ACRB - ECOLI - GREMLIN Contacts

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ACRB - Multidrug efflux pump subunit AcrB

UniProt:	P31224	Sequences: MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDAISRTSGVGDVQLFGSQYAMRIWMNPNELNKFQLTPVDVITAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRLTSTEEFGKILLKVNQDGSRVLLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPSGLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPIAKGDHGEGKKGFFGWFNRMFEKSTHHYTDSVGGILRSTGRYLVLYLIIVVGMAYLFVRLPSSFLPDEDQGVFMTMVQLPAGATQERTQKVLNEVTHYYLTKEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEENKVEAITMRATRAFSQIKDAMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARNQLLAEAAKHPDMLTSVRPNGLEDTPQFKIDIDQEKAQALGVSINDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAMELMEQLASKLPTGVGYDWTGMSYQERLSGNQAPSLYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKGLIEATLDAVRMRLRPILMTSLAFILGVMPLVISTGAGSGAQNAVGTGVMGGMVTATVLAIFFVPVFFVVVRRRFSRKNEDIEHSHTVDHH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11704
Length:	1049 (999)
Sequences:	15875 (10100)
Seq/√Len:	319.6

ECOLI - ACRB MDTB ACRF ACRD MDTC MDTF CUSA
BACSU - SWRC SECDF

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
959_G	962_E	4.157	1.00
244_E	247_G	4.077	1.00
309_E	312_K	3.968	1.00
311_A	314_E	3.940	1.00
247_G	263_R	3.914	1.00
62_T	88_V	3.846	1.00
730_D	808_R	3.684	1.00
47_A	88_V	3.646	1.00
915_A	1009_G	3.456	1.00
591_L	625_G	3.440	1.00
530_S	1020_F	3.423	1.00
304_A	334_K	3.239	1.00
426_P	429_E	3.173	1.00
248_K	263_R	3.143	1.00
425_L	433_K	3.139	1.00
150_T	153_D	3.109	1.00
3_N	7_D	3.076	1.00
586_R	589_K	3.073	1.00
532_G	965_L	3.048	1.00
75_L	92_L	2.894	1.00
188_M	203_V	2.885	1.00
694_K	697_Q	2.844	1.00
691_G	694_K	2.843	1.00
760_N	771_V	2.835	1.00
732_D	806_S	2.815	1.00
280_E	595_T	2.764	1.00
62_T	82_S	2.762	1.00
169_T	305_A	2.760	1.00
731_I	736_A	2.730	1.00
165_A	309_E	2.715	1.00
58_Q	823_P	2.665	1.00
736_A	746_I	2.657	1.00
282_N	608_S	2.642	1.00
307_R	328_D	2.625	1.00
142_V	158_V	2.617	1.00
742_S	745_D	2.596	1.00
247_G	268_I	2.587	1.00
193_L	198_L	2.576	1.00
345_V	349_I	2.562	1.00
705_E	708_K	2.561	1.00
897_I	950_K	2.541	1.00
243_T	247_G	2.523	1.00
76_M	93_T	2.516	1.00
262_L	268_I	2.486	1.00
588_Q	592_N	2.434	1.00
378_G	480_L	2.416	1.00
251_L	265_V	2.407	1.00
314_E	322_K	2.397	1.00
154_I	321_L	2.378	1.00
189_N	192_E	2.376	1.00
703_L	707_A	2.361	1.00
528_T	969_R	2.361	1.00
76_M	95_E	2.333	1.00
697_Q	701_Q	2.330	1.00
698_A	855_V	2.326	1.00
958_K	966_D	2.313	1.00
732_D	735_K	2.286	1.00
835_K	843_L	2.260	1.00
301_D	305_A	2.256	1.00
382_V	476_S	2.233	1.00
919_R	1005_T	2.230	1.00
633_D	636_D	2.227	1.00
157_Y	321_L	2.218	1.00
602_E	654_A	2.212	1.00
843_L	846_Q	2.187	1.00
784_D	787_G	2.186	1.00
204_I	773_V	2.165	1.00
952_L	956_E	2.159	1.00
187_W	269_E	2.143	1.00
186_I	207_I	2.137	1.00
574_T	629_V	2.135	1.00
188_M	200_P	2.133	1.00
536_R	961_I	2.121	1.00
182_Y	270_L	2.120	1.00
730_D	806_S	2.110	1.00
246_F	262_L	2.094	1.00
419_V	425_L	2.086	1.00
953_M	1026_F	2.071	1.00
252_K	255_Q	2.068	1.00
603_K	650_R	2.065	1.00
731_I	746_I	2.053	1.00
964_T	1027_V	2.042	1.00
952_L	958_K	2.039	1.00
419_V	437_Q	2.034	1.00
703_L	718_P	2.033	1.00
728_K	810_E	2.018	1.00
342_K	346_E	2.016	1.00
836_S	839_E	2.013	1.00
706_A	844_M	2.012	1.00
787_G	802_S	2.003	1.00
578_L	582_A	1.992	1.00
715_S	830_Q	1.987	1.00
800_P	803_A	1.971	1.00
990_V	1008_M	1.967	1.00
713_L	716_V	1.955	1.00
607_E	632_K	1.948	1.00
598_Y	651_A	1.936	1.00
65_I	69_M	1.925	1.00
709_H	843_L	1.921	1.00
429_E	433_K	1.919	1.00
729_I	805_S	1.917	1.00
242_S	245_E	1.914	1.00
533_G	537_S	1.895	1.00
700_N	703_L	1.887	1.00
305_A	308_A	1.887	1.00
55_K	59_D	1.883	1.00
143_I	324_V	1.876	1.00
280_E	588_Q	1.872	1.00
741_V	791_V	1.866	1.00
527_Y	968_V	1.863	1.00
687_Q	702_L	1.856	1.00
522_K	525_H	1.851	1.00
57_V	61_V	1.846	1.00
65_I	90_I	1.846	1.00
952_L	966_D	1.832	1.00
537_S	540_R	1.828	1.00
10_I	889_A	1.826	1.00
415_N	437_Q	1.818	1.00
450_S	479_A	1.817	1.00
522_K	526_H	1.816	1.00
244_E	248_K	1.811	1.00
267_K	776_E	1.810	1.00
961_I	1027_V	1.801	1.00
7_D	428_K	1.797	1.00
593_E	596_H	1.791	1.00
547_I	551_G	1.789	1.00
782_L	785_D	1.785	1.00
703_L	716_V	1.780	1.00
371_A	484_V	1.777	1.00
149_M	320_G	1.772	1.00
698_A	701_Q	1.770	1.00
24_G	28_L	1.754	1.00
204_I	208_K	1.754	1.00
190_P	779_Y	1.749	1.00
554_Y	557_V	1.746	1.00
597_Y	654_A	1.743	1.00
162_M	313_M	1.735	1.00
538_T	1027_V	1.734	1.00
69_M	92_L	1.733	1.00
845_E	867_R	1.730	1.00
183_A	772_Y	1.724	1.00
699_R	825_M	1.723	1.00
193_L	265_V	1.722	1.00
29_K	384_A	1.717	1.00
735_K	738_A	1.717	1.00
419_V	423_E	1.716	1.00
542_L	546_L	1.712	1.00
181_Q	273_E	1.712	1.00
304_A	308_A	1.710	1.00
147_G	284_Q	1.701	1.00
62_T	80_S	1.700	1.00
8_R	893_E	1.695	1.00
591_L	611_A	1.692	1.00
92_L	107_V	1.692	1.00
241_T	245_E	1.683	1.00
553_A	557_V	1.682	1.00
650_R	654_A	1.681	1.00
921_L	1005_T	1.667	1.00
418_R	423_E	1.659	1.00
3_N	432_R	1.659	1.00
728_K	808_R	1.657	1.00
199_T	202_D	1.654	1.00
528_T	532_G	1.653	1.00
301_D	304_A	1.647	1.00
603_K	654_A	1.646	1.00
307_R	325_Y	1.631	1.00
20_M	377_L	1.621	1.00
592_N	596_H	1.620	1.00
680_F	829_G	1.618	1.00
533_G	536_R	1.611	1.00
338_H	342_K	1.610	1.00
65_I	114_A	1.605	1.00
741_V	804_F	1.605	1.00
597_Y	657_Q	1.605	1.00
69_M	90_I	1.599	1.00
388_F	472_I	1.593	1.00
842_E	845_E	1.593	1.00
713_L	840_A	1.590	1.00
696_T	700_N	1.590	1.00
211_N	760_N	1.587	1.00
776_E	779_Y	1.585	1.00
605_N	639_G	1.574	1.00
640_E	646_A	1.573	1.00
74_N	98_T	1.571	1.00
198_L	202_D	1.569	1.00
386_F	476_S	1.569	1.00
711_D	843_L	1.569	1.00
572_F	629_V	1.564	1.00
248_K	261_L	1.558	1.00
652_T	715_S	1.558	1.00
594_V	655_F	1.556	1.00
576_V	591_L	1.552	1.00
141_G	281_F	1.550	1.00
189_N	267_K	1.550	1.00
746_I	804_F	1.549	1.00
736_A	741_V	1.538	1.00
526_H	529_D	1.534	1.00
701_Q	704_A	1.530	1.00
418_R	970_M	1.528	1.00
415_N	418_R	1.527	1.00
26_A	381_A	1.527	1.00
240_L	246_F	1.524	1.00
587_T	625_G	1.519	1.00
835_K	839_E	1.515	1.00
530_S	533_G	1.515	1.00
576_V	594_V	1.510	1.00
99_D	102_I	1.510	1.00
479_A	483_L	1.510	1.00
704_A	708_K	1.506	1.00
82_S	88_V	1.506	1.00
416_V	493_C	1.501	1.00
561_S	838_G	1.499	1.00
904_V	942_A	1.492	1.00
297_A	302_T	1.487	1.00
188_M	193_L	1.485	1.00
205_T	209_A	1.484	1.00
542_L	1028_V	1.483	1.00
207_I	249_I	1.483	1.00
885_F	898_P	1.477	1.00
78_M	92_L	1.475	1.00
201_V	205_T	1.471	1.00
549_V	553_A	1.469	1.00
839_E	842_E	1.465	1.00
192_E	196_F	1.462	1.00
307_R	311_A	1.461	1.00
142_V	162_M	1.460	1.00
729_I	807_S	1.457	1.00
578_L	590_V	1.455	1.00
598_Y	606_V	1.455	1.00
792_R	798_M	1.447	1.00
172_V	291_I	1.445	1.00
694_K	698_A	1.444	1.00
649_M	653_R	1.442	1.00
202_D	205_T	1.441	1.00
472_I	476_S	1.439	1.00
596_H	599_L	1.438	1.00
759_V	773_V	1.437	1.00
47_A	62_T	1.434	1.00
654_A	657_Q	1.433	1.00
554_Y	558_R	1.429	1.00
758_Y	770_K	1.427	1.00
961_I	965_L	1.422	1.00
951_D	955_K	1.421	1.00
639_G	650_R	1.421	1.00
98_T	103_A	1.415	1.00
328_D	331_P	1.415	1.00
379_T	477_A	1.406	1.00
865_Q	868_L	1.406	1.00
202_D	792_R	1.405	1.00
701_Q	705_E	1.403	1.00
339_E	342_K	1.401	1.00
47_A	122_V	1.396	1.00
632_K	636_D	1.394	1.00
408_D	940_K	1.393	1.00
234_I	754_W	1.393	1.00
582_A	586_R	1.389	1.00
240_L	249_I	1.389	1.00
576_V	625_G	1.387	1.00
317_F	323_I	1.386	1.00
538_T	1031_R	1.385	1.00
250_L	259_R	1.385	1.00
192_E	195_K	1.382	1.00
603_K	647_I	1.381	1.00
205_T	208_K	1.378	1.00
47_A	65_I	1.377	1.00
14_V	886_L	1.376	1.00
61_V	122_V	1.376	1.00
43_V	107_V	1.374	1.00
605_N	632_K	1.370	1.00
572_F	648_T	1.366	1.00
526_H	530_S	1.362	1.00
412_V	435_M	1.361	1.00
953_M	1030_R	1.361	1.00
793_A	797_Q	1.360	1.00
143_I	322_K	1.359	1.00
349_I	353_L	1.359	1.00
689_G	855_V	1.359	1.00
595_T	599_L	1.356	1.00
163_K	167_S	1.355	1.00
115_M	124_Q	1.353	1.00
66_E	818_R	1.353	1.00
261_L	264_D	1.349	1.00
592_N	595_T	1.341	1.00
34_Q	569_Q	1.341	1.00
704_A	707_A	1.340	1.00
209_A	737_Q	1.337	1.00
382_V	386_F	1.336	1.00
709_H	846_Q	1.334	1.00
305_A	309_E	1.330	1.00
983_I	1008_M	1.330	1.00
199_T	792_R	1.328	1.00
423_E	433_K	1.327	1.00
170_S	305_A	1.326	1.00
45_I	69_M	1.325	1.00
609_V	627_A	1.324	1.00
278_I	588_Q	1.324	1.00
983_I	1012_V	1.322	1.00
425_L	429_E	1.317	1.00
63_Q	818_R	1.315	1.00
352_F	369_T	1.311	1.00
112_Q	115_M	1.311	1.00
77_Y	820_N	1.310	1.00
613_N	625_G	1.310	1.00
589_K	593_E	1.309	1.00
599_L	609_V	1.307	1.00
699_R	718_P	1.303	1.00
846_Q	849_S	1.302	1.00
146_D	320_G	1.300	1.00
77_Y	93_T	1.300	1.00
605_N	647_I	1.298	1.00
791_V	804_F	1.298	1.00
279_A	288_G	1.297	1.00
22_A	381_A	1.294	1.00
19_I	378_G	1.292	1.00
57_V	82_S	1.291	1.00
713_L	829_G	1.286	1.00
53_D	56_T	1.286	1.00
562_S	922_T	1.284	1.00
551_G	555_L	1.283	1.00
69_M	107_V	1.281	1.00
543_V	547_I	1.279	1.00
653_R	656_S	1.279	1.00
597_Y	603_K	1.279	1.00
687_Q	695_L	1.277	1.00
202_D	252_K	1.276	1.00
543_V	550_V	1.272	1.00
528_T	966_D	1.270	1.00
245_E	248_K	1.268	1.00
572_F	651_A	1.267	1.00
950_K	955_K	1.267	1.00
606_V	629_V	1.267	1.00
27_I	341_V	1.262	1.00
165_A	316_F	1.260	1.00
374_V	488_L	1.255	1.00
433_K	436_G	1.253	1.00
3_N	436_G	1.251	1.00
13_W	895_W	1.248	1.00
958_K	962_E	1.248	1.00
962_E	966_D	1.248	1.00
58_Q	818_R	1.247	1.00
949_A	964_T	1.247	1.00
6_I	432_R	1.246	1.00
550_V	554_Y	1.246	1.00
953_M	960_L	1.243	1.00
711_D	835_K	1.242	1.00
529_D	533_G	1.241	1.00
4_F	11_F	1.240	1.00
187_W	267_K	1.239	1.00
938_S	1014_A	1.239	1.00
157_Y	161_N	1.238	1.00
156_D	769_K	1.238	1.00
74_N	95_E	1.236	1.00
26_A	384_A	1.235	1.00
43_V	104_Q	1.234	1.00
529_D	532_G	1.233	1.00
960_L	964_T	1.222	1.00
741_V	794_A	1.221	1.00
310_L	323_I	1.218	1.00
916_A	927_F	1.217	1.00
149_M	153_D	1.217	1.00
912_A	931_L	1.215	1.00
528_T	965_L	1.211	1.00
309_E	313_M	1.210	1.00
726_Q	812_G	1.209	1.00
308_A	312_K	1.207	1.00
686_D	819_Y	1.204	1.00
193_L	203_V	1.204	1.00
690_L	855_V	1.203	1.00
591_L	613_N	1.203	1.00
419_V	433_K	1.200	1.00
590_V	593_E	1.199	1.00
785_D	788_D	1.199	1.00
304_A	307_R	1.199	1.00
534_I	1024_V	1.198	1.00
6_I	491_A	1.196	1.00
247_G	267_K	1.195	1.00
607_E	630_S	1.195	1.00
578_L	587_T	1.194	1.00
140_V	323_I	1.192	1.00
45_I	92_L	1.192	1.00
218_Q	231_N	1.191	1.00
596_H	602_E	1.188	1.00
649_M	652_T	1.184	1.00
845_E	848_A	1.183	1.00
172_V	302_T	1.178	1.00
593_E	597_Y	1.171	1.00
976_L	980_L	1.170	1.00
921_L	1001_N	1.169	1.00
69_M	78_M	1.168	1.00
822_L	856_G	1.168	1.00
987_M	1008_M	1.166	1.00
312_K	315_P	1.165	1.00
415_N	948_F	1.165	1.00
57_V	88_V	1.163	1.00
688_A	824_S	1.163	1.00
149_M	321_L	1.161	1.00
546_L	550_V	1.160	1.00
138_M	306_I	1.156	1.00
206_A	249_I	1.155	1.00
250_L	261_L	1.152	1.00
864_Y	868_L	1.151	1.00
793_A	796_G	1.151	1.00
216_A	236_A	1.150	1.00
166_I	175_V	1.149	1.00
196_F	260_V	1.148	1.00
20_M	24_G	1.147	1.00
840_A	843_L	1.147	1.00
65_I	111_L	1.146	1.00
248_K	734_E	1.146	1.00
744_N	748_T	1.146	1.00
58_Q	816_L	1.143	1.00
966_D	969_R	1.141	1.00
142_V	323_I	1.139	1.00
140_V	325_Y	1.138	1.00
706_A	713_L	1.137	1.00
334_K	338_H	1.134	1.00
388_F	394_T	1.133	1.00
751_G	757_S	1.132	1.00
75_L	78_M	1.131	1.00
593_E	660_D	1.131	1.00
165_A	313_M	1.127	1.00
110_K	113_L	1.126	1.00
446_A	482_V	1.125	1.00
819_Y	860_T	1.124	1.00
871_N	874_P	1.124	1.00
645_E	649_M	1.123	1.00
752_A	757_S	1.119	1.00
761_D	770_K	1.119	1.00
447_M	887_C	1.117	1.00
303_A	330_T	1.117	1.00
68_N	114_A	1.116	1.00
598_Y	627_A	1.116	1.00
16_A	488_L	1.116	1.00
76_M	868_L	1.115	1.00
700_N	704_A	1.114	1.00
534_I	541_Y	1.114	1.00
702_L	827_I	1.112	1.00
143_I	284_Q	1.110	1.00
203_V	265_V	1.110	1.00
308_A	311_A	1.109	1.00
525_H	529_D	1.108	1.00
339_E	1000_Q	1.105	1.00
379_T	476_S	1.105	1.00
558_R	917_T	1.103	1.00
298_N	301_D	1.101	1.00
531_V	535_L	1.098	1.00
860_T	864_Y	1.097	1.00
687_Q	698_A	1.096	1.00
595_T	611_A	1.095	1.00
589_K	592_N	1.088	1.00
115_M	123_Q	1.088	1.00
540_R	543_V	1.088	1.00
951_D	956_E	1.087	1.00
593_E	658_I	1.086	1.00
597_Y	658_I	1.085	1.00
948_F	952_L	1.084	1.00
698_A	851_L	1.084	1.00
694_K	855_V	1.082	1.00
11_F	890_A	1.081	1.00
950_K	953_M	1.079	1.00
49_Y	52_A	1.078	1.00
733_Q	743_I	1.078	1.00
590_V	658_I	1.077	1.00
956_E	966_D	1.077	1.00
493_C	497_L	1.074	1.00
790_Y	798_M	1.074	1.00
235_I	726_Q	1.072	1.00
521_E	525_H	1.071	1.00
980_L	984_L	1.070	1.00
914_L	918_F	1.069	1.00
370_I	492_L	1.068	1.00
689_G	694_K	1.068	1.00
262_L	266_A	1.068	1.00
562_S	924_D	1.066	1.00
79_S	93_T	1.065	1.00
138_M	307_R	1.064	1.00
545_Y	1021_F	1.063	1.00
693_E	696_T	1.062	1.00
603_K	651_A	1.061	1.00
707_A	716_V	1.061	1.00
187_W	776_E	1.060	1.00
185_R	774_M	1.058	1.00
175_V	289_L	1.058	1.00
155_S	180_S	1.054	1.00
428_K	432_R	1.051	1.00
201_V	745_D	1.050	1.00
314_E	323_I	1.048	1.00
415_N	419_V	1.045	1.00
445_I	482_V	1.043	1.00
788_D	802_S	1.042	1.00
108_Q	112_Q	1.041	1.00
646_A	650_R	1.041	1.00
81_N	91_T	1.039	1.00
598_Y	629_V	1.039	1.00
915_A	1005_T	1.038	1.00
78_M	821_G	1.038	1.00
183_A	273_E	1.036	1.00
5_F	12_A	1.036	1.00
449_L	940_K	1.033	1.00
68_N	113_L	1.033	1.00
98_T	106_Q	1.032	1.00
311_A	315_P	1.031	1.00
66_E	80_S	1.029	1.00
831_A	840_A	1.027	1.00
80_S	818_R	1.027	1.00
555_L	914_L	1.025	1.00
979_S	1015_T	1.025	1.00
141_G	286_A	1.023	1.00
907_L	1017_L	1.023	1.00
371_A	489_T	1.022	1.00
702_L	847_L	1.022	1.00
280_E	592_N	1.020	1.00
572_F	631_L	1.020	1.00
429_E	432_R	1.020	1.00
46_S	87_T	1.019	1.00
261_L	734_E	1.018	1.00
924_D	927_F	1.015	1.00
142_V	154_I	1.015	1.00
444_G	887_C	1.015	1.00
774_M	780_R	1.011	1.00
539_G	1028_V	1.011	1.00
948_F	970_M	1.011	1.00
983_I	1011_M	1.010	1.00
534_I	1020_F	1.008	1.00
594_V	658_I	1.008	1.00
586_R	660_D	1.004	1.00
30_L	380_F	1.000	1.00
688_A	858_D	0.999	1.00
138_M	303_A	0.997	1.00
709_H	847_L	0.995	1.00
583_T	586_R	0.994	1.00
20_M	374_V	0.994	1.00
650_R	653_R	0.993	1.00
251_L	260_V	0.993	1.00
972_L	976_L	0.993	1.00
547_I	550_V	0.992	1.00
536_R	539_G	0.990	1.00
420_M	427_P	0.989	1.00
102_I	106_Q	0.988	1.00
844_M	859_W	0.988	1.00
281_F	286_A	0.987	1.00
703_L	827_I	0.987	1.00
382_V	480_L	0.987	1.00
574_T	598_Y	0.987	1.00
80_S	90_I	0.987	1.00
979_S	983_I	0.986	1.00
566_D	645_E	0.986	1.00
148_T	320_G	0.985	1.00
371_A	409_A	0.983	1.00
45_I	65_I	0.981	1.00
303_A	307_R	0.981	1.00
163_K	175_V	0.980	1.00
367_I	492_L	0.979	1.00
550_V	553_A	0.978	1.00
216_A	750_L	0.977	1.00
214_V	747_N	0.976	1.00
535_L	1027_V	0.976	1.00
13_W	17_I	0.975	1.00
518_R	522_K	0.975	1.00
539_G	543_V	0.974	1.00
370_I	488_L	0.974	1.00
595_T	609_V	0.974	1.00
892_Y	943_I	0.974	1.00
519_M	522_K	0.973	1.00
644_V	648_T	0.972	1.00
439_Q	443_V	0.969	1.00
552_M	913_L	0.969	1.00
186_I	759_V	0.967	1.00
341_V	345_V	0.965	1.00
741_V	746_I	0.965	1.00
415_N	438_I	0.965	1.00
984_L	987_M	0.964	1.00
524_T	528_T	0.963	1.00
843_L	847_L	0.962	1.00
594_V	627_A	0.959	1.00
48_S	87_T	0.959	1.00
231_N	276_D	0.958	1.00
758_Y	772_Y	0.958	1.00
444_G	891_L	0.957	1.00
719_N	817_E	0.957	1.00
538_T	1028_V	0.957	1.00
699_R	703_L	0.956	1.00
900_S	1025_F	0.954	1.00
246_F	268_I	0.953	1.00
424_G	430_A	0.949	1.00
178_F	290_G	0.949	1.00
246_F	771_V	0.948	1.00
781_M	785_D	0.947	1.00
597_Y	602_E	0.945	1.00
727_F	783_P	0.944	1.00
966_D	970_M	0.944	1.00
437_Q	951_D	0.943	1.00
460_G	872_Q	0.941	1.00
965_L	969_R	0.941	1.00
786_I	807_S	0.941	1.00
307_R	314_E	0.940	1.00
451_A	883_V	0.938	1.00
163_K	177_L	0.935	1.00
198_L	251_L	0.935	1.00
427_P	431_T	0.930	1.00
544_L	551_G	0.929	1.00
360_Q	517_N	0.928	1.00
651_A	655_F	0.928	1.00
146_D	149_M	0.926	1.00
646_A	649_M	0.926	1.00
787_G	807_S	0.926	1.00
541_Y	544_L	0.925	1.00
169_T	309_E	0.925	1.00
915_A	919_R	0.925	1.00
432_R	436_G	0.924	1.00
94_F	107_V	0.923	1.00
189_N	779_Y	0.923	1.00
307_R	330_T	0.920	1.00
949_A	1026_F	0.920	1.00
247_G	266_A	0.918	1.00
185_R	269_E	0.918	1.00
394_T	469_Q	0.918	1.00
576_V	663_V	0.917	1.00
745_D	748_T	0.917	1.00
639_G	647_I	0.917	1.00
7_D	432_R	0.917	1.00
383_L	388_F	0.916	1.00
762_F	771_V	0.916	1.00
68_N	117_L	0.915	1.00
841_M	863_S	0.915	1.00
416_V	434_S	0.914	1.00
987_M	991_I	0.911	1.00
761_D	768_V	0.910	1.00
338_H	341_V	0.907	1.00
70_N	821_G	0.906	1.00
48_S	123_Q	0.905	1.00
736_A	804_F	0.904	1.00
374_V	484_V	0.903	1.00
605_N	650_R	0.902	1.00
577_Q	662_M	0.901	1.00
16_A	374_V	0.901	1.00
701_Q	850_K	0.900	1.00
899_F	903_L	0.897	1.00
874_P	878_A	0.896	1.00
816_L	823_P	0.896	1.00
878_A	882_I	0.896	1.00
412_V	442_L	0.896	1.00
174_D	292_K	0.895	1.00
964_T	968_V	0.895	1.00
647_I	650_R	0.893	1.00
910_I	1013_T	0.892	1.00
207_I	759_V	0.892	1.00
302_T	305_A	0.891	1.00
203_V	773_V	0.890	1.00
693_E	697_Q	0.890	1.00
362_F	366_L	0.890	1.00
431_T	494_A	0.889	1.00
532_G	962_E	0.889	1.00
152_E	272_G	0.888	1.00
243_T	270_L	0.888	1.00
1030_R	1033_F	0.887	1.00
281_F	608_S	0.887	1.00
912_A	1006_G	0.885	1.00
45_I	90_I	0.885	1.00
201_V	748_T	0.884	1.00
548_I	910_I	0.884	1.00
651_A	665_A	0.883	1.00
527_Y	531_V	0.880	1.00
729_I	750_L	0.877	1.00
156_D	160_A	0.876	1.00
449_L	478_M	0.875	1.00
708_K	846_Q	0.875	1.00
153_D	156_D	0.874	1.00
283_G	595_T	0.871	1.00
783_P	787_G	0.871	1.00
687_Q	855_V	0.870	1.00
310_L	314_E	0.868	1.00
727_F	809_W	0.868	1.00
639_G	646_A	0.867	1.00
527_Y	535_L	0.865	1.00
683_E	824_S	0.865	1.00
207_I	246_F	0.863	1.00
694_K	854_G	0.861	1.00
706_A	716_V	0.860	1.00
585_E	589_K	0.860	1.00
907_L	1021_F	0.860	1.00
252_K	260_V	0.859	1.00
186_I	266_A	0.858	1.00
535_L	1024_V	0.857	1.00
439_Q	486_L	0.857	1.00
949_A	967_A	0.856	1.00
190_P	775_S	0.855	1.00
102_I	105_V	0.854	1.00
71_G	110_K	0.853	1.00
551_G	554_Y	0.849	1.00
658_I	661_A	0.849	1.00
582_A	587_T	0.847	1.00
524_T	969_R	0.846	1.00
960_L	1027_V	0.844	1.00
166_I	309_E	0.844	1.00
193_L	196_F	0.843	1.00
313_M	317_F	0.842	1.00
756_G	774_M	0.842	1.00
881_L	902_M	0.841	1.00
739_L	799_V	0.841	1.00
1018_A	1022_V	0.839	1.00
1012_V	1016_V	0.836	1.00
81_N	815_R	0.836	1.00
885_F	895_W	0.835	1.00
655_F	663_V	0.834	1.00
167_S	174_D	0.834	1.00
611_A	627_A	0.833	1.00
521_E	524_T	0.831	1.00
139_V	290_G	0.831	1.00
155_S	159_A	0.830	1.00
465_A	468_R	0.829	1.00
184_M	762_F	0.828	1.00
278_I	584_Q	0.827	1.00
535_L	964_T	0.826	1.00
209_A	742_S	0.826	1.00
198_L	203_V	0.825	1.00
44_T	91_T	0.825	1.00
4_F	8_R	0.823	1.00
688_A	856_G	0.821	1.00
588_Q	613_N	0.819	1.00
346_E	349_I	0.818	1.00
599_L	602_E	0.818	1.00
820_N	858_D	0.818	1.00
270_L	764_D	0.817	1.00
605_N	638_P	0.817	1.00
741_V	793_A	0.816	1.00
158_V	289_L	0.815	1.00
204_I	752_A	0.815	1.00
716_V	829_G	0.814	1.00
608_S	630_S	0.813	1.00
559_L	913_L	0.813	1.00
705_E	847_L	0.813	1.00
695_L	825_M	0.812	1.00
288_G	610_F	0.812	1.00
50_P	123_Q	0.812	1.00
753_A	789_W	0.811	1.00
683_E	826_E	0.811	1.00
519_M	523_S	0.810	1.00
13_W	495_T	0.810	1.00
77_Y	819_Y	0.810	1.00
62_T	90_I	0.810	1.00
188_M	773_V	0.809	1.00
555_L	917_T	0.809	1.00
572_F	644_V	0.809	1.00
753_A	775_S	0.808	1.00
713_L	844_M	0.808	1.00
191_N	788_D	0.807	1.00
535_L	965_L	0.807	1.00
841_M	867_R	0.805	1.00
273_E	770_K	0.805	1.00
120_Q	124_Q	0.803	1.00
47_A	125_Q	0.802	1.00
253_V	259_R	0.802	1.00
532_G	961_I	0.802	1.00
695_L	855_V	0.800	1.00
448_V	940_K	0.799	1.00
278_I	613_N	0.799	1.00
919_R	1009_G	0.799	1.00
10_I	895_W	0.797	1.00
687_Q	827_I	0.797	1.00
317_F	321_L	0.797	1.00
438_I	446_A	0.796	1.00
450_S	475_V	0.795	1.00
95_E	98_T	0.795	1.00
361_N	364_A	0.795	1.00
594_V	597_Y	0.795	1.00
696_T	825_M	0.795	1.00
200_P	752_A	0.793	1.00
138_M	325_Y	0.793	1.00
941_N	1014_A	0.793	1.00
203_V	262_L	0.792	1.00
845_E	849_S	0.791	1.00
25_L	29_K	0.790	1.00
94_F	103_A	0.789	1.00
381_A	385_A	0.788	1.00
735_K	803_A	0.788	1.00
177_L	180_S	0.786	1.00
720_G	825_M	0.785	1.00
520_F	524_T	0.785	1.00
240_L	762_F	0.784	1.00
863_S	867_R	0.783	1.00
279_A	286_A	0.783	1.00
924_D	1002_A	0.781	1.00
1027_V	1031_R	0.781	1.00
331_P	334_K	0.781	1.00
1025_F	1029_V	0.780	1.00
841_M	859_W	0.780	1.00
870_G	874_P	0.780	1.00
49_Y	57_V	0.780	1.00
848_A	857_Y	0.780	1.00
46_S	89_Q	0.779	1.00
194_N	790_Y	0.779	1.00
137_L	302_T	0.778	1.00
698_A	702_L	0.778	1.00
404_L	982_F	0.777	1.00
727_F	807_S	0.776	1.00
746_I	801_F	0.775	1.00
851_L	857_Y	0.775	1.00
203_V	206_A	0.774	1.00
501_A	504_D	0.774	1.00
159_A	163_K	0.773	1.00
191_N	194_N	0.773	1.00
652_T	665_A	0.772	1.00
337_I	395_M	0.771	1.00
457_A	475_V	0.770	1.00
556_F	913_L	0.770	1.00
631_L	647_I	0.769	1.00
702_L	848_A	0.769	1.00
532_G	536_R	0.768	1.00
542_L	1024_V	0.768	1.00
383_L	473_T	0.765	0.99
749_T	791_V	0.764	0.99
923_N	928_Q	0.764	0.99
397_G	401_A	0.764	0.99
534_I	537_S	0.764	0.99
710_P	713_L	0.764	0.99
488_L	492_L	0.763	0.99
169_T	302_T	0.760	0.99
752_A	773_V	0.759	0.99
58_Q	62_T	0.759	0.99
2_P	435_M	0.758	0.99
232_A	727_F	0.758	0.99
413_V	493_C	0.757	0.99
209_A	744_N	0.757	0.99
758_Y	761_D	0.757	0.99
204_I	757_S	0.757	0.99
404_L	981_A	0.757	0.99
572_F	665_A	0.756	0.99
541_Y	1021_F	0.756	0.99
379_T	480_L	0.755	0.99
140_V	289_L	0.755	0.99
185_R	271_G	0.755	0.99
818_R	823_P	0.755	0.99
590_V	660_D	0.755	0.99
69_M	111_L	0.754	0.99
545_Y	549_V	0.754	0.99
586_R	590_V	0.753	0.99
552_M	914_L	0.753	0.99
246_F	249_I	0.753	0.99
549_V	910_I	0.753	0.99
166_I	289_L	0.752	0.99
189_N	776_E	0.751	0.99
945_I	968_V	0.751	0.99
168_R	309_E	0.750	0.99
416_V	431_T	0.749	0.99
188_M	266_A	0.748	0.99
291_I	306_I	0.748	0.99
141_G	326_P	0.747	0.99
250_L	253_V	0.746	0.99
138_M	310_L	0.745	0.99
957_G	963_A	0.744	0.99
468_R	472_I	0.744	0.99
428_K	494_A	0.743	0.99
1015_T	1018_A	0.743	0.99
358_F	977_M	0.743	0.99
751_G	755_G	0.743	0.99
118_L	122_V	0.742	0.99
74_N	97_G	0.742	0.99
137_L	303_A	0.742	0.99
331_P	335_I	0.742	0.99
574_T	627_A	0.741	0.99
404_L	408_D	0.740	0.99
953_M	1034_S	0.739	0.99
960_L	1030_R	0.738	0.99
897_I	1030_R	0.737	0.99
64_V	114_A	0.736	0.99
42_A	93_T	0.736	0.99
549_V	552_M	0.734	0.99
63_Q	67_Q	0.734	0.99
449_L	982_F	0.734	0.99
391_N	394_T	0.734	0.99
576_V	627_A	0.734	0.99
231_N	622_Q	0.733	0.99
916_A	1006_G	0.733	0.99
252_K	259_R	0.732	0.99
552_M	555_L	0.731	0.99
441_A	951_D	0.730	0.99
201_V	204_I	0.730	0.99
900_S	1022_V	0.730	0.99
347_A	351_V	0.729	0.99
839_E	843_L	0.729	0.99
84_S	87_T	0.729	0.99
960_L	1031_R	0.728	0.99
239_R	763_I	0.728	0.99
923_N	931_L	0.727	0.99
203_V	251_L	0.727	0.99
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739_L	793_A	0.545	0.95
971_R	978_T	0.544	0.95
422_E	973_R	0.544	0.95
101_D	129_V	0.544	0.95
72_I	107_V	0.544	0.95
136_F	292_K	0.544	0.95
410_I	977_M	0.544	0.95
563_F	925_V	0.544	0.95
671_I	674_L	0.544	0.95
691_G	855_V	0.543	0.95
255_Q	258_S	0.543	0.95
420_M	499_P	0.543	0.95
37_T	295_T	0.542	0.95
953_M	959_G	0.542	0.95
702_L	844_M	0.542	0.95
945_I	967_A	0.542	0.95
177_L	287_S	0.542	0.95
30_L	384_A	0.541	0.95
574_T	594_V	0.541	0.95
130_E	174_D	0.541	0.95
535_L	961_I	0.541	0.95
916_A	921_L	0.539	0.95
526_H	533_G	0.539	0.95
427_P	494_A	0.539	0.95
371_A	375_V	0.539	0.95
551_G	557_V	0.538	0.95
686_D	824_S	0.538	0.95
944_L	982_F	0.538	0.95
1031_R	1034_S	0.538	0.95
139_V	327_Y	0.537	0.95
647_I	651_A	0.537	0.95
522_K	529_D	0.537	0.95
749_T	792_R	0.536	0.95
916_A	922_T	0.536	0.95
990_V	993_T	0.536	0.95
140_V	307_R	0.536	0.95
411_V	985_G	0.535	0.95
658_I	663_V	0.535	0.95
698_A	857_Y	0.535	0.95
56_T	213_Q	0.535	0.95
754_W	789_W	0.535	0.95
692_H	696_T	0.534	0.95
446_A	485_A	0.534	0.95
718_P	827_I	0.533	0.95
270_L	769_K	0.533	0.95
343_T	347_A	0.533	0.95
729_I	801_F	0.532	0.95
484_V	489_T	0.532	0.95
424_G	499_P	0.532	0.95
209_A	745_D	0.532	0.95
881_L	935_I	0.531	0.94
10_I	13_W	0.531	0.94
344_L	348_I	0.531	0.94
37_T	133_S	0.530	0.94
375_V	379_T	0.529	0.94
57_V	62_T	0.527	0.94
910_I	914_L	0.526	0.94
684_L	702_L	0.526	0.94
2_P	6_I	0.526	0.94
41_P	94_F	0.526	0.94
453_F	474_I	0.525	0.94
73_D	106_Q	0.525	0.94
230_L	581_G	0.524	0.94
901_V	945_I	0.524	0.94
210_Q	240_L	0.523	0.94
968_V	972_L	0.523	0.94
58_Q	82_S	0.523	0.94
46_S	128_S	0.523	0.94
367_I	493_C	0.523	0.94
483_L	487_I	0.522	0.94
355_M	406_V	0.522	0.94
31_P	387_G	0.522	0.94
595_T	598_Y	0.522	0.94
21_L	882_I	0.522	0.94
196_F	265_V	0.522	0.94
442_L	486_L	0.522	0.94
606_V	651_A	0.521	0.94
12_A	491_A	0.520	0.94
648_T	651_A	0.520	0.94
741_V	745_D	0.520	0.94
397_G	473_T	0.519	0.94
694_K	701_Q	0.519	0.94
783_P	809_W	0.519	0.94
115_M	125_Q	0.518	0.94
314_E	318_P	0.518	0.94
216_A	729_I	0.517	0.94
360_Q	365_T	0.516	0.94
539_G	546_L	0.516	0.94
711_D	839_E	0.514	0.93
851_L	855_V	0.514	0.93
688_A	822_L	0.513	0.93
844_M	847_L	0.513	0.93
336_S	392_T	0.513	0.93
81_N	817_E	0.513	0.93
187_W	271_G	0.513	0.93
104_Q	108_Q	0.512	0.93
653_R	708_K	0.512	0.93
876_L	879_I	0.511	0.93
747_N	750_L	0.511	0.93
216_A	747_N	0.511	0.93
404_L	940_K	0.510	0.93
169_T	172_V	0.510	0.93
778_K	781_M	0.510	0.93
72_I	110_K	0.510	0.93
681_D	830_Q	0.509	0.93
757_S	773_V	0.509	0.93
16_A	19_I	0.509	0.93
166_I	169_T	0.508	0.93
160_A	767_R	0.508	0.93
1030_R	1034_S	0.508	0.93
408_D	445_I	0.508	0.93
420_M	425_L	0.508	0.93
21_L	25_L	0.507	0.93
647_I	654_A	0.507	0.93
348_I	351_V	0.507	0.93
350_L	984_L	0.507	0.93
634_W	637_R	0.506	0.93
915_A	1013_T	0.506	0.93
201_V	752_A	0.505	0.93
5_F	8_R	0.505	0.93
593_E	657_Q	0.505	0.93
745_D	792_R	0.505	0.93
114_A	118_L	0.505	0.93
442_L	445_I	0.505	0.93
575_M	624_T	0.504	0.93
903_L	1022_V	0.504	0.93
529_D	534_I	0.504	0.93
538_T	1024_V	0.504	0.93
193_L	200_P	0.504	0.93
686_D	858_D	0.504	0.93
411_V	438_I	0.503	0.93
33_A	469_Q	0.503	0.93
169_T	306_I	0.503	0.93
519_M	529_D	0.503	0.93
376_L	398_M	0.503	0.93
207_I	771_V	0.503	0.93
396_F	1000_Q	0.502	0.93
346_E	353_L	0.502	0.93
50_P	125_Q	0.501	0.93
527_Y	534_I	0.501	0.93
979_S	982_F	0.501	0.93
873_A	928_Q	0.501	0.93
348_I	369_T	0.501	0.93
927_F	1002_A	0.501	0.93
17_I	886_L	0.501	0.93
698_A	705_E	0.500	0.93
9_P	494_A	0.500	0.93

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4k0jA	3	0.9161	100	0.226	Contact Map
4mt1A	3	0.9581	100	0.28	Contact Map
3w9iA	3	0.9781	100	0.288	Contact Map
3ne5A	3	0.9476	100	0.294	Contact Map
4dx5A	3	0.9886	100	0.302	Contact Map
3aqpA	1	0.6606	100	0.726	Contact Map
4r86A	1	0.2765	100	0.752	Contact Map
2ew9A	1	0.1411	88.4	0.98	Contact Map
4n8nA	1	0.0953	83.3	0.981	Contact Map
4u9rA	1	0.1296	71.5	0.983	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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