GREMLIN Database
POTH - Putrescine transport system permease protein PotH
UniProt: P31135 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11631
Length: 317 (258)
Sequences: 69554 (44619)
Seq/√Len: 2777.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
227_K231_T4.2041.00
100_L104_Q3.2101.00
55_S86_F3.0371.00
204_Y208_I3.0101.00
219_L228_T2.9791.00
98_A273_V2.7421.00
126_H215_V2.6471.00
97_D100_L2.6291.00
215_V233_I2.6051.00
224_R227_K2.5561.00
218_A228_T2.5431.00
108_I188_Y2.4711.00
112_C192_V2.4591.00
84_G87_L2.4521.00
96_F100_L2.3871.00
268_I276_Q2.3861.00
206_A240_G2.3861.00
110_T245_S2.3351.00
84_G88_Q2.3151.00
226_L230_F2.3091.00
203_I241_I2.3071.00
225_P228_T2.2721.00
118_Y229_F2.1461.00
87_L91_D2.1321.00
129_P132_R2.0851.00
223_A227_K2.0841.00
227_K230_F2.0681.00
283_D286_V2.0111.00
125_A208_I2.0051.00
207_L237_T1.9971.00
199_M244_G1.9741.00
214_L236_L1.9461.00
218_A223_A1.8581.00
53_K57_A1.8571.00
114_L245_S1.8131.00
118_Y237_T1.8091.00
49_L53_K1.7931.00
97_D101_Q1.7641.00
219_L225_P1.7381.00
106_A249_F1.7341.00
117_G199_M1.7281.00
136_L204_Y1.7211.00
215_V228_T1.7151.00
303_M307_K1.6981.00
124_V200_V1.6501.00
104_Q108_I1.6451.00
120_L200_V1.6221.00
109_S252_A1.6171.00
118_Y203_I1.6171.00
88_Q286_V1.5941.00
52_F292_I1.5751.00
128_K132_R1.5151.00
215_V219_L1.5091.00
34_A38_I1.4871.00
105_V269_M1.4641.00
256_F260_E1.4491.00
131_T134_I1.4461.00
184_N267_S1.4361.00
273_V277_E1.4251.00
121_A203_I1.4221.00
212_Y215_V1.4181.00
234_V241_I1.4151.00
46_L50_I1.4061.00
243_A247_L1.3951.00
125_A204_Y1.3951.00
83_L87_L1.3921.00
50_I54_I1.3721.00
207_L233_I1.3691.00
199_M248_V1.3681.00
203_I244_G1.3511.00
126_H212_Y1.3231.00
218_A232_V1.3141.00
82_N85_N1.3111.00
113_C248_V1.3081.00
256_F275_W1.3021.00
190_G262_L1.2991.00
94_L97_D1.2921.00
115_L119_P1.2861.00
212_Y216_E1.2651.00
88_Q91_D1.2611.00
258_I262_L1.2601.00
104_Q184_N1.2601.00
102_S270_I1.2531.00
118_Y241_I1.2191.00
122_W207_L1.2181.00
263_G267_S1.2171.00
277_E283_D1.2141.00
158_L186_A1.1861.00
213_S216_E1.1831.00
108_I111_F1.1821.00
224_R228_T1.1801.00
210_I236_L1.1721.00
29_R33_I1.1621.00
86_F292_I1.1611.00
187_V259_P1.1581.00
38_I42_L1.1541.00
61_R80_T1.1531.00
27_H31_L1.1391.00
51_V292_I1.1321.00
111_F115_L1.1311.00
134_I137_L1.1301.00
203_I240_G1.1251.00
307_K310_Q1.1151.00
101_Q104_Q1.1141.00
90_T96_F1.1001.00
28_G32_V1.0841.00
114_L241_I1.0821.00
268_I273_V1.0771.00
26_K29_R1.0741.00
238_K242_I1.0721.00
31_L35_L1.0641.00
277_E281_N1.0631.00
269_M272_R1.0621.00
185_L189_I1.0611.00
196_V200_V1.0601.00
236_L239_G1.0561.00
122_W225_P1.0521.00
134_I138_L1.0481.00
215_V225_P1.0471.00
58_E61_R1.0451.00
122_W229_F1.0391.00
112_C188_Y1.0391.00
202_P244_G1.0321.00
276_Q280_N1.0311.00
99_Y270_I1.0311.00
125_A207_L1.0281.00
108_I112_C1.0271.00
109_S191_I1.0231.00
156_G160_N1.0181.00
109_S113_C1.0181.00
88_Q92_D1.0171.00
119_P123_A1.0121.00
304_W308_H1.0101.00
273_V290_V1.0101.00
181_L184_N1.0091.00
255_E259_P1.0091.00
28_G31_L1.0051.00
259_P269_M0.9941.00
103_L107_A0.9931.00
307_K311_K0.9921.00
223_A228_T0.9901.00
268_I272_R0.9901.00
255_E258_I0.9811.00
31_L34_A0.9721.00
191_I252_A0.9661.00
50_I53_K0.9601.00
132_R208_I0.9591.00
154_W262_L0.9571.00
228_T231_T0.9541.00
95_Y290_V0.9481.00
188_Y192_V0.9471.00
85_N285_P0.9441.00
60_A63_I0.9361.00
54_I288_S0.9281.00
206_A237_T0.9271.00
278_F287_A0.9231.00
107_A111_F0.9201.00
109_S188_Y0.9191.00
130_S133_N0.9181.00
89_L293_I0.9031.00
121_A125_A0.9011.00
104_Q107_A0.8891.00
99_Y103_L0.8891.00
238_K241_I0.8881.00
104_Q185_L0.8851.00
260_E272_R0.8821.00
111_F245_S0.8821.00
30_K34_A0.8771.00
56_L81_L0.8761.00
229_F234_V0.8711.00
33_I37_Y0.8701.00
154_W190_G0.8701.00
237_T240_G0.8661.00
41_I45_L0.8631.00
113_C117_G0.8611.00
117_G200_V0.8571.00
26_K30_K0.8561.00
199_M203_I0.8521.00
133_N136_L0.8481.00
51_V288_S0.8471.00
151_V257_V0.8471.00
112_C115_L0.8471.00
230_F234_V0.8451.00
140_I201_L0.8431.00
147_F194_A0.8391.00
203_I237_T0.8391.00
277_E290_V0.8241.00
108_I192_V0.8231.00
248_V252_A0.8171.00
124_V136_L0.8171.00
56_L82_N0.8161.00
57_A61_R0.8161.00
121_A207_L0.8141.00
88_Q283_D0.8101.00
214_L232_V0.8051.00
173_V185_L0.8021.00
105_V184_N0.8021.00
121_A200_V0.7981.00
304_W307_K0.7971.00
273_V276_Q0.7881.00
151_V261_L0.7871.00
59_M63_I0.7871.00
51_V291_A0.7851.00
190_G258_I0.7801.00
100_L103_L0.7801.00
46_L49_L0.7791.00
105_V191_I0.7791.00
54_I57_A0.7781.00
228_T233_I0.7761.00
210_I237_T0.7751.00
300_V304_W0.7751.00
123_A129_P0.7711.00
155_M159_K0.7671.00
225_P229_F0.7651.00
182_H265_P0.7631.00
186_A190_G0.7631.00
102_S271_G0.7621.00
275_W279_F0.7591.00
277_E286_V0.7551.00
286_V290_V0.7531.00
25_M29_R0.7521.00
229_F233_I0.7511.00
212_Y219_L0.7461.00
185_L188_Y0.7461.00
113_C199_M0.7461.00
124_V135_L0.7431.00
35_L38_I0.7421.00
120_L196_V0.7381.00
98_A270_I0.7351.00
274_L290_V0.7341.00
288_S292_I0.7321.00
98_A101_Q0.7291.00
106_A110_T0.7281.00
298_L302_I0.7281.00
140_I143_S0.7241.00
113_C195_Y0.7221.00
114_L203_I0.7221.00
203_I207_L0.7121.00
92_D96_F0.7111.00
238_K308_H0.7101.00
186_A262_L0.7091.00
255_E269_M0.7071.00
124_V204_Y0.7041.00
241_I244_G0.7031.00
270_I294_M0.7031.00
259_P272_R0.7021.00
150_R193_Y0.7001.00
32_V36_P0.6991.00
110_T249_F0.6971.00
87_L90_T0.6921.00
58_E80_T0.6911.00
110_T114_L0.6851.00
57_A78_S0.6841.00
223_A231_T0.6821.00
117_G203_I0.6821.00
32_V35_L0.6821.00
55_S59_M0.6811.00
96_F99_Y0.6771.00
58_E79_I0.6761.00
305_F308_H0.6751.00
233_I236_L0.6741.00
240_G244_G0.6731.00
105_V187_V0.6711.00
123_A127_S0.6691.00
86_F289_A0.6691.00
147_F257_V0.6681.00
159_K181_L0.6681.00
116_I196_V0.6671.00
271_G294_M0.6641.00
57_A80_T0.6641.00
81_L84_G0.6631.00
217_A221_L0.6611.00
105_V188_Y0.6581.00
143_S197_P0.6551.00
187_V191_I0.6541.00
89_L286_V0.6531.00
195_Y248_V0.6501.00
83_L86_F0.6491.00
241_I245_S0.6481.00
89_L290_V0.6471.00
27_H30_K0.6451.00
113_C252_A0.6451.00
61_R79_I0.6431.00
41_I44_F0.6431.00
257_V261_L0.6431.00
288_S291_A0.6331.00
101_Q267_S0.6331.00
128_K133_N0.6321.00
93_P97_D0.6301.00
263_G268_I0.6291.00
156_G159_K0.6291.00
40_L44_F0.6281.00
202_P240_G0.6241.00
131_T135_L0.6241.00
116_I192_V0.6241.00
217_A220_D0.6231.00
113_C192_V0.6201.00
37_Y41_I0.6171.00
195_Y251_P0.6121.00
106_A252_A0.6051.00
181_L185_L0.6051.00
120_L139_V0.6031.00
54_I58_E0.6021.00
143_S198_F0.5991.00
129_P135_L0.5991.00
250_I254_G0.5981.00
136_L201_L0.5971.00
55_S289_A0.5971.00
102_S253_V0.5961.00
77_L80_T0.5941.00
121_A204_Y0.5911.00
47_P59_M0.5891.00
272_R276_Q0.5871.00
139_V197_P0.5861.00
284_W287_A0.5841.00
52_F56_L0.5801.00
154_W157_I0.5791.00
274_L291_A0.5761.00
93_P96_F0.5751.00
82_N86_F0.5741.00
294_M298_L0.5721.00
148_L261_L0.5701.00
114_L118_Y0.5701.00
106_A253_V0.5691.00
228_T232_V0.5681.00
187_V263_G0.5681.00
30_K33_I0.5671.00
224_R230_F0.5661.00
155_M181_L0.5651.00
45_L49_L0.5631.00
127_S130_S0.5621.00
194_A197_P0.5591.00
284_W288_S0.5591.00
191_I255_E0.5591.00
183_T186_A0.5571.00
85_N88_Q0.5551.00
285_P288_S0.5551.00
145_T149_I0.5531.00
299_I303_M0.5521.00
135_L139_V0.5521.00
105_V109_S0.5511.00
128_K212_Y0.5501.00
78_S81_L0.5491.00
55_S292_I0.5481.00
210_I215_V0.5481.00
56_L83_L0.5471.00
147_F151_V0.5461.00
133_N137_L0.5461.00
257_V260_E0.5421.00
110_T252_A0.5421.00
151_V155_M0.5401.00
242_I245_S0.5401.00
57_A79_I0.5401.00
25_M28_G0.5391.00
122_W233_I0.5381.00
94_L273_V0.5361.00
245_S248_V0.5351.00
36_P40_L0.5351.00
191_I259_P0.5271.00
251_P254_G0.5271.00
109_S192_V0.5231.00
94_L268_I0.5221.00
130_S134_I0.5211.00
142_P197_P0.5201.00
80_T83_L0.5181.00
92_D286_V0.5161.00
158_L181_L0.5161.00
138_L142_P0.5151.00
259_P263_G0.5141.00
181_L186_A0.5141.00
101_Q269_M0.5141.00
104_Q188_Y0.5131.00
137_L141_L0.5121.00
114_L119_P0.5121.00
282_R286_V0.5111.00
230_F233_I0.5101.00
244_G248_V0.5091.00
80_T84_G0.5091.00
120_L123_A0.5081.00
90_T293_I0.5071.00
184_N188_Y0.5061.00
124_V129_P0.5051.00
42_L46_L0.5041.00
272_R275_W0.5031.00
191_I194_A0.5021.00
34_A37_Y0.5011.00
127_S132_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2onkC 2 0.795 100 0.333 Contact Map
3d31C 2 0.7823 100 0.355 Contact Map
4tquM 1 0.8612 100 0.359 Contact Map
3rlfG 1 0.8454 100 0.409 Contact Map
3rlfF 1 0.9148 100 0.416 Contact Map
4tquN 1 0.8423 100 0.417 Contact Map
4ymuD 2 0.6782 100 0.54 Contact Map
3tuiA 2 0.6593 99.9 0.566 Contact Map
2kogA 1 0.1703 16.5 0.951 Contact Map
1pw4A 1 0.6688 12.9 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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