GREMLIN Database
POTG - Putrescine transport ATP-binding protein PotG
UniProt: P31134 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11630
Length: 377 (299)
Sequences: 10801 (8834)
Seq/√Len: 510.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_N37_D4.9011.00
232_G236_E4.1941.00
46_E219_R4.1251.00
23_R75_Q4.0181.00
21_E41_T3.9611.00
49_A217_A3.6831.00
33_H36_D3.5311.00
22_I25_L3.2001.00
214_M235_E3.0571.00
26_T73_A2.9611.00
233_E236_E2.8241.00
36_D227_K2.8031.00
135_G140_Q2.7401.00
27_K64_M2.6591.00
62_L206_V2.6541.00
25_L71_P2.6301.00
43_Y46_E2.4181.00
48_F221_A2.4071.00
26_T37_D2.4021.00
24_N39_S2.3591.00
109_E113_A2.3391.00
106_M114_F2.3261.00
21_E77_M2.3061.00
28_S33_H2.2491.00
22_I40_L2.1831.00
27_K72_S2.1091.00
127_A131_N2.0861.00
23_R77_M2.0181.00
26_T33_H1.9561.00
64_M71_P1.9251.00
122_P125_E1.9211.00
62_L172_L1.8891.00
105_H148_H1.8831.00
28_S72_S1.8661.00
79_D169_K1.8391.00
42_I48_F1.8151.00
27_K69_E1.7911.00
64_M76_I1.7911.00
35_V64_M1.7381.00
133_M165_A1.7001.00
320_V323_I1.6951.00
63_R69_E1.6531.00
142_F145_R1.6391.00
109_E144_K1.6271.00
319_E322_H1.6061.00
283_A287_V1.5851.00
63_R68_F1.5461.00
66_A172_L1.5381.00
129_R132_E1.5151.00
312_G315_F1.4941.00
173_L203_C1.4821.00
40_L221_A1.4641.00
128_S132_E1.4431.00
121_L124_A1.4411.00
322_H325_Y1.4371.00
35_V38_V1.4231.00
92_P169_K1.4171.00
313_C319_E1.3971.00
103_F106_M1.3791.00
222_I237_I1.3771.00
288_V291_V1.3721.00
229_V243_T1.3651.00
224_N229_V1.3551.00
253_V256_F1.3381.00
94_N168_P1.3381.00
26_T36_D1.3381.00
193_V215_T1.3341.00
312_G320_V1.3241.00
49_A213_A1.3201.00
20_L170_L1.3081.00
109_E127_A1.3071.00
138_H187_R1.2851.00
106_M110_Q1.2741.00
23_R39_S1.2731.00
295_V298_R1.2711.00
314_N317_V1.2691.00
272_S275_L1.2631.00
129_R167_R1.2611.00
235_E239_E1.2561.00
65_L204_V1.2471.00
281_V284_D1.2411.00
131_N135_G1.2401.00
145_R149_Q1.2331.00
111_N162_R1.2301.00
134_L143_A1.2291.00
275_L279_L1.2281.00
71_P76_I1.2281.00
305_C308_P1.2251.00
221_A228_F1.2211.00
221_A231_I1.2191.00
107_T110_Q1.2121.00
125_E128_S1.2021.00
124_A128_S1.1911.00
110_Q113_A1.1821.00
24_N73_A1.1781.00
323_I326_L1.1751.00
38_V61_L1.1621.00
146_K149_Q1.1581.00
284_D288_V1.1521.00
51_L222_I1.1521.00
109_E131_N1.1511.00
300_E304_L1.1491.00
28_S73_A1.1461.00
35_V61_L1.1421.00
267_G270_L1.1341.00
269_V272_S1.1281.00
284_D287_V1.1191.00
275_L278_P1.1181.00
286_S290_N1.1181.00
131_N139_M1.1181.00
305_C309_P1.1111.00
312_G319_E1.1101.00
300_E303_M1.1091.00
292_P296_A1.1091.00
268_L272_S1.1071.00
318_G321_I1.1041.00
94_N163_S1.0961.00
228_F231_I1.0931.00
311_N314_N1.0921.00
22_I65_L1.0891.00
29_Y34_A1.0821.00
297_L300_E1.0811.00
315_F318_G1.0751.00
115_G162_R1.0741.00
22_I76_I1.0611.00
270_L273_P1.0571.00
207_T213_A1.0531.00
45_G202_T1.0471.00
42_I202_T1.0471.00
195_I201_V1.0421.00
25_L64_M1.0401.00
205_M217_A1.0371.00
46_E218_G1.0371.00
278_P281_V1.0351.00
283_A290_N1.0341.00
272_S276_V1.0291.00
299_P303_M1.0281.00
282_D286_S1.0271.00
132_E135_G1.0241.00
19_L44_K1.0151.00
53_A56_C1.0101.00
298_R302_I1.0091.00
22_I61_L1.0081.00
147_P158_V1.0081.00
271_D275_L1.0011.00
131_N143_A1.0011.00
290_N297_L1.0001.00
113_A117_K1.0001.00
48_F204_V0.9991.00
313_C317_V0.9991.00
28_S34_A0.9961.00
125_E129_R0.9941.00
192_V203_C0.9921.00
167_R201_V0.9891.00
25_L76_I0.9881.00
48_F219_R0.9821.00
285_A288_V0.9821.00
273_P276_V0.9821.00
108_V150_L0.9751.00
319_E323_I0.9701.00
28_S31_G0.9691.00
185_R209_D0.9691.00
106_M111_N0.9671.00
277_H280_K0.9661.00
304_L307_E0.9651.00
306_E310_A0.9561.00
311_N317_V0.9551.00
324_A327_G0.9501.00
123_K126_I0.9501.00
113_A130_V0.9481.00
160_L173_L0.9401.00
323_I327_G0.9381.00
301_K304_L0.9341.00
299_P306_E0.9321.00
315_F319_E0.9321.00
313_C323_I0.9311.00
20_L78_L0.9301.00
320_V326_L0.9271.00
137_V161_A0.9251.00
287_V291_V0.9211.00
96_M156_Q0.9171.00
303_M306_E0.9161.00
317_V320_V0.9141.00
287_V290_N0.9131.00
102_L111_N0.9101.00
96_M163_S0.9101.00
320_V327_G0.9091.00
266_D270_L0.9071.00
270_L274_G0.9061.00
213_A217_A0.9021.00
317_V323_I0.9021.00
313_C316_A0.9011.00
224_N227_K0.9001.00
236_E240_H0.8921.00
253_V258_G0.8901.00
248_E252_S0.8881.00
314_N318_G0.8861.00
270_L275_L0.8821.00
182_K186_D0.8771.00
278_P282_D0.8751.00
309_P313_C0.8721.00
274_G277_H0.8721.00
238_Y241_P0.8711.00
109_E130_V0.8571.00
114_F118_Q0.8551.00
18_P77_M0.8541.00
61_L223_M0.8541.00
253_V257_E0.8501.00
171_L201_V0.8501.00
268_L273_P0.8481.00
280_K283_A0.8471.00
126_I130_V0.8471.00
317_V321_I0.8421.00
219_R230_Q0.8411.00
111_N147_P0.8411.00
313_C320_V0.8391.00
121_L125_E0.8381.00
249_F252_S0.8381.00
30_D33_H0.8351.00
112_I165_A0.8351.00
109_E143_A0.8321.00
132_E136_L0.8261.00
19_L41_T0.8211.00
43_Y219_R0.8211.00
285_A289_D0.8191.00
282_D285_A0.8181.00
314_N319_E0.8171.00
104_P148_H0.8171.00
311_N319_E0.8141.00
279_L286_S0.8141.00
219_R231_I0.8121.00
251_G254_N0.8111.00
107_T146_K0.8111.00
66_A95_M0.8101.00
193_V216_M0.8101.00
27_K60_T0.8091.00
250_I253_V0.8071.00
279_L283_A0.8061.00
56_C223_M0.8051.00
316_A320_V0.8021.00
289_D293_V0.7941.00
123_K127_A0.7921.00
293_V296_A0.7921.00
246_S249_F0.7911.00
112_I115_G0.7901.00
247_A251_G0.7901.00
45_G200_G0.7901.00
302_I305_C0.7851.00
293_V297_L0.7801.00
309_P312_G0.7801.00
316_A319_E0.7781.00
310_A313_C0.7771.00
265_E268_L0.7771.00
288_V292_P0.7761.00
290_N293_V0.7741.00
281_V285_A0.7711.00
283_A288_V0.7691.00
279_L287_V0.7681.00
244_R248_E0.7661.00
279_L282_D0.7641.00
103_F111_N0.7621.00
47_I203_C0.7611.00
271_D276_V0.7581.00
290_N294_H0.7571.00
21_E80_G0.7541.00
308_P311_N0.7521.00
17_T44_K0.7501.00
247_A250_I0.7491.00
269_V273_P0.7481.00
294_H298_R0.7471.00
246_S250_I0.7471.00
172_L204_V0.7451.00
322_H326_L0.7441.00
319_E326_L0.7411.00
301_K305_C0.7411.00
321_I325_Y0.7401.00
29_Y60_T0.7371.00
50_L221_A0.7361.00
81_V169_K0.7361.00
286_S289_D0.7361.00
301_K307_E0.7301.00
280_K284_D0.7211.00
18_P21_E0.7211.00
273_P277_H0.7191.00
280_K285_A0.7181.00
50_L223_M0.7141.00
190_L194_D0.7131.00
286_S293_V0.7121.00
283_A286_S0.7111.00
318_G322_H0.7111.00
27_K35_V0.7071.00
115_G166_K0.7071.00
121_L126_I0.7051.00
133_M161_A0.7021.00
313_C327_G0.7001.00
291_V295_V0.6971.00
291_V294_H0.6961.00
108_V158_V0.6951.00
64_M72_S0.6941.00
264_Q270_L0.6921.00
268_L271_D0.6891.00
116_L120_K0.6881.00
276_V280_K0.6881.00
311_N315_F0.6871.00
133_M136_L0.6841.00
227_K231_I0.6841.00
304_L308_P0.6821.00
234_P238_Y0.6811.00
169_K201_V0.6791.00
105_H146_K0.6751.00
44_K169_K0.6701.00
48_F231_I0.6671.00
296_A299_P0.6661.00
254_N258_G0.6651.00
253_V260_L0.6651.00
307_E310_A0.6621.00
281_V288_V0.6611.00
276_V283_A0.6601.00
94_N203_C0.6591.00
44_K79_D0.6581.00
295_V300_E0.6561.00
297_L304_L0.6511.00
297_L302_I0.6511.00
281_V286_S0.6501.00
111_N114_F0.6501.00
319_E327_G0.6491.00
40_L231_I0.6491.00
205_M213_A0.6491.00
222_I241_P0.6471.00
293_V300_E0.6451.00
296_A300_E0.6431.00
287_V294_H0.6421.00
299_P302_I0.6401.00
189_Q215_T0.6401.00
308_P312_G0.6391.00
114_F117_K0.6381.00
47_I216_M0.6341.00
264_Q268_L0.6321.00
315_F320_V0.6311.00
270_L276_V0.6311.00
276_V279_L0.6291.00
311_N316_A0.6291.00
295_V299_P0.6291.00
240_H243_T0.6271.00
271_D274_G0.6241.00
248_E255_V0.6231.00
312_G317_V0.6221.00
275_L280_K0.6221.00
304_L309_P0.6201.00
205_M216_M0.6201.00
17_T43_Y0.6191.00
283_A297_L0.6151.00
271_D277_H0.6131.00
312_G316_A0.6121.00
298_R304_L0.6111.00
266_D269_V0.6061.00
211_E215_T0.6051.00
270_L277_H0.6020.99
220_I234_P0.6020.99
157_R180_L0.6010.99
297_L301_K0.6010.99
289_D296_A0.6000.99
68_F97_F0.5990.99
122_P126_I0.5980.99
109_E112_I0.5970.99
266_D271_D0.5970.99
290_N299_P0.5940.99
217_A220_I0.5940.99
298_R301_K0.5920.99
182_K189_Q0.5900.99
292_P297_L0.5900.99
207_T212_E0.5890.99
288_V293_V0.5860.99
42_I204_V0.5830.99
110_Q117_K0.5790.99
126_I131_N0.5780.99
256_F260_L0.5780.99
290_N295_V0.5740.99
284_D289_D0.5700.99
117_K123_K0.5680.99
104_P155_R0.5650.99
238_Y242_T0.5650.99
28_S32_Q0.5630.99
168_P171_L0.5630.99
317_V322_H0.5600.99
50_L204_V0.5590.99
241_P244_R0.5570.99
318_G327_G0.5550.99
277_H283_A0.5530.99
111_N116_L0.5530.99
77_M80_G0.5520.99
241_P245_Y0.5510.99
257_E260_L0.5480.99
175_E208_H0.5460.99
108_V114_F0.5460.99
300_E305_C0.5430.99
312_G323_I0.5420.99
289_D292_P0.5410.99
272_S277_H0.5410.99
283_A289_D0.5400.99
304_L310_A0.5390.99
223_M228_F0.5390.99
290_N298_R0.5380.99
244_R247_A0.5370.99
279_L285_A0.5360.99
248_E251_G0.5360.99
284_D290_N0.5350.99
267_G271_D0.5340.99
288_V295_V0.5340.99
206_V209_D0.5330.99
269_V274_G0.5310.99
283_A291_V0.5300.99
319_E325_Y0.5280.99
285_A290_N0.5280.99
301_K306_E0.5270.99
297_L305_C0.5250.99
239_E242_T0.5250.99
294_H297_L0.5250.99
277_H282_D0.5240.99
252_S255_V0.5230.99
178_G189_Q0.5230.99
271_D280_K0.5220.99
37_D73_A0.5210.99
314_N320_V0.5200.99
69_E72_S0.5190.98
47_I205_M0.5180.98
152_G157_R0.5170.98
302_I306_E0.5160.98
292_P306_E0.5160.98
19_L43_Y0.5150.98
205_M212_E0.5150.98
263_R266_D0.5120.98
94_N166_K0.5110.98
94_N98_Q0.5110.98
254_N257_E0.5100.98
310_A314_N0.5090.98
273_P280_K0.5080.98
173_L205_M0.5070.98
49_A216_M0.5060.98
293_V301_K0.5060.98
186_D252_S0.5050.98
290_N302_I0.5040.98
110_Q144_K0.5040.98
265_E269_V0.5030.98
180_L188_M0.5020.98
280_K287_V0.5010.98
134_L139_M0.5010.98
102_L147_P0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2it1A 1 0.9257 100 0.254 Contact Map
1v43A 2 0.9098 100 0.256 Contact Map
3rlfA 2 0.9337 100 0.26 Contact Map
2yyzA 1 0.9231 100 0.26 Contact Map
3d31A 2 0.9204 100 0.261 Contact Map
1oxxK 1 0.9072 100 0.262 Contact Map
1g291 4 0.939 100 0.264 Contact Map
3fvqA 2 0.9151 100 0.272 Contact Map
1z47A 2 0.9125 100 0.273 Contact Map
4ry2A 2 0.6393 100 0.291 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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