GREMLIN Database
YDEJ - Protein YdeJ
UniProt: P31131 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11645
Length: 172 (152)
Sequences: 4599 (3555)
Seq/√Len: 288.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_S59_F2.7501.00
33_L109_V2.7291.00
94_A114_T2.6061.00
79_S96_E2.5411.00
73_M80_Q2.3041.00
82_S96_E2.2901.00
29_I58_K2.1991.00
46_L113_I2.1951.00
132_W145_V2.1291.00
36_T107_A2.0791.00
82_S93_V2.0451.00
80_Q84_E1.9991.00
91_E95_A1.9541.00
43_G51_C1.9351.00
48_S52_A1.8651.00
86_Y92_K1.8331.00
95_A143_T1.8231.00
102_I136_H1.7981.00
45_K160_V1.7861.00
132_W143_T1.7331.00
49_A160_V1.6851.00
47_A60_Y1.6791.00
62_A105_A1.6771.00
62_A74_K1.6401.00
33_L108_D1.6081.00
66_T97_M1.5701.00
45_K48_S1.5101.00
135_W166_Q1.4931.00
83_L88_A1.4891.00
101_A110_S1.4461.00
69_D88_A1.4361.00
62_A71_A1.4321.00
48_S156_L1.4291.00
38_A76_L1.4141.00
99_T141_N1.4101.00
165_A169_Q1.3851.00
52_A156_L1.3831.00
79_S82_S1.3801.00
91_E132_W1.3751.00
95_A99_T1.3741.00
47_A65_V1.3621.00
75_I104_R1.3611.00
37_T46_L1.3531.00
34_R61_G1.3531.00
54_E120_E1.3481.00
109_V137_I1.3241.00
133_F146_M1.3201.00
21_T49_A1.3111.00
151_D154_T1.3091.00
102_I138_K1.3071.00
116_Y126_T1.2991.00
61_G70_Q1.2741.00
35_L50_L1.2511.00
130_T145_V1.2421.00
46_L163_A1.2351.00
38_A101_A1.2301.00
50_L60_Y1.2251.00
45_K156_L1.2211.00
98_A136_H1.2181.00
27_R168_L1.2061.00
130_T147_H1.2061.00
25_S53_A1.2031.00
81_Q85_R1.1431.00
146_M162_F1.1421.00
66_T71_A1.1371.00
23_A168_L1.1321.00
74_K106_D1.1131.00
86_Y90_S1.1111.00
27_R31_D1.1071.00
144_A166_Q1.1061.00
165_A168_L1.1041.00
28_L33_L1.1031.00
71_A105_A1.1001.00
61_G107_A1.0981.00
22_S26_Q1.0981.00
108_D138_K1.0971.00
64_F101_A1.0861.00
142_Y170_L1.0781.00
150_G155_V1.0771.00
36_T101_A1.0741.00
162_F165_A1.0681.00
37_T60_Y1.0531.00
148_F162_F1.0391.00
116_Y121_G1.0331.00
109_V167_L1.0271.00
64_F105_A1.0141.00
51_C60_Y1.0121.00
112_A134_A1.0011.00
136_H141_N0.9981.00
48_S160_V0.9941.00
144_A162_F0.9911.00
24_L168_L0.9791.00
77_S104_R0.9751.00
113_I159_A0.9731.00
35_L167_L0.9721.00
133_F162_F0.9711.00
113_I163_A0.9611.00
135_W170_L0.9561.00
37_T63_G0.9561.00
24_L167_L0.9551.00
78_V100_G0.9531.00
34_R108_D0.9431.00
47_A63_G0.9261.00
27_R30_A0.9191.00
26_Q29_I0.9061.00
25_S50_L0.9041.00
37_T47_A0.9011.00
137_I140_Q0.9011.00
91_E145_V0.8771.00
87_S126_T0.8741.00
102_I110_S0.8691.00
111_I167_L0.8661.00
21_T53_A0.8661.00
58_K120_E0.8531.00
19_N22_S0.8501.00
153_E156_L0.8501.00
18_E22_S0.8471.00
51_C56_T0.8411.00
41_C113_I0.8301.00
150_G154_T0.8291.00
64_F75_I0.8211.00
95_A141_N0.8121.00
36_T105_A0.8101.00
73_M83_L0.8050.99
131_V159_A0.8030.99
25_S29_I0.7990.99
21_T52_A0.7930.99
61_G68_T0.7910.99
98_A134_A0.7860.99
154_T158_L0.7850.99
126_T130_T0.7850.99
25_S56_T0.7850.99
70_Q74_K0.7820.99
37_T111_I0.7760.99
45_K49_A0.7760.99
24_L164_L0.7710.99
41_C131_V0.7670.99
51_C156_L0.7650.99
26_Q30_A0.7590.99
102_I137_I0.7580.99
52_A153_E0.7500.99
76_L97_M0.7490.99
21_T25_S0.7470.99
78_V93_V0.7360.99
55_D152_C0.7330.99
111_I163_A0.7310.99
28_L109_V0.7290.99
62_A75_I0.7280.99
121_G127_P0.7220.99
49_A52_A0.7170.99
128_A155_V0.7160.99
33_L137_I0.7160.99
46_L160_V0.7080.99
82_S92_K0.7080.99
99_T136_H0.7070.99
25_S28_L0.7030.99
69_D123_E0.7010.99
166_Q170_L0.6930.98
131_V155_V0.6920.98
91_E143_T0.6920.98
101_A105_A0.6880.98
149_A158_L0.6860.98
18_E26_Q0.6830.98
153_E157_A0.6740.98
99_T103_E0.6730.98
150_G158_L0.6720.98
98_A110_S0.6680.98
20_L168_L0.6670.98
28_L35_L0.6640.98
78_V82_S0.6630.98
162_F166_Q0.6630.98
23_A26_Q0.6620.98
155_V159_A0.6580.98
99_T102_I0.6570.98
74_K104_R0.6440.98
134_A143_T0.6390.97
121_G125_G0.6350.97
49_A161_R0.6340.97
20_L24_L0.6280.97
69_D87_S0.6280.97
90_S93_V0.6250.97
82_S86_Y0.6220.97
116_Y123_E0.6120.97
71_A75_I0.6040.96
64_F104_R0.6000.96
68_T87_S0.5990.96
157_A161_R0.5960.96
23_A27_R0.5950.96
56_T59_F0.5920.96
120_E123_E0.5870.96
49_A157_A0.5870.96
98_A143_T0.5860.96
34_R107_A0.5830.96
88_A126_T0.5770.95
18_E23_A0.5730.95
64_F71_A0.5700.95
137_I170_L0.5650.95
94_A112_A0.5630.95
121_G128_A0.5620.95
64_F76_L0.5610.95
29_I59_F0.5610.95
96_E100_G0.5590.94
133_F163_A0.5590.94
37_T50_L0.5580.94
82_S90_S0.5560.94
48_S153_E0.5550.94
94_A132_W0.5520.94
98_A102_I0.5520.94
120_E128_A0.5500.94
45_K153_E0.5410.93
83_L93_V0.5390.93
46_L50_L0.5380.93
158_L161_R0.5380.93
50_L53_A0.5350.93
70_Q106_D0.5350.93
97_M112_A0.5350.93
87_S116_Y0.5330.93
41_C121_G0.5310.93
66_T76_L0.5250.92
92_K96_E0.5200.92
144_A169_Q0.5200.92
158_L165_A0.5110.91
161_R165_A0.5090.91
45_K157_A0.5090.91
109_V138_K0.5070.91
24_L50_L0.5070.91
149_A155_V0.5060.91
121_G124_D0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uuwA 2 0.9593 100 0.12 Contact Map
2a9sA 2 0.9477 100 0.126 Contact Map
3wvaA 2 0.75 97.5 0.856 Contact Map
3zdoA 3 0.2616 12.6 0.951 Contact Map
2oarA 7 0.186 10.9 0.953 Contact Map
4mt1A 3 0.8372 9 0.954 Contact Map
3h2tA 2 0.4012 8.9 0.954 Contact Map
4kyzA 1 0.5174 8.1 0.955 Contact Map
2i1qA 1 0.8081 7.7 0.956 Contact Map
3o9xA 2 0.4593 7 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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