GREMLIN Database
THTM - 3-mercaptopyruvate sulfurtransferase
UniProt: P31142 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11600
Length: 281 (262)
Sequences: 4465 (3189)
Seq/√Len: 197.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_H117_S3.5171.00
7_V11_W3.4591.00
156_K159_D3.0981.00
15_H18_D2.8561.00
214_K218_E2.8161.00
80_R143_G2.7781.00
125_G129_D2.7451.00
13_A131_L2.6931.00
12_L119_L2.6901.00
39_A43_L2.6761.00
177_A181_N2.5471.00
22_Q88_K2.5281.00
45_G127_Q2.4561.00
178_A184_V2.3851.00
123_L133_L2.3661.00
45_G135_E2.3421.00
11_W15_H2.3281.00
118_I249_L2.3221.00
215_T218_E2.3121.00
8_G120_G2.2931.00
113_V145_F2.2421.00
75_F79_M2.2181.00
71_R74_T2.1431.00
177_A201_N2.1391.00
178_A183_E2.0701.00
12_L23_I1.9001.00
248_L261_L1.8951.00
157_V275_L1.8891.00
9_A125_G1.8871.00
24_I84_V1.8711.00
8_G11_W1.8701.00
23_I47_I1.8691.00
264_G268_E1.8601.00
76_A80_R1.8551.00
214_K222_I1.8491.00
9_A129_D1.8471.00
216_T220_D1.8181.00
86_Q146_N1.8021.00
157_V272_R1.7931.00
80_R144_E1.7711.00
134_E138_V1.7521.00
85_N143_G1.7481.00
54_D57_A1.7301.00
102_P245_A1.7271.00
9_A131_L1.7231.00
76_A147_A1.7111.00
155_V160_V1.6981.00
42_Y46_H1.6821.00
169_A235_I1.6501.00
244_A261_L1.6501.00
272_R275_L1.6181.00
24_I51_V1.6141.00
220_D224_F1.5991.00
209_R212_E1.5551.00
69_L107_M1.5331.00
53_F82_L1.5311.00
196_I199_A1.5241.00
252_A257_P1.5121.00
22_Q140_L1.5111.00
157_V161_L1.4871.00
125_G212_E1.4841.00
75_F111_F1.4781.00
179_R243_T1.4761.00
155_V260_K1.4711.00
174_A247_V1.4671.00
163_A235_I1.4611.00
85_N88_K1.4491.00
10_D14_E1.4221.00
79_M108_L1.4221.00
155_V159_D1.4141.00
202_V226_R1.4121.00
202_V222_I1.4101.00
150_N153_A1.3901.00
154_V263_D1.3831.00
155_V235_I1.3801.00
77_V81_E1.3731.00
6_F213_L1.3691.00
89_H115_K1.3481.00
157_V268_E1.3481.00
92_V104_A1.3231.00
69_L110_T1.3001.00
248_L259_V1.2901.00
26_A92_V1.2881.00
163_A169_A1.2861.00
207_L223_F1.2811.00
76_A146_N1.2651.00
236_V251_L1.2601.00
170_Q232_K1.2441.00
84_V90_L1.2411.00
43_L137_A1.2281.00
209_R214_K1.2201.00
207_L219_L1.2151.00
72_P76_A1.2141.00
114_E150_N1.2141.00
109_R252_A1.2041.00
233_P260_K1.1991.00
85_N144_E1.1961.00
161_L275_L1.1951.00
160_V235_I1.1741.00
229_S232_K1.1731.00
216_T254_L1.1721.00
234_I251_L1.1561.00
236_V259_V1.1451.00
160_V163_A1.1371.00
185_D193_R1.1191.00
218_E221_A1.1111.00
251_L259_V1.0981.00
22_Q84_V1.0951.00
250_A254_L1.0951.00
7_V15_H1.0901.00
42_Y138_V1.0891.00
160_V164_S1.0771.00
75_F107_M1.0731.00
56_E67_H1.0631.00
230_Y256_V1.0601.00
74_T77_V1.0591.00
127_Q133_L1.0581.00
5_W253_T1.0511.00
45_G133_L1.0491.00
110_T149_F1.0431.00
220_D230_Y1.0401.00
39_A57_A1.0401.00
15_H21_I1.0331.00
233_P258_N1.0301.00
163_A171_I1.0231.00
21_I91_I1.0211.00
27_R95_E1.0141.00
40_Q44_N1.0131.00
251_L256_V1.0121.00
221_A225_G1.0101.00
160_V169_A1.0091.00
75_F108_L1.0081.00
213_L253_T1.0061.00
43_L136_G0.9951.00
196_I237_S0.9901.00
163_A166_E0.9901.00
99_F243_T0.9861.00
24_I104_A0.9851.00
102_P249_L0.9841.00
206_E222_I0.9831.00
123_L127_Q0.9800.99
86_Q145_F0.9800.99
249_L253_T0.9710.99
171_I237_S0.9690.99
240_S267_S0.9610.99
21_I89_H0.9550.99
5_W252_A0.9540.99
48_P126_W0.9510.99
207_L247_V0.9500.99
213_L246_V0.9490.99
266_W270_G0.9480.99
160_V171_I0.9430.99
40_Q43_L0.9420.99
86_Q144_E0.9390.99
92_V108_L0.9330.99
7_V117_S0.9260.99
176_P184_V0.9210.99
79_M84_V0.9090.99
84_V88_K0.9080.99
28_M52_F0.8980.99
105_W248_L0.8930.99
159_D163_A0.8920.99
92_V105_W0.8900.99
155_V169_A0.8840.99
6_F120_G0.8810.99
45_G123_L0.8810.99
78_A81_E0.8780.99
20_E89_H0.8720.99
110_T153_A0.8710.99
256_V259_V0.8700.99
74_T78_A0.8700.99
124_A128_R0.8670.99
51_V138_V0.8670.99
15_H89_H0.8560.99
207_L222_I0.8560.99
13_A132_L0.8530.99
214_K219_L0.8520.99
179_R240_S0.8510.99
105_W252_A0.8480.99
170_Q229_S0.8480.99
77_V142_E0.8440.98
39_A52_F0.8410.98
7_V12_L0.8410.98
238_C265_A0.8380.98
94_D101_A0.8370.98
190_G270_G0.8370.98
179_R239_G0.8350.98
170_Q200_L0.8310.98
155_V163_A0.8310.98
262_Y268_E0.8270.98
164_S198_G0.8150.98
24_I53_F0.8110.98
223_F251_L0.8080.98
202_V223_F0.8070.98
79_M145_F0.8000.98
22_Q51_V0.8000.98
219_L223_F0.7960.98
64_P268_E0.7950.98
178_A181_N0.7940.98
177_A206_E0.7930.98
202_V207_L0.7910.98
65_L68_M0.7910.98
76_A143_G0.7900.98
21_I88_K0.7900.98
80_R142_E0.7890.98
51_V82_L0.7860.98
134_E137_A0.7850.98
221_A224_F0.7810.97
51_V140_L0.7770.97
109_R248_L0.7760.97
55_I242_V0.7740.97
217_D220_D0.7720.97
67_H242_V0.7700.97
219_L222_I0.7690.97
207_L246_V0.7670.97
176_P205_T0.7620.97
180_F195_H0.7600.97
213_L250_A0.7580.97
69_L154_V0.7540.97
67_H240_S0.7500.97
236_V248_L0.7490.97
86_Q113_V0.7490.97
159_D162_L0.7490.97
195_H199_A0.7480.97
163_A233_P0.7440.97
24_I82_L0.7430.97
67_H179_R0.7400.97
98_L101_A0.7390.96
6_F249_L0.7380.96
182_A194_G0.7380.96
53_F78_A0.7370.96
105_W109_R0.7360.96
186_E193_R0.7340.96
39_A54_D0.7310.96
81_E142_E0.7240.96
223_F247_V0.7230.96
170_Q234_I0.7220.96
59_S107_M0.7200.96
47_I126_W0.7200.96
97_N208_V0.7190.96
41_E44_N0.7170.96
98_L213_L0.7160.96
196_I278_E0.7150.96
60_D71_R0.7140.96
53_F104_A0.7140.96
158_T161_L0.7080.96
176_P179_R0.7080.96
98_L246_V0.7070.95
96_G124_A0.7000.95
180_F199_A0.7000.95
247_V250_A0.6980.95
252_A259_V0.6920.95
70_P103_R0.6910.95
20_E87_D0.6900.95
270_G277_V0.6890.95
84_V108_L0.6880.95
204_W208_V0.6880.95
199_A237_S0.6870.95
203_P206_E0.6850.95
245_A261_L0.6830.95
12_L21_I0.6780.94
266_W276_P0.6770.94
268_E271_A0.6750.94
105_W116_V0.6740.94
216_T253_T0.6740.94
90_L108_L0.6730.94
86_Q143_G0.6730.94
42_Y136_G0.6730.94
64_P271_A0.6700.94
124_A127_Q0.6700.94
80_R85_N0.6670.94
218_E222_I0.6630.94
98_L118_I0.6630.94
92_V116_V0.6620.94
267_S270_G0.6620.94
157_V164_S0.6600.94
152_E260_K0.6560.93
90_L113_V0.6530.93
58_L104_A0.6530.93
125_G128_R0.6510.93
72_P147_A0.6500.93
5_W249_L0.6480.93
234_I256_V0.6440.93
153_A260_K0.6430.93
58_L79_M0.6420.93
97_N124_A0.6410.93
42_Y51_V0.6400.92
209_R218_E0.6400.92
10_D131_L0.6370.92
170_Q228_V0.6320.92
239_G243_T0.6290.92
109_R114_E0.6290.92
164_S171_I0.6270.92
78_A82_L0.6270.92
12_L91_I0.6250.92
119_L126_W0.6230.91
266_W277_V0.6220.91
46_H93_Y0.6210.91
15_H20_E0.6170.91
219_L250_A0.6080.90
175_R199_A0.5980.90
252_A258_N0.5960.90
42_Y50_A0.5940.89
6_F253_T0.5920.89
86_Q114_E0.5920.89
228_V256_V0.5920.89
176_P243_T0.5910.89
245_A248_L0.5870.89
161_L276_P0.5860.89
10_D129_D0.5850.89
28_M38_V0.5850.89
9_A13_A0.5830.89
189_P270_G0.5830.89
13_A17_D0.5810.88
38_V41_E0.5810.88
85_N145_F0.5800.88
95_E124_A0.5790.88
172_I202_V0.5790.88
98_L208_V0.5780.88
105_W249_L0.5780.88
158_T162_L0.5770.88
206_E226_R0.5770.88
28_M56_E0.5730.88
50_A93_Y0.5730.88
20_E88_K0.5700.87
159_D260_K0.5690.87
86_Q148_A0.5680.87
80_R146_N0.5680.87
92_V118_I0.5660.87
93_Y123_L0.5660.87
126_W131_L0.5650.87
77_V80_R0.5640.87
262_Y265_A0.5620.87
12_L126_W0.5620.87
70_P107_M0.5590.86
68_M263_D0.5580.86
185_D188_R0.5570.86
15_H19_P0.5570.86
41_E95_E0.5540.86
25_D42_Y0.5530.86
110_T154_V0.5500.86
159_D233_P0.5500.86
172_I234_I0.5490.85
178_A186_E0.5480.85
24_I92_V0.5470.85
57_A81_E0.5460.85
61_H74_T0.5430.85
79_M111_F0.5420.85
175_R266_W0.5420.85
5_W117_S0.5400.84
243_T246_V0.5400.84
208_V246_V0.5400.84
47_I119_L0.5390.84
172_I200_L0.5390.84
56_E59_S0.5370.84
110_T150_N0.5370.84
222_I226_R0.5370.84
59_S67_H0.5360.84
161_L269_W0.5350.84
188_R239_G0.5350.84
94_D98_L0.5330.84
229_S233_P0.5330.84
235_I260_K0.5330.84
236_V247_V0.5320.84
46_H134_E0.5280.83
111_F145_F0.5270.83
60_D63_S0.5250.83
46_H50_A0.5240.83
207_L250_A0.5230.83
157_V262_Y0.5230.83
44_N135_E0.5220.82
67_H239_G0.5220.82
5_W89_H0.5170.82
172_I247_V0.5160.82
125_G131_L0.5150.82
38_V52_F0.5140.81
89_H92_V0.5130.81
195_H201_N0.5130.81
111_F147_A0.5130.81
193_R266_W0.5130.81
230_Y233_P0.5120.81
94_D103_R0.5100.81
69_L106_W0.5100.81
105_W118_I0.5100.81
134_E140_L0.5060.80
87_D143_G0.5040.80
66_P188_R0.5030.80
73_E76_A0.5020.80
172_I228_V0.5020.80
109_R153_A0.5020.80
166_E169_A0.5020.80
220_D257_P0.5010.80
170_Q233_P0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1urhA 1 0.9324 100 0.252 Contact Map
1rhsA 1 0.9929 100 0.28 Contact Map
4jgtA 1 0.9751 100 0.283 Contact Map
1e0cA 1 0.9466 100 0.288 Contact Map
3utnX 1 0.9893 100 0.288 Contact Map
1uarA 1 0.9466 100 0.299 Contact Map
3aayA 1 0.9502 100 0.306 Contact Map
2wlrA 1 0.9466 100 0.317 Contact Map
3hzuA 2 0.9466 100 0.318 Contact Map
1okgA 1 0.9537 100 0.319 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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