_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pw4A 1 0.9695 100 0.153 Contact Map
2gfpA 2 0.9442 100 0.174 Contact Map
3o7qA 1 0.9619 100 0.179 Contact Map
3wdoA 1 0.9721 100 0.183 Contact Map
4j05A 3 0.9188 100 0.188 Contact Map
4pypA 1 0.9569 100 0.209 Contact Map
2cfqA 1 0.967 100 0.223 Contact Map
4xnjA 1 0.9721 100 0.241 Contact Map
4w6vA 1 0.9569 100 0.246 Contact Map
4zw9A 1 0.9695 100 0.262 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0135 seconds.